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公开(公告)号：US20120135494A1
公开(公告)日：2012-05-31
申请号：US12957254
申请日：2010-11-30
申请人： Sunil Srinivasa Murthy , James William Bray , Shankar Chandrasekaran , Arvind Kumar Tiwari , Aaron Joseph Dulgar-Tulloch , Munish Vishwas Inamdar
发明人： Sunil Srinivasa Murthy , James William Bray , Shankar Chandrasekaran , Arvind Kumar Tiwari , Aaron Joseph Dulgar-Tulloch , Munish Vishwas Inamdar
CPC分类号： B07C5/344 , B03C1/0332 , B03C1/288 , B03C2201/26 , C07K1/14 , C12M47/02 , C12M47/10 , C12N1/02 , C12N13/00
摘要： A magnetic separator comprising a separation chamber is provided. The magnetic separator comprises an inlet and at least one outlet, and a magnetic source operatively coupled to the separation chamber and comprising a plurality of magnets that can be selectively turned off and on to create a dynamic magnetic field in the separation chamber.
摘要翻译： 提供了一种包括分离室的磁选机。 磁分离器包括入口和至少一个出口，以及可操作地耦合到分离室的磁源，并且包括可以选择性地关闭和打开以在分离室中产生动态磁场的多个磁体。
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公开(公告)号：US20120132593A1
公开(公告)日：2012-05-31
申请号：US12957240
申请日：2010-11-30
申请人： Sunil Srinivasa Murthy , James William Bray , Shankar Chandrasekaran , Arvind Kumar Tiwari , Aaron Joseph Dulgar-Tulloch , Munish Vishwas Inamdar
发明人： Sunil Srinivasa Murthy , James William Bray , Shankar Chandrasekaran , Arvind Kumar Tiwari , Aaron Joseph Dulgar-Tulloch , Munish Vishwas Inamdar
CPC分类号： C12M47/10 , B03C1/0332 , B03C1/288 , B03C2201/26 , B07C5/344 , C12M47/02
摘要： A magnetic separator comprising a separation chamber is provided. The separation chamber comprises a having an inlet and at least one outlet opposite the inlet in a downstream direction, and a magnetic source operatively coupled to the separation chamber. The magnetic source comprises a plurality of magnets that can be selectively turned off and on to create a dynamic magnetic field in the separation chamber.
摘要翻译： 提供了一种包括分离室的磁选机。 分离室包括具有入口和在下游方向上与入口相对的至少一个出口以及可操作地耦合到分离室的磁源。 磁源包括可以选择性地关闭和接通以在分离室中产生动态磁场的多个磁体。
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3.发明授权公开(公告)号：US08083069B2
公开(公告)日：2011-12-27
申请号：US12533180
申请日：2009-07-31
申请人： Sunil Srinivasa Murthy , Aaron Joseph Dulgar-Tulloch , James William Bray , Shankar Chandrasekaran , Arvind Kumar Tiwari
发明人： Sunil Srinivasa Murthy , Aaron Joseph Dulgar-Tulloch , James William Bray , Shankar Chandrasekaran , Arvind Kumar Tiwari
CPC分类号： B03C1/288 , B03C1/0332 , B03C1/0335 , B03C2201/18 , B03C2201/26
摘要： The present application discloses a process for the high throughput separation of at least one distinct biological material from a sample using magnetic tags and a magnetic separation set up capable of processing at least about 106 units/second. A magnetic field gradient is used to deflect target material bearing a magnet tag from one laminar flow stream to another so that the magnetically tagged target material exits a separation chamber via a different outlet than the rest of the sample. The process is applicable to isolating several distinct biological materials by directing each via magnetic deflection to its own unique outlet. The application also discloses a system for performing the process and a kit that includes the system and the magnetic tags.
摘要翻译： 本申请公开了一种使用磁性标签和至少能够处理至少约106单位/秒的磁分离装置从至少一种不同的生物材料与样品分离高通量的方法。 使用磁场梯度将具有磁性标签的目标材料从一个层流流转移到另一层，使得磁标记的靶材料通过与样品其余部分不同的出口离开分离室。 该方法适用于通过将每个通过磁偏转指向其自己的独特出口来分离几种不同的生物材料。 本申请还公开了一种用于执行该过程的系统和包括该系统和磁性标签的套件。
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4.发明申请公开(公告)号：US20110024331A1
公开(公告)日：2011-02-03
申请号：US12533180
申请日：2009-07-31
申请人： Sunil Srinivasa Murthy , Aaron Joseph Dulgar-Tulloch , James William Bray , Shankar Chandrasekaran , Arvind Kumar Tiwari
发明人： Sunil Srinivasa Murthy , Aaron Joseph Dulgar-Tulloch , James William Bray , Shankar Chandrasekaran , Arvind Kumar Tiwari
IPC分类号： B03C1/01
CPC分类号： B03C1/288 , B03C1/0332 , B03C1/0335 , B03C2201/18 , B03C2201/26
摘要： The present application discloses a process for the high throughput separation of at least one distinct biological material from a sample using magnetic tags and a magnetic separation set up capable of processing at least about 106 units/second. A magnetic field gradient is used to deflect target material bearing a magnet tag from one laminar flow stream to another so that the magnetically tagged target material exits a separation chamber via a different outlet than the rest of the sample. The process is applicable to isolating several distinct biological materials by directing each via magnetic deflection to its own unique outlet. The application also discloses a system for performing the process and a kit that includes the system and the magnetic tags.
