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1.发明申请Systems, methods and devices for in vivo monitoring of a localized response via a radiolabeled analyte in a subject 审中-公开通过受试者中的放射性标记的分析物体内监测局部应答的系统，方法和装置公开(公告)号：US20050287065A1
公开(公告)日：2005-12-29
申请号：US11208983
申请日：2005-08-22
CPC分类号： A61K51/0491 , A61B6/037 , A61B6/486 , A61B6/507 , A61B6/508 , A61K49/0004
摘要： System for analyzing an in vivo response of a subject include a radiation detector for detecting radiation present in at least one localized solid tissue region of interest in a subject associated with internal activity of an administered quantity of an analyte comprising at least one of C-14 labeled glucose, a C-14 labeled constituent thereof, and a C-14 labeled glucose derivative, in the at least one solid tissue region of interest over a desired time interval of interest; and a reader in communication with the implantable detector for collecting radiation data from the detector associated with the detected radiation to determine at least one of the following; the in vivo dynamic, kinetic, and metabolic response of the subject.
摘要翻译： 用于分析受试者的体内反应的系统包括用于检测存在于受试者中的至少一个局部固定组织感兴趣区域中的辐射的辐射检测器，其与施用量的分析物的内部活性相关，所述分析物包含C-14 标记的葡萄糖，其C-14标记的组分和C-14标记的葡萄糖衍生物，在目标的所需时间间隔内的至少一个实体组织区域中; 以及与所述可植入检测器通信的读取器，用于从与所述检测到的辐射相关联的所述检测器收集辐射数据，以确定以下中的至少一个; 受试者的体内动态，动力学和代谢反应。
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2.发明申请Methods, systems, and associated implantable devices for detecting radiation in patients undergoing treatment for cancer 有权用于检测接受癌症治疗的患者的辐射的方法，系统和相关的可植入装置公开(公告)号：US20050251033A1
公开(公告)日：2005-11-10
申请号：US11185284
申请日：2005-07-20
申请人： Charles Scarantino , H. Nagle , Lester Hall , Jeffrey Mueller
发明人： Charles Scarantino , H. Nagle , Lester Hall , Jeffrey Mueller
IPC分类号： A61B5/00 , A61B10/00 , A61N5/10 , G01N27/416 , G01N27/44 , H03F1/32 , A61N5/02 , A61B5/07 , A61B6/00
CPC分类号： A61B5/14539 , A61B5/0031 , A61B5/1473 , A61B5/1486 , A61B5/14865 , A61B5/1495 , A61B5/417 , A61B6/507 , A61B2562/028 , A61B2562/085 , A61N5/1048 , A61N5/1071 , G06F19/00 , G06F19/3481 , Y10S128/903 , Y10S128/904 , Y10S128/92
摘要： Methods and systems for evaluating external beam radiation therapy delivered to a subject include: (a) placing at least one wireless implantable sensor in a first subject at a target location; (b) administering a first dose of radiation therapy into the first subject; (c) obtaining radiation data from the at least one wireless implantable sensor; and (d) calculating a radiation dose amount received by the first subject at the target location based on the radiation data obtained from the at least one wireless sensor during and/or after exposure to the first administered dose of radiation to determine and/or verify a dose amount of radiation delivered to the target location.
摘要翻译： 用于评估递送给受试者的外部束放射治疗的方法和系统包括：（a）将至少一个无线可植入传感器放置在目标位置的第一受试者中; （b）向第一受试者施用第一剂量的放射治疗; （c）从所述至少一个无线可植入传感器获得辐射数据; 以及（d）基于在暴露于第一次施用的辐射剂量之后和/或之后从至少一个无线传感器获得的辐射数据来计算由目标位置处的第一受试者接收的辐射剂量量，以确定和/或验证 输送到目标位置的剂量的辐射。
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3.发明申请Methods, systems, and associated implantable devices for dynamic monitoring of physiological and biological properties of tumors 有权用于动态监测肿瘤的生理和生物学特性的方法，系统和相关的可植入装置公开(公告)号：US20050228247A1
公开(公告)日：2005-10-13
申请号：US11148608
申请日：2005-06-09
申请人： Charles Scarantino , H. Nagle , Lester Hall , Jeffrey Mueller , Bahram Kermani
发明人： Charles Scarantino , H. Nagle , Lester Hall , Jeffrey Mueller , Bahram Kermani
CPC分类号： A61B5/14539 , A61B5/0031 , A61B5/1473 , A61B5/1486 , A61B5/14865 , A61B5/1495 , A61B5/417 , A61B6/507 , A61B2562/028 , A61B2562/085 , A61N5/1048 , A61N5/1071 , G06F19/00 , G06F19/3481 , Y10S128/903 , Y10S128/904 , Y10S128/92
摘要： Biocompatible sensors configured for implantation include a first body in communication with a plurality of remote sensor bodies to detect physiological parameters in vivo.
