Patent search ap:"David A. Oare" Page 1

1.

发明申请
IMIDAZO[4,5-c]PYRIDINE COMPOUNDS AND METHODS OF ANTIVIRAL TREATMENT 有权
Title translation: 咪唑并[4,5-c]吡啶化合物和抗病毒治疗方法

公开(公告)号：US20100028301A1

公开(公告)日：2010-02-04

申请号：US12577865

申请日：2009-10-13

Applicant: Steven S. Bondy , Eric Davis Dowdy , Choung U. Kim , David A. Oare , Johan Neyts , Vahid Zia , Gerhard Pürstinger

Inventor： Steven S. Bondy , Eric Davis Dowdy , Choung U. Kim , David A. Oare , Johan Neyts , Vahid Zia , Gerhard Pürstinger

IPC: A61K31/437 , C07D471/04 , A61P3/12 , A61K38/21 , A61K31/708

CPC classification number: C07D471/04

Abstract: The present invention relates to pharmaceutical compositions for the treatment or prevention of viral infections comprising as an active principle at least one imidazo[4,5-c]pyridine prodrug having the general Formula (A) wherein the substituents are described in the specification. The invention also relates to processes for the preparation and screening of compounds according to the invention having above mentioned general Formula and their use in the treatment or prophylaxis of viral infections.

Abstract translation: 本发明涉及用于治疗或预防病毒感染的药物组合物，其包含作为活性成分的至少一种具有通式（A）的咪唑并[4,5-c]吡啶前药，其中取代基在说明书中描述。本发明还涉及制备和筛选具有上述通式的本发明化合物及其在治疗或预防病毒感染中的用途的方法。

2.

发明授权
Therapeutic phosphonate compounds 有权
Title translation: 治疗性膦酸酯化合物

公开(公告)号：US07645747B2

公开(公告)日：2010-01-12

申请号：US11258621

申请日：2005-10-25

Applicant: Constantine G. Boojamra , Carina E. Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Manoj Desai , Maria Fardis , Craig S. Gibbs , Ralph F. Hirschmann , Alan X. Huang , Haolun Jin , Choung U. Kim , Thorsten A. Kirschberg , Steven Krawczyk , Christopher P. Lee , William A. Lee , Kuei-Ying Lin , Richard L. Mackman , David Y. Markevitch , Peter H. Nelson , David A. Oare , Vidya K. Prasad , Hyung-Jung Pyun , Adrian S. Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang , Lijun Zhang

Inventor： Constantine G. Boojamra , Carina E. Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Manoj Desai , Maria Fardis , Craig S. Gibbs , Ralph F. Hirschmann , Alan X. Huang , Haolun Jin , Choung U. Kim , Thorsten A. Kirschberg , Steven Krawczyk , Christopher P. Lee , William A. Lee , Kuei-Ying Lin , Richard L. Mackman , David Y. Markevitch , Peter H. Nelson , David A. Oare , Vidya K. Prasad , Hyung-Jung Pyun , Adrian S. Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang , Lijun Zhang

IPC: A61K31/661 , A61K31/662 , C07F9/06 , C07F9/28

CPC classification number: C07F9/65616 , C07F9/4006 , C07F9/4465 , C07F9/5304 , C07F9/650952 , C07F9/653 , C07F9/65507 , C07F9/65515 , C07F9/65517 , C07F9/65583 , C07F9/65586 , C07F9/6561

Abstract: The invention is related to phosphorus substituted therapeutic agents, compositions containing such phosphorus substituted agents, and therapeutic methods that include the administration of such phosphorus substituted agents, as well as to processes and intermediates useful for preparing such agents.

Abstract translation: 本发明涉及磷取代的治疗剂，含有这种磷取代剂的组合物，以及包括施用这种磷取代剂的治疗方法，以及可用于制备这种药剂的方法和中间体。

3.

发明授权
Antiviral phosphonate analogs 有权
Title translation: 抗病毒膦酸酯类似物

公开(公告)号：US07429565B2

公开(公告)日：2008-09-30

申请号：US10832815

申请日：2004-04-26

Applicant: Constantine G. Boojamra , Carina Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Maria Fardis , Haolun Jin , Ralph F. Hirschmann , Alan X. Huang , Choung U. Kim , Thorsten Kirschberg , Christopher P. Lee , William A. Lee , Richard L. Mackman , David Y. Markevitch , David A. Oare , Vidya K. Prasad , Hyung-Jung Pyun , Adrian S. Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang

