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1.发明授权Amphiphilic cationic associative polymers, preparation process, use as thickeners and composition comprising them 失效两亲阳离子缔合聚合物，制备方法，用作增稠剂和包含它们的组合物公开(公告)号：US06939938B2
公开(公告)日：2005-09-06
申请号：US10347414
申请日：2003-01-21
CPC分类号： C08G18/0814 , A61K8/87 , A61K2800/5426 , A61Q19/00 , C08G18/10 , C08G18/2875
摘要： Novel water-soluble or water-dispersible amphiphilic cationic associative polymers, a process for preparing them and their use in compositions for topical application, such as for cosmetic use, as thickeners, and the compositions comprising these polymers.
摘要翻译： 新型水溶性或水分散性两亲性阳离子缔合聚合物，其制备方法及其在局部应用的组合物中的用途，例如用于化妆品用途，作为增稠剂，以及包含这些聚合物的组合物。
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公开(公告)号：US07358346B2
公开(公告)日：2008-04-15
申请号：US11110864
申请日：2005-04-21
IPC分类号： C07H15/00
CPC分类号： C07H15/00
摘要： The present invention relates to novel C-glycoside compounds of given absolute configuration, to a process for synthesising them and to compositions containing them. The invention also relates to the cosmetic use of these C-glycoside compounds as agents to stimulate the synthesis of glycosaminoglycans containing a D-glucosamine and/or N-acetyl-D-glucosamine residue, advantageously hyaluronic acid, and/or of proteoglycans, advantageously proteoglycans containing hyaluronic acid, by fibroblasts and/or keratinocytes. The invention also relates to a cosmetic process for treating keratin materials using a composition containing at least one C-glycoside compound according to the invention.
摘要翻译： 本发明涉及给定绝对构型的新型C-糖苷化合物，其合成方法和含有它们的组合物。 本发明还涉及这些C-糖苷化合物的化妆品用途，有利地刺激含有D-葡糖胺和/或N-乙酰基-D-葡糖胺残基（有利地为透明质酸）和/或蛋白聚糖的糖胺聚糖的合成 含有透明质酸的蛋白聚糖，通过成纤维细胞和/或角质形成细胞。 本发明还涉及使用含有至少一种本发明的C-糖苷化合物的组合物来治疗角蛋白材料的美容方法。
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公开(公告)号：US20050250708A1
公开(公告)日：2005-11-10
申请号：US11110864
申请日：2005-04-21
IPC分类号： A61K31/70 , A61K31/715
CPC分类号： C07H15/00
摘要： The present invention relates to novel C-glycoside compounds of given absolute configuration, to a process for synthesising them and to compositions containing them. The invention also relates to the cosmetic use of these C-glycoside compounds as agents to stimulate the synthesis of glycosaminoglycans containing a D-glucosamine and/or N-acetyl-D-glucosamine residue, advantageously hyaluronic acid, and/or of proteoglycans, advantageously proteoglycans containing hyaluronic acid, by fibroblasts and/or keratinocytes. The invention also relates to a cosmetic process for treating keratin materials using a composition containing at least one C-glycoside compound according to the invention.