摘要翻译： 配置用于植入的生物相容性传感器包括与多个远程传感器体通信的第一体，以检测体内生理参数。
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4.发明申请METHODS, SYSTEMS, AND ASSOCIATED IMPLANTABLE DEVICES FOR DETECTING RADIATION IN PATIENTS UNDERGOING TREATMENT FOR CANCER 有权用于检测癌症治疗患者辐射的方法，系统和相关可植入装置公开(公告)号：US20060241407A1
公开(公告)日：2006-10-26
申请号：US11381223
申请日：2006-05-02
申请人： Charles Scarantino , H. Nagle , Lester Hall , Jeffrey Mueller
发明人： Charles Scarantino , H. Nagle , Lester Hall , Jeffrey Mueller
IPC分类号： A61B5/05
CPC分类号： A61B5/14539 , A61B5/0031 , A61B5/1473 , A61B5/1486 , A61B5/14865 , A61B5/1495 , A61B5/417 , A61B6/507 , A61B2562/028 , A61B2562/085 , A61N5/1048 , A61N5/1071 , G06F19/00 , G06F19/3481 , Y10S128/903 , Y10S128/904 , Y10S128/92
摘要： Methods and systems for evaluating external beam radiation therapy delivered to a subject include: (a) placing at least one wireless implantable sensor in a first subject at a target location; (b) administering a first dose of radiation therapy into tile first subject; (c) obtaining radiation data from the at least one wireless implantable sensor; and (d) calculating a radiation dose amount received by the first subject at the target location based on the radiation data obtained from the at least one wireless sensor during and/or after exposure to the first administered dose of radiation to determine and/or verify a dose amount of radiation delivered to the target location.
摘要翻译： 用于评估递送给受试者的外部束放射治疗的方法和系统包括：（a）将至少一个无线可植入传感器放置在目标位置的第一受试者中; （b）向第一受试者施用第一剂量的放射治疗; （c）从所述至少一个无线可植入传感器获得辐射数据; 以及（d）基于在暴露于第一次施用的辐射剂量之后和/或之后从至少一个无线传感器获得的辐射数据来计算由目标位置处的第一受试者接收的辐射剂量量，以确定和/或验证 输送到目标位置的剂量的辐射。
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公开(公告)号：US20060206026A1
公开(公告)日：2006-09-14
申请号：US11381233
申请日：2006-05-02
申请人： Charles Scarantino , H. Nagle , Lester Hall , Jeffrey Mueller
发明人： Charles Scarantino , H. Nagle , Lester Hall , Jeffrey Mueller
CPC分类号： A61B5/14539 , A61B5/0031 , A61B5/1473 , A61B5/1486 , A61B5/14865 , A61B5/1495 , A61B5/417 , A61B6/507 , A61B2562/028 , A61B2562/085 , A61N5/1048 , A61N5/1071 , G06F19/00 , G06F19/3481 , Y10S128/903 , Y10S128/904 , Y10S128/92
摘要： Methods and systems for evaluating external beam radiation therapy delivered to a subject include: (a) placing at least one wireless implantable sensor in a first subject at a target location; (b) administering a first dose of radiation therapy into the first subject; (c) obtaining radiation data from the at least one wireless implantable sensor; and (d) calculating a radiation dose amount received by the first subject at the target location based on the radiation data obtained from the at least one wireless sensor during and/or after exposure to the first administered dose of radiation to determine and/or verify a dose amount of radiation delivered to the target location.
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