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公开(公告)号：US20230051263A1
公开(公告)日：2023-02-16
申请号：US17791790
申请日：2021-01-11
发明人： Xudong FAN , Wen XUE , Xiaotian TAN , Mark A. ILGEN , Girish KULKARNI , Maung Kyaw KHAING OO
摘要： An automated microfluidic bioreactor device and methods to rapidly detect drugs of abuse from human sweat are provided. The bioreactor can perform either single-plexed measurements (detecting only one target analyte at a time) or multiplexed measurement (detecting multiple analytes simultaneously). The bioreactor device has a cartridge comprising a capillary array that employs competitive enzyme-linked immunosorbent assay (ELISA) to detect the presence of various drugs or metabolite compounds. For example, four common drugs, methadone, methamphetamine, amphetamine, and tetrahydrocannabinol, were detected rapidly and quantitatively in about 16 minutes with a low sweat sample volume (about 4 μL per analyte) and a large dynamic range (methadone: 0.0016 ng/mL-1 ng/mL; METH: 0.016 ng/mL-25 ng/mL; amphetamine: 0.005 ng/mL-10 ng/mL; THC: 0.02 ng/mL-1000 ng/mL).
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公开(公告)号：US20180164261A1
公开(公告)日：2018-06-14
申请号：US15571792
申请日：2016-05-04
发明人： Xudong FAN , Hongbo ZHU , Robert NIDETZ , Katsuo KURABAYASHI , Menglian ZHOU , Jiwon LEE
CPC分类号： G01N30/64 , G01N27/66 , G01N27/68 , G01N30/6095 , G01N30/74 , G01N2030/642
摘要： A rapid flow-through, highly sensitive microfluidic photoionization detector (PID) which is micro-fabricated directly onto a substrate, such as a conductive silicon wafer, is provided. The microfluidic PID has an ionization chamber volume of less than 9 μL. The microfluidic PID may have a flow through design with a microfluidic channel defines a serpentine pattern on the substrate. The flow through design of the microfluidic PID results in negligible dead volume, thus allowing a shortened response time over existing commercially available designs. Such microfluidic PIDs are particularly useful with gas chromatography (GC), including microGC and multi-dimensional microGC systems. Methods for calibrating PIDs are also provided.
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公开(公告)号：US20230152230A1
公开(公告)日：2023-05-18
申请号：US17919671
申请日：2021-04-30
发明人： Xudong FAN , Qiushu CHEN , Yunlu SUN
IPC分类号： G01N21/64
CPC分类号： G01N21/6458 , G01N21/6428 , G01N2021/6439 , G01N2021/6421
摘要： The present disclosure provides an imaging system. The imaging system may include a laser cavity that is configured to receive a biological sample, where the biological sample is treated with a dye; an excitation light source that is configured to direct energy at the laser cavity so as to cause an emission from the biological sample, where the emission includes a laser emission at a first spectral band and a fluorescence emission at a second spectral band; a first detector that is configured to measure the laser emission generated by the biological sample; a second detector that is configured to measure the fluorescence emission generated by the biological sample; a splitter that is configured to direct the laser emission to the first detector and the fluorescence emission to the second detector; and a controller interfaced with the excitation light source, the first detector, and the second detector.
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公开(公告)号：US20180059058A1
公开(公告)日：2018-03-01
申请号：US15685139
申请日：2017-08-24
发明人： Xudong FAN , Hongbo ZHU , Katsuo KURABAYASHI
IPC分类号： G01N27/66
摘要： A discharge ionization current detector for ionizing and detecting a sample component where the sample component is ionized by UV light is provided. The detector includes a UV light source, and a microfluidic channel having a first surface including a conducting or semiconducting material and an opposing second surface including a conducting or semiconducting material, one of the first surface and the second surface being a collection electrode and the other of the first surface and the second surface being a bias electrode, the microfluidic channel being configured to receive a sample component. The microfluidic channel is in fluid communication with the UV light source such that, when activated, UV light from the UV light source can enter the microfluidic channel and ionize the sample component, which releases an electron, and the ionized sample component and electron are detected by the collection and bias electrodes.
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公开(公告)号：US20240252099A1
公开(公告)日：2024-08-01
申请号：US18428514
申请日：2024-01-31
发明人： Xudong FAN , Anjali Devi SIVAKUMAR
CPC分类号： A61B5/4266 , A61B5/681 , B01D53/02 , B01D53/266 , A61B2560/0252 , A61B2562/029 , B01D2257/702 , B01D2257/80
摘要： Transepidermal water loss (TEWL) measurement approach is presented that achieves accurate and continuous monitoring completely independent of ambient environmental variations. This new measurement approach uses short dry air purges to dry the skin surface and the water vapor collection chamber, thus refreshing the measurement site each time during skin barrier analysis. These dry air purges help maintain a highly controlled localized measuring environment without disturbing any inherent skin properties, enabling one to produce reproducible TEWL results. A mathematical model developed based on Fick's laws of diffusion is presented, and shown to have excellent agreement with the mathematical model of a commercial TEWL device. The application of this mathematical model in deciphering the TEWL values from the transient microclimate behavior in the vapor measuring chamber of the new TEWL approach is also discussed.
