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    NANOSCALE COATINGS FOR ENCAPSULATION OF BIOLOGICAL ENTITIES
    1.
    发明申请
    NANOSCALE COATINGS FOR ENCAPSULATION OF BIOLOGICAL ENTITIES 审中-公开

    公开(公告)号：US20190151253A1

    公开(公告)日：2019-05-23

    申请号：US16255709

    申请日：2019-01-23

    Applicant: The Regents of the University of California

    Inventor： Inanc Ortac ,  Gen Yong ,  Michael Benchimol ,  Sadik C. Esener

    IPC: A61K9/51 ,  A61K35/76

    Abstract: Methods, systems, and devices are disclosed for encapsulating biological entities with preservation of their biological activity. In one aspect, a method of encapsulating a biological entity includes templating a biocompatible material onto a biological structure to form a coating structure enclosing the biological structure, the coating structure having a size in the nanometer range, in which the coated biological structure preserves its biological activity within the coating structure. In some implementations of the method, the biological structure includes a virus and the biocompatible material includes silica.

    ENZYME-ENCAPSULATED NANOPARTICLE PLATFORM
    3.
    发明申请
    ENZYME-ENCAPSULATED NANOPARTICLE PLATFORM 审中-公开

    公开(公告)号：US20160243262A1

    公开(公告)日：2016-08-25

    申请号：US15022551

    申请日：2014-09-17

    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  DEVACELL, INC.

    Inventor： Inanc Ortac ,  Sadik C. Esener ,  Ibrahim Gokce Yayla ,  Bradley Messmer

    IPC: A61K49/00 ,  A61B5/00 ,  A61B5/1455 ,  A61B5/145 ,  C12Q1/54 ,  A61K49/22

    CPC classification number: A61K49/0093 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/6831 ,  A61B5/7278 ,  A61B2503/40 ,  A61K9/5115 ,  A61K38/50 ,  A61K49/225 ,  C12Q1/00 ,  C12Q1/30 ,  C12Q1/54

    Abstract: Disclosed are methods, systems, and devices for implementing nanoparticles to encapsulate biomolecules such as enzymes. In one aspect, a nanoparticle device includes a shell structure including an internal layer structured to enclose a hollow interior region and include one or more holes penetrating through the internal layer, and an external layer formed of a porous material around the internal layer; and an enzyme contained within the interior region of the shell structure, the enzyme having entered the shell structure through the one or more holes and incapable of passing through the external layer, in which the pores are of a size that prevents the enzyme to pass through the pores while permitting substances smaller than the pore size to pass through the pores.

    Abstract translation: 公开了用于实现纳米颗粒以包封生物分子如酶的方法，系统和装置。 一方面，纳米颗粒装置包括壳结构，其包括被构造成包围中空内部区域的内层，并且包括穿过内层的一个或多个孔以及由内层周围的多孔材料形成的外层; 以及包含在壳结构的内部区域内的酶，所述酶通过所述一个或多个孔进入所述壳结构，并且不能穿过所述外层，其中所述孔具有防止酶通过的尺寸 同时允许小于孔径的物质通过孔。

    ACOUSTICALLY TRIGGERED NANO/MICRO-SCALE PROPULSION DEVICES
    5.
    发明申请
    ACOUSTICALLY TRIGGERED NANO/MICRO-SCALE PROPULSION DEVICES 有权
    有声触发的纳米/微尺度推进装置

    公开(公告)号：US20150013304A1

    公开(公告)日：2015-01-15

    申请号：US14379279

    申请日：2013-02-19

    Applicant: The Regents of the University of California

    Inventor： Joseph Wang ,  Sadik C. Esener ,  Daniel Kagan ,  Michael Benchimol ,  Jonathan Claussen

    IPC: F02K7/02 ,  A61M37/00

    CPC classification number: F02K7/02 ,  A61M37/0092 ,  B82B1/006 ,  B82Y5/00 ,  B82Y30/00 ,  F03G7/005

    Abstract: Techniques, devices and systems are disclosed for implementing acoustically triggered propulsion of nano- and micro-scale structures. In one aspect, an ultrasound responsive propulsion device includes a tube that includes one or more layers including an inner layer having an electrostatic surface, and an ultrasound-responsive substance coupled to the inner layer and configured to form gaseous bubbles in a fluid in response to an ultrasound pulse, in which the bubbles exit the tube to propel the tube to move in the fluid.

