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1.发明授权Method and system for propelling and controlling displacement of a microrobot in a blood vessel 有权用于推动和控制血管中微型机器人的位移的方法和系统公开(公告)号：US07962194B2
公开(公告)日：2011-06-14
申请号：US10417475
申请日：2003-04-15
IPC分类号： A61B5/05
CPC分类号： A61B1/00156 , A61B34/70 , A61B34/72 , A61B34/73
摘要： A magnetic resonance imager (MRI) controllably propels at least one magnetic field responsive body within a subject. The MRI comprises a bore magnet producing an intense magnetic field sufficient to magnetically saturate the magnetic field responsive body. A magnetic field gradient generator is configured to apply variable magnetic gradients to at least a portion of the subject containing the magnetically-saturated body. A controller instructs the magnetic field gradient generator to acquire image data of the magnetically-saturated body within the subject and to apply a calculated magnetic gradient that will propel the magnetically-saturated body towards a target location in the subject. A tracking unit of the MRI provides position feedback information of the magnetically-saturated body within the subject.
摘要翻译： 磁共振成像仪（MRI）可控制地推进受试者内的至少一个磁场响应体。 该MRI包括产生强磁场的孔磁体，其足以使磁场响应体磁化饱和。 磁场梯度发生器被配置为将可变磁梯度应用于包含磁饱和体的受试者的至少一部分。 控制器指示磁场梯度发生器获取被摄体内的磁饱和体的图像数据，并施加计算出的磁梯度，该磁梯度将磁饱和体推向受试者的目标位置。 MRI的跟踪单元提供受试者内的磁饱和体的位置反馈信息。
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2.发明授权公开(公告)号：US07925064B2
公开(公告)日：2011-04-12
申请号：US10579381
申请日：2004-11-15
IPC分类号： G06K9/00
CPC分类号： A61B5/02007 , A61B8/0858 , G06K9/34 , G06K9/6278 , G06K2209/05 , G06T7/12 , G06T7/149 , G06T2207/10132 , G06T2207/20161 , G06T2207/30101
摘要： The present invention generally relates to intravascular ultrasound (IVUS) image segmentation methods, and is more specifically concerned with an intravascular ultrasound image segmentation method for characterizing blood vessel vascular layers. The proposed image segmentation method for estimating boundaries of layers in a multi-layered vessel provides image data which represent a plurality of image elements of the multi-layered vessel. The method also determines a plurality of initial interfaces corresponding to regions of the image data to segment and further concurrently propagates the initial interfaces corresponding to the regions to segment. The method thereby allows to estimate the boundaries of the layers of the multi-layered vessel by propagating the initial interfaces using a fast marching model based on a probability function which describes at least one characteristic of the image elements.
摘要翻译： 本发明一般涉及血管内超声（IVUS）图像分割方法，更具体地涉及用于表征血管血管层的血管内超声图像分割方法。 用于估计多层容器中的层的边界的所提出的图像分割方法提供了表示多层容器的多个图像元素的图像数据。 该方法还确定对应于图像数据的区域的多个初始界面以分段，并且进一步同时地将对应于该区域的初始界面传播到段。 因此，该方法允许通过使用基于描述图像元素的至少一个特征的概率函数的快速行进模型传播初始界面来估计多层容器的层的边界。
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公开(公告)号：US20110286925A1
公开(公告)日：2011-11-24
申请号：US13112289
申请日：2011-05-20
申请人： Sophie Lerouge , Gilles Soulez , Ahmed Fatimi , Jean-Michel Coutu , Jean Raymond
发明人： Sophie Lerouge , Gilles Soulez , Ahmed Fatimi , Jean-Michel Coutu , Jean Raymond
IPC分类号： A61K49/00 , A61P9/00 , A61K31/722 , B65D71/00 , B65D25/00
CPC分类号： A61L24/08 , A61K31/167 , A61K31/722 , A61K45/06 , A61K49/0457 , A61L24/001 , A61L24/0031 , A61L2400/04 , A61L2400/06 , A61L2430/36 , A61K2300/00 , C08L5/08
摘要： A sclerosing embolizing hydrogel comprising from about 0.1% by weight to about 4.0% by weight of chitosan; from about 0.01M to about 1M of hydrochloric acid; from 0% by volume to about 40% by volume of iopamidol; from 0.5% by weight to about 25% by weight of β-glycerophosphate disodium salt; and from about 0.05% by weight to about 4% by weight of sodium tetradecyl sulphate. Also a kit for synthesizing the hydrogel and a method using the hydrogel to treat a vascular defect in a subject.
