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公开(公告)号：US10857226B2
公开(公告)日：2020-12-08
申请号：US16132610
申请日：2018-09-17
申请人： Transgene S.A.
摘要： The present invention provides a composition comprising hepatitis B virus (HBV) component(s), and which may be either nucleic acid- or polypeptide-based as well as nucleic acid molecules and vectors encoding such HBV component(s). It also relates to infectious viral particles and host cells comprising such nucleic acid molecules or vectors. It also provides composition and kits of parts comprising such nucleic acid molecules, vectors, infectious viral particles or host cells and the therapeutic use thereof for preventing or treating HBV infections.
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公开(公告)号：US10662414B2
公开(公告)日：2020-05-26
申请号：US16257784
申请日：2019-01-25
申请人： Transgene S.A.
摘要： The present invention relates to polymerase HBV mutant polypeptides comprising a mutated polymerase domain which is functionally disrupted for polymerase activity and fusion proteins comprising such polymerase mutant polypeptide. The present invention also relates to a nucleic acid molecule and an expression vector for expressing said polymerase mutant polypeptide as well as a composition which can be used for eliciting an immune response to HBV with the goal of providing a protective or therapeutic effect against HBV infection.
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公开(公告)号：US20190144840A1
公开(公告)日：2019-05-16
申请号：US16257784
申请日：2019-01-25
申请人： Transgene S.A.
摘要： The present invention relates to polymerase HBV mutant polypeptides comprising a mutated polymerase domain which is functionally disrupted for polymerase activity and fusion proteins comprising such polymerase mutant polypeptide. The present invention also relates to a nucleic acid molecule and an expression vector for expressing said polymerase mutant polypeptide as well as a composition which can be used for eliciting an immune response to HBV with the goal of providing a protective or therapeutic effect against HBV infection.
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4.发明申请公开(公告)号：US20130244246A1
公开(公告)日：2013-09-19
申请号：US13723946
申请日：2012-12-21
申请人： TRANSGENE S.A.`
发明人： Philippe Erbs , Marina Kapfer , Nathalie Silvestre
IPC分类号： C12N15/90
CPC分类号： C12N15/907 , C12N7/00 , C12N15/902 , C12N2710/24152 , C12N2800/80
摘要： This invention relates to immortalized avian cells, and to the use of these cells for the production of viruses. The cells according to the invention are particularly useful for the production of recombinant viral vectors which can be used for the preparation of therapeutic and/or prophylactic compositions for the treatment of animals and more particularly humans.
摘要翻译： 本发明涉及永生化鸟类细胞，以及这些细胞用于生产病毒的用途。 根据本发明的细胞特别可用于生产重组病毒载体，所述重组病毒载体可用于制备用于治疗动物，更特别是人的治疗和/或预防组合物。
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公开(公告)号：US20170145392A1
公开(公告)日：2017-05-25
申请号：US15369118
申请日：2016-12-05
申请人： Transgene S.A.
CPC分类号： C12N9/1252 , A61K38/00 , A61K39/292 , A61K2039/53 , C07K14/005 , C07K2319/02 , C07K2319/03 , C07K2319/40 , C12N7/00 , C12N9/1276 , C12N9/22 , C12N2730/10122 , C12N2730/10134 , C12N2799/022 , C12N2799/023 , C12P21/02 , C12Y207/07007 , C12Y301/26004
摘要： The present invention relates to polymerase HBV mutant polypeptides comprising a mutated polymerase domain which is functionally disrupted for polymerase activity and fusion proteins comprising such polymerase mutant polypeptide. The present invention also relates to a nucleic acid molecule and an expression vector for expressing said polymerase mutant polypeptide as well as a composition which can be used for eliciting an immune response to HBV with the goal of providing a protective or therapeutic effect against HBV infection.
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公开(公告)号：US08809056B2
公开(公告)日：2014-08-19
申请号：US13723946
申请日：2012-12-21
申请人： Transgene S.A.
CPC分类号： C12N15/907 , C12N7/00 , C12N15/902 , C12N2710/24152 , C12N2800/80
摘要： This invention relates to immortalized avian cells, and to the use of these cells for the production of viruses. The cells according to the invention are particularly useful for the production of recombinant viral vectors which can be used for the preparation of therapeutic and/or prophylactic compositions for the treatment of animals and more particularly humans.
摘要翻译： 本发明涉及永生化鸟类细胞，以及这些细胞用于生产病毒的用途。 根据本发明的细胞特别可用于生产重组病毒载体，所述重组病毒载体可用于制备用于治疗动物，更特别是人的治疗和/或预防组合物。
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公开(公告)号：US20170072047A1
公开(公告)日：2017-03-16
申请号：US15203046
申请日：2016-07-06
申请人： Transgene S.A.
CPC分类号： A61K39/29 , A61K39/12 , A61K39/292 , A61K2039/53 , A61K2039/545 , A61K2039/57 , C12N7/00 , C12N9/1252 , C12N15/86 , C12N2710/10043 , C12N2710/24143 , C12N2730/10134 , C12Y207/07007
摘要： The present invention provides a composition comprising hepatitis B virus (HBV) component(s), and which may be either nucleic acid- or polypeptide-based as well as nucleic acid molecules and vectors encoding such HBV component(s). It also relates to infectious viral particles and host cells comprising such nucleic acid molecules or vectors. It also provides composition and kits of parts comprising such nucleic acid molecules, vectors, infectious viral particles or host cells and the therapeutic use thereof for preventing or treating HBV infections.
摘要翻译： 本发明提供包含乙型肝炎病毒（HBV）组分的组合物，其可以是基于核酸或多肽的核酸分子以及编码这样的HBV组分的载体。 它还涉及包含这种核酸分子或载体的感染性病毒颗粒和宿主细胞。 它还提供包含这种核酸分子，载体，感染性病毒颗粒或宿主细胞的组分和试剂盒以及用于预防或治疗HBV感染的治疗用途。
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公开(公告)号：US20190070285A1
公开(公告)日：2019-03-07
申请号：US16132610
申请日：2018-09-17
申请人： Transgene S.A.
IPC分类号： A61K39/29 , A61K39/12 , C07K14/005
摘要： The present invention provides a composition comprising hepatitis B virus (HBV) component(s), and which may be either nucleic acid- or polypeptide-based as well as nucleic acid molecules and vectors encoding such HBV component(s). It also relates to infectious viral particles and host cells comprising such nucleic acid molecules or vectors. It also provides composition and kits of parts comprising such nucleic acid molecules, vectors, infectious viral particles or host cells and the therapeutic use thereof for preventing or treating HBV infections.
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公开(公告)号：US10190105B2
公开(公告)日：2019-01-29
申请号：US15369118
申请日：2016-12-05
申请人： Transgene S.A.
摘要： The present invention relates to polymerase HBV mutant polypeptides comprising a mutated polymerase domain which is functionally disrupted for polymerase activity and fusion proteins comprising such polymerase mutant polypeptide. The present invention also relates to a nucleic acid molecule and an expression vector for expressing said polymerase mutant polypeptide as well as a composition which can be used for eliciting an immune response to HBV with the goal of providing a protective or therapeutic effect against HBV infection.
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