    Abstract translation: 公开了用于实现声学触发的纳米和微尺度结构的推进的技术，装置和系统。 一方面，超声响应推进装置包括管，其包括一个或多个包括具有静电表面的内层的层，以及耦合到内层的超声响应物质，并且被配置成在流体中形成响应于 超声脉冲，其中气泡离开管以推动管在流体中移动。

    Ultra-sensitive force sensing based on evanescent light
    8.
    发明授权
    Ultra-sensitive force sensing based on evanescent light 有权
    基于ev逝光的超敏感力感测

    公开(公告)号：US09459163B2

    公开(公告)日：2016-10-04

    申请号：US14762792

    申请日：2014-01-22

    Applicant: The Regents of the University of California

    Inventor： Donald J. Sirbuly ,  Sadik C. Esener ,  Ilsun Yoon

    IPC: G01N21/00 ,  G01L1/24

    CPC classification number: G01L1/243 ,  G01L1/242

    Abstract: Methods, structures, devices and systems are disclosed for implementing a fiber optic force sensing transducer. In one aspect, an exemplary fiber optic force sensing transducer device includes an optical fiber coated by at least one layer of a polyelectrolyte material that utilizes the movement of optical structures coupled to the external polyelectrolyte layer in an evanescent field produced by the optical fiber to detect forces imposing on the fiber. In one aspect, an optical sensing device includes an optical waveguide that internally guides light, one or more layers formed outside the optical waveguide within an evanescent field of the guided light in the optical waveguide, and one or more optical structures coupled to the one or more layers in the evanescent field to emit light based on interaction with the evanescent field to indicate a position of an optical structure relative to an external surface of the optical waveguide.

    Abstract translation: 公开了用于实现光纤力感测传感器的方法，结构，装置和系统。 在一个方面，一种示例性光纤力感测换能器装置包括由至少一层聚电解质材料涂覆的光纤，该光纤利用由光纤产生的消逝场中耦合到外部聚电解质层的光学结构的运动来检测 力量强加在纤维上。 在一个方面，一种光学感测装置包括光波导，其内部引导光，在光波导内的引导光的消逝场内形成在光波导外部的一个或多个层，以及耦合到该光波导中的一个或多个光学结构 ev逝场中的更多层基于与渐逝场的相互作用发光，以指示光学结构相对于光波导的外表面的位置。

    Ex-Vivo Multi-Dimensional System For The Separation And Isolation Of Cells, Vesicles, Nanoparticles, And Biomarkers
    9.
    发明申请
    Ex-Vivo Multi-Dimensional System For The Separation And Isolation Of Cells, Vesicles, Nanoparticles, And Biomarkers 有权
    用于分离和分离细胞，囊泡，纳米颗粒和生物标志物的体内多维体系

    公开(公告)号：US20140048417A1

    公开(公告)日：2014-02-20

    申请号：US14063884

    申请日：2013-10-25

    Applicant: The Regents of the University of California

    Inventor： Michael Heller ,  Benjamin Sullivan ,  Rajaram Krishnan ,  Dennis Carson ,  Sadik C. Esener

    IPC: B03C5/00

    CPC classification number: B03C5/005 ,  G01N27/447 ,  G01N30/0005 ,  G01N33/491

    Abstract: Devices and techniques are described that involve a combination of multidimensional electrokinetic, dielectrophoretic, electrophoretic and fluidic forces and effects for separating cells, nanovesicles, nanoparticulates and biomarkers (DNA, RNA, antibodies, proteins) in high conductance (ionic) strength biological samples and buffers. In disclosed embodiments, a combination of continuous and/or pulsed dielectrophoretic (DEP) forces, continuous and/or pulsed field DC electrophoretic forces, microelectrophoresis and controlled fluidics are utilized with arrays of electrodes. In particular, the use of chambered DEP devices and of a properly scaled relatively larger electrode array devices that combines fluid, electrophoretic and DEP forces enables both larger and/or clinically relevant volumes of blood, serum, plasma or other samples to be more directly, rapidly and efficiently analyzed. The invention enables the creation of “seamless” sample-to-answer diagnostic systems and devices. The devices and techniques described can also carry out the assisted self-assembly of molecules, polymers, nanocomponents and mesoscale entities into three dimensional higher order structures.

    Abstract translation: 描述了涉及多维电动，介电泳，电泳和流体力的组合的装置和技术，以及用于在高电导（离子）强度生物样品和缓冲液中分离细胞，纳米囊，纳米颗粒和生物标志物（DNA，RNA，抗体，蛋白质）的作用 。 在所公开的实施例中，连续和/或脉冲介电电泳（DEP）力，连续和/或脉冲场DC电泳力，微电泳和受控流体学的组合被利用于电极阵列。 特别地，使用腔室DEP装置和结合流体，电泳和DEP力的适当缩放的相对较大的电极阵列装置的使用使得血液，血清，血浆或其它样品的较大和/或临床相关体积能够更直接地， 快速有效地分析。 本发明能够创建“无缝”的样本到应答诊断系统和设备。 所描述的装置和技术还可以将分子，聚合物，纳米组分和中尺度实体的辅助自组装执行成三维高阶结构。

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