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公开(公告)号：US11951176B2
公开(公告)日：2024-04-09
申请号：US16771588
申请日：2018-11-30
Applicant: The Regents of the University of California
Inventor： Heather D. Maynard , Natalie Boehnke
IPC: A61K47/58 , A61K47/69 , C07K14/605 , C08F8/34 , C08F220/28 , C08F220/38 , C08G81/02 , A61K38/00
CPC classification number: A61K47/6903 , A61K47/58 , C07K14/605 , C08F8/34 , C08F220/282 , C08F220/385 , C08G81/025 , A61K38/00 , C08F2800/10 , C08F2810/20
Abstract: Trehalose-based nanogels for stabilizing and controlled releasing biomolecules such as glucagons are disclosed. Specifically, trehalose-based nanogels comprise (a) a copolymer comprising first methacrylate units and second methacrylate units, wherein (i) the first methacrylate units comprise trehalose side chains; and (ii) the second methacrylate units comprise disulfide side chains; (b) dithiol cross-linkers; wherein the dithiol cross-linkers cross link the copolymer through the disulfide side chains of the second methacrylate units.
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公开(公告)号：US20200085964A1
公开(公告)日：2020-03-19
申请号：US16469786
申请日：2017-12-19
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Heather D. Maynard , Natalie Boehnke , Samantha J. Paluck
Abstract: Non-crushable pill formulations and methods of using the formulations are disclosed. A non-crushable pill formulation for preventing unintended use of a drug, comprising a polymer, the polymer forming a polymer backbone of the complex; cross-linkers, the cross-linkers connecting the polymer backbone through covalently bonding to form at least one inner cavity within the complex; and the drug, the drug being trapped either covalently or non-covalently in the at least one inner cavity within the complex, wherein the drug is protected from releasing outside of the complex.
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公开(公告)号：US10543280B2
公开(公告)日：2020-01-28
申请号：US15882120
申请日：2018-01-29
Applicant: The Regents of the University of California
Inventor： Heather D. Maynard , Rock J. Mancini , Juneyoung Lee , En-Wei Lin
IPC: A61K47/58 , C07H3/04 , C08F110/00 , C08F10/00 , C08F210/00 , C07H17/04 , A61K31/713 , A61K38/47
Abstract: Compositions and methods for stabilizing biomolecules are disclosed. Specifically, the compositions include novel homopolymers or copolymers containing trehalose side chains conjugated to biomolecules. When such homopolymers or copolymers are placed in close proximity to biomolecules, such as proteins, the homopolymers or copolymers protect and/or stabilize the biomolecule. The compositions and methods may be suitable for use in various industries such as healthcare (pharmaceuticals), molecular biology, biofuels, paper, personal care, detergent, photographic, rubber, brewing, dairy and food processing industries.
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公开(公告)号：US11541125B2
公开(公告)日：2023-01-03
申请号：US16469786
申请日：2017-12-19
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Heather D. Maynard , Natalie Boehnke , Samantha J. Paluck
Abstract: Non-crushable pill formulations and methods of using the formulations are disclosed. A non-crushable pill formulation for preventing unintended use of a drug, comprising a polymer, the polymer forming a polymer backbone of the complex; cross-linkers, the cross-linkers connecting the polymer backbone through covalently bonding to form at least one inner cavity within the complex; and the drug, the drug being trapped either covalently or non-covalently in the at least one inner cavity within the complex, wherein the drug is protected from releasing outside of the complex.
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公开(公告)号：US10662295B2
公开(公告)日：2020-05-26
申请号：US15503348
申请日：2015-08-12
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Heather D. Maynard
IPC: C08J3/075 , C08F12/32 , A61K9/06 , A61K38/28 , A61K9/00 , A61K47/36 , C08F12/22 , C08F212/14 , A23K20/163 , A61K47/32 , C12N9/16 , C12N9/96
Abstract: Trehalose-based hydrogels and methods of making such hydrogels are disclosed. Specifically, a method of creating a trehalose-based hydrogel, comprising the steps of: a) forming a trehalose homopolymer or co-polymer; b) preparing a cross-linker; and c) reacting the trehalose homopolymer or co-polymer with the cross-linker to form the trehalose-based hydrogel.