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公开(公告)号：US20230062256A1
公开(公告)日：2023-03-02
申请号：US17795581
申请日：2021-01-28
发明人： Xudong FAN , Xueding WANG , Xuzhou LI , Wei ZHANG , William Yanli WANG , Xiaoqin WU , Xiaotian TAN , Brendon BAKER , Yannis M. PAULUS
摘要： An imaging system for cell-based therapies is provided. The imagining system includes one or more optical tags configured for insertion into a cell or biological tissue, an excitation light source configured to illuminate the one or more optical tags; a detector configured to measure optical emission of the one or more optical tags; an imaging subsystem configured to determine a three-dimensional location of each of the one or more optical tags in the cell or biological tissue; and a controller in electrical communication with the excitation light source, the detector, and the imaging subsystem. Each of the one or more optical tags has a contrasting feature and includes a fluorescent material. The contrasting feature may be defined by at least one of a refractive index, shape, color, and laser emission of each optical tag of the one or more optical tags.
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公开(公告)号：US20220410122A1
公开(公告)日：2022-12-29
申请号：US17779247
申请日：2020-11-25
发明人： Xudong FAN , Hongbo ZHU , Jinyan SHE , Maxwell Wei-Hao LI , Katsuo KURABAYASHI
IPC分类号： B01J20/287 , B01J20/285 , G01N30/60 , B01J20/32
摘要： A gas chromatography device for peak focusing of one or more target analytes is provided that include a chromatographic column with an inlet and an outlet. A stationary phase is deposited inside the chromatographic column and has a positive thickness gradient. The stationary phase extends from the inlet to the outlet and has a first thickness at the inlet of the chromatographic column and a second thickness at the outlet of the chromatographic column. The second thickness is at least about 10% greater than the first thickness. Methods of peak focusing in a gas chromatography device, method of verifying peak focusing in a gas chromatography device and creating a gas chromatography device having a chromatographic column with a positive thickness gradient are also provided.
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公开(公告)号：US20200158641A1
公开(公告)日：2020-05-21
申请号：US16473584
申请日：2017-12-27
发明人： Xudong FAN , Yu-Cheng CHEN , Qiushu CHEN
摘要： Laser emission based microscope devices and methods of using such devices for detecting laser emissions from a tissue sample are provided. The scanning microscope has first and second reflection surfaces and a scanning cavity holding a stationary tissue sample with at least one fluorophore/lasing energy responsive species. At least a portion of the scanning cavity corresponds to a high quality factor (Q) Fabry-Pérot resonator cavity. A lasing pump source directs energy at the scanning cavity while a detector receives and detects emissions generated by the fluorophore(s) or lasing energy responsive species. The second reflection surface and/or the lasing pump source are translatable with respect to the stationary tissue sample for generating a two-dimensional scan of the tissue sample. Methods for detecting multiplexed emissions or quantifying one or more biomarkers in a histological tissue sample, for example for detection and diagnosis of cancer, or other disorders/diseases are provided.
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公开(公告)号：US20220099573A1
公开(公告)日：2022-03-31
申请号：US17421809
申请日：2020-01-09
发明人： Xudong FAN , Xueding WANG , Xuzhou LI , Yu QIN , Xiaotian TAN , Yu-Cheng CHEN , Qiushu CHEN
摘要： A laser whose emission is modulated by ultrasound is presented. The laser is usually micron-sized. In response to ultra-sound modulation, the laser emission increases and decreases. Such a change in emission can be detected by external optical detectors. This type of laser can be used as a new type of imaging modality, in which laser emission in combination with sound waves or ultra-sound waves, is used for imaging Laser emission has a much narrower spectral linewidth and stronger intensity than fluorescence and therefore is able to achieve higher sensitivity, whereas sound waves are used to provide a better spatial resolution of the laser emission from the laser. In ultrasound modulated laser based imaging, multiple lasers can be placed inside cells or tissues.
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10.发明申请公开(公告)号：US20210341422A1
公开(公告)日：2021-11-04
申请号：US17282671
申请日：2019-10-02
发明人： Xudong FAN , Hongbo ZHU , Katsuo KURABAYASHI
摘要： An integrated microfluidic photoionization detector (PID) is provided including a microfluidic ionization chamber a microfluidic ultraviolet radiation chamber that is configured to generate ultraviolet photons. An ultrathin transmissive window is disposed between the microfluidic ionization chamber and the microfluidic ultraviolet radiation chamber that permits the ultraviolet photons to pass from the microfluidic ultraviolet radiation chamber into the microfluidic ionization chamber. Detection systems for one or more VOC analytes are also provided that include a gas chromatography (GC) unit including at least one gas chromatography column and an integrated microfluidic photoionization detector (PID) disposed downstream of the gas chromatography (GC) unit.
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