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公开(公告)号：US06484052B1
公开(公告)日：2002-11-19
申请号：US09281371
申请日：1999-03-30
IPC分类号： A61N130
CPC分类号： A61M37/0092 , A61B2018/263 , A61M2037/0007
摘要： High frequency acoustic waves, analogous to ultrasound, can enhance the delivery of therapeutic compounds into cells. The compounds delivered may be chemotherapeutic drugs, antibiotics, photodynamic drugs or gene therapies. The therapeutic compounds are administered systemically, or preferably locally to the targeted site. Local delivery can be accomplished through a needle, cannula, or through a variety of vascular catheters, depending on the location of routes of access. To enhance the systemic or local delivery of the therapeutic compounds, high frequency acoustic waves are generated locally near the target site, and preferably near the site of compound administration. The acoustic waves are produced via laser radiation interaction with an absorbing media and can be produced via thermoelastic expansion, thermodynamic vaporization, material ablation, or plasma formation. Acoustic waves have the effect of temporarily permeabilizing the membranes of local cells, increasing the diffusion of the therapeutic compound into the cells, allowing for decreased total body dosages, decreased side effects, and enabling new therapies.
摘要翻译： 类似于超声的高频声波可以增强治疗性化合物递送到细胞中。 所递送的化合物可以是化疗药物，抗生素，光动力药物或基因疗法。 治疗性化合物系统地或优选局部施用于靶向部位。 取决于进入路线的位置，可以通过针头，插管或通过各种血管导管实现局部输送。 为了增强治疗化合物的全身或局部递送，在靶位点局部产生高频声波，优选在化合物给药部位附近产生高频声波。 声波通过与吸收介质的激光辐射相互作用产生，并且可以通过热弹性膨胀，热力学蒸发，材料消融或等离子体形成来产生。 声波具有临时透化局部细胞膜的作用，增加治疗化合物向细胞的扩散，允许减少全身剂量，减少副作用，并使新疗法成为可能。
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公开(公告)号：US06368318B1
公开(公告)日：2002-04-09
申请号：US09012379
申请日：1998-01-23
申请人： Steven R. Visuri , Luiz B. Da Silva , Peter M. Celliers , Richard A. London , William Benett , Kathryn Broughton , Victor Esch
发明人： Steven R. Visuri , Luiz B. Da Silva , Peter M. Celliers , Richard A. London , William Benett , Kathryn Broughton , Victor Esch
IPC分类号： A61B1818
CPC分类号： A61B18/26 , A61B18/245 , A61B2017/22061 , A61B2018/00029 , A61B2018/2211
摘要： Fiber delivered laser pulses emulsify thrombus by mechanical stresses that include a combination of pressure, tension and shear stress. Laser radiation is delivered to the locality of a thrombus and the radiation is absorbed by blood, blood dot, or other present materials. The combination of a leading pressure wave and subsequent vapor bubble cause efficient, emulsification of thrombus. Operating the laser in a low average power mode alleviates potential thermal complications. The laser is operated in a high repetition rate mode to take advantage of ultrasound frequency effects of thrombus dissolution as well as to decrease the total procedure time. Specific parameter ranges for operation are described. The device includes optical fibers surrounding a lumen intended for flow of a cooling agent. The fibers may be arranged concentrically around the lumen to deliver radiation and heat over as large an area as possible. An alternative design approach incorporates the optical fibers into the wall of the guiding catheter and utilizes the catheter lumen as the cooling channel. An eccentric tip enables rotation of the device to address all parts of the vasculature. The eccentricity can be provided via a variety of means: spring dip, balloon, protrusion, etc.
