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1.发明申请Nucleic acids and corresponding proteins entitled 58P1D12 useful in treatment and detection of cancer 失效题为58P1D12的核酸和相应的蛋白质可用于治疗和检测癌症公开(公告)号：US20050136435A1
公开(公告)日：2005-06-23
申请号：US10919654
申请日：2004-08-16
申请人： Steven Kanner , Aya Jakobovits , Pia Challita-Eid , Wangmao Ge , Arthur Raitano
发明人： Steven Kanner , Aya Jakobovits , Pia Challita-Eid , Wangmao Ge , Arthur Raitano
IPC分类号： A61K38/00 , A61K39/00 , C07K14/705 , C12Q1/68 , C07H21/04 , C07K16/40 , C12N9/16 , G01N33/574
CPC分类号： C07K14/7056 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K16/30 , C07K2317/73 , C12N2799/026 , C12N2799/027 , C12Q1/6881 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/574 , G01N33/57434 , G01N2500/04
摘要： A novel gene 58P1D12 and its encoded protein, and variants thereof, are described wherein 58P1D12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 58P1D12 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 58P1D12 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 58P1D12 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因58P1D12及其编码的蛋白及其变体，其中58P1D12在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，58P1D12提供诊断，预后，预防和/ 或癌症的治疗靶标。 58P1D12基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与58P1D12反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号：US20050208039A1
公开(公告)日：2005-09-22
申请号：US10776773
申请日：2004-02-10
申请人： Aya Jakobovits , Robert Morrison , Arthur Raitano , Pia Challita-Eid , Juan Perez-Villar , Karen Morrison , Mary Faris , Wangmao Ge , Jean Gudas , Steven Kanner
发明人： Aya Jakobovits , Robert Morrison , Arthur Raitano , Pia Challita-Eid , Juan Perez-Villar , Karen Morrison , Mary Faris , Wangmao Ge , Jean Gudas , Steven Kanner
CPC分类号： C07K16/18 , A61K38/00 , A61K47/646 , A61K47/6813 , A61K51/1093 , C07K14/47 , C07K16/30 , C07K16/3038 , C07K2317/54 , C07K2317/55 , C07K2317/622 , G01N33/57484 , Y10T436/25
摘要： A novel gene (designated 158P1D7) and its encoded protein are described. While 158P1D7 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in multiple cancers including set forth in Table 1. Consequently, 158P1D7 provides a diagnostic and/or therapeutic target for cancers. The 158P1D7 gene or fragment thereof, or its encoded protein or a fragment thereof, can be used to elicit an immune response.
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3.发明申请Nucleic acids and corresponding proteins entitled 158P3D2 useful in treatment and detection of cancer 失效题为158P3D2的核酸和相应的蛋白质可用于治疗和检测癌症公开(公告)号：US20050191312A1
公开(公告)日：2005-09-01
申请号：US10994106
申请日：2004-11-19
申请人： Arthur Raitano , Aya Jakobovits , Pia Challita-Eid , Steven Kanner , Wangmao Ge , Juan Perez-Villar , Robert Morrison
发明人： Arthur Raitano , Aya Jakobovits , Pia Challita-Eid , Steven Kanner , Wangmao Ge , Juan Perez-Villar , Robert Morrison
CPC分类号： C07K14/4748 , A61K39/00 , C07K16/30
摘要： A novel gene 158P3D2 and its encoded protein, and variants thereof, are described wherein 158P3D2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 158P3D2 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 158P3D2 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 158P3D2 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因158P3D2及其编码的蛋白及其变体，其中158P3D2在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，158P3D2提供诊断，预后，预防和/ 或癌症的治疗靶标。 158P3D2基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与158P3D2反应的抗体或T细胞可用于主动或被动免疫。
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4.发明申请Nucleic acids and corresponding proteins entitled 109P1D4 useful in treatment and detection of cancer 失效称为109P1D4的核酸和相应的蛋白质可用于治疗和检测癌症公开(公告)号：US20050191311A1
公开(公告)日：2005-09-01
申请号：US10837269
申请日：2004-04-30
申请人： Arthur Raitano , Pia Challita-Eid , Wangmao Ge , Juan Perez-Villar , Steven Kanner , Aya Jakobovits
发明人： Arthur Raitano , Pia Challita-Eid , Wangmao Ge , Juan Perez-Villar , Steven Kanner , Aya Jakobovits
IPC分类号： A61K39/00 , A61K39/395
CPC分类号： C07K14/47 , A61K47/646 , A61K47/6851 , A61K47/6901 , A61K51/1045
摘要： A novel gene 109P1D4 and its encoded protein, and variants thereof, are described wherein 109P1D4 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 109P1D4 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 109P1D4 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 109P1D4 can be used in active or passive immunization.
