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11 条记录 (耗时 0.02 秒)

    System for detecting rare cells
    1.
    发明授权
    System for detecting rare cells 有权

    公开(公告)号：US10317406B2

    公开(公告)日：2019-06-11

    申请号：US15091830

    申请日：2016-04-06

    申请人： The Regents of the University of Michigan

    发明人： Hyeun Joong Yoon ,  Apoorv Shanker ,  Jinsang Kim ,  Sunitha Nagrath ,  Vasudha Murlidhar

    IPC分类号： G01N33/543 ,  G01N33/574 ,  G01N33/545 ,  C08L33/26

    摘要： A system for detecting rare cells in a fluid is disclosed. The system includes a substrate and a mixture disposed on the substrate and including a carrier and a thermo-responsive polymer for capture and release of the rare cells. Also disclosed is a method for detecting rare cells in a fluid using a system including a substrate and a mixture that is disposed on the substrate. The mixture includes a carrier and a thermo-responsive polymer. The method includes providing the system and introducing a sample of fluid containing the rare cells into the system such that the sample interacts with the carrier for capturing the rare cells.

    Functionalized Polydiacetylene Sensors
    3.
    发明申请
    Functionalized Polydiacetylene Sensors 有权
    官能化聚二乙炔传感器

    公开(公告)号：US20150268232A1

    公开(公告)日：2015-09-24

    申请号：US14157670

    申请日：2014-01-17

    申请人： The Regents of the University of Michigan

    发明人： Jinsang Kim ,  Jiseok Lee

    IPC分类号： G01N33/543

    CPC分类号： G01N33/5432 ,  C07B2200/11 ,  C07C233/20 ,  C07C233/49 ,  C07C233/55 ,  C07C251/48 ,  C07D251/30 ,  C07H21/00 ,  C40B40/04 ,  C40B80/00 ,  G01N33/52 ,  G01N33/542 ,  G01N33/582

    摘要： A microarray includes a solid substrate having a surface, the surface having a plurality of binding spots and a plurality of reaction moieties bound to the binding spots. A reaction moiety includes a plurality of polyacetylene monomers, the polyacetylene monomers having a first coupling region and a second coupling region, the first coupling region having a first functional group operable to bind to the binding spot and the second coupling region comprising a second functional group operable to bind to an accessory molecule; and an accessory molecule having a binding region and an analyte reaction region, the analyte reaction region operable to selectively bind to the target analyte, and the binding region operable to bind to the second coupling region of the polyacetylene monomer. Upon binding a target analyte with the reaction moiety, a color change from the polyacetylene monomer occurs and the reaction moiety produces fluorescence.

    摘要翻译： 微阵列包括具有表面的固体基质，该表面具有多个结合点和与结合点结合的多个反应部分。 反应部分包括多个聚乙炔单体，所述聚乙炔单体具有第一耦合区域和第二耦合区域，所述第一耦合区域具有可操作以结合至所述结合点的第一官能团，所述第二耦合区域包含第二官能团 可操作地结合辅助分子; 以及具有结合区域和分析物反应区域的辅助分子，所述分析物反应区域可操作以选择性地结合靶分析物，以及结合区域可操作以结合聚乙炔单体的第二耦合区域。 在将目标分析物与反应部分结合时，发生来自聚乙炔单体的颜色变化，并且反应部分产生荧光。

    Functionalized polydiacetylene sensors
    4.
    发明授权
    Functionalized polydiacetylene sensors 有权
    功能化聚二乙炔传感器

    公开(公告)号：US09523683B2

    公开(公告)日：2016-12-20

    申请号：US14157670

    申请日：2014-01-17

    申请人： The Regents of the University of Michigan

    发明人： Jinsang Kim ,  Jiseok Lee

    IPC分类号： G01N33/542 ,  G01N33/543 ,  C07C233/20 ,  C07C233/49 ,  C07C233/55 ,  C07C251/48 ,  C07D251/30 ,  C07H21/00 ,  C40B40/04 ,  C40B80/00 ,  G01N33/52 ,  G01N33/58

    CPC分类号： G01N33/5432 ,  C07B2200/11 ,  C07C233/20 ,  C07C233/49 ,  C07C233/55 ,  C07C251/48 ,  C07D251/30 ,  C07H21/00 ,  C40B40/04 ,  C40B80/00 ,  G01N33/52 ,  G01N33/542 ,  G01N33/582

    摘要： A microarray includes a solid substrate having a surface, the surface having a plurality of binding spots and a plurality of reaction moieties bound to the binding spots. A reaction moiety includes a plurality of polyacetylene monomers, the polyacetylene monomers having a first coupling region and a second coupling region, the first coupling region having a first functional group operable to bind to the binding spot and the second coupling region comprising a second functional group operable to bind to an accessory molecule; and an accessory molecule having a binding region and an analyte reaction region, the analyte reaction region operable to selectively bind to the target analyte, and the binding region operable to bind to the second coupling region of the polyacetylene monomer. Upon binding a target analyte with the reaction moiety, a color change from the polyacetylene monomer occurs and the reaction moiety produces fluorescence.