摘要翻译： 本发明涉及给定绝对构型的新型C-糖苷化合物，其合成方法和含有它们的组合物。 本发明还涉及这些C-糖苷化合物的化妆品用途，有利地刺激含有D-葡糖胺和/或N-乙酰基-D-葡糖胺残基（有利地为透明质酸）和/或蛋白聚糖的糖胺聚糖的合成 含有透明质酸的蛋白聚糖，通过成纤维细胞和/或角质形成细胞。 本发明还涉及使用含有至少一种本发明的C-糖苷化合物的组合物来治疗角蛋白材料的美容方法。
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4.发明授权Biaromatic compounds and pharmaceutical and cosmetic compositions comprising them 失效双酚化合物和包含它们的药物和化妆品组合物公开(公告)号：US06849658B2
公开(公告)日：2005-02-01
申请号：US09984830
申请日：2001-10-31
IPC分类号： A61K8/00 , A61K8/14 , A61K8/30 , A61K8/31 , A61K8/33 , A61K8/35 , A61K8/36 , A61K8/368 , A61K8/37 , A61K8/39 , A61K8/44 , A61K8/46 , A61K8/49 , A61K8/60 , A61K8/64 , A61K31/192 , A61K31/22 , A61K31/35 , A61K31/352 , A61K31/382 , A61P9/00 , A61P9/10 , A61P11/00 , A61P17/00 , A61P17/02 , A61P17/06 , A61P17/10 , A61P17/14 , A61P17/16 , A61P19/02 , A61P27/02 , A61P29/00 , A61P35/00 , A61P37/08 , A61Q5/00 , A61Q5/02 , A61Q19/00 , A61Q19/02 , A61Q19/10 , C07C65/19 , C07C65/28 , C07C69/76 , C07D213/79 , C07D311/58 , C07D335/06 , C07D405/06 , C07D409/06 , A61K31/37 , A61K31/381 , C07D319/16 , C07D335/04
CPC分类号： C07D213/79 , A61K8/31 , A61K8/33 , A61K8/35 , A61K8/36 , A61K8/39 , A61K8/44 , A61K8/46 , A61K8/49 , A61K8/4926 , A61K8/4973 , A61K8/4986 , A61K8/60 , A61K8/64 , A61K2800/92 , A61Q5/00 , A61Q19/00 , A61Q19/02 , A61Q19/10 , C07D311/58 , C07D335/06 , C07D405/06 , C07D409/06
摘要： The invention concerns bi-aromatic compounds of formula (I) in which Ar represents (a), Z being O or S, R1 is CH3, —CH2—O—R6, —OR6 or —COR7; R2 is —OR8, —SR8 or a polyether radical if in the latter case R4 is C1-C20alkyl and is in ortho or meta position relative to X—Ar; R3 is alkyl or R2 and R3 together form a cycle optionally interrupted by O or S; R4 is aryl radical; R5 is H, halogen, C1-C20 alkyl or —OR8; R6 is H, alkyl or —COR9; R7 is H, alkyl, —N(r′)(r″) or —OR10; R8 is H, alkyl or —COR9; R9 is alkyl; R10 is H, C1-C20 alkyl, alkenyl, monohydroxyalkyl or polyhydroxyalkyl, aryl or aralkyl or a sugar residue, r′ and r″ are H, alkyl mono- or polyhydroxyalkyl, aryl, an amino acid or sugar residue or together form a heterocycle, X represents a radical of formula (d) or (e) in which R11 is H or —OR6; R12 is H or alkyl; or R11 and R12 form an oxo radical, and the salts, optical and geometrical isomers of the compounds of formula (I).
摘要翻译： 本发明涉及式（I）的二芳族化合物，其中Ar表示（a），Z为O或S，R 1为CH 3，-CH 2 -O-R6，-OR 6或-COR 7; 如果在后一种情况下R 4是C 1 -C 20烷基并且相对于X-Ar处于邻位或间位，则R2是-OR8，-SR8或聚醚基团; R3是烷基或R2和R3一起形成任选被O或S中断的循环; R4是芳基; R5是H，卤素，C1-C20烷基或-OR8; R6是H，烷基或-COR9; R 7为H，烷基，-N（R'）（r“）或-OR 10; R8是H，烷基或-COR9; R9为烷基; R 10是H，C 1 -C 20烷基，烯基，单羟基烷基或多羟基烷基，芳基或芳烷基或糖残基，r'和r“是H，烷基单 - 或多羟基烷基，芳基，氨基酸或糖残基或一起形成 杂环，X表示式（d）或（e）的基团，其中R 11为H或-OR 6; R 12为H或烷基; 或R 11和R 12形成氧基，以及式（I）化合物的盐，光学和几何异构体。
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5.发明授权Biaromatic compounds and pharmaceutical and cosmetic compositions comprising them 失效双芳族化合物和包含它们的药物和化妆品组合物公开(公告)号：US06346546B1
公开(公告)日：2002-02-12
申请号：US09577345
申请日：2000-05-25
IPC分类号： A61K31235
CPC分类号： C07D213/79 , A61K8/31 , A61K8/33 , A61K8/35 , A61K8/36 , A61K8/39 , A61K8/44 , A61K8/46 , A61K8/49 , A61K8/4926 , A61K8/4973 , A61K8/4986 , A61K8/60 , A61K8/64 , A61K2800/92 , A61Q5/00 , A61Q19/00 , A61Q19/02 , A61Q19/10 , C07D311/58 , C07D335/06 , C07D405/06 , C07D409/06
摘要： Biaromatic compounds connected by a propynylene or ailenylene bond, corresponding to the formula (I).
