公开(公告)号：US20240033311A1

公开(公告)日：2024-02-01

申请号：US18483161

申请日：2023-10-09

Applicant: TSUBOTA LABORATORY, INC. ,  ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Kazuo TSUBOTA ,  Toshihide KURIHARA

IPC: A61K36/16 ,  A61P27/10 ,  A61K9/00 ,  A61K31/05 ,  A61K31/202

CPC classification number: A61K36/16 ,  A61P27/10 ,  A61K9/0056 ,  A61K31/05 ,  A61K31/202

Abstract: The ophthalmic composition effective for the prevention or treatment of myopia or ocular diseases are provided. In particular, the present invention provides an ophthalmic composition effective in a growing child or a young person in whom myopia develops and progresses, as well as a middle-aged and elderly person in whom age-related ocular diseases such as cataract, glaucoma, retinal detachment, retinopathy, maculopathy, choroidal neovascularization, posterior staphyloma, and optic neuropathy develop, a functional food containing the ophthalmic composition, and a screening method capable of searching for the same. [Solution] The above problem is solved by an ophthalmic composition or functional food product containing at least one component selected from the group consisting of crocetin and its pharmaceutically acceptable salts and ginkgo leaf extract.

公开(公告)号：US20200171112A1

公开(公告)日：2020-06-04

申请号：US16614176

申请日：2018-05-15

Applicant: TSUBOTA LABORATORY, INC. ,  ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Kazuo TSUBOTA ,  Toshihide KURIHARA

IPC: A61K36/16 ,  A61K31/202 ,  A61K31/05 ,  A61K9/00 ,  A61P27/10

Abstract: The ophthalmic composition effective for the prevention or treatment of myopia or ocular diseases are provided. In particular, the present invention provides an ophthalmic composition effective in a growing child or a young person in whom myopia develops and progresses, as well as a middle-aged and elderly person in whom age-related ocular diseases such as cataract, glaucoma, retinal detachment, retinopathy, maculopathy, choroidal neovascularization, posterior staphyloma, and optic neuropathy develop, a functional food containing the ophthalmic composition, and a screening method capable of searching for the same. [Solution] The above problem is solved by an ophthalmic composition or functional food product containing at least one component selected from the group consisting of crocetin and its pharmaceutically acceptable salts and ginkgo leaf extract.

公开(公告)号：US20240366626A1

公开(公告)日：2024-11-07

申请号：US18561634

申请日：2022-05-17

Applicant: TSUBOTA LABORATORY, INC.

Inventor： Heonuk JEONG ,  Toshihide KURIHARA ,  Kazuo TSUBOTA

IPC: A61K31/551 ,  A61K9/00 ,  A61P27/10

Abstract: To provide a new ophthalmic preparation for myopia suppression. The above-described problem is solved by using an ophthalmic preparation containing bunazosin as an ophthalmic preparation for myopia suppression. This ophthalmic preparation for myopia suppression is effective for myopia suppression.

公开(公告)号：US20210023384A1

公开(公告)日：2021-01-28

申请号：US16982152

申请日：2019-03-19

Applicant: TSUBOTA LABORATORY, INC.

Inventor： Hidenaga KOBASHI ,  Kazuo TSUBOTA

IPC: A61N5/06 ,  A61F9/00

Abstract: To provide a device and a method for strengthening a cornea or a sclera or suppressing a progression of a disease in a non-invasive manner, enabling treatment in daily life without treatment in a confined state at a medical institution for a fixed period of time and without ablation of the corneal epithelium as in conventional corneal crosslinking. The above-described problem is solved by a non-invasive cornea and sclera strengthening device that irradiates violet light toward an eye administered with an administration agent used to strengthen a corneal tissue or a scleral tissue, and is configured so that an irradiance of the violet light onto a surface of the eye is within a range of 0.1 to 1 mW/cm2, and a time of irradiation of the violet light onto the eye is within a range of one to five hours per day.

公开(公告)号：US20180297888A1

公开(公告)日：2018-10-18

申请号：US15995379

申请日：2018-06-01

Applicant: ASAHI GLASS COMPANY, LIMITED ,  TSUBOTA LABORATORY, INC.

Inventor： Kensuke NAGAI ,  Tetsuya NAKASHIMA ,  Yutaka KUROIWA ,  Hiroyuki HIJIYA ,  Masamichi TANIDA ,  AKIO KOIKE ,  Manabu NISHIZAWA ,  Kazuo TSUBOTA ,  Toshihide KURIHARA ,  Hidemasa TORII

IPC: C03C4/08 ,  C03C3/095 ,  C03C3/083 ,  C03C3/085 ,  C03C3/087 ,  C03C3/091 ,  G02B5/20

Abstract: A wavelength-selective transmissive glass has a light transmittance Tmore than 315 nm and 400 nm or less at a wavelength of more than 315 nm and 400 nm or less represented by the formula shown below of 1% or more in terms of a plate thickness of 6 mm and a light transmittance T315 nm or less at a wavelength of 315 nm or less represented by the formula shown below of 60% or less in terms of a plate thickness of 6 mm. Ak is a weighting factor at a wavelength k (nm) for calculating T (light transmittance) defined in ISO-9050:2003, and Tk is a transmittance at the wavelength k (nm) in terms of a plate thickness of 6 mm: Tmore than 315 nm and 400 nm or less=(Σk=more than 315400 Ak×Tk)/(Σk=more than 315400 Ak) T315 nm or less=(Σk=300315 Ak×Tk)/(Σk=300315 Ak).

公开(公告)号：US20210308481A1

公开(公告)日：2021-10-07

申请号：US17264176

申请日：2019-08-01

Applicant: TSUBOTA LABORATORY, INC. ,  SUMITOMO DAINIPPON PHARMA CO., LTD.