摘要翻译： 本申请公开了一种使用磁性标签和至少能够处理至少约106单位/秒的磁分离装置从至少一种不同的生物材料与样品分离高通量的方法。 使用磁场梯度将具有磁性标签的目标材料从一个层流流转移到另一层，使得磁标记的靶材料通过与样品其余部分不同的出口离开分离室。 该方法适用于通过将每个通过磁偏转指向其自己的独特出口来分离几种不同的生物材料。 本申请还公开了一种用于执行该过程的系统和包括该系统和磁性标签的套件。
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5.发明授权Automated systems and methods for isolating regenerative cells from adipose tissue 有权用于从脂肪组织分离再生细胞的自动系统和方法公开(公告)号：US09109198B2
公开(公告)日：2015-08-18
申请号：US13097827
申请日：2011-04-29
申请人： Zaeem Ashraf Khan , Aaron Joseph Dulgar-Tulloch , Stefan Rakuff , Philip Alexander Shoemaker , Erik Leeming Kvam , Xiaohui Chen , Jaydeep Roy
发明人： Zaeem Ashraf Khan , Aaron Joseph Dulgar-Tulloch , Stefan Rakuff , Philip Alexander Shoemaker , Erik Leeming Kvam , Xiaohui Chen , Jaydeep Roy
CPC分类号： C12M45/09 , B01F5/0057 , B01F5/0206 , B01F5/0231 , B01F5/0256 , B01F5/10 , C12M27/00 , C12M47/04 , C12N5/0653 , C12N2501/70 , C12N2501/734 , C12N2521/00
摘要： A method of processing an adipose tissue to collect adipose derived regenerative cells is provided, wherein the method comprises providing a vessel comprising a fluid jet mixer; introducing the adipose tissue into the vessel; introducing a buffer solution into the vessel; washing the adipose tissue using the fluid jet mixer; introducing an enzyme solution into the vessel; initiating jet mixing into the vessel comprising the adipose tissue, the enzyme solution, and the buffer solution using the fluid jet mixer to digest the adipose tissue to form a digestion product; phase-separating the digestion product into a digested buoyant fat layer and a non-buoyant aqueous layer; and collecting the non-buoyant aqueous layer comprising the adipose derived regenerative cells. A system of processing an adipose tissue to collect adipose derived regenerative cells is also provided.
摘要翻译： 提供了一种处理脂肪组织以收集脂肪来源的再生细胞的方法，其中所述方法包括提供包含流体喷射混合器的容器; 将脂肪组织引入血管; 将缓冲溶液引入容器中; 使用流体喷射混合器洗涤脂肪组织; 将酶溶液引入容器中; 使用流体喷射混合器将包含脂肪组织，酶溶液和缓冲溶液的射流混合到消化脂肪组织以形成消化产物; 将消化产物相分离成消化的浮力脂肪层和非浮力水层; 并收集包含脂肪来源的再生细胞的非浮力水层。 还提供了一种处理脂肪组织以收集脂肪来源的再生细胞的系统。
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6.发明申请AUTOMATED SYSTEMS AND METHODS FOR ISOLATING REGENERATIVE CELLS FROM ADIPOSE TISSUE 有权用于从ADIPOSE TISSUE分离再生细胞的自动系统和方法公开(公告)号：US20120276628A1
公开(公告)日：2012-11-01
申请号：US13097827
申请日：2011-04-29
申请人： Zaeem Ashraf Khan , Aaron Joseph Dulgar-Tulloch , Stefan Rakuff , Philip Alexander Shoemaker , Erik Leeming Kvam , Xiaohui Chen , Jaydeep Roy
发明人： Zaeem Ashraf Khan , Aaron Joseph Dulgar-Tulloch , Stefan Rakuff , Philip Alexander Shoemaker , Erik Leeming Kvam , Xiaohui Chen , Jaydeep Roy
CPC分类号： C12M45/09 , B01F5/0057 , B01F5/0206 , B01F5/0231 , B01F5/0256 , B01F5/10 , C12M27/00 , C12M47/04 , C12N5/0653 , C12N2501/70 , C12N2501/734 , C12N2521/00
摘要： A method of processing an adipose tissue to collect adipose derived regenerative cells is provided, wherein the method comprises providing a vessel comprising a fluid jet mixer; introducing the adipose tissue into the vessel; introducing a buffer solution into the vessel; washing the adipose tissue using the fluid jet mixer; introducing an enzyme solution into the vessel; initiating jet mixing into the vessel comprising the adipose tissue, the enzyme solution, and the buffer solution using the fluid jet mixer to digest the adipose tissue to form a digestion product; phase-separating the digestion product into a digested buoyant fat layer and a non-buoyant aqueous layer; and collecting the non-buoyant aqueous layer comprising the adipose derived regenerative cells. A system of processing an adipose tissue to collect adipose derived regenerative cells is also provided.
摘要翻译： 提供了一种处理脂肪组织以收集脂肪来源的再生细胞的方法，其中所述方法包括提供包含流体喷射混合器的容器; 将脂肪组织引入血管; 将缓冲溶液引入容器中; 使用流体喷射混合器洗涤脂肪组织; 将酶溶液引入容器中; 使用流体喷射混合器将包含脂肪组织，酶溶液和缓冲溶液的射流混合到消化脂肪组织以形成消化产物; 将消化产物相分离成消化的浮力脂肪层和非浮力水层; 并收集包含脂肪来源的再生细胞的非浮力水层。 还提供了一种处理脂肪组织以收集脂肪来源的再生细胞的系统。
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