摘要翻译： 纤维传递的激光脉冲通过机械应力乳化血栓，包括压力，张力和剪切应力的组合。 激光辐射被输送到血栓的位置，并且辐射被血液，血液点或其他现有材料吸收。 导致压力波和随后的蒸汽气泡的组合导致血栓的有效的乳化。 以较低的平均功率模式操作激光可以减轻潜在的并发症。 激光以高重复率模式运行，以利用血栓溶解的超声频率效应以及减少总的手术时间。 描述操作的具体参数范围。 该装置包括围绕用于冷却剂流动的内腔的光纤。 纤维可以围绕内腔同心地布置，以在尽可能大的面积上传送辐射和热量。 另一种设计方法将光纤结合到引导导管的壁中并利用导管内腔作为冷却通道。 偏心的尖端能够使装置旋转以解决脉管系统的所有部分。 偏心度可以通过各种方式提供：弹簧浸渍，气球，突起等
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公开(公告)号：US06638238B1
公开(公告)日：2003-10-28
申请号：US09458134
申请日：1999-12-09
IPC分类号： A61B1720
CPC分类号： A61B17/320068 , A61B17/32002 , A61B2017/00738 , A61B2217/005 , A61M1/008 , A61M2202/08 , Y10S604/902
摘要： A liposuction apparatus and method optionally having a sonic or ultrasonic source with an axial lumen passage in which the shaft can be made to reciprocate (oscillate) in a non-rectilinear fashion. The apparatus may also contain the concomitant use of rectilinear reciprocation motion in addition to ultrasonic motion or energy along the shaft of the apparatus. The advantages of the liposuction apparatus are as follows: 1) non-rectilinear single shaft reciprocating cannula, 2) sonic or ultrasonic energy delivered to the distal tip, 3) rectilinear reciprocating cannula with ultrasonic energy along the shaft from the handle, and 4) any of the above reciprocating components powered by excess unused vacuum capacity in the liposuction aspirator (suction engine) apparatus. There are three (3) primary sources of energy applied to the cannula shaft: the first is the oscillating surgeon's arm motion (approximately 1-2 hertz); the reciprocating motion (of about 100 Hz); and the optional concomitant motion as delivered by the ultrasonic energy (e.g. 25 KHz).
摘要翻译： 一种抽脂装置和方法，其可选地具有带轴向腔通道的声波或超声波源，其中轴可以以非直线方式往复运动（振荡）。 该装置还可以包含除沿着装置的轴的超声波运动或能量之外的直线往复运动的伴随使用。 吸脂装置的优点如下：1）非直线单轴往复式套管，2）输送到远端的声波或超声波能量，3）从手柄沿着轴的超声能量的直线往复插管，4） 在吸脂抽吸器（吸引发动机）装置中由上述过度未使用的真空容量供电的上述往复运动部件中的任何一个。 有三（3）个主要能源应用于插管轴：第一个是摆动外科医生的手臂运动（约1-2赫兹）; 往复运动（约100Hz）; 以及由超声能量（例如25KHz）传递的可选的伴随运动。
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公开(公告)号：US07413711B2
公开(公告)日：2008-08-19
申请号：US10621657
申请日：2003-07-16
IPC分类号： B01L3/02
CPC分类号： B01L3/0217 , B01L2400/0487 , G01N35/1016 , G01N35/1065 , G01N2035/1034
摘要： A dispensing system delivers a precise amount of fluid for biological or chemical processing and/or analysis. Dispensing means moves the fluid. The dispensing means is operated by a pneumatic force. Connection means delivers the fluid to the desired location. An actuator means provides the pneumatic force to the dispensing means. Valving means transmits the pneumatic force from the actuator means to the dispensing means.
