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公开(公告)号：US06428531B1
公开(公告)日：2002-08-06
申请号：US09604454
申请日：2000-06-27
申请人： Steven R. Visuri , Luiz B. Da Silva , Peter M. Celliers , Richard A. London , Duncan J. Maitland, IV , Victor C. Esch
发明人： Steven R. Visuri , Luiz B. Da Silva , Peter M. Celliers , Richard A. London , Duncan J. Maitland, IV , Victor C. Esch
IPC分类号： A61B1818
CPC分类号： A61B18/245 , A61B2018/20359 , A61B2018/2211
摘要： Partial or total occlusions of fluid passages within the human body are removed by positioning an array of optical fibers in the passage and directing treatment radiation pulses along the fibers, one at a time, to generate a shock wave and hydrodynamics flows that strike and emulsify the occlusions. A preferred application is the removal of blood clots (thrombin and embolic) from small cerebral vessels to reverse the effects of an ischemic stroke. The operating parameters and techniques are chosen to minimize the amount of heating of the fragile cerebral vessel walls occurring during this photo acoustic treatment. One such technique is the optical monitoring of the existence of hydrodynamics flow generating vapor bubbles when they are expected to occur and stopping the heat generating pulses propagated along an optical fiber that is not generating such bubbles.
摘要翻译： 通过将光纤阵列定位在通道中并沿着纤维一次一个地引导处理辐射脉冲来去除人体内的流体通道的部分或全部闭塞，以产生冲击波和流体动力学流动，其冲击和乳化 闭塞。 优选的应用是从小脑血管去除血块（凝血酶和栓塞）以逆转缺血性卒中的作用。 选择操作参数和技术以最小化在此光声处理期间发生的脆弱的脑血管壁的加热量。 一种这样的技术是当期望发生流体动力学流动产生蒸汽气泡的存在时的光学监测，并且停止沿着不产生这种气泡的光纤传播的发热脉冲。
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公开(公告)号：US06368318B1
公开(公告)日：2002-04-09
申请号：US09012379
申请日：1998-01-23
申请人： Steven R. Visuri , Luiz B. Da Silva , Peter M. Celliers , Richard A. London , William Benett , Kathryn Broughton , Victor Esch
发明人： Steven R. Visuri , Luiz B. Da Silva , Peter M. Celliers , Richard A. London , William Benett , Kathryn Broughton , Victor Esch
IPC分类号： A61B1818
CPC分类号： A61B18/26 , A61B18/245 , A61B2017/22061 , A61B2018/00029 , A61B2018/2211
摘要： Fiber delivered laser pulses emulsify thrombus by mechanical stresses that include a combination of pressure, tension and shear stress. Laser radiation is delivered to the locality of a thrombus and the radiation is absorbed by blood, blood dot, or other present materials. The combination of a leading pressure wave and subsequent vapor bubble cause efficient, emulsification of thrombus. Operating the laser in a low average power mode alleviates potential thermal complications. The laser is operated in a high repetition rate mode to take advantage of ultrasound frequency effects of thrombus dissolution as well as to decrease the total procedure time. Specific parameter ranges for operation are described. The device includes optical fibers surrounding a lumen intended for flow of a cooling agent. The fibers may be arranged concentrically around the lumen to deliver radiation and heat over as large an area as possible. An alternative design approach incorporates the optical fibers into the wall of the guiding catheter and utilizes the catheter lumen as the cooling channel. An eccentric tip enables rotation of the device to address all parts of the vasculature. The eccentricity can be provided via a variety of means: spring dip, balloon, protrusion, etc.
