公开(公告)号：US20220195387A1

公开(公告)日：2022-06-23

申请号：US17558543

申请日：2021-12-21

Applicant: The Research Foundation for the State University of New York

Inventor： Susan Sharfstein ,  Yubing Xie ,  Pujhitha Ramesh ,  James Castracane ,  Melinda Larsen

IPC: C12N5/071 ,  D01D5/00

Abstract: The present disclosure relates to compositions, apparatus and methods for generating one or more scaffolds, including: mixing a hydrogel material and/or an extracellular matrix (ECM) protein in an aqueous solvent to generate an aqueous process solution; and cryoelectrospinning the aqueous process solution onto a plurality of conductive probes extending from a conductive surface of a collector plate disposed within a process chamber under conditions sufficient to generate one or more scaffolds configured to mimic a preselected soft tissue decellularized extracellular matrix. Scaffold compositions are also provided having preselected or tuned characteristics.

公开(公告)号：US20240139379A1

公开(公告)日：2024-05-02

申请号：US18108395

申请日：2023-02-10

Applicant: The Research Foundation for the State University of New York

Inventor： Susan Sharfstein ,  Yubing Xie ,  Pujhitha Ramesh ,  James Castracane ,  Melinda Larsen ,  Nicholas Moskwa

IPC: A61L27/52 ,  A61L27/26 ,  A61L27/38 ,  A61L27/54 ,  C08L5/04 ,  C08L89/06

CPC classification number: A61L27/52 ,  A61L27/26 ,  A61L27/3834 ,  A61L27/54 ,  C08L5/04 ,  C08L89/06 ,  A61L2300/414 ,  A61L2430/34

Abstract: The present disclosure relates to compositions, apparatus and methods for generating one or more scaffolds, including: mixing a hydrogel material and/or an extracellular matrix (ECM) protein in an aqueous solvent to generate an aqueous process solution; and cryoelectrospinning the aqueous process solution onto a plurality of conductive probes extending from a conductive surface of a collector plate disposed within a process chamber under conditions sufficient to generate one or more scaffolds configured to mimic a preselected soft tissue decellularized extracellular matrix. Scaffold compositions are also provided having preselected or tuned characteristics. The scaffolds provide a promising stromal cell delivery vehicle for the remediation of fibrosis.

公开(公告)号：US10117990B2

公开(公告)日：2018-11-06

申请号：US15371493

申请日：2016-12-07

Applicant: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK ,  ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.

Inventor： James Castracane ,  Logan Butt ,  David Entenberg ,  Lauren Sfakis ,  John Condeelis

IPC: A61M31/00 ,  A61M5/142 ,  A61M5/172 ,  A61M39/24 ,  A61B17/02 ,  A61M37/00 ,  A61D1/00 ,  A61B5/15

Abstract: A microfluidic intravital window includes an intravital imaging window adapted for implantation adjacent target tissue of a live animal, and a microfluidic fluid source and delivery system physically integrated into the window for controlled delivery of fluids to target tissue via the window. The microfluidic fluid source and delivery system is self-contained and completely located within the intravital imaging window, and includes at least one preloaded fluid reservoir, at least one fluid port in fluidic communication with both the at least one preloaded fluid reservoir and the target tissue, and at least one light activated fluid flow control device situated between the at least one preloaded fluid reservoir and at least one fluid port, to facilitate simultaneous in vivo viewing and remotely controlled fluid delivery to the target tissue.

公开(公告)号：US09812591B2

公开(公告)日：2017-11-07

申请号：US15501961

申请日：2016-06-10

Applicant: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK

Inventor： James Castracane ,  Natalya Tokranova ,  Leigh Lydecker

IPC: H01L31/00 ,  H01L31/02 ,  H01L31/147 ,  G01J1/44

CPC classification number: H01L31/02024 ,  G01J1/44 ,  G01J2001/446 ,  H01L31/02005 ,  H01L31/022408 ,  H01L31/09 ,  H01L31/101 ,  H01L31/147 ,  H01L31/164

Abstract: A self-balancing optical position sensitive detector includes a pair of spaced apart, parallel, longitudinally extending doped regions on a first surface on a front side of a substrate 16 of opposite doping type with contact pads on the front side at respective ends of a first doped region of the pair. A voltage source applies a potential difference between the contact pads of the first doped region. On the front side, a contact pad of the second doped region of the pair provides an analog output signal representative of a longitudinal position of a center of gravity of an incident light pattern along the doped regions without external circuitry processing the output signal to obtain a readout of the longitudinal position. A resistive line may directly overly, abut and be in contact with at least a portion of the first doped region. A conductive line may directly overly, abut and be in contact with at least a portion of the second doped region. No backside contact or processing of the substrate is required or employed.