摘要翻译： 分配系统提供精确量的用于生物或化学处理和/或分析的流体。 分液装置移动流体。 分配装置通过气动力操作。 连接装置将流体输送到所需位置。 致动器装置向分配装置提供气动力。 阀装置将气动力从致动器装置传递到分配装置。
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公开(公告)号：US06538739B1
公开(公告)日：2003-03-25
申请号：US08941015
申请日：1997-09-30
IPC分类号： G01B1100
CPC分类号： G01N21/431 , A61B18/20 , A61B18/26 , A61B2017/00057 , A61B2017/22008 , A61B2018/00636
摘要： The present invention is intended as a means of diagnosing the presence of a gas bubble and incorporating the information into a feedback system for opto-acoustic thrombolysis. In opto-acoustic thrombolysis, pulsed laser radiation at ultrasonic frequencies is delivered intraluminally down an optical fiber and directed toward a thrombus or otherwise occluded vessel. Dissolution of the occlusion is therefore mediated through ultrasonic action of propagating pressure or shock waves. A vapor bubble in the fluid surrounding the occlusion may form as a result of laser irradiation. This vapor bubble may be used to directly disrupt the occlusion or as a means of producing a pressure wave. It is desirable to detect the formation and follow the lifetime of the vapor bubble. Knowledge of the bubble formation and lifetime yields critical information as to the maximum size of the bubble, density of the absorbed radiation, and properties of the absorbing material. This information can then be used in a feedback system to alter the irradiation conditions.
摘要翻译： 本发明旨在作为诊断气泡的存在并将该信息并入用于光声溶解的反馈系统中的手段。 在光声波溶解中，超声频率下的脉冲激光辐射在光纤内向内递送并引向血栓或其它闭塞血管。 因此，阻塞的溶解通过传播压力或冲击波的超声波作用来介导。 作为激光照射的结果，可以形成围绕闭塞的流体中的蒸气泡。 该气泡可用于直接破坏闭塞或产生压力波的手段。 需要检测形成并遵循蒸气泡的寿命。 关于气泡形成和寿命的知识产生关于气泡的最大尺寸，吸收辐射的密度和吸收材料的性质的关键信息。 然后可以在反馈系统中使用该信息来改变照射条件。
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公开(公告)号：US06875207B2
公开(公告)日：2005-04-05
申请号：US10427611
申请日：2003-04-30
CPC分类号： A61B17/320068 , A61B17/32002 , A61B2017/00738 , A61B2217/005 , A61M1/008 , A61M2202/08 , Y10S604/902
摘要： A liposuction apparatus and method optionally having a sonic or ultrasonic source with an axial lumen passage in which the shaft can be made to reciprocate (oscillate) in a non-rectilinear fashion. The apparatus may also contain the concomitant use of rectilinear reciprocation motion in addition to ultrasonic motion or energy along the shaft of the apparatus. The advantages of the liposuction apparatus are as follows: 1) non-rectilinear single shaft reciprocating cannula, 2) sonic or ultrasonic energy delivered to the distal tip, 3) rectilinear reciprocating cannula with ultrasonic energy along the shaft from the handle, and 4) any of the above reciprocating components powered by excess unused vacuum capacity in the liposuction aspirator (suction engine) apparatus. There are three (3) primary sources of energy applied to the cannula shaft: the first is the oscillating surgeon's arm motion (approximately 1-2 hertz); the reciprocating motion (of about 100 Hz); and the optional concomitant motion as delivered by the ultrasonic energy (e.g. 25 KHz).
