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    HIGH-DENSITY MICROCHAMBER ARRAY AND MANUFACTURING METHOD THEREOF
    3.
    发明申请
    HIGH-DENSITY MICROCHAMBER ARRAY AND MANUFACTURING METHOD THEREOF 审中-公开
    高密度MICROCHAMBER阵列及其制造方法

    公开(公告)号：US20160296928A1

    公开(公告)日：2016-10-13

    申请号：US14913470

    申请日：2014-08-18

    申请人： THE UNIVERSITY OF TOKYO

    发明人： Hiroyuki NOJI ,  Rikiya WATANABE ,  Hiroaki SUGA ,  Daishi FUJITA

    IPC分类号： B01L3/00 ,  B01J19/00

    CPC分类号： B01L3/5085 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00331 ,  B01J2219/00662 ,  B01J2219/00725 ,  B01J2219/00734 ,  B01L3/502769 ,  B01L2200/0689 ,  B01L2200/12 ,  B01L2300/0819 ,  B01L2300/0861 ,  B01L2300/0893 ,  B01L2300/0896 ,  B01L2300/165 ,  G01N33/48721

    摘要： A material film is formed as a thin film having a thickness of 1 μm on a surface of a glass substrate. A plurality of micro-chambers having a diameter of 5 μm are formed in the material film to be arrayed at a high density. The respective chambers filled with an aqueous test solution have openings that are liquid-sealed by a lipid bilayer membrane to provide a high-density micro-chamber array. Significant downsizing of the micro-chambers enhances a change in concentration by a reaction of one biomolecule in the chamber and thereby increases the detection sensitivity. In the configuration that a large number of micro-chambers are formed at a high density, even in the case of an extremely slow reaction of the biomolecule, the reaction proceeds in any of the chambers. This configuration accordingly enables the reaction of the biomolecule to be detected with high sensitivity.

    摘要翻译： 在玻璃基板的表面上形成厚度为1μm的薄膜。 在材料膜中形成多个直径为5μm的微室，以高密度排列。 填充有水性测试溶液的各个室具有通过脂质双层膜液体密封以提供高密度微室阵列的开口。 微室的显着缩小通过室中的一个生物分子的反应增强了浓度的变化，从而增加了检测灵敏度。 在以高密度形成大量微室的结构中，即使在生物分子反应极慢的情况下，也可以在任何室内进行反应。 因此，能够高灵敏度地检测生物分子的反应。

    C-Met Protein Agonist
    5.
    发明申请
    C-Met Protein Agonist 有权
    C-Met蛋白激动剂

    公开(公告)号：US20160237119A1

    公开(公告)日：2016-08-18

    申请号：US15025239

    申请日：2014-10-15

    申请人： THE UNIVERSITY OF TOKYO

    发明人： Hiroaki SUGA ,  Kenichiro ITO

    IPC分类号： C07K7/08 ,  C07K1/00

    CPC分类号： C07K7/08 ,  A61K38/00 ,  C07K1/00 ,  C07K1/1075 ,  C07K14/71 ,  C07K2319/00

    摘要： Object of the present invention is to provide a peptide functioning as a c-Met agonist. The present invention provides a peptide complex comprising two or more peptides that bind to a c-Met protein and a linker that links the two or more peptides to one another. Such a peptide complex promotes autophosphorylation of the c-Met protein and induces cell growth.

    摘要翻译： 本发明的目的是提供用作c-Met激动剂的肽。 本发明提供了包含两个或更多个结合c-Met蛋白的肽的肽复合物和将两个或多个肽彼此连接的连接体。 这种肽复合物促进c-Met蛋白的自磷酸化并诱导细胞生长。

    Macrocyclic Peptide, Method for Producing Same, and Screening Method Using Macrocyclic Peptide Library
    6.
    发明申请
    Macrocyclic Peptide, Method for Producing Same, and Screening Method Using Macrocyclic Peptide Library 审中-公开
    大环肽，其生产方法和使用大环肽库的筛选方法

    公开(公告)号：US20160209421A1

    公开(公告)日：2016-07-21

    申请号：US14914634

    申请日：2014-08-26

    申请人： THE UNIVERSITY OF TOKYO

    发明人： Hiroaki SUGA

    IPC分类号： G01N33/68 ,  C12P21/02 ,  C07K7/64

    CPC分类号： G01N33/6845 ,  C07K7/06 ,  C07K7/08 ,  C07K7/64 ,  C12P21/02 ,  G01N2500/04

    摘要： An object of the present invention is to provide a peptide excellent in resistance against metabolism, having a stable structure in vivo, and capable of penetrating a cell membrane and reaching in cells.The present invention provides a macrocyclic peptide having a macrocyclic structure comprised of four or more amino acids. At least two amino acids not adjacent to each other have a hydrophobic side chain and the hydrophobic side chains interact with each other inside the ring of the macrocyclic peptide in a hydrophilic environment.

    摘要翻译： 本发明的目的是提供抗代谢性优异的肽，其体内结构稳定，能够穿透细胞膜并达到细胞。 本发明提供具有由四个或更多个氨基酸组成的大环结构的大环肽。 彼此不相邻的至少两个氨基酸在亲水环境中具有疏水侧链，并且疏水侧链在大环的环内彼此相互作用。