摘要翻译： 通过丙炔或亚烯基键连接的双芳族化合物对应于式（I）。
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公开(公告)号：US20080146516A1
公开(公告)日：2008-06-19
申请号：US12037106
申请日：2008-02-26
CPC分类号： C07H15/00
摘要： The present invention relates to novel C-glycoside compounds of given absolute configuration, to a process for synthesising them and to compositions containing them. The invention also relates to the cosmetic use of these C-glycoside compounds as agents to stimulate the synthesis of glycosaminoglycans containing a D-glucosamine and/or N-acetyl-D-glucosamine residue, advantageously hyaluronic acid, and/or of proteoglycans, advantageously proteoglycans containing hyaluronic acid, by fibroblasts and/or keratinocytes. The invention also relates to a cosmetic process for treating keratin materials using a composition containing at least one C-glycoside compound according to the invention.
摘要翻译： 本发明涉及给定绝对构型的新型C-糖苷化合物，其合成方法和含有它们的组合物。 本发明还涉及这些C-糖苷化合物的化妆品用途，有利地刺激含有D-葡糖胺和/或N-乙酰基-D-葡糖胺残基（有利地为透明质酸）和/或蛋白聚糖的糖胺聚糖的合成 含有透明质酸的蛋白聚糖，通过成纤维细胞和/或角质形成细胞。 本发明还涉及使用含有至少一种本发明的C-糖苷化合物的组合物来治疗角蛋白材料的美容方法。
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公开(公告)号：US08853169B2
公开(公告)日：2014-10-07
申请号：US12037106
申请日：2008-02-26
CPC分类号： C07H15/00
摘要： The present invention relates to novel C-glycoside compounds of given absolute configuration, to a process for synthesizing them and to compositions containing them. The invention also relates to the cosmetic use of these C-glycoside compounds as agents to stimulate the synthesis of glycosaminoglycans containing a D-glucosamine and/or N-acetyl-D-glucosamine residue, advantageously hyaluronic acid, and/or of proteoglycans, advantageously proteoglycans containing hyaluronic acid, by fibroblasts and/or keratinocytes. The invention also relates to a cosmetic process for treating keratin materials using a composition containing at least one C-glycoside compound according to the invention.