摘要翻译： 一种硬化栓塞水凝胶，其包含约0.1重量％至约4.0重量％的壳聚糖; 约0.01M至约1M盐酸; 从0体积％至约40体积％的碘帕醇; 0.5重量％至约25重量％的甘油磷酸二钠盐; 和约0.05重量％至约4重量％的十四烷基硫酸钠。 还有一种用于合成水凝胶的试剂盒和使用该水凝胶来治疗受试者血管缺陷的方法。
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公开(公告)号：US20080144935A1
公开(公告)日：2008-06-19
申请号：US11948247
申请日：2007-11-30
IPC分类号： G06K9/34
CPC分类号： G06T7/149 , G06T7/11 , G06T2207/10132 , G06T2207/30016 , G06T2207/30101
摘要： A method for segmenting elements on an image, comprising: i) creating an active contour from at least one identified point on the image; ii) defining a reference intensity value from the pixels of the active contour; iii) simplifying the image by comparing the pixels of the image to the reference intensity value to give a propagation value to the pixels of the image; and iv) propagating the active contour in a selected one of an expansion/contraction direction as a function of the propagation value of the pixels adjacent to the active contour in the image; wherein ii), iii) and iv) are repeated in the selected direction whereby the active contour finally represents the element segmented in the image.
摘要翻译： 一种用于分割图像上的元素的方法，包括：i）从图像上的至少一个识别点创建活动轮廓; ii）从活动轮廓的像素定义参考强度值; iii）通过将图像的像素与参考强度值进行比较来简化图像，以给予图像的像素的传播值; 以及iv）根据与所述图像中的所述有效轮廓相邻的所述像素的传播值，在所述扩展/收缩方向中选定的一个中传播所述活动轮廓; 其中ii），iii）和iv）在所选方向上重复，由此活动轮廓最终表示在图像中分割的元素。
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5.发明申请公开(公告)号：US20050123178A1
公开(公告)日：2005-06-09
申请号：US10495407
申请日：2002-11-05
申请人： Pierre Teppaz , Salah Qanadli , Guy Cloutier , Gilles Soulez , Richard Cimon , Louis-Gilles Durand
发明人： Pierre Teppaz , Salah Qanadli , Guy Cloutier , Gilles Soulez , Richard Cimon , Louis-Gilles Durand
CPC分类号： A61B6/583 , A61B5/0035 , A61B5/055 , A61B8/587 , B33Y80/00 , G01R33/58 , G09B23/286
摘要： A multimodality imaging phantom is disclosed which is useful for calibrating devices for imaging vascular conduits. The phantom is compatible with X-ray, ultrasound and magnetic resonance imaging techniques. It allows testing, calibration, and inter-modality comparative study of imaging devices, in static or dynamic flow conditions. It also provides a geometric reference for evaluation of accuracy of imaging devices. The tissue-mimicking material is preferably an agar-based solidified gel. A vessel of known desired geometry runs throughout the gel and is connected to an inlet and outlet at its extremities for generating a flow circulation in the vessel. Said phantom also contains fiducial markers detectable in the above-mentioned modalities. The markers are preferably made of glass and are embedded in a layer of agar gel containing a fat component. The markers are implanted at precise known locations to allow identification and orientation of plane views, and they can be used for calibration, resealing and fusion of 3D images obtained from different modalities, and 3D image reconstruction from angiographic plane views. Also disclosed is a process for manufacturing said phantom.
摘要翻译： 公开了一种多模态成像体模，其用于校准用于成像血管导管的装置。 幻影与X射线，超声和磁共振成像技术兼容。 它允许在静态或动态流动条件下的成像装置的测试，校准和模式间比较研究。 它还提供了用于评估成像设备精度的几何参考。 组织模拟材料优选为基于琼脂的固化凝胶。 具有已知所需几何形状的容器在整个凝胶中运行，并连接到其末端的入口和出口，以在容器中产生流动循环。 所述幻影还包含在上述方式中可检测的基准标记。 标记物优选由玻璃制成并嵌入含有脂肪成分的琼脂凝胶层中。 标记植入在精确的已知位置以允许平面视图的识别和取向，并且它们可用于从不同模态获得的3D图像的校准，重新密封和融合以及来自血管造影平面视图的3D图像重建。 还公开了用于制造所述体模的方法。
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公开(公告)号：US20070282202A1
公开(公告)日：2007-12-06
申请号：US10588421
申请日：2005-02-09
申请人： Roch Maurice , Guy Cloutier , Jacques Ohayon , Gilles Soulez
发明人： Roch Maurice , Guy Cloutier , Jacques Ohayon , Gilles Soulez
IPC分类号： A61B8/00
CPC分类号： A61B5/02007 , A61B5/0066 , A61B8/08 , A61B8/0891 , A61B8/485 , A61B8/587 , G06T7/0012 , G06T7/20 , G06T2207/10132 , G06T2207/30101 , G06T2207/30241
摘要： The method for vascular elastography comprises: i) obtaining a sequence of radio-frequency (RF) images including pre-tissue-motion and post-tissue-motion images in digital form of a vessel delimited by a vascular wall; the pre-tissue-motion and post-tissue-motion images being representative of first and second time-delayed configuration, of the whole vessel; ii) partitioning both the pre-tissue-motion and post-tissue-motion images within the vascular wall into corresponding data windows; approximating a trajectory between the pre- and post-tissue-motion for corresponding data windows; and using the trajectory for each data window to compute the full strain tensor in each data window, which allow determining the Von Mises coefficient. The method can be adapted for non-invasive vascular elastography (NIVE), for non-invasive vascular micro-elastography (MicroNIVE) on small vessels, and for endovascular elastography (EVE).