Inventor： Constantine G. Boojamra , Carina Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Maria Fardis , Haolun Jin , Ralph F. Hirschmann , Alan X. Huang , Choung U. Kim , Thorsten Kirschberg , Christopher P. Lee , William A. Lee , Richard L. Mackman , David Y. Markevitch , David A. Oare , Vidya K. Prasad , Hyung-Jung Pyun , Adrian S. Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang

IPC: A61K38/00 , C07D267/22

CPC classification number: C07F9/65616 , A61K31/662 , A61K31/7072 , A61K31/7076 , A61K47/548 , C07D205/04 , C07D211/58 , C07D409/06 , C07D409/14 , C07D413/14 , C07D475/00 , C07F9/4075 , C07F9/5728 , C07F9/58 , C07F9/60 , C07F9/65031 , C07F9/650905 , C07F9/653 , C07F9/6539 , C07F9/65515 , C07F9/655354 , C07F9/6561 , C07H15/00 , C07H17/00 , C07H19/056 , C07H19/10 , C07H19/20 , C07H21/00 , Y02A50/393 , Y02A50/465

Abstract: The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Abstract translation: 本发明涉及具有抗病毒活性的磷取代的化合物，含有这些化合物的组合物和包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。

4.

发明授权
Pyridazine compound and use thereof 失效
Title translation: 哒嗪化合物及其用途

公开(公告)号：US08569487B2

公开(公告)日：2013-10-29

申请号：US12303207

申请日：2007-07-06

Applicant: Steven S. Bondy , Terrence C. Dahl , David A. Oare , Reza Oliyai , Winston C. Tse , Vahid Zia

Inventor： Steven S. Bondy , Terrence C. Dahl , David A. Oare , Reza Oliyai , Winston C. Tse , Vahid Zia

IPC: C07D237/08

CPC classification number: C07D403/14

Abstract: A compound of formula (1) and its salts and solvates are provided for the treatment or prophylaxis of hepatitis C virus infections. Methods of making and formulating compound (1) are provided.

Abstract translation: 提供式（1）化合物及其盐和溶剂合物用于治疗或预防丙型肝炎病毒感染。提供制备和配制化合物（1）的方法。

5.

发明申请
NOVEL PYRIDAZINE COMPOUND AND USE THEREOF 有权
Title translation: 新颖的吡啶化合物及其用途

公开(公告)号：US20100152444A1

公开(公告)日：2010-06-17

申请号：US12708119

申请日：2010-02-18

Applicant: Steven S. Bondy , Terrenc C. Dahl , David A. Oare , Reza Oliyai , Winston C. Tse , Vahid Zia

Inventor： Steven S. Bondy , Terrenc C. Dahl , David A. Oare , Reza Oliyai , Winston C. Tse , Vahid Zia

IPC: C07D471/04 , C07D237/08

CPC classification number: C07D403/14

Abstract: A compound of formula (1) and its salts and solvates are provided for the treatment or prophylaxis of hepatitis C virus infections Methods of making and formulating compound (1) are provided.

Abstract translation: 提供式（1）化合物及其盐和溶剂合物用于治疗或预防丙型肝炎病毒感染提供制备和配制化合物（1）的方法。

6.

发明申请
ANTI-CANCER PHOSPHONATE ANALOGS 审中-公开
Title translation: 抗癌剂磷酸酯类似物

公开(公告)号：US20100022467A1

公开(公告)日：2010-01-28

申请号：US12202719

申请日：2008-09-02

Applicant: Constantine G. Boojamra , Carina Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Maria Fardis , Alan X. Huang , Choung U. Kim , Thorsten Kirschberg , Steven Krawczyk , Christopher P. Lee , Kuei-Ying Lin , Richard L. Mackman , David Y. Markevitch , Peter H. Nelson , David A. Oare , Vidya K. Prasad , Hyung-Jung Pyun , Adrian S. Ray , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang , Lijun Zhang

Inventor： Constantine G. Boojamra , Carina Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Maria Fardis , Alan X. Huang , Choung U. Kim , Thorsten Kirschberg , Steven Krawczyk , Christopher P. Lee , Kuei-Ying Lin , Richard L. Mackman , David Y. Markevitch , Peter H. Nelson , David A. Oare , Vidya K. Prasad , Hyung-Jung Pyun , Adrian S. Ray , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang , Lijun Zhang

IPC: A61K31/7076 , C07H19/20 , A61P35/00

CPC classification number: A61K31/7076 , A61K31/675 , A61K31/7072 , A61K47/548 , C07H19/04

Abstract: The invention is related to phosphorus substituted anti-cancer compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Abstract translation: 本发明涉及磷取代的抗癌化合物，含有这些化合物的组合物和包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。

7.