摘要翻译： 纤维传递的激光脉冲通过机械应力乳化血栓，包括压力，张力和剪切应力的组合。 激光辐射被输送到血栓的位置，并且辐射被血液，血液点或其他现有材料吸收。 导致压力波和随后的蒸汽气泡的组合导致血栓的有效的乳化。 以较低的平均功率模式操作激光可以减轻潜在的并发症。 激光以高重复率模式运行，以利用血栓溶解的超声频率效应以及减少总的手术时间。 描述操作的具体参数范围。 该装置包括围绕用于冷却剂流动的内腔的光纤。 纤维可以围绕内腔同心地布置，以在尽可能大的面积上传送辐射和热量。 另一种设计方法将光纤结合到引导导管的壁中并利用导管内腔作为冷却通道。 偏心的尖端能够使装置旋转以解决脉管系统的所有部分。 偏心度可以通过各种方式提供：弹簧浸渍，气球，突起等
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公开(公告)号：US06538739B1
公开(公告)日：2003-03-25
申请号：US08941015
申请日：1997-09-30
IPC分类号： G01B1100
CPC分类号： G01N21/431 , A61B18/20 , A61B18/26 , A61B2017/00057 , A61B2017/22008 , A61B2018/00636
摘要： The present invention is intended as a means of diagnosing the presence of a gas bubble and incorporating the information into a feedback system for opto-acoustic thrombolysis. In opto-acoustic thrombolysis, pulsed laser radiation at ultrasonic frequencies is delivered intraluminally down an optical fiber and directed toward a thrombus or otherwise occluded vessel. Dissolution of the occlusion is therefore mediated through ultrasonic action of propagating pressure or shock waves. A vapor bubble in the fluid surrounding the occlusion may form as a result of laser irradiation. This vapor bubble may be used to directly disrupt the occlusion or as a means of producing a pressure wave. It is desirable to detect the formation and follow the lifetime of the vapor bubble. Knowledge of the bubble formation and lifetime yields critical information as to the maximum size of the bubble, density of the absorbed radiation, and properties of the absorbing material. This information can then be used in a feedback system to alter the irradiation conditions.
摘要翻译： 本发明旨在作为诊断气泡的存在并将该信息并入用于光声溶解的反馈系统中的手段。 在光声波溶解中，超声频率下的脉冲激光辐射在光纤内向内递送并引向血栓或其它闭塞血管。 因此，阻塞的溶解通过传播压力或冲击波的超声波作用来介导。 作为激光照射的结果，可以形成围绕闭塞的流体中的蒸气泡。 该气泡可用于直接破坏闭塞或产生压力波的手段。 需要检测形成并遵循蒸气泡的寿命。 关于气泡形成和寿命的知识产生关于气泡的最大尺寸，吸收辐射的密度和吸收材料的性质的关键信息。 然后可以在反馈系统中使用该信息来改变照射条件。
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公开(公告)号：US06491685B2
公开(公告)日：2002-12-10
申请号：US09516999
申请日：2000-03-01
申请人： Steven R. Visuri , Anthony J. Makarewicz , Richard A. London , William J. Benett , Peter Krulevitch , Luiz B. Da Silva
发明人： Steven R. Visuri , Anthony J. Makarewicz , Richard A. London , William J. Benett , Peter Krulevitch , Luiz B. Da Silva
IPC分类号： A61B1722
CPC分类号： A61B18/26 , A61B2018/263
摘要： An acoustic focusing device whose acoustic waves are generated by laser radiation through an optical fiber. The acoustic energy is capable of efficient destruction of renal and biliary calculi and deliverable to the site of the calculi via an endoscopic procedure. The device includes a transducer tip attached to the distal end of an optical fiber through which laser energy is directed. The transducer tip encapsulates an exogenous absorbing dye. Under proper irradiation conditions (high absorbed energy density, short pulse duration) a stress wave is produced via thermoelastic expansion of the absorber for the destruction of the calculi. The transducer tip can be configured into an acoustic lens such that the transmitted acoustic wave is shaped or focused. Also, compressive stress waves can be reflected off a high density/low density interface to invert the compressive wave into a tensile stress wave, and tensile stresses may be more effective in some instances in disrupting material as most materials are weaker in tension than compression. Estimations indicate that stress amplitudes provided by this device can be magnified more than 100 times, greatly improving the efficiency of optical energy for targeted material destruction.
摘要翻译： 声波聚焦装置，其声波通过激光辐射通过光纤产生。 声能能够有效地破坏肾脏和胆汁结石，并可通过内窥镜手术递送至结石部位。 该装置包括附接到光纤的远端的换能器尖端，通过激光能量被引导。 换能器尖端封装外源吸收染料。 在适当的照射条件（高吸收能量密度，短脉冲持续时间）下，通过吸收器的热弹性膨胀产生应力波，以破坏结石。 换能器尖端可以被配置成声透镜，使得发射的声波成形或聚焦。 此外，压应力波可以从高密度/低密度界面反射，以将压缩波反转成拉伸应力波，并且拉伸应力在某些情况下在破坏材料中可能更有效，因为大多数材料的张力比压缩弱。 估计表明，该装置提供的应力幅度可以放大100倍以上，大大提高了光能量对目标材料的破坏效率。
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公开(公告)号：US5986234A
公开(公告)日：1999-11-16
申请号：US829519
申请日：1997-03-28
申请人： Dennis L. Matthews , Peter M. Celliers , Lloyd Hackel , Luiz B. Da Silva , C. Brent Dane , Stanley Mrowka
发明人： Dennis L. Matthews , Peter M. Celliers , Lloyd Hackel , Luiz B. Da Silva , C. Brent Dane , Stanley Mrowka
CPC分类号： B23K26/032 , B08B7/0042 , B23K26/066 , B23K26/0884 , B23K26/142 , B23K26/1476
摘要： A compact laser system that removes surface coatings (such as paint, dirt, etc.) at a removal rate as high as 1000 ft.sup.2 /hr or more without damaging the surface. A high repetition rate laser with multiple amplification passes propagating through at least one optical amplifier is used, along with a delivery system consisting of a telescoping and articulating tube which also contains an evacuation system for simultaneously sweeping up the debris produced in the process. The amplified beam can be converted to an output beam by passively switching the polarization of at least one amplified beam. The system also has a personal safety system which protects against accidental exposures.
