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    Controlling hydrogen-deuterium exchange on a spectrum by spectrum basis
    1.
    发明授权
    Controlling hydrogen-deuterium exchange on a spectrum by spectrum basis 有权
    通过频谱控制氢氘交换

    公开(公告)号：US09484194B2

    公开(公告)日：2016-11-01

    申请号：US13885913

    申请日：2011-11-16

    Applicant: Jeffery Mark Brown ,  Steven Derek Pringle ,  Keith Richardson

    Inventor： Jeffery Mark Brown ,  Steven Derek Pringle ,  Keith Richardson

    IPC: H01J49/00 ,  H01J49/06 ,  H01J49/26

    CPC classification number: H01J49/0077 ,  H01J49/00 ,  H01J49/0031 ,  H01J49/0036 ,  H01J49/0054 ,  H01J49/0072 ,  H01J49/06 ,  H01J49/065 ,  H01J49/26

    Abstract: A mass spectrometer is disclosed comprising a liquid chromatography device for separating ions. A gas phase ion-neutral reaction device is arranged downstream to perform a gas phase ion-neutral reaction such as Hydrogen-Deuterium exchange. A control system is arranged to automatically and repeatedly switch the reaction device back and forth between a first mode of operation and a second mode of operation, wherein in the first mode of operation at least some parent or precursor ions are caused to react within the reaction device and wherein in the second mode of operation substantially fewer or no parent or precursor ions are caused to react.

    Abstract translation: 公开了一种质谱仪，其包括用于分离离子的液相色谱装置。 气相离子中性反应装置设置在下游以进行气相离子 - 中性反应如氢氘交换。 控制系统被布置成在第一操作模式和第二操作模式之间来回自动重复地切换反应装置，其中在第一操作模式中，使至少一些母体或前体离子在反应中反应 器件，并且其中在第二操作模式中基本上较少或没有使母体或前体离子发生反应。

    Mass spectrometer
    3.
    发明授权
    Mass spectrometer 有权
    质谱仪

    公开(公告)号：US08952320B2

    公开(公告)日：2015-02-10

    申请号：US11719665

    申请日：2005-11-18

    Applicant: Robert Harold Bateman ,  Kevin Giles ,  Steven Derek Pringle ,  Jason Lee Wildgoose

    Inventor： Robert Harold Bateman ,  Kevin Giles ,  Steven Derek Pringle ,  Jason Lee Wildgoose

    IPC: H01J49/26 ,  H01J49/42

    CPC classification number: H01J49/4215 ,  H01J49/428

    Abstract: A mass spectrometer is disclosed comprising a quadrupole rod set ion guide or mass filter device (6). A broadband frequency signal (10) having one or more notches (11a, 11b, 11c) is applied to the rods of the quadrupole rod set (6). The notched broadband frequency signal (10) causes undesired ions to be resonantly ejected from the ion guide (6). The notched broadband frequency signal (10) has frequency components missing which correspond with the resonance frequency of ions which are desired to be onwardly transmitted. The ion guide or mass filter device (6) enables a plurality of desired ions having different mass to charge ratios to be simultaneously transmitted by the ion guide or mass filter device (6) whilst other ions are resonantly ejected from the ion guide or mass filter device (6).

    Abstract translation: 公开了一种质谱仪，其包括四极杆离子导向器或质量过滤装置（6）。 具有一个或多个凹口（11a，11b，11c）的宽频率信号（10）被施加到四极杆组（6）的杆上。 有缺口的宽带频率信号（10）使不想要的离子从离子导向器（6）共振地弹出。 缺口宽带频率信号（10）具有与期望向前发射的离子的谐振频率相对应的频率分量。 离子导向器或质量过滤装置（6）使得具有不同质荷比的多个所需离子能够由离子导向器或质量过滤装置（6）同时传输，而其它离子从离子导向器或质量过滤器 装置（6）。

    Method of screening a sample for the presence of one or more known compounds of interest and a mass spectrometer performing this method
    4.
    发明授权
    Method of screening a sample for the presence of one or more known compounds of interest and a mass spectrometer performing this method 有权
    筛选样品中存在一种或多种已知的目标化合物的方法和进行该方法的质谱仪

    公开(公告)号：US08822914B2

    公开(公告)日：2014-09-02

    申请号：US13394089

    申请日：2010-09-06

    Applicant: Jeffrey Alan Goshawk ,  Steven Derek Pringle ,  Steve Smith

    Inventor： Jeffrey Alan Goshawk ,  Steven Derek Pringle ,  Steve Smith

    IPC: B01D59/44

    CPC classification number: H01J49/40 ,  H01J49/0027 ,  H01J49/004

    Abstract: A method of screening a sample for the presence of one or more known compounds of interest is disclosed. A fragmentation device is repeatedly switched between a fragmentation mode of operation and a non-fragmentation mode of operation. A determination is made whether a candidate parent ion of interest is present in a non-fragmentation data set and whether one or more corresponding fragment ions of interest are present in a fragmentation data set. A further determination is made to check if the candidate parent ion of interest and the one or more corresponding fragment ions of interest have substantially similar elution or retention times and/or ion mobility drift times.

    Abstract translation: 公开了筛选样品中存在一种或多种已知化合物的方法。 分段设备在分段操作模式和非分段操作模式之间重复切换。 确定感兴趣的候选母体离子是否存在于非碎裂数据集中，以及感兴趣的一个或多个相应的碎片离子是否存在于碎裂数据集中。 进一步确定检查感兴趣的候选亲本离子和感兴趣的一个或多个相应碎片离子是否具有基本相似的洗脱或保留时间和/或离子迁移率漂移时间。

    Gas electron multiplier detector
    7.
    发明授权
    Gas electron multiplier detector 有权
    气体电子倍增检测器

    公开(公告)号：US08294088B2

    公开(公告)日：2012-10-23

    申请号：US12745265

    申请日：2008-12-01

    Applicant: Steven Derek Pringle

    Inventor： Steven Derek Pringle

    IPC: H01J49/02

    CPC classification number: H01J49/025 ,  H01J47/02

    Abstract: A mass spectrometer is disclosed comprising a Gas Electron Multiplier ion detector. The ion detector comprises three gas electron multiplier stages GEM1, GEM2, GEM3 wherein a counter electrode (12) is arranged adjacent the first electron multiplier stage GEM1.