摘要翻译： 一种抽脂装置和方法，其可选地具有带轴向腔通道的声波或超声波源，其中轴可以以非直线方式往复运动（振荡）。 该装置还可以包含除沿着装置的轴的超声波运动或能量之外的直线往复运动的伴随使用。 吸脂装置的优点如下：1）非直线单轴往复式套管，2）输送到远端的声波或超声波能量，3）从手柄沿着轴的超声能量的直线往复插管，4） 在吸脂抽吸器（吸引发动机）装置中由上述过度未使用的真空容量供电的上述往复运动部件中的任何一个。 有三（3）个主要能源应用于插管轴：第一个是摆动外科医生的手臂运动（约1-2赫兹）; 往复运动（约100Hz）; 以及由超声能量（例如25KHz）传递的可选的伴随运动。
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公开(公告)号：US06491685B2
公开(公告)日：2002-12-10
申请号：US09516999
申请日：2000-03-01
申请人： Steven R. Visuri , Anthony J. Makarewicz , Richard A. London , William J. Benett , Peter Krulevitch , Luiz B. Da Silva
发明人： Steven R. Visuri , Anthony J. Makarewicz , Richard A. London , William J. Benett , Peter Krulevitch , Luiz B. Da Silva
IPC分类号： A61B1722
CPC分类号： A61B18/26 , A61B2018/263
摘要： An acoustic focusing device whose acoustic waves are generated by laser radiation through an optical fiber. The acoustic energy is capable of efficient destruction of renal and biliary calculi and deliverable to the site of the calculi via an endoscopic procedure. The device includes a transducer tip attached to the distal end of an optical fiber through which laser energy is directed. The transducer tip encapsulates an exogenous absorbing dye. Under proper irradiation conditions (high absorbed energy density, short pulse duration) a stress wave is produced via thermoelastic expansion of the absorber for the destruction of the calculi. The transducer tip can be configured into an acoustic lens such that the transmitted acoustic wave is shaped or focused. Also, compressive stress waves can be reflected off a high density/low density interface to invert the compressive wave into a tensile stress wave, and tensile stresses may be more effective in some instances in disrupting material as most materials are weaker in tension than compression. Estimations indicate that stress amplitudes provided by this device can be magnified more than 100 times, greatly improving the efficiency of optical energy for targeted material destruction.
摘要翻译： 声波聚焦装置，其声波通过激光辐射通过光纤产生。 声能能够有效地破坏肾脏和胆汁结石，并可通过内窥镜手术递送至结石部位。 该装置包括附接到光纤的远端的换能器尖端，通过激光能量被引导。 换能器尖端封装外源吸收染料。 在适当的照射条件（高吸收能量密度，短脉冲持续时间）下，通过吸收器的热弹性膨胀产生应力波，以破坏结石。 换能器尖端可以被配置成声透镜，使得发射的声波成形或聚焦。 此外，压应力波可以从高密度/低密度界面反射，以将压缩波反转成拉伸应力波，并且拉伸应力在某些情况下在破坏材料中可能更有效，因为大多数材料的张力比压缩弱。 估计表明，该装置提供的应力幅度可以放大100倍以上，大大提高了光能量对目标材料的破坏效率。
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公开(公告)号：US06428531B1
公开(公告)日：2002-08-06
申请号：US09604454
申请日：2000-06-27
申请人： Steven R. Visuri , Luiz B. Da Silva , Peter M. Celliers , Richard A. London , Duncan J. Maitland, IV , Victor C. Esch
发明人： Steven R. Visuri , Luiz B. Da Silva , Peter M. Celliers , Richard A. London , Duncan J. Maitland, IV , Victor C. Esch
IPC分类号： A61B1818
CPC分类号： A61B18/245 , A61B2018/20359 , A61B2018/2211
摘要： Partial or total occlusions of fluid passages within the human body are removed by positioning an array of optical fibers in the passage and directing treatment radiation pulses along the fibers, one at a time, to generate a shock wave and hydrodynamics flows that strike and emulsify the occlusions. A preferred application is the removal of blood clots (thrombin and embolic) from small cerebral vessels to reverse the effects of an ischemic stroke. The operating parameters and techniques are chosen to minimize the amount of heating of the fragile cerebral vessel walls occurring during this photo acoustic treatment. One such technique is the optical monitoring of the existence of hydrodynamics flow generating vapor bubbles when they are expected to occur and stopping the heat generating pulses propagated along an optical fiber that is not generating such bubbles.
摘要翻译： 通过将光纤阵列定位在通道中并沿着纤维一次一个地引导处理辐射脉冲来去除人体内的流体通道的部分或全部闭塞，以产生冲击波和流体动力学流动，其冲击和乳化 闭塞。 优选的应用是从小脑血管去除血块（凝血酶和栓塞）以逆转缺血性卒中的作用。 选择操作参数和技术以最小化在此光声处理期间发生的脆弱的脑血管壁的加热量。 一种这样的技术是当期望发生流体动力学流动产生蒸汽气泡的存在时的光学监测，并且停止沿着不产生这种气泡的光纤传播的发热脉冲。
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