摘要翻译： 一种紧凑的激光系统，可以以高达1000 ft2 / hr或更高的去除率去除表面涂层（如油漆，污垢等），而不会损坏表面。 使用通过至少一个光学放大器传播的具有多次放大的高重复率激光，以及包括伸缩和铰接管的输送系统，该输送系统还包含用于同时扫掠在该过程中产生的碎片的抽空系统。 放大的光束可以通过被动地切换至少一个放大的光束的偏振而被转换成输出光束。 该系统还具有防止意外暴露的个人安全系统。
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公开(公告)号：US06875207B2
公开(公告)日：2005-04-05
申请号：US10427611
申请日：2003-04-30
CPC分类号： A61B17/320068 , A61B17/32002 , A61B2017/00738 , A61B2217/005 , A61M1/008 , A61M2202/08 , Y10S604/902
摘要： A liposuction apparatus and method optionally having a sonic or ultrasonic source with an axial lumen passage in which the shaft can be made to reciprocate (oscillate) in a non-rectilinear fashion. The apparatus may also contain the concomitant use of rectilinear reciprocation motion in addition to ultrasonic motion or energy along the shaft of the apparatus. The advantages of the liposuction apparatus are as follows: 1) non-rectilinear single shaft reciprocating cannula, 2) sonic or ultrasonic energy delivered to the distal tip, 3) rectilinear reciprocating cannula with ultrasonic energy along the shaft from the handle, and 4) any of the above reciprocating components powered by excess unused vacuum capacity in the liposuction aspirator (suction engine) apparatus. There are three (3) primary sources of energy applied to the cannula shaft: the first is the oscillating surgeon's arm motion (approximately 1-2 hertz); the reciprocating motion (of about 100 Hz); and the optional concomitant motion as delivered by the ultrasonic energy (e.g. 25 KHz).
摘要翻译： 一种抽脂装置和方法，其可选地具有带轴向腔通道的声波或超声波源，其中轴可以以非直线方式往复运动（振荡）。 该装置还可以包含除沿着装置的轴的超声波运动或能量之外的直线往复运动的伴随使用。 吸脂装置的优点如下：1）非直线单轴往复式套管，2）输送到远端的声波或超声波能量，3）从手柄沿着轴的超声能量的直线往复插管，4） 在吸脂抽吸器（吸引发动机）装置中由上述过度未使用的真空容量供电的上述往复运动部件中的任何一个。 有三（3）个主要能源应用于插管轴：第一个是摆动外科医生的手臂运动（约1-2赫兹）; 往复运动（约100Hz）; 以及由超声能量（例如25KHz）传递的可选的伴随运动。
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公开(公告)号：US06638238B1
公开(公告)日：2003-10-28
申请号：US09458134
申请日：1999-12-09
IPC分类号： A61B1720
CPC分类号： A61B17/320068 , A61B17/32002 , A61B2017/00738 , A61B2217/005 , A61M1/008 , A61M2202/08 , Y10S604/902
摘要： A liposuction apparatus and method optionally having a sonic or ultrasonic source with an axial lumen passage in which the shaft can be made to reciprocate (oscillate) in a non-rectilinear fashion. The apparatus may also contain the concomitant use of rectilinear reciprocation motion in addition to ultrasonic motion or energy along the shaft of the apparatus. The advantages of the liposuction apparatus are as follows: 1) non-rectilinear single shaft reciprocating cannula, 2) sonic or ultrasonic energy delivered to the distal tip, 3) rectilinear reciprocating cannula with ultrasonic energy along the shaft from the handle, and 4) any of the above reciprocating components powered by excess unused vacuum capacity in the liposuction aspirator (suction engine) apparatus. There are three (3) primary sources of energy applied to the cannula shaft: the first is the oscillating surgeon's arm motion (approximately 1-2 hertz); the reciprocating motion (of about 100 Hz); and the optional concomitant motion as delivered by the ultrasonic energy (e.g. 25 KHz).
