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公开(公告)号:US4873225A
公开(公告)日:1989-10-10
申请号:US158628
申请日:1988-02-22
申请人: Sumio Umezawa , Tsutomu Tsuchiya , Tomio Takeuchi , Kazuo Umezawa , Yoshiaki Takahashi , Tetsuo Shitara , Yoshihiko Kobayashi , Yasushi Takagi
发明人: Sumio Umezawa , Tsutomu Tsuchiya , Tomio Takeuchi , Kazuo Umezawa , Yoshiaki Takahashi , Tetsuo Shitara , Yoshihiko Kobayashi , Yasushi Takagi
IPC分类号: C07H15/234 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61P31/04 , C07H15/236
CPC分类号: C07H15/234
摘要: As new compound are now provided ten compounds, namely 1-N-{(2R,3R)-4-amino-3-fluoro-2-hydroxybutyryl}kanamycin A; 1-N-{(2R,3R)-4-amino-3-fluoro-2-hydroxybutyryl}-2',3'-dideoxykanamycin A; 1-N-{(2R,3R)-4-amino-3-fluoro-2-hydroxybutyryl}-2',3'-dideoxy-2'-fluorokanamycin A; 1-N-{(2R,3R)-4-amino-3-fluoro-2-hydroxybutyryl}-5-deoxy-5-fluorokanamycin A; 1-N-{(2R,3R)-4-amino-3-fluoro-2-hydroxybutyryl}-kanamycin B; 1-N-{(2R,3R)-4-amino-3-fluoro-2-hydroxybutyryl}-3'-deoxykanamycin B; 1-N-{(2R,3R)-4-amino-3-fluoro-2-hydroxybutyryl}-3',4'-dideoxykanamycin B; 1-N-{(2R,3R) -4-amino-3-fluoro-2-hydroxybutyryl}-5-deoxy-5-fluorokanamycin B; 1-N-{(2R,3R)-4-amino-3-fluoro-2-hydroxybutyryl}-5,3'-dideoxy-5-fluorokanamycin B; and 1-N{(2R,3R)-4-amino-3-fluoro-2-hydroxybutyryl}-5,3',4'-trideoxy-5-fluorokanamycin B, which are all useful as antibacterial agent in the therapeutic treatment of bacterial infections.
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公开(公告)号:US4845082A
公开(公告)日:1989-07-04
申请号:US899100
申请日:1986-08-22
IPC分类号: C07H15/234 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61P31/04 , C07H15/236
CPC分类号: C07H15/234 , Y02P20/55
摘要: New compound, 3',4'-dideoxy-3'-fluorokanamycin B is now provided, which is useful as antibacterial agent.3',4'-Dideoxy-3'-fluorokanamycin B is prepared by a process comprising halogenating an N,O-protected derivative of 3'-deoxy-3'-fluoro-4'-O-sulfonylkanamycin B with a metal halide, reducing the resulting 4'- halogenated 3'-deoxy-3'-fluorokanamycin B derivative to convert its 4'-halo group into a hydrogen atom, and thereby to produce an N,O-protected derivative of 3',4'-dideoxy-3'-fluorokanamycin B, and removing the remaining amino-protecting groups and the remaining hydroxyl-protecting groups from the reduction product by conventional deprotecting methods.
摘要翻译: 现在提供新的化合物3',4'-二脱氧-3'-氟卡那霉素B,其可用作抗菌剂。 3',4'-二脱氧-3'-氟卡那霉素B通过包括用金属卤化物卤化3'-脱氧-3'-氟-4'-O-磺酰基卡那霉素B的N,O-保护的衍生物的方法制备, 减少所得的4'-卤代3'-脱氧-3'-氟卡那霉素B衍生物以将其4'-卤基转化成氢原子,从而产生3',4'-二脱氧的N,O-保护的衍生物 -3'-氟卡那霉素B,并通过常规去保护方法从还原产物中除去剩余的氨基保护基团和剩余的羟基保护基团。
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公开(公告)号:US08148504B2
公开(公告)日:2012-04-03
申请号:US12227861
申请日:2007-06-01
申请人: Yoshihiko Kobayashi , Yoshihisa Akiyama , Takeshi Murakami , Nobuto Minowa , Masaki Tsushima , Yukiko Hiraiwa , Shoichi Murakami , Mitsuhiro Abe , Kazushige Sasaki , Shigeru Hoshiko , Toshiaki Miyake , Yoshiaki Takahashi , Daishiro Ikeda
发明人: Yoshihiko Kobayashi , Yoshihisa Akiyama , Takeshi Murakami , Nobuto Minowa , Masaki Tsushima , Yukiko Hiraiwa , Shoichi Murakami , Mitsuhiro Abe , Kazushige Sasaki , Shigeru Hoshiko , Toshiaki Miyake , Yoshiaki Takahashi , Daishiro Ikeda
IPC分类号: C07H13/02
CPC分类号: C07H15/234 , C07H15/224
摘要: This invention relates to novel aminoglycoside antibiotics, which have potent antimicrobial activity against bacteria, which induce infectious diseases, particularly MRSA, and has no significant nephrotoxicity, and process for producing them. More particularly, the present invention relates to compounds represented by formula (Ia) or their pharmacologically acceptable salts or solvates, or their diastereomer mixtures, antimicrobial agents comprising them, and a process for producing them.
