中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

14 records (took 0.019 seconds)

    PARTICLE-DROP STRUCTURES AND METHODS FOR MAKING AND USING THE SAME
    1.
    发明申请
    PARTICLE-DROP STRUCTURES AND METHODS FOR MAKING AND USING THE SAME 有权

    公开(公告)号：US20250018386A1

    公开(公告)日：2025-01-16

    申请号：US18901981

    申请日：2024-09-30

    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

    Inventor： Dino Di Carlo ,  Chueh-Yu Wu

    IPC: B01L3/02 ,  B01L3/00 ,  C12N1/04 ,  C12N5/071 ,  C12N5/0783 ,  C12Q1/6806 ,  G01N33/543

    Abstract: Sub-millimeter scale three-dimensional (3D) structures are disclosed with customizable chemical properties and/or functionality. The 3D structures are referred to as drop-carrier particles. The drop-carrier particles allow the selective association of one solution (i.e., a dispersed phased) with an interior portion of each of the drop-carrier particles, while a second non-miscible solution (i.e., a continuous phase) associates with an exterior portion of each of the drop-carrier particles due to the specific chemical and/or physical properties of the interior and exterior regions of the drop-carrier particles. The combined drop-carrier particle with the dispersed phase contained therein is referred to as a particle-drop. The selective association results in compartmentalization of the dispersed phase solution into sub-microliter-sized volumes contained in the drop-carrier particles. The compartmentalized volumes can be used for single-molecule assays as well as single-cell, and other single-entity assays.

    Particle-drop structures and methods for making and using the same
    3.
    发明授权
    Particle-drop structures and methods for making and using the same 有权

    公开(公告)号：US12239973B2

    公开(公告)日：2025-03-04

    申请号：US18901981

    申请日：2024-09-30

    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

    Inventor： Dino Di Carlo ,  Chueh-Yu Wu

    IPC: B01L3/02 ,  B01L3/00 ,  C12N1/04 ,  C12N5/071 ,  C12N5/0783 ,  C12Q1/6806 ,  G01N33/543

    Abstract: Sub-millimeter scale three-dimensional (3D) structures are disclosed with customizable chemical properties and/or functionality. The 3D structures are referred to as drop-carrier particles. The drop-carrier particles allow the selective association of one solution (i.e., a dispersed phased) with an interior portion of each of the drop-carrier particles, while a second non-miscible solution (i.e., a continuous phase) associates with an exterior portion of each of the drop-carrier particles due to the specific chemical and/or physical properties of the interior and exterior regions of the drop-carrier particles. The combined drop-carrier particle with the dispersed phase contained therein is referred to as a particle-drop. The selective association results in compartmentalization of the dispersed phase solution into sub-microliter-sized volumes contained in the drop-carrier particles. The compartmentalized volumes can be used for single-molecule assays as well as single-cell, and other single-entity assays.

    THREE-DIMENSIONAL SHAPED MICROPARTICLES HAVING PROTECTED REGIONS FOR HOLDING CELLS AND USES THEREOF
    4.
    发明申请
    THREE-DIMENSIONAL SHAPED MICROPARTICLES HAVING PROTECTED REGIONS FOR HOLDING CELLS AND USES THEREOF 有权

    公开(公告)号：US20210292490A1

    公开(公告)日：2021-09-23

    申请号：US17340926

    申请日：2021-06-07

    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

    Inventor： Dino Di Carlo ,  Chueh-Yu Wu

    IPC: C08J3/075 ,  B01J19/00

    Abstract: A method of forming three-dimensional shaped microparticles in a microfluidic device includes flowing a mixture of a monomer and photoinitiator in a microfluidic channel having a plurality of pillars disposed therein to define a flow stream having a pre-defined shape and temporarily stopping the same. One or more portions of the flow stream are polymerized by passing polymerizing light through one or more masks and onto the flow stream, the polymerization process forming a plurality of three-dimensional shaped microparticles. The three-dimensional shape of the microparticle may be geometrically complex by using non-rectangular 2D orthogonal shapes for the flow and/or masked light source. The microparticles may include protected regions on which cells can be adhered to and protected from shear forces. The flow stream is restarted to flush out the newly formed microparticles and prepare the device for the next cycle of particle formation.

    PARTICLE-DROP STRUCTURES AND METHODS FOR MAKING AND USING THE SAME
    5.
    发明申请
    PARTICLE-DROP STRUCTURES AND METHODS FOR MAKING AND USING THE SAME 审中-公开

    公开(公告)号：US20190381497A1

    公开(公告)日：2019-12-19

    申请号：US16550105

    申请日：2019-08-23

    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

    Inventor： Dino Di Carlo ,  Chueh-Yu Wu ,  Ghulam Destgeer ,  Mengxing Ouyang

    IPC: B01L3/02 ,  B01L3/00 ,  G01N33/543

    Abstract: Sub-millimeter scale three-dimensional (3D) structures are disclosed with customizable chemical properties and/or functionality. The 3D structures are referred to as drop-carrier particles. The drop-carrier particles allow the selective association of one solution (i.e., a dispersed phased) with an interior portion of each of the drop-carrier particles, while a second non-miscible solution (i.e., a continuous phase) associates with an exterior portion of each of the drop-carrier particles due to the specific chemical and/or physical properties of the interior and exterior regions of the drop-carrier particles. The combined drop-carrier particle with the dispersed phase contained therein is referred to as a particle-drop. The selective association results in compartmentalization of the dispersed phase solution into sub-microliter-sized volumes contained in the drop-carrier particles. The compartmentalized volumes can be used for single-molecule assays as well as single-cell, and other single-entity assays.