摘要翻译： 一种抽脂装置和方法，其可选地具有带轴向腔通道的声波或超声波源，其中轴可以以非直线方式往复运动（振荡）。 该装置还可以包含除沿着装置的轴的超声波运动或能量之外的直线往复运动的伴随使用。 吸脂装置的优点如下：1）非直线单轴往复式套管，2）输送到远端的声波或超声波能量，3）从手柄沿着轴的超声能量的直线往复插管，4） 在吸脂抽吸器（吸引发动机）装置中由上述过度未使用的真空容量供电的上述往复运动部件中的任何一个。 有三（3）个主要能源应用于插管轴：第一个是摆动外科医生的手臂运动（约1-2赫兹）; 往复运动（约100Hz）; 以及由超声能量（例如25KHz）传递的可选的伴随运动。
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公开(公告)号：US06729336B2
公开(公告)日：2004-05-04
申请号：US10109150
申请日：2002-03-28
申请人： Luiz B. Da Silva , Victor C. Esch , Alexander M. Rubenchik , Jonathan Hares , Joseph D. Kilkenny , Gilbert W. Collins , Paul J. Weber
发明人： Luiz B. Da Silva , Victor C. Esch , Alexander M. Rubenchik , Jonathan Hares , Joseph D. Kilkenny , Gilbert W. Collins , Paul J. Weber
IPC分类号： A61B1900
CPC分类号： A61B5/02007 , A61B5/05 , A61B5/0507 , A61B8/08 , A61N1/40
摘要： A medical device is described that can be used to detect in stent restenosis. This invention consists of a stent of current or modified technology, an electromagnetic wave transmitter to excite the stent and an acoustic sensor to detect stent acoustic oscillations.
摘要翻译： 描述了可用于检测支架再狭窄的医疗装置。 本发明由电流或改进技术的支架，用于激励支架的电磁波发射器和用于检测支架声振荡的声传感器组成。
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公开(公告)号：US07147606B1
公开(公告)日：2006-12-12
申请号：US10673916
申请日：2003-09-26
IPC分类号： A61B5/00
CPC分类号： A61B5/0031 , A61B5/036 , A61B5/205 , A61B5/6882
摘要： A diagnostic system is disclosed. The diagnostic system comprises a sensing device having a retrieval wire. The sensing device is configured to collect data. The system also includes a deployable housing that has a body defining an interior and an exterior. The housing is configured to allow fluid to flow through the housing and the housing completely encloses the sensing device. The system also includes a disposer for disposing the housing into a body part. The system also includes a processing device configured to receive the data from the sensing device. The processing device is configured to transmit the data.
摘要翻译： 公开了诊断系统。 诊断系统包括具有回收线的感测装置。 感测装置被配置为收集数据。 该系统还包括具有限定内部和外部的主体的可展开外壳。 壳体构造成允许流体流过壳体并且壳体完全包围感测装置。 该系统还包括用于将壳体设置到主体部分中的处理器。 该系统还包括配置成从感测装置接收数据的处理装置。 处理装置被配置为发送数据。
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公开(公告)号：US07494492B2
公开(公告)日：2009-02-24
申请号：US11216595
申请日：2005-08-30
申请人： Luiz B. Da Silva , George Choi
发明人： Luiz B. Da Silva , George Choi
IPC分类号： A61B18/08
CPC分类号： A61B18/082 , A61B2017/00734 , A61B2017/00761
摘要： A compact hand held device is provided that can be safely used by those suffering from acne, blemished skin or fine wrinkles. The hand held device includes an on/off switch and a button that pulses the device when it is placed on the target site. A battery within the device powers a circuit board and drives a short pulse of current through a heating element, which heats up to approximately 300° C. in less than 0.1 sec. Thermal conduction transfers the heat to the skin and causes a biological response that accelerates acne clearing, treats blemished skin or fine wrinkles. The total heat transferred is low enough to prevent burns. Application of acne treatment creams and gels further accelerates treatment
摘要翻译： 提供了一个紧凑的手持装置，可以被那些患有痤疮，瑕疵的皮肤或细皱纹的人安全使用。 手持设备包括一个开/关开关和一个按钮，当设备放置在目标站点上时，该按钮将脉冲。 设备内的电池为电路板供电，并通过加热元件驱动短脉冲电流，加热元件在小于0.1秒内加热至约300°C。 热传导将热量转移到皮肤，并引起加速痤疮清除，治疗瑕疵皮肤或细皱纹的生物反应。 传热的总热量足够低以防止灼伤。 痤疮治疗霜和凝胶的应用进一步加速治疗
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