摘要翻译: 本发明涉及对细菌具有强力抗微生物活性的新型氨基糖苷类抗生素,其诱导感染性疾病,特别是MRSA,并且没有显着的肾毒性,以及生产它们的方法。 更具体地,本发明涉及由式(Ia)表示的化合物或其药理学上可接受的盐或溶剂合物或其非对映体混合物,包含它们的抗微生物剂及其制备方法。
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公开(公告)号:US20090186841A1
公开(公告)日:2009-07-23
申请号:US12227861
申请日:2007-06-01
申请人: Yoshihiko Kobayashi , Yoshihisa Akiyama , Takeshi Murakami , Nobuto Minowa , Masaki Tsushima , Yukiko Hiraiwa , Shoichi Murakami , Mitsuhiro Abe , Kazushige Sasaki , Shigeru Hoshiko , Toshiaki Miyake , Yoshiaki Takahashi , Daishiro Ikeda
发明人: Yoshihiko Kobayashi , Yoshihisa Akiyama , Takeshi Murakami , Nobuto Minowa , Masaki Tsushima , Yukiko Hiraiwa , Shoichi Murakami , Mitsuhiro Abe , Kazushige Sasaki , Shigeru Hoshiko , Toshiaki Miyake , Yoshiaki Takahashi , Daishiro Ikeda
IPC分类号: A61K31/7036 , C07H15/234 , A61P31/04
CPC分类号: C07H15/234 , C07H15/224
摘要: This invention relates to novel aminoglycoside antibiotics, which have potent antimicrobial activity against bacteria, which induce infectious diseases, particularly MRSA, and has no significant nephrotoxicity, and process for producing them. More particularly, the present invention relates to compounds represented by formula (Ia) or their pharmacologically acceptable salts or solvates, or their diastereomer mixtures, antimicrobial agents comprising them, and a process for producing them.
摘要翻译: 本发明涉及对细菌具有强力抗微生物活性的新型氨基糖苷类抗生素,其诱导感染性疾病,特别是MRSA,并且没有显着的肾毒性,以及生产它们的方法。 更具体地,本发明涉及由式(Ia)表示的化合物或其药理学上可接受的盐或溶剂合物或其非对映体混合物,包含它们的抗微生物剂及其制备方法。
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公开(公告)号:US20120165283A1
公开(公告)日:2012-06-28
申请号:US13413979
申请日:2012-03-07
申请人: Yoshihiko Kobayashi , Yoshihisa Akiyama , Takeshi Murakami , Nobuto Minowa , Masaki Tsushima , Yukiko Hiraiwa , Shoichi Murakami , Mitsuhiro Abe , Kazushige Sasaki , Shigeru Hoshiko , Toshiaki Miyake , Yoshiaki Takahashi , Daishiro Ikeda
发明人: Yoshihiko Kobayashi , Yoshihisa Akiyama , Takeshi Murakami , Nobuto Minowa , Masaki Tsushima , Yukiko Hiraiwa , Shoichi Murakami , Mitsuhiro Abe , Kazushige Sasaki , Shigeru Hoshiko , Toshiaki Miyake , Yoshiaki Takahashi , Daishiro Ikeda
IPC分类号: A61K31/7036 , C07H1/00 , C07H15/234 , A61P31/04 , C07H15/224
CPC分类号: C07H15/234 , C07H15/224
摘要: This invention relates to novel aminoglycoside antibiotics, which have potent antimicrobial activity against bacteria, which induce infectious diseases, particularly MRSA, and has no significant nephrotoxicity, and process for producing them. More particularly, the present invention relates to compounds represented by formula (Ia) or their pharmacologically acceptable salts or solvates, or their diastereomer mixtures, antimicrobial agents comprising them, and a process for producing them.