摘要翻译： 描述了一种新颖的基因109P1D4及其编码的蛋白及其变体，其中109P1D4在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，109P1D4提供诊断，预后，预防和/ 或癌症的治疗靶标。 109P1D4基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与109P1D4反应的抗体或T细胞可用于主动或被动免疫。
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5.发明申请Nucleic acid and corresponding protein entitled 98P4B6 useful in treatment and detection of cancer 有权核酸和相应的蛋白质98P4B6可用于治疗和检测癌症公开(公告)号：US20070253900A1
公开(公告)日：2007-11-01
申请号：US11588203
申请日：2006-10-25
申请人： Arthur Raitano , Wangmao Ge , Aya Jakobovits , Pia Challita-Eid , Mary Faris
发明人： Arthur Raitano , Wangmao Ge , Aya Jakobovits , Pia Challita-Eid , Mary Faris
IPC分类号： A61K38/00 , A01K67/00 , A61K31/395 , A61K39/00 , A61K49/00 , A61K51/10 , C07H21/04 , C07K7/00 , C12Q1/68 , G01N33/574 , G01N33/567 , G01N33/53 , C12N5/12 , C07K14/00 , C07H21/02 , A61K49/16 , A61K39/44 , A61K31/7088 , A61K35/12
CPC分类号： C07K14/705 , A61K38/00 , A61K39/00 , A61K51/1045 , A61K2039/505 , C07K14/4748 , C07K16/30 , C07K16/3069 , C07K2319/00 , C07K2319/30 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/154 , C12Q2600/16 , G01N33/574
摘要： A novel gene 098P4B6 (also designated STEAP-2) and its encoded protein, and variants thereof, are described wherein 98P4B6 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table 1. Consequently, 98P4B6 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 98P4B6 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 98P4B6 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因098P4B6（也称为STEAP-2）及其编码的蛋白及其变体，其中98P4B6在正常成人组织中表现出组织特异性表达，并且在表1中列出的癌症中异常表达。因此，98P4B6提供 诊断，预后，预防和/或治疗靶标。 98P4B6基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与98P4B6反应的抗体或T细胞可用于主动或被动免疫。
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6.发明申请NUCLEIC ACIDS AND CORRESPONDING PROTEINS ENTITLED 251P5G2 USEFUL IN TREATMENT AND DETECTION OF CANCER 有权核酸和相关蛋白质251P5G2可用于治疗和检测癌症公开(公告)号：US20070231261A1
公开(公告)日：2007-10-04
申请号：US11549900
申请日：2006-10-16
申请人： Arthur Raitano , Pia Challita-Eid , Aya Jakobovits , Mary Faris , Wangmao Ge
发明人： Arthur Raitano , Pia Challita-Eid , Aya Jakobovits , Mary Faris , Wangmao Ge
IPC分类号： A61K38/00 , A61K31/70 , A61K38/43 , A61K39/00 , A61K39/395 , C07H21/04 , C07K14/00 , C12N5/06 , C12Q1/68 , G01N33/53
CPC分类号： C12N5/0693 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K47/6851 , A61K2039/505 , C07K14/435 , C07K14/47 , C07K2319/00 , G01N33/57484 , Y02A50/466
摘要： A novel gene 251P5G2 and its encoded protein, and variants thereof, are described wherein 251P5G2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 251P5G2 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 251P5G2 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 251P5G2 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因251P5G2及其编码的蛋白及其变体，其中251P5G2在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，251P5G2提供诊断，预后，预防和/ 或癌症的治疗靶标。 251P5G2基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与251P5G2反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号：US20070061901A9
公开(公告)日：2007-03-15
申请号：US10147368
申请日：2002-05-15
申请人： Aya Jakobovits , Mary Faris , Arthur Raitano , Robert Morrison , Douglas Saffran , Wangmao Ge , Pia Challita-Eid
发明人： Aya Jakobovits , Mary Faris , Arthur Raitano , Robert Morrison , Douglas Saffran , Wangmao Ge , Pia Challita-Eid
CPC分类号： G01N33/68 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/47 , C07K14/705 , C07K16/28 , C07K2317/34 , G01N33/5017 , G01N33/57434
摘要： A novel gene (designated 101P3A11 or PHOR-1) and its encoded protein, and variants thereof, are described wherein 101P3A11 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 101P3A11 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 101P3A11 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 101P3A11 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因（称为101P3A11或PHOR-1）及其编码蛋白及其变体，其中101P3A11在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，101P3A11提供 诊断，预后，预防和/或治疗靶标。 101P3A11基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与101P3A11反应的抗体或T细胞可用于主动或被动免疫。
