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41 条记录 (耗时 0.047 秒)

    Imidazo[4,5-d]pyrimidines, their uses and methods of preparation
    3.
    发明申请
    Imidazo[4,5-d]pyrimidines, their uses and methods of preparation 有权
    咪唑并[4,5-d]嘧啶，其用途和制备方法

    公开(公告)号：US20060052602A1

    公开(公告)日：2006-03-09

    申请号：US11190751

    申请日：2005-07-26

    申请人： Choung Kim ,  Johan Neyts ,  David Oare ,  Gerhard Puerstinger

    发明人： Choung Kim ,  Johan Neyts ,  David Oare ,  Gerhard Puerstinger

    IPC分类号： C07D473/02

    CPC分类号： C07D471/04 ,  C07D473/00 ,  C07D473/30

    摘要： The present invention relates to pharmaceutical compositions for the treatment or prevention of viral infections comprising as an active principle at least one imidazo[4,5-c]pyrimidine having the general formula (A): wherein the substituents are described in the specification. The invention also relates to processes for the preparation of compounds according to the invention having above mentioned general formula, their pharmaceutically acceptable formulations and their use as a medicine or to treat or prevent viral infections.

    摘要翻译： 本发明涉及用于治疗或预防病毒感染的药物组合物，其包含作为活性成分的至少一种具有通式（A）的咪唑并[4,5-c]嘧啶：

    Viral inhibitors
    5.
    发明申请
    Viral inhibitors 有权
    病毒抑制剂

    公开(公告)号：US20050239821A1

    公开(公告)日：2005-10-27

    申请号：US10519756

    申请日：2003-07-03

    申请人： Johan Neyts ,  Gerhard Purstinger ,  Erik De Clercq

    发明人： Johan Neyts ,  Gerhard Purstinger ,  Erik De Clercq

    IPC分类号： G01N33/50 ,  A61K31/437 ,  A61K31/444 ,  A61K31/7056 ,  A61K38/21 ,  A61K45/00 ,  A61P31/12 ,  A61P43/00 ,  C07D471/04 ,  G01N33/15 ,  A61K31/4745

    CPC分类号： C07D471/04

    摘要： The present invention relates to a pharmaceutical composition for the treatment or prevention of viral infections comprising as an active principle at least one imidazo[4,5-c]pyridine derivative having the general formula (Z): (formula). The invention also relates to processes for the preparation of compounds according to the invention having above mentioned general formula and their use as a medicine or to treat or prevent viral infections.

    摘要翻译： 本发明涉及用于治疗或预防病毒感染的药物组合物，其包含具有通式（Z）：（式）的至少一种咪唑并[4,5-c]吡啶衍生物作为活性成分。 本发明还涉及制备具有上述通式的本发明化合物及其用作药物或治疗或预防病毒感染的方法。

    Nucleoside aryl phosphoramidates and their use as anti-viral agents for the treatment of hepatitis C virus
    10.
    发明授权
    Nucleoside aryl phosphoramidates and their use as anti-viral agents for the treatment of hepatitis C virus 失效
    核苷芳基氨基磷酸酯及其作为抗病毒药物用于治疗丙型肝炎病毒的用途

    公开(公告)号：US08658616B2

    公开(公告)日：2014-02-25

    申请号：US12516253

    申请日：2007-11-23

    申请人： Christopher McGuigan ,  Plinio Perrone ,  Johan Neyts

    发明人： Christopher McGuigan ,  Plinio Perrone ,  Johan Neyts

    IPC分类号： A61K31/70 ,  A01N43/04 ,  C07H19/167 ,  C07H19/173

    CPC分类号： C07H19/20

    摘要： Compounds having the general formula (I): are provided which have enhanced inhibitory potency and are thus useful in methods of prophylaxis or treatment of a viral infection such as hepatitis C virus. The compounds are phosphoramidate derivatives of nucleoside compounds derived from bases such as adenine and guanine. The glycoside moiety of the nucleoside compound can be substituted at the ss-2′ position with methyl and the phosphoramidate group can be 1-naphthyl linked by —O— to the P atom. These compounds can be administered as pharmaceutical compositions, and methods for their preparation are also provided.

    摘要翻译： 提供具有通式（I）的化合物，其具有增强的抑制效力，因此可用于预防或治疗病毒感染如丙型肝炎病毒的方法。 这些化合物是衍生自诸如腺嘌呤和鸟嘌呤的碱的核苷化合物的氨基磷酸衍生物。 核苷化合物的糖苷部分可以在β-2'位被甲基取代，氨基磷酸酯基可以通过-O-连接到P原子上的1-萘基。 这些化合物可以作为药物组合物施用，并且还提供了它们的制备方法。