摘要翻译: 本发明涉及对细菌具有强力抗微生物活性的新型氨基糖苷类抗生素,其诱导感染性疾病,特别是MRSA,并且没有显着的肾毒性,以及生产它们的方法。 更具体地,本发明涉及由式(Ia)表示的化合物或其药理学上可接受的盐或溶剂合物或其非对映体混合物,包含它们的抗微生物剂及其制备方法。
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公开(公告)号:US08541394B2
公开(公告)日:2013-09-24
申请号:US13413979
申请日:2012-03-07
申请人: Yoshihiko Kobayashi , Yoshihisa Akiyama , Takeshi Murakami , Nobuto Minowa , Masaki Tsushima , Yukiko Hiraiwa , Shoichi Murakami , Mitsuhiro Abe , Kazushige Sasaki , Shigeru Hoshiko , Toshiaki Miyake , Yoshiaki Takahashi , Daishiro Ikeda
发明人: Yoshihiko Kobayashi , Yoshihisa Akiyama , Takeshi Murakami , Nobuto Minowa , Masaki Tsushima , Yukiko Hiraiwa , Shoichi Murakami , Mitsuhiro Abe , Kazushige Sasaki , Shigeru Hoshiko , Toshiaki Miyake , Yoshiaki Takahashi , Daishiro Ikeda
IPC分类号: A61K31/702 , A61P31/04
CPC分类号: C07H15/234 , C07H15/224
摘要: This invention relates to novel aminoglycoside antibiotics, which have potent antimicrobial activity against bacteria, which induce infectious diseases, particularly MRSA, and has no significant nephrotoxicity, and process for producing them. More particularly, the present invention relates to compounds represented by formula (Ia) or their pharmacologically acceptable salts or solvates, or their diastereomer mixtures, antimicrobial agents comprising them, and a process for producing them.
摘要翻译: 本发明涉及对细菌具有强力抗微生物活性的新型氨基糖苷类抗生素,其诱导感染性疾病,特别是MRSA,并且没有明显的肾毒性,以及生产它们的方法。 更具体地,本发明涉及由式(Ia)表示的化合物或其药理学上可接受的盐或溶剂合物或其非对映体混合物,包含它们的抗微生物剂及其制备方法。
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公开(公告)号:US20080008221A1
公开(公告)日:2008-01-10
申请号:US11769818
申请日:2007-06-28
申请人: Takashi Ueda , Koji Yamada , Tomoki Nozawa , Yoshihiko Kobayashi
发明人: Takashi Ueda , Koji Yamada , Tomoki Nozawa , Yoshihiko Kobayashi
IPC分类号: H01S5/026
CPC分类号: H01S5/0683 , H01L2224/45144 , H01L2224/48091 , H01S5/02252 , H01S5/02276 , H01L2924/00014 , H01L2924/00
摘要: A semiconductor laser device of the invention is provided with: a supporting substrate, on the surface of which there is formed a wiring pattern; a LD that is fixed on the surface of the supporting substrate and that has a signal output section that emits signal laser light and a monitoring output section that emits monitoring laser light; and a monitoring PD. The monitoring PD has: a semiconductor substrate having a region that transmits light of the wavelength of the monitoring laser light; and a light receiving section for photoelectric conversion formed on the surface of the semiconductor substrate, one incident surface of the side surfaces of the semiconductor substrate being arranged in a position to which the monitoring laser light can be made incident, the light receiving section being arranged in a position higher than the monitoring output section, and a back surface of the semiconductor substrate and the wiring pattern being fixed on the supporting substrate so as to oppose to each other.
摘要翻译: 本发明的半导体激光装置设置有:支撑基板,其表面上形成有布线图案; 固定在支撑基板的表面上并且具有发射信号激光的信号输出部分和发出监视激光的监视输出部分的LD; 和监控PD。 监视PD具有:具有透射监测激光的波长的光的区域的半导体衬底; 以及形成在所述半导体衬底的表面上的用于光电转换的光接收部分,所述半导体衬底的侧表面的一个入射表面被布置在可以使所述监控激光入射的位置,所述光接收部分被布置 在比监视输出部分高的位置上,并且半导体衬底的背面和布线图案被固定在支撑衬底上以彼此相对。
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公开(公告)号:US07143595B2
公开(公告)日:2006-12-05
申请号:US11029392
申请日:2005-01-06
申请人: Shigetoshi Doi , Toshiyuki Ebara , Yoshiaki Kurosawa , Mitsuhiko Ishino , Eiji Fukuda , Yoshihiko Kobayashi , Aritomo Yoshida
发明人: Shigetoshi Doi , Toshiyuki Ebara , Yoshiaki Kurosawa , Mitsuhiko Ishino , Eiji Fukuda , Yoshihiko Kobayashi , Aritomo Yoshida
IPC分类号: F25B49/02
CPC分类号: F25B9/008 , F25B2309/061 , F25B2600/21 , F25B2600/2513 , F25B2700/197 , F25B2700/2104 , F25B2700/2106 , F25B2700/21175
摘要: An object of the present invention is to improve a heat exchanging capability in an evaporator in a refrigerant cycle system in which a high pressure side is operated at a supercritical pressure. The refrigerant cycle system is a refrigerant cycle system in which a compressor, a gas cooler, an expansion valve and an evaporator are sequentially connected in a cyclic form and a high pressure side is operated at a supercritical pressure, wherein the degree of opening of the expansion valve is adjusted based on the temperature and pressure of a refrigerant at an outlet of the evaporator so as to control the degree of superheat at the outlet of the evaporator. An abstract of the present invention is to make large the degree of superheat at the outlet of the evaporator by means of the expansion valve.