摘要翻译： 用于血管弹性成像的方法包括：i）获得包括由血管壁限定的血管数字形式的组织前运动和组织后运动图像的射频（RF）图像序列; 组织运动和组织后运动图像代表整个血管的第一和第二时间延迟构型; ii）将血管壁内的组织前运动和组织后运动图像分成相应的数据窗口; 逼近相应数据窗口的组织前和组织运动之间的轨迹; 并且使用每个数据窗口的轨迹来计算每个数据窗口中的全应变张量，这允许确定Von Mises系数。 该方法可适用于非侵入性血管弹性成像（NIVE），用于小血管的非侵入性血管微弹性成像（MicroNIVE）和血管内弹性成像（EVE）。
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7.发明申请公开(公告)号：US20070165916A1
公开(公告)日：2007-07-19
申请号：US10579381
申请日：2004-11-15
IPC分类号： G06K9/00
CPC分类号： A61B5/02007 , A61B8/0858 , G06K9/34 , G06K9/6278 , G06K2209/05 , G06T7/12 , G06T7/149 , G06T2207/10132 , G06T2207/20161 , G06T2207/30101
摘要： The present invention generally relates to intravascular ultrasound (IVUS) image segmentation methods, and is more specifically concerned with an intravascular ultrasound image segmentation method for characterizing blood vessel vascular layers. The proposed image segmentation method for estimating boundaries of layers in a multi-layered vessel provides image data which represent a plurality of image elements of the multi-layered vessel. The method also determines a plurality of initial interfaces corresponding to regions of the image data to segment and further concurrently propagates the initial interfaces corresponding to the regions to segment. The method thereby allows to estimate the boundaries of the layers of the multi-layered vessel by propagating the initial interfaces using a fast marching model based on a probability function which describes at least one characteristic of the image elements.
摘要翻译： 本发明一般涉及血管内超声（IVUS）图像分割方法，更具体地涉及用于表征血管血管层的血管内超声图像分割方法。 用于估计多层容器中的层的边界的所提出的图像分割方法提供了表示多层容器的多个图像元素的图像数据。 该方法还确定对应于图像数据的区域的多个初始界面以分段，并且进一步同时地将对应于该区域的初始界面传播到段。 因此，该方法允许通过使用基于描述图像元素的至少一个特征的概率函数的快速行进模型传播初始界面来估计多层容器的层的边界。
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公开(公告)号：US08840867B2
公开(公告)日：2014-09-23
申请号：US13112289
申请日：2011-05-20
申请人： Lerouge Sophie , Gilles Soulez , Ahmed Fatimi , Jean-Michel Coutu , Jean Raymond
发明人： Lerouge Sophie , Gilles Soulez , Ahmed Fatimi , Jean-Michel Coutu , Jean Raymond
IPC分类号： A61K49/00 , B65D25/08 , B65D69/00 , A01N43/04 , A61K31/167 , A61K31/722 , A61L24/00 , A61K45/06 , A61K49/04 , A61L24/08
CPC分类号： A61L24/08 , A61K31/167 , A61K31/722 , A61K45/06 , A61K49/0457 , A61L24/001 , A61L24/0031 , A61L2400/04 , A61L2400/06 , A61L2430/36 , A61K2300/00 , C08L5/08
摘要： A sclerosing embolizing hydrogel comprising from about 0.1% by weight to about 4.0% by weight of chitosan; from about 0.01M to about 1M of hydrochloric acid; from 0% by volume to about 40% by volume of iopamidol; from 0.5% by weight to about 25% by weight of β-glycerophosphate disodium salt; and from about 0.05% by weight to about 4% by weight of sodium tetradecyl sulphate. Also a kit for synthesizing the hydrogel and a method using the hydrogel to treat a vascular defect in a subject.
