-
公开(公告)号：US20240083954A1
公开(公告)日：2024-03-14
申请号：US18449739
申请日：2023-08-15
发明人： Leopold Kong , Ian A. Wilson , Natalia de Val , Andrew B. Ward , Dennis Burton , Linling He , Jiang Zhu
IPC分类号： C07K14/16 , A61K39/21 , A61K47/69 , C07K14/005
CPC分类号： C07K14/162 , A61K39/21 , A61K47/6929 , C07K14/005 , A61K39/12 , C12N2740/16122 , C12N2740/16134
摘要： The present invention provides HIV-1 vaccine immunogens. Some of the immunogens contain a soluble gp140-derived protein that harbors a modified N-terminus of the HR1 region in gp41. Some of the immunogens contain an HIV-1 Env-derived trimer protein that is presented on a nanoparticle platform. The invention also provides methods of using the HIV-1 vaccine immunogens for eliciting an immune response or treating HIV infections.
-
公开(公告)号：US20190048043A1
公开(公告)日：2019-02-14
申请号：US16176200
申请日：2018-10-31
发明人： Leopold Kong , Ian A. Wilson , Natalia De Val , Andrew B. Ward , Dennis Burton , Linling He , Jiang Zhu
IPC分类号： C07K14/005
摘要： The present invention provides HIV-1 vaccine immunogens. Some of the immunogens contain a soluble gp140-derived protein that harbors a modified N-terminus of the HR1 region in gp41. Some of the immunogens contain an HIV-1 Env-derived trimer protein that is presented on a nanoparticle platform. The invention also provides methods of using the HIV-1 vaccine immunogens for eliciting an immune response or treating HIV infections.
-
公开(公告)号：US20190002539A1
公开(公告)日：2019-01-03
申请号：US16075211
申请日：2017-01-26
申请人： NATIONAL CENTER FOR AIDS/STD CONTROL & PREVENTION, CHINESE CENTER FOR DISEASE CONTROL & PREVENTION , THE SCRIPPS RESEARCH INSTITUTE
发明人： Yiming Shao , Jiang Zhu , Yuxing Li , Ian A. Wilson , Leopold Kong , Bin Ju , Linling He , Li Ren , Yajing Chen , Jiandong Liu
IPC分类号： C07K16/10 , A61P31/18 , C12N15/113 , G01N33/569 , G01N33/577
摘要： Broadly neutralizing antibodies against HIV-1 which specifically bind to gp120 of HIV-1, a method of preparing such antibodies and the use thereof are provided.
-
公开(公告)号：US11236134B2
公开(公告)日：2022-02-01
申请号：US16780495
申请日：2020-02-03
发明人： Leopold Kong , Ian A. Wilson , Natalia De Val , Andrew B. Ward , Dennis Burton , Linling He , Jiang Zhu
摘要： The present invention provides HIV-1 vaccine immunogens. Some of the immunogens contain a soluble gp140-derived protein that harbors a modified N-terminus of the HR1 region in gp41. Some of the immunogens contain an HIV-1 Env-derived trimer protein that is presented on a nanoparticle platform. The invention also provides methods of using the HIV-1 vaccine immunogens for eliciting an immune response or treating HIV infections.
-
公开(公告)号：US10934345B2
公开(公告)日：2021-03-02
申请号：US16075211
申请日：2017-01-26
申请人： NATIONAL CENTER FOR AIDS/STD CONTROL & PREVENTION, CHINESE CENTER FOR DISEASE CONTROL AND PREVENTION , THE SCRIPPS RESEARCH INSTITUTE
发明人： Yiming Shao , Jiang Zhu , Yuxing Li , Ian A. Wilson , Leopold Kong , Bin Ju , Linling He , Li Ren , Yajing Chen , Jiandong Liu
IPC分类号： C07K16/10 , A61P31/18 , C12N15/113 , G01N33/569 , G01N33/577
摘要： Broadly neutralizing antibodies against HIV-1 which specifically bind to gp120 of HIV-1, a method of preparing such antibodies and the use thereof are provided.
-
公开(公告)号：US11767347B2
公开(公告)日：2023-09-26
申请号：US17553070
申请日：2021-12-16
发明人： Leopold Kong , Ian A. Wilson , Natalia De Val , Andrew B. Ward , Dennis Burton , Linling He , Jiang Zhu
CPC分类号： C07K14/162 , A61K39/21 , A61K47/6929 , C07K14/005 , A61K39/12 , A61K47/64 , A61K2039/5258 , A61K2039/6031 , A61K2039/645 , C12N2740/16122 , C12N2740/16134
摘要： The present invention provides HIV-1 vaccine immunogens. Some of the immunogens contain a soluble gp140-derived protein that harbors a modified N-terminus of the HR1 region in gp41. Some of the immunogens contain an HIV-1 Env-derived trimer protein that is presented on a nanoparticle platform. The invention also provides methods of using the HIV-1 vaccine immunogens for eliciting an immune response or treating HIV infections.
-
公开(公告)号：US20220098244A1
公开(公告)日：2022-03-31
申请号：US17553070
申请日：2021-12-16
发明人： Leopold Kong , Ian A. Wilson , Natalia De Val , Andrew B. Ward , Dennis Burton , Linling He , Jiang Zhu
IPC分类号： C07K14/16 , A61K47/69 , A61K39/21 , C07K14/005
摘要： The present invention provides HIV-1 vaccine immunogens. Some of the immunogens contain a soluble gp140-derived protein that harbors a modified N-terminus of the HR1 region in gp41. Some of the immunogens contain an HIV-1 Env-derived trimer protein that is presented on a nanoparticle platform. The invention also provides methods of using the HIV-1 vaccine immunogens for eliciting an immune response or treating HIV infections.
-
公开(公告)号：US20200165303A1
公开(公告)日：2020-05-28
申请号：US16780495
申请日：2020-02-03
发明人： Leopold Kong , Ian A. Wilson , Natalia De Val , Andrew B. Ward , Dennis Burton , Linling He , Jiang Zhu
IPC分类号： C07K14/005 , A61K39/12 , A61K47/64 , A61K47/69
摘要： The present invention provides HIV-1 vaccine immunogens. Some of the immunogens contain a soluble gp140-derived protein that harbors a modified N-terminus of the HR1 region in gp41. Some of the immunogens contain an HIV-1 Env-derived trimer protein that is presented on a nanoparticle platform. The invention also provides methods of using the HIV-1 vaccine immunogens for eliciting an immune response or treating HIV infections.
-
9.发明授权公开(公告)号：US10647748B2
公开(公告)日：2020-05-12
申请号：US16176200
申请日：2018-10-31
发明人： Leopold Kong , Ian A. Wilson , Natalia De Val , Andrew B. Ward , Dennis Burton , Linling He , Jiang Zhu
IPC分类号： C07K14/005 , A61K39/12 , A61K47/64 , A61K47/69 , A61K39/00
摘要： The present invention provides HIV-1 vaccine immunogens. Some of the immunogens contain a soluble gp140-derived protein that harbors a modified N-terminus of the HR1 region in gp41. Some of the immunogens contain an HIV-1 Env-derived trimer protein that is presented on a nanoparticle platform. The invention also provides methods of using the HIV-1 vaccine immunogens for eliciting an immune response or treating HIV infections.
-
-
-
-
-
-
-
-
搜索结果
9 条记录 (耗时 0.015 秒)