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Patent Agency Ranking
公开(公告)号：US10273333B2
公开(公告)日：2019-04-30
申请号：US15394483
申请日：2016-12-29
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Heather D. Maynard
IPC: C08G63/91 , C07H3/04 , C08G63/78 , A61K47/34 , A61K38/19 , C12P19/12 , C08B37/00 , A61K47/30 , C08G63/685 , C08G63/688 , C08G63/08 , C08F220/28 , A61K38/00
Abstract: Structures and methods of making biodegradable trehalose co-polymers are disclosed. Specifically, biodegradable trehalose co-polymers consist of the general structure R5—[R1R2C—CR3R4]n-[DG]m—R6, wherein R1-R4 are independently selected from hydrogen or a side chain comprising at least one carbon atom, and wherein at least one of R1-R4 is a side chain comprising -L-trehalose, wherein L is a linker molecule that links trehalose to the monomer through at least one of the trehalose hydroxyl groups (—OH), wherein DG is a biodegradable group, and wherein R5 and R6 are end groups.
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公开(公告)号：US20180312630A1
公开(公告)日：2018-11-01
申请号：US15503350
申请日：2015-08-13
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Heather D. Maynard
IPC: C08G63/91 , A61K47/34 , A61K38/19 , C08G63/08 , C08G63/688
CPC classification number: C08G63/91 , A61K38/00 , A61K38/193 , A61K47/30 , A61K47/34 , C07H3/04 , C08B37/0006 , C08F2220/285 , C08F2438/03 , C08G63/6852 , C08G63/6882 , C08G63/78 , C08G63/912 , C12P19/12
Abstract: Structures and methods of making biodegradable trehalose co-polymers are disclosed. Specifically, biodegradable trehalose co-polymers consist of the general structure R5[R1R2C—CR3R4]n-[DG]m-R6, wherein R1-R4 are independently selected from hydrogen or a side chain comprising at least one carbon atom, and wherein at least one of R1-R4 is a side chain comprising -L-trehalose, wherein L is a linker molecule that links trehalose to the monomer through at least one of the trehalose hydroxyl groups (—OH), wherein DG is a biodegradable group, and wherein R5 and R6 are end groups.
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公开(公告)号：US20170240711A1
公开(公告)日：2017-08-24
申请号：US15503348
申请日：2015-08-12
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Heather D. Maynard
Abstract: Trehalose-based hydrogels and methods of making such hydrogels are disclosed. Specifically, a method of creating a trehalose-based hydrogel, comprising the steps of: a) forming a trehalose homopolymer or co-polymer; b) preparing a cross-linker; and c) reacting the trehalose homopolymer or co-polymer with the cross-linker to form the trehalose-based hydrogel.
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9.发明申请公开(公告)号：US20180112034A1
公开(公告)日：2018-04-26
申请号：US15394483
申请日：2016-12-29
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Heather D. Maynard
CPC classification number: C08G63/912 , A61K38/00 , A61K38/193 , A61K47/24 , A61K47/34 , A61K47/58 , A61K47/593 , C07H3/04 , C08B37/0006 , C08F220/40 , C08F2220/285 , C08F2438/03 , C08G63/08 , C08G63/6852 , C08G63/688 , C08G63/6882 , C08G63/78 , C08G63/91 , C08G2230/00 , C12P19/12 , C08F216/38
Abstract: Structures and methods of making biodegradable trehalose co-polymers are disclosed. Specifically, biodegradable trehalose co-polymers consist of the general structure R5—[R1R2C—CR3R4]n-[DG]m—R6, wherein R1-R4 are independently selected from hydrogen or a side chain comprising at least one carbon atom, and wherein at least one of R1-R4 is a side chain comprising -L-trehalose, wherein L is a linker molecule that links trehalose to the monomer through at least one of the trehalose hydroxyl groups (—OH), wherein DG is a biodegradable group, and wherein R5 and R6 are end groups.
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公开(公告)号：US20170143795A1
公开(公告)日：2017-05-25
申请号：US15427918
申请日：2017-02-08
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Heather D. Maynard , Thi Nguyen
IPC: A61K38/18 , C08F212/14 , A61K31/78 , A61K47/32 , A61K31/795 , C07K14/50 , C08F220/28
CPC classification number: A61K38/1825 , A61K31/78 , A61K31/795 , A61K47/32 , A61K47/58 , C07K14/503 , C08F212/14 , C08F220/28 , C08F2220/286 , Y02A50/385 , Y02A50/411
Abstract: A heparin mimicking polymer, its conjugate with bFGF, and method of making and using the same are disclosed. In particular, described herein are conjugates of biologic agents (e.g., bFGF) and heparin mimicking polymers having superior stability while retaining full native activity after a variety of stressors.
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