    Abstract translation: 公开了一种质谱仪，其包括气体电子倍增器离子检测器。 离子检测器包括三个气体电子倍增器级GEM1，GEM2，GEM3，其中相对电极（12）被布置为与第一电子倍增器级GEM1相邻。

    Mass spectrometer
    8.
    发明授权
    Mass spectrometer 有权
    质谱仪

    公开(公告)号：US08153960B2

    公开(公告)日：2012-04-10

    申请号：US11916438

    申请日：2006-06-05

    Applicant: Kevin Giles ,  Martin Green ,  Steven Derek Pringle ,  Jason Lee Wildgoose

    Inventor： Kevin Giles ,  Martin Green ,  Steven Derek Pringle ,  Jason Lee Wildgoose

    IPC: H01J49/26

    CPC classification number: H01J49/427 ,  H01J49/4235

    Abstract: An ion guide or ion trap (1) is disclosed having an entrance electrode (2) and an exit electrode (3). The potential of the exit electrode (3) is periodically dropped for a relatively short period of time allowing some ions to escape from the ion guide or ion trap (1) via an aperture in the exit electrode (3). The period of time that the potential of the exit electrode (3) is dropped for is progressively increased and ions emerge from the ion guide or ion trap (1) in a mass to charge ratio dependent manner. The ion guide or ion trap (1) may be operated as a mass separator or low resolution mass analyser.

    Abstract translation: 公开了一种具有入口电极（2）和出口电极（3）的离子导向器或离子阱（1）。 出口电极（3）的电位周期性地下降相当短的时间段，允许一些离子通过出射电极（3）中的孔从离子导向器或离子阱（1）逸出。 退出电极（3）的电位下降的时间段逐渐增加，并且离子导向器或离子阱（1）以质荷比依赖的方式出现离子。 离子导向器或离子阱（1）可以作为质量分离器或低分辨率质量分析器来操作。

    Mass spectrometer
    9.
    发明授权
    Mass spectrometer 有权
    质谱仪

    公开(公告)号：US08076637B2

    公开(公告)日：2011-12-13

    申请号：US12524378

    申请日：2008-01-25

    Applicant: Steven Derek Pringle ,  Jason Lee Wildgoose

    Inventor： Steven Derek Pringle ,  Jason Lee Wildgoose

    IPC: H01J49/42 ,  H01J49/00

    CPC classification number: H01J49/428

    Abstract: A mass spectrometer is disclosed comprising a quadrupole rod set ion guide or mass filter device. Broadband frequency-signals (13, 14, 15) having a plurality of frequency notches (16a; 16b; 16c) are applied sequentially to the rods of the quadrupole rod set. The notched broadband frequency signals (16a, 16b, 16c) cause undesired ions to be resonantly or parametrically ejected from the ion guide. The resulting ion signals are deconvoluted to provide a mass spectrum.

    Abstract translation: 公开了一种质谱仪，其包括四极棒离子导向器或质量过滤器装置。 具有多个频率切口（16a; 16b; 16c）的宽带频率信号（13,14,15）被依次施加到四极杆组的杆上。 缺口宽带频率信号（16a，16b，16c）使离子引导不需要的离子共振或参数地喷出。 所得到的离子信号被去卷积以提供质谱。

    Mass Spectrometer
    10.
    发明申请
    Mass Spectrometer 有权
    质谱仪

    公开(公告)号：US20090194688A1

    公开(公告)日：2009-08-06

    申请号：US11719665

    申请日：2005-11-18

    Applicant: Robert Harold Bateman ,  Kevin Giles ,  Steven Derek Pringle ,  Jason Lee Wildgoose

    Inventor： Robert Harold Bateman ,  Kevin Giles ,  Steven Derek Pringle ,  Jason Lee Wildgoose

    IPC: H01J49/00 ,  B01D59/44

    CPC classification number: H01J49/4215 ,  H01J49/428

    Abstract: A mass spectrometer is disclosed comprising a quadrupole rod set ion guide or mass filter device (6). A broadband frequency signal (10) having one or more notches (11a, 11b, 11c) is applied to the rods of the quadrupole rod set (6). The notched broadband frequency signal (10) causes undesired ions to be resonantly ejected from the ion guide (6). The notched broadband frequency signal (10) has frequency components missing which correspond with the resonance frequency of ions which are desired to be onwardly transmitted. The ion guide or mass filter device (6) enables a plurality of desired ions having different mass to charge ratios to be simultaneously transmitted by the ion guide or mass filter device (6) whilst other ions are resonantly ejected from the ion guide or mass filter device (6).

    Abstract translation: 公开了一种质谱仪，其包括四极杆离子导向器或质量过滤装置（6）。 具有一个或多个凹口（11a，11b，11c）的宽频率信号（10）被施加到四极杆组（6）的杆上。 有缺口的宽带频率信号（10）使不想要的离子从离子导向器（6）共振地弹出。 缺口宽带频率信号（10）具有与期望向前发射的离子的谐振频率相对应的频率分量。 离子导向器或质量过滤装置（6）使得具有不同质荷比的多个所需离子能够由离子导向器或质量过滤装置（6）同时传输，而其它离子从离子导向器或质量过滤器 装置（6）。

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