摘要翻译： 本发明涉及给定绝对构型的新型C-糖苷化合物，其合成方法和含有它们的组合物。 本发明还涉及这些C-糖苷化合物的化妆品用途，有利地刺激含有D-葡糖胺和/或N-乙酰基-D-葡糖胺残基（有利地为透明质酸）和/或蛋白聚糖的糖胺聚糖的合成 含有透明质酸的蛋白聚糖，通过成纤维细胞和/或角质形成细胞。 本发明还涉及使用含有至少一种本发明的C-糖苷化合物的组合物来治疗角蛋白材料的美容方法。
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8.发明授权Biaromatic compounds and pharmaceutical and cosmetic compositions comprising them 失效双酚化合物和包含它们的药物和化妆品组合物公开(公告)号：US06703416B2
公开(公告)日：2004-03-09
申请号：US09984830
申请日：2001-10-31
IPC分类号： A61K3137
CPC分类号： C07D213/79 , A61K8/31 , A61K8/33 , A61K8/35 , A61K8/36 , A61K8/39 , A61K8/44 , A61K8/46 , A61K8/49 , A61K8/4926 , A61K8/4973 , A61K8/4986 , A61K8/60 , A61K8/64 , A61K2800/92 , A61Q5/00 , A61Q19/00 , A61Q19/02 , A61Q19/10 , C07D311/58 , C07D335/06 , C07D405/06 , C07D409/06
摘要： The invention concerns bi-aromatic compounds of formula (I) in which Ar represents (a), Z being O or S, R1 is CH3, —CH2—O—R6, —OR6 or —COR7; R2 is —OR8, —SR8 or a polyether radical if in the latter case R4 is C1-C20alkyl and is in ortho or meta position relative to X—Ar; R3 is alkyl or R2 and R3 together form a cycle optionally interrupted by O or S; R4 is aryl radical; R5 is H, halogen, C1-C20 alkyl or —OR8; R6 is H, alkyl or —COR9; R7 is H, alkyl, —N(r′)(r″) or —OR10; R8 is H, alkyl or —COR9; R9 is alkyl; R10 is H, C1-C20 alkyl, alkenyl, monohydroxyalkyl or polyhydroxyalkyl, aryl or aralkyl or a sugar residue, r′ and r″ are H, alkyl mono- or polyhydroxyalkyl, aryl, an amino acid or sugar residue or together form a heterocycle, X represents a radical of formula (d) or (e) in which R11 is H or —OR6; R12 is H or alkyl; or R11 and R12 form an oxo radical, and the salts, optical and geometrical isomers of the compounds of formula (I).
摘要翻译： 本发明涉及式（I）的二芳族化合物，其中Ar表示（a），Z为O或S，R 1为CH 3，-CH 2 -O-R6，-OR 6或-COR 7; 如果在后一种情况下R 4是C 1 -C 20烷基并且相对于X-Ar处于邻位或间位，则R2是-OR8，-SR8或聚醚基团; R3是烷基或R2和R3一起形成任选被O或S中断的循环; R4是芳基; R5是H，卤素，C1-C20烷基或-OR8; R6是H，烷基或-COR9; R 7为H，烷基，-N（R'）（r“）或-OR 10; R8是H，烷基或-COR9; R9为烷基; R 10是H，C 1 -C 20烷基，烯基，单羟基烷基或多羟基烷基，芳基或芳烷基或糖残基，r'和r“是H，烷基单 - 或多羟基烷基，芳基，氨基酸或糖残基或一起形成 杂环，X表示式（d）或（e）的基团，其中R 11为H或-OR 6; R 12为H或烷基; 或R 11和R 12形成氧基，以及式（I）化合物的盐，光学和几何异构体。
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9.发明授权Bi-aromatic compounds and pharmaceutical and cosmetic compositions containing same 失效双芳族化合物和含有它们的药物和化妆品组合物
公开(公告)号：US6103762A
公开(公告)日：2000-08-15
申请号：US242130
申请日：1999-03-23
