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    Polynucleotides encoding chemokine &agr;-6
    4.
    发明授权
    Polynucleotides encoding chemokine &agr;-6 失效
    编码趋化因子α-6的多核苷酸

    公开(公告)号：US06372456B1

    公开(公告)日：2002-04-16

    申请号：US09177304

    申请日：1998-10-23

    申请人： Ying-Fei Wei ,  Steven M. Ruben ,  Craig A. Rosen

    发明人： Ying-Fei Wei ,  Steven M. Ruben ,  Craig A. Rosen

    IPC分类号： C12N1519

    CPC分类号： C07K16/24 ,  A61K38/00 ,  C07K14/522

    摘要： The present invention relates to a novel CK(&agr;-6 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CK&agr;-6 protein. CK&agr;-6 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of CK&agr;-6 activity. Also provided are diagnostic methods for detecting CNS and immune system-related disorders and therapeutic methods for treating CNS and immune system-related disorders.

    摘要翻译： 本发明涉及一种新的CK（α-6蛋白，其是α趋化因子家族的成员，特别是编码人CKalpha-6蛋白的分离的核酸分子，也提供了CKalpha-6多肽 本发明还涉及用于鉴定CKalpha-6活性的激动剂和拮抗剂的筛选方法，还提供了用于检测CNS和免疫系统相关疾病的诊断方法以及用于治疗CNS和 免疫系统相关疾病。

    Antibodies to Chemokine Alpha-5
    8.
    发明授权
    Antibodies to Chemokine Alpha-5 失效
    趋化因子α-5抗体

    公开(公告)号：US07320869B2

    公开(公告)日：2008-01-22

    申请号：US11224076

    申请日：2005-09-13

    申请人： Ying-Fei Wei ,  Yi Li ,  Jian Ni ,  Craig A. Rosen ,  Steven M. Ruben

    发明人： Ying-Fei Wei ,  Yi Li ,  Jian Ni ,  Craig A. Rosen ,  Steven M. Ruben

    IPC分类号： G01N33/53 ,  C12N5/12 ,  C07K16/24

    CPC分类号： C07K14/521 ,  A61K38/00 ,  C07K14/522 ,  C07K2319/00 ,  C12N2799/026 ,  Y02A50/423 ,  Y10T436/143333

    摘要： The present invention relates to a novel CKα-5 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CKα-5 protein. CKα-5 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Antibodies and fragments thereof that specifically bind to CKα-5 polypeptides are also disclosed, as are compositions and methods for making such antibodies. The invention further relates to screening methods for identifying agonists and antagonists of CKα-5 activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.

    摘要翻译： 本发明涉及作为α趋化因子家族成员的新型CKalpha-5蛋白。 特别地，提供编码人CKalpha-5蛋白的分离的核酸分子。 还提供了CKalpha-5多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。 还公开了特异性结合CKalpha-5多肽的抗体及其片段，以及制备此类抗体的组合物和方法。 本发明还涉及鉴定CKalpha-5活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

    Antibodies to chemokine Alpha-6
    9.
    发明授权
    Antibodies to chemokine Alpha-6 失效
    趋化因子α-6抗体

    公开(公告)号：US07217529B2

    公开(公告)日：2007-05-15

    申请号：US11081021

    申请日：2005-03-16

    申请人： Ying-Fei Wei ,  Steven M. Ruben ,  Craig A. Rosen

    发明人： Ying-Fei Wei ,  Steven M. Ruben ,  Craig A. Rosen

    IPC分类号： C07K16/24 ,  C12N5/12 ,  G01N33/53

    CPC分类号： C07K16/24 ,  A61K38/00 ,  C07K14/522

    摘要： The present invention relates to a novel CKα-6 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CKα-6 protein. CKα-6 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of CKα-6 activity. Also provided are diagnostic methods for detecting CNS and immune system-related disorders and therapeutic methods for treating CNS and immune system-related disorders.

    摘要翻译： 本发明涉及作为α趋化因子家族成员的新型CKalpha-6蛋白。 特别地，提供编码人CKalpha-6蛋白的分离的核酸分子。 还提供了CKalpha-6多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及鉴定CKalpha-6活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测CNS和免疫系统相关疾病的诊断方法以及用于治疗CNS和免疫系统相关疾病的治疗方法。