    摘要翻译： 微阵列包括具有表面的固体基质，该表面具有多个结合点和与结合点结合的多个反应部分。 反应部分包括多个聚乙炔单体，所述聚乙炔单体具有第一耦合区域和第二耦合区域，所述第一耦合区域具有可操作以结合至所述结合点的第一官能团，所述第二耦合区域包含第二官能团 可操作地结合辅助分子; 以及具有结合区域和分析物反应区域的辅助分子，所述分析物反应区域可操作以选择性地结合靶分析物，以及结合区域可操作以结合聚乙炔单体的第二耦合区域。 在将目标分析物与反应部分结合时，发生来自聚乙炔单体的颜色变化，并且反应部分产生荧光。

    Molecularly engineered high thermal conductivity polymers and methods for making the same
    8.
    发明授权
    Molecularly engineered high thermal conductivity polymers and methods for making the same 有权

    公开(公告)号：US10696885B2

    公开(公告)日：2020-06-30

    申请号：US16002809

    申请日：2018-06-07

    申请人： The Regents of the University of Michigan

    发明人： Jinsang Kim ,  Chen Li ,  Apoorv Shanker ,  Kevin Pipe ,  Gun-Ho Kim

    IPC分类号： C08F26/10 ,  C08F20/06 ,  C09K5/14 ,  C08K3/08 ,  C08J5/18 ,  C09D139/06 ,  C09D133/02 ,  B29C71/02 ,  B29C41/04 ,  B29K33/04

    摘要： Methods of increasing thermal conductivity of a bulk polymer are provided. The methods include contacting a bulk polyelectrolyte polymer comprising an ionizable repeating pendant group with an aqueous liquid having a pH that ionizes the pendant group and isotropically extend the polyelectrolyte polymer to an extended non-globular chain conformation. The polyelectrolyte polymer so treated thus exhibits a thermal conductivity of greater than or equal to about 0.6 W/m·K and optionally greater than or equal to about 1 W/m·K. In other aspects, the present disclosure provides a high thermal conductivity material comprising a bulk polyelectrolyte polymer bearing a repeating charged group and having an extended non-globular chain conformation and that exhibits a thermal conductivity of greater than or equal to about 0.6 W/m·K and optionally greater than or equal to about 1 W/m·K. The high thermal conductivity material may be used in electronic devices, including as housings/encapsulation and thermal interfaces.

    System for Detecting Rare Cells
    10.
    发明申请
    System for Detecting Rare Cells 审中-公开
    检测稀有细胞系统

    公开(公告)号：US20160291019A1

    公开(公告)日：2016-10-06

    申请号：US15091830

    申请日：2016-04-06

    申请人： The Regents of the University of Michigan

    发明人： Hyeun Joong Yoon ,  Apoorv Shanker ,  Jinsang Kim ,  Sunitha Nagrath ,  Vasudha Murlidhar

    IPC分类号： G01N33/574 ,  G01N33/543 ,  G01N33/545

    CPC分类号： G01N33/574 ,  G01N33/54353 ,  G01N33/545

    摘要： A system for detecting rare cells in a fluid is disclosed. The system includes a substrate and a mixture disposed on the substrate and including a carrier and a thermo-responsive polymer for capture and release of the rare cells. Also disclosed is a method for detecting rare cells in a fluid using a system including a substrate and a mixture that is disposed on the substrate. The mixture includes a carrier and a thermo-responsive polymer. The method includes providing the system and introducing a sample of fluid containing the rare cells into the system such that the sample interacts with the carrier for capturing the rare cells.

    摘要翻译： 公开了一种用于检测流体中稀有细胞的系统。 该系统包括基材和设置在基材上的混合物，并且包括用于捕获和释放稀有细胞的载体和热响应聚合物。 还公开了使用包括基板和设置在基板上的混合物的系统来检测流体中的稀有电池的方法。 该混合物包括载体和热响应聚合物。 该方法包括提供系统并将含有罕见细胞的流体样品引入系统，使得样品与载体相互作用以捕获稀有细胞。