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8.发明申请Nucleic acid and corresponding protein entitled 184P1E2 useful in treatment and detection of cancer 失效核酸和相应的题为184P1E2的蛋白质可用于治疗和检测癌症公开(公告)号：US20070054284A1
公开(公告)日：2007-03-08
申请号：US11368284
申请日：2006-03-02
申请人： Pia Challita-Eid , Arthur Raitano , Mary Faris , Rene Hubert , Karen Morrison , Robert Morrison , Wangmao Ge , Aya Jakobovits
发明人： Pia Challita-Eid , Arthur Raitano , Mary Faris , Rene Hubert , Karen Morrison , Robert Morrison , Wangmao Ge , Aya Jakobovits
CPC分类号： C07K14/47 , A61K38/00 , C12N9/78 , Y10T436/25
摘要： A novel gene (designated 184P1E2) and its encoded protein, and variants thereof, are described wherein 184P1E2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 184P1E2 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 184P1E2 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 184P1E2 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因（称为184P1E2）及其编码的蛋白及其变体，其中184P1E2在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，184P1E2提供诊断，预后， 癌症的预防和/或治疗靶标。 184P1E2基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与184P1E2反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号：US20070041968A1
公开(公告)日：2007-02-22
申请号：US11156231
申请日：2005-06-17
申请人： Aya Jakobovits , Pia Challita-Eid , Mary Faris , Wangmao Ge , Rene Hubert , Karen Morrison , Robert Morrison , Arthur Raitano , Daniel Afar
发明人： Aya Jakobovits , Pia Challita-Eid , Mary Faris , Wangmao Ge , Rene Hubert , Karen Morrison , Robert Morrison , Arthur Raitano , Daniel Afar
IPC分类号： A61K48/00 , A61K39/395 , C12N15/861
CPC分类号： C07K14/47 , A61K47/646 , A61K47/6851 , A61K47/6901 , A61K51/1045
摘要： Novel genes designated and set forth in FIG. 2 and their respective encoded proteins, and variants thereof, are described wherein a gene of the invention exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers such as those listed in Table I. Consequently, of gene products of a gene of FIG. 2 provide diagnostic, prognostic, prophylactic and/or therapeutic targets for cancer. A gene of FIG. 2 or fragment thereof, its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with a gene product of FIG. 2 can be used in active or passive immunization.
摘要翻译： 图中指定和阐述的新基因。 2及其各自编码的蛋白质及其变体，其中本发明的基因在正常成人组织中表现出组织特异性表达，并且在诸如表I所列的癌症中异常表达。因此， 基因 2提供癌症的诊断，预后，预防和/或治疗靶点。 图1的基因 2或其片段，其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与图1的基因产物反应的抗体或T细胞。 2可用于主动或被动免疫。
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10.发明申请NUCLEIC ACIDS AND CORRESPONDING PROTEINS ENTITLED 202P5A5 USEFUL IN TREATMENT AND DETECTION OF CANCER 失效核酸和对照蛋白质202P5A5有用于治疗和检测癌症公开(公告)号：US20080181885A1
公开(公告)日：2008-07-31
申请号：US11548626
申请日：2006-10-11
申请人： Arthur Raitano , Mary Faris , Pia Challita-Eid , Aya Jakobovits , Wangmao Ge
发明人： Arthur Raitano , Mary Faris , Pia Challita-Eid , Aya Jakobovits , Wangmao Ge
IPC分类号： A61K39/395 , A01K67/00 , A61K31/70 , C07H21/04 , C12N5/06 , G01N33/574 , C12Q1/68 , C07K14/00 , A61P43/00 , A61K38/00
CPC分类号： C12N5/0693 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K47/6851 , A61K2039/505 , C07K14/435 , C07K14/47 , C07K2319/00 , G01N33/57484 , Y02A50/466
摘要： A novel gene 202P5A5 and its encoded protein, and variants thereof, are described wherein 202P5A5 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 202P5A5 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 202P5A5 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 202P5A5 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因202P5A5及其编码的蛋白质及其变体，其中202P5A5在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，202P5A5提供诊断，预后，预防和/ 或癌症的治疗靶标。 202P5A5基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与202P5A5反应的抗体或T细胞可用于主动或被动免疫。
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