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    SYSTEMS, METHODS AND COMPONENTS FOR ISOLATING CELLS FROM A FLUID SAMPLE
    1.
    发明申请
    SYSTEMS, METHODS AND COMPONENTS FOR ISOLATING CELLS FROM A FLUID SAMPLE 审中-公开
    用于从流体样品中分离细胞的系统，方法和组分

    公开(公告)号：US20150285717A1

    公开(公告)日：2015-10-08

    申请号：US14403542

    申请日：2013-05-29

    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  CYTOLUMINA TECHNOLOGIES CORP.

    Inventor： Hsian-Rong Tseng ,  Mitch A. Garcia ,  Min Song ,  Libo Zhao ,  Shuang Hou ,  Tom Lee ,  Daniel Wang ,  Bo Tao

    IPC: G01N1/28 ,  B01L3/00

    CPC classification number: G01N1/28 ,  B01L3/502715 ,  B01L3/502761 ,  B01L9/527 ,  B01L2200/027 ,  B01L2200/0647 ,  B01L2300/0609 ,  B01L2300/0816 ,  B01L2300/0883 ,  G01N1/286 ,  G01N1/4077 ,  G01N33/56966 ,  G01N33/574 ,  G01N2001/284 ,  G01N2001/2886

    Abstract: A system for isolating preselected cell types from a fluid sample that includes a plurality of cell types includes a cell-capture fluidic chip, and a chip holder configured to receive the cell-capture fluidic chip and to maintain the cell-capture fluidic chip with a substantially fluid-tight seal while in operation. The chip holder is further configured to release the cell-capture fluidic chip to be removed from the chip holder for further processing. The cell-capture fluidic chip includes a substrate, a laser micro-dissection membrane disposed on the substrate, and a channel-defining layer disposed on the laser micro-dissection membrane. The laser micro-dissection membrane has a surface adapted to capture preselected cell types preferentially over other cell types of the plurality of cell types. The channel-defining layer is removable from the laser micro-dissection membrane for further processing of the cell-capture fluidic chip.124

    Abstract translation: 用于从包括多个细胞类型的流体样品中分离预选细胞类型的系统包括细胞捕获流体芯片和被配置为接收细胞捕获流体芯片并且将细胞捕获流体芯片维持在 在运行时基本上是流体密封的。 芯片保持器进一步构造成释放要从芯片保持器移除的细胞捕获流体芯片用于进一步处理。 细胞捕获流体芯片包括基板，设置在基板上的激光微解剖膜和设置在激光微分离膜上的通道限定层。 激光微解剖膜具有适于比多种细胞类型的其它细胞类型优先捕获预选细胞类型的表面。 通道限定层可从激光微解剖膜移除，用于细胞捕获流体芯片的进一步处理。 124

    SELECTIVE CAPTURE AND STIMULATED RELEASE OF CIRCULATING TUMOR CELLS ON NANOSTRUCTURED DEVICES
    5.
    发明申请
    SELECTIVE CAPTURE AND STIMULATED RELEASE OF CIRCULATING TUMOR CELLS ON NANOSTRUCTURED DEVICES 审中-公开
    循环肿瘤细胞在纳米结构设备上的选择性捕获和刺激释放

    公开(公告)号：US20150260710A1

    公开(公告)日：2015-09-17

    申请号：US14418406

    申请日：2013-07-31

    Applicant: The Regents of the University of California ,  RIKEN

    Inventor： Hsian-Rong Tseng ,  Shuang Hou ,  Libo Zhao ,  Hsiao-Hua Yu ,  Shyh-Chyang Luo ,  Haichao Zhao

    IPC: G01N33/545 ,  G01N33/543

    CPC classification number: G01N33/545 ,  G01N33/54306 ,  G01N33/54346 ,  G01N2333/70596

    Abstract: A device for capturing preselected cell types from a fluid sample that includes a plurality of cell types includes a substrate, a plurality of nanowires at least one of attached to or integral with a surface of the substrate such that each nanowire of the plurality of nanowires has an unattached end, and a layer of temperature-responsive material formed on at least the unattached end of each of the plurality of nanowires. The layer of temperature-responsive material has a compact configuration at a first temperature and an expanded configuration at a second temperature so as to facilitate release of cells captured at the first temperature to be released at the second temperature.

    Abstract translation: 用于从包括多个细胞类型的流体样品中捕获预选细胞类型的装置包括基底，多个纳米线，其至少一个附着到基底的表面或与该基底的表面成一体，使得多个纳米线中的每个纳米线具有 至少在所述多个纳米线中的每一个的未附着端部上形成一层温度响应材料。 温度响应性材料层在第一温度下具有紧凑的结构，在第二温度下具有膨胀构型，以便于在第二温度下在第一温度下捕获的细胞释放以释放。

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