Inventor： Motoshi HAYANO ,  Kazuo TSUBOTA

IPC: A61N5/06

Abstract: To provide a brain wave and cell activity control device and method based on light stimulation in which light having a specific wavelength, such as violet light, is irradiated using continuous light or a specific blinking frequency, and a device for improvement, prevention, or increase in brain function. The above-described problem is solved by a brain wave and cell activity control device, based on light stimulation, that controls brain waves or cell activity by irradiating light having a specific wavelength onto a subject using continuous light or a specific blinking frequency. The brain wave and cell activity control device comprises a light source that irradiates the light having a specific wavelength using continuous light or a specific blinking frequency, and a control unit that controls an emission of light that induces specific brain waves, the brain waves of the subject having received the light being the same or substantially the same as, or different from a frequency of the light in an irradiation state. At this time, the light is preferably violet light, and the irradiation state of the light is preferably continuous light or a blinking frequency greater than 0 Hz and less than or equal to 150 Hz.

公开(公告)号：US20200150457A1

公开(公告)日：2020-05-14

申请号：US16561776

申请日：2019-09-05

Applicant: TSUBOTA LABORATORY, INC.

Inventor： Shinichi IKEDA ,  Xiaoyan JIANG ,  Kazuo TSUBOTA ,  Toshihide KURIHARA

IPC: G02C7/06 ,  A01K67/02 ,  A61K31/575 ,  A61K9/00

Abstract: A model that closely resembles human excessive myopia can be prepared by mounting a minus lens (2) and a protector (4) to a juvenile mouse, the minus lens having an angle and a width adjustable in response to growth of the mouse. Further, this model analysis shows that myopia induction causes endoplasmic reticulum stress in a sclera and the endoplasmic reticulum stress induces myopia. Furthermore, it is revealed that an endoplasmic reticulum stress suppressant, particularly, phenylbutyrate and tauroursodeoxycholic acid act as a myopia prevention/suppression agent.

公开(公告)号：US20230218164A1

公开(公告)日：2023-07-13

申请号：US18000601

申请日：2022-03-10

Applicant: TSUBOTA LABORATORY, INC.

Inventor： Kazuo TSUBOTA ,  Hidenaga KOBASHI ,  Naoko KATO

IPC: A61B3/107 ,  A61B3/14

CPC classification number: A61B3/107 ,  A61B3/14 ,  A61B2560/06

Abstract: A simple diagnosis assisting device (10) for keratoconus and/or astigmatism, including a mobile terminal (10A) including a camera (2) and a transceiver function (3), and integrally or separately provided with a light source (1) for simultaneously projecting ring light onto both eyes. The light source (1) emits the ring light upon being attached to the mobile terminal (10A) in a case of being separately provided to the mobile terminal (10A), and emits the ring light from the mobile terminal (10A) in a case of being integrally provided to the mobile terminal (10A). The camera (2) simultaneously captures a projected image of both eyes onto which the ring light is projected. The ring light may be multiplex ring light or simplex ring light, and is configured in a ring shape by a plurality of point light sources or is configured in a ring shape by a single linear light source.

公开(公告)号：US20200092971A1

公开(公告)日：2020-03-19

申请号：US16473487

申请日：2017-12-26

Applicant: TSUBOTA LABORATORY, INC.

Inventor： Kazuo TSUBOTA

IPC: H05B37/02 ,  G06F3/147

Abstract: To provide a display system such as a smartphone, a game console, a personal computer, or a liquid crystal television, including a light-emitting element that irradiates light having a specific wavelength toward a user. The above-described problem is solved by a display system (1) including a first light-emitting element (6) that emits light used for image display, a second light-emitting element (3) that irradiates light (7) within a wavelength range of 360 nm to 400 nm, inclusive, toward a user, and a control unit (10) that controls irradiation of the light (7) from the second light-emitting element (3). At this time, the second light-emitting element (3) may be a single light-emitting element integrated with the first light-emitting element (6) or a light-emitting element provided separately from the first light-emitting element (6). When separately provided from the first light-emitting element (6), the second light-emitting element (3) is preferably provided to a peripheral frame (4) of a display screen (2), in the display screen (2), or as an accessory (5).

公开(公告)号：US20170168320A1

公开(公告)日：2017-06-15

申请号：US15366558

申请日：2016-12-01

Applicant: TSUBOTA LABORATORY, INC.

Inventor： Kazuo TSUBOTA ,  Kazuno NEGISHI ,  Hidemasa TORII ,  Toshihide KURIHARA

IPC: G02C7/10 ,  G02C11/04 ,  F21V9/00

CPC classification number: G02C7/104 ,  A61F2/16 ,  A61F9/00 ,  F21S2/00 ,  F21V9/00 ,  G02C7/00 ,  G02C7/02 ,  G02C7/04 ,  G02C11/04 ,  G02C2202/24

Abstract: The purpose of the present invention is to provide a myopia prevention device. A myopia prevention device of the present invention comprises a light transmission part selected from a group consisting of an eyesight correcting tool, an eye protection tool, a face protection tool, a sunshade, a display device, a window, a wall, a light source covering, and a coating material. The light transmission part of the device transmits light having a wavelength within a range of 350 nm to 400 nm inclusive and thus suppresses the occurrence and progression of myopia. Further, a myopia prevention device comprises a light emission part selected from a group consisting of lighting equipment, a display device, and a light irradiation device. The light emission part of the device emits light having a wavelength within a range of 350 nm to 400 nm inclusive and thus suppresses the occurrence and progression of myopia.