    Particle-drop structures and methods for making and using the same
    6.
    发明授权
    Particle-drop structures and methods for making and using the same 有权

    公开(公告)号：US12233407B2

    公开(公告)日：2025-02-25

    申请号：US18161322

    申请日：2023-01-30

    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

    Inventor： Dino Di Carlo ,  Chueh-Yu Wu

    IPC: B01L3/02 ,  B01L3/00 ,  C12N1/04 ,  C12N5/071 ,  C12N5/0783 ,  C12Q1/6806 ,  G01N33/543

    Abstract: Sub-millimeter scale three-dimensional (3D) structures are disclosed with customizable chemical properties and/or functionality. The 3D structures are referred to as drop-carrier particles. The drop-carrier particles allow the selective association of one solution (i.e., a dispersed phased) with an interior portion of each of the drop-carrier particles, while a second non-miscible solution (i.e., a continuous phase) associates with an exterior portion of each of the drop-carrier particles due to the specific chemical and/or physical properties of the interior and exterior regions of the drop-carrier particles. The combined drop-carrier particle with the dispersed phase contained therein is referred to as a particle-drop. The selective association results in compartmentalization of the dispersed phase solution into sub-microliter-sized volumes contained in the drop-carrier particles. The compartmentalized volumes can be used for single-molecule assays as well as single-cell, and other single-entity assays.

    PARTICLE-DROP STRUCTURES AND METHODS FOR MAKING AND USING THE SAME
    8.
    发明申请
    PARTICLE-DROP STRUCTURES AND METHODS FOR MAKING AND USING THE SAME 有权

    公开(公告)号：US20210354121A1

    公开(公告)日：2021-11-18

    申请号：US17387990

    申请日：2021-07-28

    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

    Inventor： Dino Di Carlo ,  Chueh-Yu Wu ,  Ghulam Destgeer ,  Mengxing Ouyang

    IPC: B01L3/02 ,  B01L3/00 ,  G01N33/543

    Abstract: Sub-millimeter scale three-dimensional (3D) structures are disclosed with customizable chemical properties and/or functionality. The 3D structures are referred to as drop-carrier particles. The drop-carrier particles allow the selective association of one solution (i.e., a dispersed phased) with an interior portion of each of the drop-carrier particles, while a second non-miscible solution (i.e., a continuous phase) associates with an exterior portion of each of the drop-carrier particles due to the specific chemical and/or physical properties of the interior and exterior regions of the drop-carrier particles. The combined drop-carrier particle with the dispersed phase contained therein is referred to as a particle-drop. The selective association results in compartmentalization of the dispersed phase solution into sub-microliter-sized volumes contained in the drop-carrier particles. The compartmentalized volumes can be used for single-molecule assays as well as single-cell, and other single-entity assays.

    PARTICLE-DROP STRUCTURES AND METHODS FOR MAKING AND USING THE SAME
    10.
    发明申请
    PARTICLE-DROP STRUCTURES AND METHODS FOR MAKING AND USING THE SAME 有权

    公开(公告)号：US20250161933A1

    公开(公告)日：2025-05-22

    申请号：US19030825

    申请日：2025-01-17

    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

    Inventor： Dino Di Carlo ,  Chueh-Yu Wu

    IPC: B01L3/02 ,  B01L3/00 ,  C12N1/04 ,  C12N5/071 ,  C12N5/0783 ,  C12Q1/6806 ,  G01N33/543

    Abstract: Sub-millimeter scale three-dimensional (3D) structures are disclosed with customizable chemical properties and/or functionality. The 3D structures are referred to as drop-carrier particles. The drop-carrier particles allow the selective association of one solution (i.e., a dispersed phased) with an interior portion of each of the drop-carrier particles, while a second non-miscible solution (i.e., a continuous phase) associates with an exterior portion of each of the drop-carrier particles due to the specific chemical and/or physical properties of the interior and exterior regions of the drop-carrier particles. The combined drop-carrier particle with the dispersed phase contained therein is referred to as a particle-drop. The selective association results in compartmentalization of the dispersed phase solution into sub-microliter-sized volumes contained in the drop-carrier particles. The compartmentalized volumes can be used for single-molecule assays as well as single-cell, and other single-entity assays.

Patent Agency Ranking