摘要翻译: 本发明的目的是提高制冷剂循环系统中的蒸发器中的高压侧在超临界压力下运行的热交换能力。 制冷剂循环系统是一种制冷剂循环系统,其中压缩机,气体冷却器,膨胀阀和蒸发器以循环状态顺序连接,高压侧以超临界压力运行,其中, 基于蒸发器出口处的制冷剂的温度和压力来调节膨胀阀,以便控制蒸发器出口处的过热度。 本发明的摘要是通过膨胀阀使蒸发器出口处的过热度变大。
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公开(公告)号:US20050150240A1
公开(公告)日:2005-07-14
申请号:US11029392
申请日:2005-01-06
申请人: Shigetoshi Doi , Toshiyuki Ebara , Yoshiaki Kurosawa , Mitsuhiko Ishino , Eiji Fukuda , Yoshihiko Kobayashi , Aritomo Yoshida
发明人: Shigetoshi Doi , Toshiyuki Ebara , Yoshiaki Kurosawa , Mitsuhiko Ishino , Eiji Fukuda , Yoshihiko Kobayashi , Aritomo Yoshida
CPC分类号: F25B9/008 , F25B2309/061 , F25B2600/21 , F25B2600/2513 , F25B2700/197 , F25B2700/2104 , F25B2700/2106 , F25B2700/21175
摘要: An object of the present invention is to improve a heat exchanging capability in an evaporator in a refrigerant cycle system in which a high pressure side is operated at a supercritical pressure. The refrigerant cycle system is a refrigerant cycle system in which a compressor, a gas cooler, an expansion valve and an evaporator are sequentially connected in a cyclic form and a high pressure side is operated at a supercritical pressure, wherein the degree of opening of the expansion valve is adjusted based on the temperature and pressure of a refrigerant at an outlet of the evaporator so as to control the degree of superheat at the outlet of the evaporator. An abstract of the present invention is to make large the degree of superheat at the outlet of the evaporator by means of the expansion valve.
摘要翻译: 本发明的目的是提高制冷剂循环系统中的蒸发器中的高压侧在超临界压力下运行的热交换能力。 制冷剂循环系统是一种制冷剂循环系统,其中压缩机,气体冷却器,膨胀阀和蒸发器以循环状态顺序连接,高压侧以超临界压力运行,其中, 基于蒸发器出口处的制冷剂的温度和压力来调节膨胀阀,以便控制蒸发器出口处的过热度。 本发明的摘要是通过膨胀阀使蒸发器出口处的过热度变大。
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公开(公告)号:US5509730A
公开(公告)日:1996-04-23
申请号:US390477
申请日:1995-02-17
申请人: Hiromi Ando , Kenji Sano , Yoshihiko Kobayashi
发明人: Hiromi Ando , Kenji Sano , Yoshihiko Kobayashi
CPC分类号: B60T8/4291 , B60T8/404 , B60T8/5012 , B60T8/5037 , Y10S303/901
摘要: A brake fluid pressure control apparatus includes a second pump communicating port disposed to face a first pump communicating port approximately perpendicularly to the direction of movement of a spool. The first and second pump communicating ports are connected to a master cylinder, and a check valve is provided between the master cylinder and the first and second pump communicating ports. The check valve is adapted to open when the master cylinder-side brake fluid pressure becomes a predetermined value higher than the pump discharge-side brake fluid pressure. A master cylinder communicating port is provided to extend along the direction of movement of the spool. A cut-off valve is provided between the master cylinder communicating port and the master cylinder. The cut-off valve is closed when the spool is moved to provide communication between the pump communicating ports and a wheel cylinder communicating port.
摘要翻译: 一种制动液压控制装置包括:第二泵连通口,设置成与阀芯的运动方向近似垂直的第一泵连通口。 第一和第二泵连通口连接到主缸,并且止回阀设置在主缸和第一和第二泵连通口之间。 当主缸侧制动器流体压力变得高于泵排出侧制动液压力的预定值时,止回阀适于打开。 主缸连通口设置成沿着阀芯的移动方向延伸。 在主缸连通口和主缸之间设有截止阀。 当阀芯移动时,截止阀关闭,以提供泵连通口和轮缸连通口之间的连通。
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