摘要翻译： 一种硬化栓塞水凝胶，其包含约0.1重量％至约4.0重量％的壳聚糖; 约0.01M至约1M盐酸; 从0体积％至约40体积％的碘帕醇; 0.5重量％至约25重量％的甘油磷酸二钠盐; 和约0.05重量％至约4重量％的十四烷基硫酸钠。 还有一种用于合成水凝胶的试剂盒和使用该水凝胶来治疗受试者血管缺陷的方法。
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公开(公告)号：US20100312092A1
公开(公告)日：2010-12-09
申请号：US12590715
申请日：2009-11-12
IPC分类号： A61B5/055
CPC分类号： A61B5/02007 , A61B5/0066 , A61B8/08 , A61B8/0891 , A61B8/485 , A61B8/587 , G06T7/0012 , G06T7/20 , G06T2207/10132 , G06T2207/30101 , G06T2207/30241
摘要： The method for vascular elastography comprises: i) obtaining a sequence of radio-frequency (RF) images including pre-tissue-motion and post-tissue-motion images in digital form of a vessel delimited by a vascular wall; the pre-tissue-motion and post-tissue-motion images being representative of first and second time-delayed configuration, of the whole vessel; ii) partitioning both the pre-tissue-motion and post-tissue-motion images within the vascular wall into corresponding data windows; approximating a trajectory between the pre- and post-tissue-motion for corresponding data windows; and using the trajectory for each data window to compute the full strain tensor in each data window, which allow determining the Von Mises coefficient. The method can be adapted for non-invasive vascular elastography (NIVE), for non-invasive vascular micro-elastography (MicroNlVE) on small vessels, and for endovascular elastography (EVE).
摘要翻译： 用于血管弹性成像的方法包括：i）获得包括由血管壁限定的血管数字形式的组织前运动和组织后运动图像的射频（RF）图像序列; 组织运动和组织后运动图像代表整个血管的第一和第二时间延迟构型; ii）将血管壁内的组织前运动和组织后运动图像分成相应的数据窗口; 逼近相应数据窗口的组织前和组织运动之间的轨迹; 并且使用每个数据窗口的轨迹来计算每个数据窗口中的全应变张量，这允许确定Von Mises系数。 该方法可适用于非侵入性血管弹性成像（NIVE），用于小血管上的非侵入性血管微弹性成像（MicroNlVE）和血管内弹性成像（EVE）。
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10.发明授权公开(公告)号：US07439493B2
公开(公告)日：2008-10-21
申请号：US10495407
申请日：2002-11-05
申请人： Pierre Teppaz , Salah Dine Qanadli , Guy Cloutier , Gilles Soulez , Richard Cimon , Louis-Gilles Durand
发明人： Pierre Teppaz , Salah Dine Qanadli , Guy Cloutier , Gilles Soulez , Richard Cimon , Louis-Gilles Durand
IPC分类号： G01D18/00
CPC分类号： A61B6/583 , A61B5/0035 , A61B5/055 , A61B8/587 , B33Y80/00 , G01R33/58 , G09B23/286
摘要： A multimodality imaging phantom is disclosed which is useful for calibrating devices for imaging vascular conduits. The phantom is compatible with X-ray, ultrasound and magnetic resonance imaging techniques. It allows testing, calibration, and inter-modality comparative study of imaging devices, in static or dynamic flow conditions. It also provides a geometric reference for evaluation of accuracy of imaging devices. The tissue-mimicking material is preferably an agar-based solidified gel. A vessel of known desired geometry runs throughout the gel and is connected to an inlet and outlet at its extremities for generating a flow circulation in the vessel. Said phantom also contains fiducial markers detectable in the above-mentioned modalities. The markers are preferably made of glass and are embedded in a layer of agar gel containing a fat component. The markers are implanted at precise known locations to allow identification and orientation of plane views, and they can be used for calibration, resealing and fusion of 3D images obtained from different modalities, and 3D image reconstruction from angiographic plane views. Also disclosed is a process for manufacturing said phantom.
摘要翻译： 公开了一种多模态成像体模，其用于校准用于成像血管导管的装置。 幻影与X射线，超声和磁共振成像技术兼容。 它允许在静态或动态流动条件下的成像装置的测试，校准和模式间比较研究。 它还提供了用于评估成像设备精度的几何参考。 组织模拟材料优选为基于琼脂的固化凝胶。 具有已知所需几何形状的容器在整个凝胶中运行，并连接到其末端的入口和出口，以在容器中产生流动循环。 所述幻影还包含在上述方式中可检测的基准标记。 标记物优选由玻璃制成并嵌入含有脂肪成分的琼脂凝胶层中。 标记植入在精确的已知位置以允许平面视图的识别和取向，并且它们可用于从不同模态获得的3D图像的校准，重新密封和融合以及来自血管造影平面视图的3D图像重建。 还公开了用于制造所述体模的方法。
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