发明授权
Imidazo 4,5-c pyridine compounds and methods of antiviral treatment 有权
Title translation: 咪唑4,5-C吡啶化合物和抗病毒治疗方法

公开(公告)号：US07648998B2

公开(公告)日：2010-01-19

申请号：US10583814

申请日：2004-12-21

Applicant: Steven S. Bondy , Eric Davis Dowdy , Choung U. Kim , David A. Oare , Johan Neyts , Vahid Zia , Gerhard Pürstinger

Inventor： Steven S. Bondy , Eric Davis Dowdy , Choung U. Kim , David A. Oare , Johan Neyts , Vahid Zia , Gerhard Pürstinger

IPC: C07D471/04 , A61K31/437

CPC classification number: C07D471/04

Abstract: The present invention relates to a pharmaceutical composition for the treatment or prevention of viral infections comprising as an active principle at least one imidazo[4,5-c]pyridine prodrug having the general Formula (A) wherein the substituents are described in the specification. The invention also relates to processes for the preparation and screening ofcompounds according to the invention having above mentioned general Formula and their use in the treatment or prophylaxis of viral infections.

Abstract translation: 本发明涉及用于治疗或预防病毒感染的药物组合物，其包含作为活性成分的至少一种具有通式（A）的咪唑并[4,5-c]吡啶前药，其中取代基在说明书中描述。本发明还涉及根据具有上述通式的本发明的化合物的制备和筛选方法及其在治疗或预防病毒感染中的用途。

8.

发明申请
Imidazo[4,5-d]pyrimidines, their uses and methods of preparation 审中-公开
Title translation: 咪唑并[4,5-d]嘧啶，其用途和制备方法

公开(公告)号：US20090208456A1

公开(公告)日：2009-08-20

申请号：US11658625

申请日：2005-07-26

Applicant: Gerhard Puerstinger , Choung U. Kim , Johan Neyts , David A. Oare

Inventor： Gerhard Puerstinger , Choung U. Kim , Johan Neyts , David A. Oare

IPC: A61K38/21 , C12Q1/70 , A61K31/708 , A61K31/52 , A61K31/437 , C07D473/00 , C07D471/00

CPC classification number: C07D471/04 , C07D473/00 , C07D473/30

Abstract: The present invention relates to pharmaceutical compositions for the treatment of prevention of viral infections comprising as an active principle at least one imidazo[4,5-c]pyrimidine having the general formula (A), wherein the substituents are described in the specification. The invention also relates to processes for the preparation of compounds according to the invention having above mentioned general formula, their pharmaceutically acceptable formulations and their use as a medicine or to treat or prevent viral infections.

Abstract translation: 本发明涉及用于治疗预防病毒感染的药物组合物，其包含作为活性成分的至少一种具有通式（A）的咪唑并[4,5-c]嘧啶，其中取代基在说明书中描述。本发明还涉及制备具有上述通式的本发明化合物及其药学上可接受的制剂及其作为药物的用途或用于治疗或预防病毒感染的化合物的方法。

9.

发明授权
Imidazo[4,5-c]pyridine compounds and methods of antiviral treatment 有权
Title translation: 咪唑并[4,5-c]吡啶化合物和抗病毒治疗方法

公开(公告)号：US08329727B2

公开(公告)日：2012-12-11

申请号：US12577865

申请日：2009-10-13

Applicant: Steven S. Bondy , Eric Davis Dowdy , Choung U. Kim , David A. Oare , Johan Neyts , Vahid Zia , Gerhard Pürstinger

Inventor： Steven S. Bondy , Eric Davis Dowdy , Choung U. Kim , David A. Oare , Johan Neyts , Vahid Zia , Gerhard Pürstinger

IPC: A61K31/437 , A61K38/21 , A61K31/708 , C07D471/04 , A61P3/12

CPC classification number: C07D471/04

Abstract: The present invention relates to pharmaceutical compositions for the treatment or prevention of viral infections comprising as an active principle at least one imidazo[4,5-c]pyridine prodrug having the general Formula (A) wherein the substituents are described in the specification. The invention also relates to processes for the preparation and screening of compounds according to the invention having above mentioned general Formula and their use in the treatment or prophylaxis of viral infections.

Abstract translation: 本发明涉及用于治疗或预防病毒感染的药物组合物，其包含作为活性成分的至少一种具有通式（A）的咪唑并[4,5-c]吡啶前药，其中取代基在说明书中描述。本发明还涉及制备和筛选具有上述通式的本发明化合物及其在治疗或预防病毒感染中的用途的方法。