公开(公告)号：US11248034B2

公开(公告)日：2022-02-15

申请号：US16319450

申请日：2017-07-21

申请人： UNIVERSITY OF UTAH RESEARCH FOUNDATION ,  THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH

发明人： John Gerbrandt Tasman Menting ,  Brian Smith ,  Danny Hung-Chieh Chou ,  Helena Safavi-Hemami ,  Michael Colin Lawrence ,  Baldomero M. Olivera

IPC分类号： C07K14/62 ,  G16B15/00 ,  C30B29/58 ,  C30B7/02 ,  C07K14/435 ,  A61K38/00 ,  A61P3/10

摘要： The present invention relates to insulin analogs, particularly insulin analogs having shortened B chains. The present invention also relates to the crystal structure of insulin from the venom of cone snails and to methods of using the crystal and related structural information to screen for and design insulin analogs that interact with or modulate the insulin receptor. The present invention also relates to therapeutic and prophylactic methods using insulin analogs.

公开(公告)号：US20150198619A1

公开(公告)日：2015-07-16

申请号：US14430220

申请日：2013-09-18

申请人： THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH

发明人： Michael Colin Lawrence ,  John Gerbrandt Tasman Menting ,  Brian John Smith

IPC分类号： G01N33/74 ,  G06F19/12 ,  G01N23/207 ,  C07K14/62

CPC分类号： G01N33/74 ,  C07K14/62 ,  C07K14/72 ,  C07K2299/00 ,  G01N23/207 ,  G16B5/00

摘要： The present invention relates to the crystal structure of the insulin receptor ectodomain in complex with human insulin and to methods of using the crystal and related structural information to identify, design and screen for compounds that interact with or modulate the insulin receptor and insulin receptor signalling.

摘要翻译： 本发明涉及与人胰岛素复合的胰岛素受体胞外域的晶体结构以及使用晶体的方法和相关结构信息来鉴定，设计和筛选与胰岛素受体和胰岛素受体信号传导相互作用或调节的化合物。