IPC分类号： A61K8/00 , A61K8/14 , A61K8/30 , A61K8/31 , A61K8/33 , A61K8/35 , A61K8/36 , A61K8/368 , A61K8/37 , A61K8/39 , A61K8/44 , A61K8/46 , A61K8/49 , A61K8/60 , A61K8/64 , A61K31/192 , A61K31/22 , A61K31/35 , A61K31/352 , A61K31/382 , A61P9/00 , A61P9/10 , A61P11/00 , A61P17/00 , A61P17/02 , A61P17/06 , A61P17/10 , A61P17/14 , A61P17/16 , A61P19/02 , A61P27/02 , A61P29/00 , A61P35/00 , A61P37/08 , A61Q5/00 , A61Q5/02 , A61Q19/00 , A61Q19/02 , A61Q19/10 , C07C65/19 , C07C65/28 , C07C69/76 , C07D213/79 , C07D311/58 , C07D335/06 , C07D405/06 , C07D409/06 , A61K31/015 , A61K7/02 , A61K31/19 , A61K31/215
CPC分类号： C07D213/79 , A61K8/31 , A61K8/33 , A61K8/35 , A61K8/36 , A61K8/39 , A61K8/44 , A61K8/46 , A61K8/49 , A61K8/4926 , A61K8/4973 , A61K8/4986 , A61K8/60 , A61K8/64 , A61Q19/00 , A61Q19/02 , A61Q19/10 , A61Q5/00 , C07D311/58 , C07D335/06 , C07D405/06 , C07D409/06 , A61K2800/92
摘要： The invention concerns bi-aromatic compounds of formula (I) in which Ar represents (a), Z being O or S, R.sub.1 is --CH.sub.3, --CH.sub.2 --O--R.sub.6, --OR.sub.6 or --COR.sub.7 ; R.sub.2 is --OR.sub.8, --SR.sub.8 or a polyether radical if in the latter case R.sub.4 is C.sub.1 -C.sub.20 alkyl and is in ortho or meta position relative to X--Ar; R.sub.3 is alkyl or R.sub.2 and R.sub.3 together form a cycle optionally interrupted by O or S; R.sub.4 is aryl radical; R.sub.5 is H, halogen, C.sub.1 -C.sub.20 alkyl or --OR.sub.8 ; R.sub.6 is H, alkyl or --COR.sub.9 ; R.sub.7 is H, alkyl, --N(r')(r") or --OR.sub.10 ; R.sub.8 is H, alkyl or --COR.sub.9 ; R.sub.9 is alkyl; R.sub.10 is H, C.sub.1 -C.sub.20 alkyl, alkenyl, monohydroxyalkyl or polyhydroxyalkyl, aryl or aralkyl or a sugar residue, r' and r" are H, alkyl mono- or polyhydroxyalkyl, aryl, an amino acid or sugar residue or together form a heterocycle, X represents a radical of formula (d) or (e) in which R.sub.11 is H or --OR.sub.6 ; R.sub.12 is H or alkyl; or R.sub.11 and R.sub.12 form an oxo radical, and the salts, optical and geometrical isomers of the compounds of formula (I). ##STR1##
摘要翻译： PCT No.PCT / FR98 / 01238 Sec。 371 1999年3月23日 102（e）1999年3月23日PCT提交1998年6月12日PCT公布。 公开号WO98 / 56783 日期：1998年12月17日本发明涉及式（I）的双芳族化合物，其中Ar表示（a），Z为O或S，R 1为-CH 3，-CH 2 -O-R6，-OR 6或-COR 7; 如果在后一种情况下R 4为C 1 -C 20烷基且相对于X-Ar为邻位或间位，则R2为-OR8，-SR8或聚醚基团; R3是烷基或R2和R3一起形成任选被O或S中断的循环; R4是芳基; R5是H，卤素，C1-C20烷基或-OR8; R6是H，烷基或-COR9; R 7为H，烷基，-N（R'）（r“）或-OR 10; R8是H，烷基或-COR9; R9为烷基; R 10是H，C 1 -C 20烷基，烯基，单羟基烷基或多羟基烷基，芳基或芳烷基或糖残基，r'和r“是H，烷基单 - 或多羟基烷基，芳基，氨基酸或糖残基或一起形成 杂环，X表示式（d）或（e）的基团，其中R 11为H或-OR 6; R 12为H或烷基; 或R 11和R 12形成氧基，以及式（I）化合物的盐，光学和几何异构体。
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