公开(公告)号：US20240398736A1

公开(公告)日：2024-12-05

申请号：US18266103

申请日：2021-09-01

Applicant: Tsubota Laboratory, Inc. ,  ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Kazuo Tsubota ,  Toshihide Kurihara ,  Shinichi Ikeda ,  Kiwako Mori ,  Xiaoyan Jiang

IPC: A61K31/192 ,  A61P27/10 ,  G01N33/50

Abstract: The present invention provides a screening method for searching a component inhibiting or treating scleral thinning, and eyedrops that contain the active ingredient, and hence can inhibit excessive thinning of the sclera, and as a result, can treat a posterior segment eye disease associated with the scleral thinning. The problems are solved by eyedrops containing, as an active ingredient, a component capable of simultaneously inhibiting the PERK pathway and/or the ATF6 pathway. The problems are solved by a screening method for a component capable of simultaneously inhibiting the PERK pathway and/or the ATF6 pathway, including a step of contacting a candidate substance with an eye-derived cell, and a step of selecting the candidate substance using, as an indicator, influence on scleral thinning in the cell.

公开(公告)号：US11813299B2

公开(公告)日：2023-11-14

申请号：US16614176

申请日：2018-05-15

Applicant: TSUBOTA LABORATORY, INC. ,  ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Kazuo Tsubota ,  Toshihide Kurihara

IPC: A61K36/16 ,  A61P27/10 ,  A61K9/00 ,  A61K31/05 ,  A61K31/202

CPC classification number: A61K36/16 ,  A61K9/0056 ,  A61K31/05 ,  A61K31/202 ,  A61P27/10

Abstract: The ophthalmic composition effective for the prevention or treatment of myopia or ocular diseases are provided. In particular, the present invention provides an ophthalmic composition effective in a growing child or a young person in whom myopia develops and progresses, as well as a middle-aged and elderly person in whom age-related ocular diseases such as cataract, glaucoma, retinal detachment, retinopathy, maculopathy, choroidal neovascularization, posterior staphyloma, and optic neuropathy develop, a functional food containing the ophthalmic composition, and a screening method capable of searching for the same. [Solution] The above problem is solved by an ophthalmic composition or functional food product containing at least one component selected from the group consisting of crocetin and its pharmaceutically acceptable salts and ginkgo leaf extract.

公开(公告)号：US20240041806A1

公开(公告)日：2024-02-08

申请号：US18266102

申请日：2021-09-01

Applicant: Tsubota Laboratory, Inc.

Inventor： Kazuo Tsubota ,  Toshihide Kurihara ,  Shinichi Ikeda ,  Kiwako Mori ,  Xiaoyan Jiang

IPC: A61K31/192 ,  A61K9/00 ,  A61P27/10 ,  G01N33/50

CPC classification number: A61K31/192 ,  A61K9/0048 ,  A61P27/10 ,  G01N33/5058

Abstract: The present invention provides a screening method for searching a component inhibiting the PERK pathway and/or the ATF6 pathway, and by obtaining, by the screening method, an active ingredient inhibiting myopia progression without impairing normal growth of the eyeballs (emmetropization) in children, provides eyedrops and a composition containing the active ingredient. The problems are solved by eyedrops for inhibiting myopia progression in children containing, as an active ingredient, an inhibitor of the PERK (PKR-like endoplasmic reticulum kinase) pathway and/or the ATF6 (activating transcription factor 6) pathway. The problems are solved by a screening method for an inhibitor of myopia progression in children, including a step of contacting a candidate substance with an eye-derived cell, and a step of selecting the candidate substance using, as an index, change in a protein and/or a gene of the signal transduction system of PERK and/or ATF6.

公开(公告)号：US11007375B2

公开(公告)日：2021-05-18

申请号：US16044909

申请日：2018-07-25

Applicant: TOSHIBA MATERIALS CO., LTD. ,  TSUBOTA LABORATORY, INC.

Inventor： Masahiko Yamakawa ,  Hidemasa Torii ,  Toshihide Kurihara ,  Kazuo Tsubota

IPC: A61N5/00 ,  A61N5/06 ,  A61F9/00 ,  F21S2/00 ,  H01L33/50 ,  F21V9/38 ,  C09K11/77 ,  H01L25/075

Abstract: A light source for myopia prevention article includes a light emitter to emit light having an emission spectrum continuing from a first wavelength of not less than 360 nm nor more than 400 nm to a second wavelength of more than 400 nm.

公开(公告)号：US20180351050A1

公开(公告)日：2018-12-06

申请号：US16044909

申请日：2018-07-25

Applicant: TOSHIBA MATERIALS CO., LTD. ,  TSUBOTA LABORATORY, INC.

Inventor： Masahiko Yamakawa ,  Hidemasa Torii ,  Toshihide Kurihara ,  Kazuo Tsubota

IPC: H01L33/50 ,  H01L25/075 ,  C09K11/77

CPC classification number: A61F9/00 ,  A61N5/06 ,  F21S2/00 ,  F21V9/30 ,  H01L33/50

Abstract: A light source for myopia prevention article includes a light emitter to emit light having an emission spectrum continuing from a first wavelength of not less than 360 nm nor more than 400 nm to a second wavelength of more than 400 nm.

公开(公告)号：US20180341122A1

公开(公告)日：2018-11-29

申请号：US15778015

申请日：2015-11-25

Applicant: JINS INC. ,  Tsubota Laboratory, Inc.

Inventor： Shunsuke Shioya ,  Kazuo Tsubota ,  Toshihide Kurihara ,  Hidemasa Toril

IPC: G02C7/04 ,  G02B5/23 ,  G02C7/10 ,  G02C7/02

Abstract: An optical element has a transmission spectrum characterized in that a local maximum falls within a wavelength region longer than 315 nm but shorter than or equal to 400 nm, a local minimum falls within a wavelength region longer than or equal to 380 nm but shorter than or equal to 500 nm, and the wavelength at the local maximum is shorter than the wavelength at the local minimum.

公开(公告)号：US10133092B2

公开(公告)日：2018-11-20

申请号：US15366558

申请日：2016-12-01

Applicant: TSUBOTA LABORATORY, INC.

Inventor： Kazuo Tsubota ,  Kazuno Negishi ,  Hidemasa Torii ,  Toshihide Kurihara

IPC: G02C7/14 ,  G02C3/00 ,  G02C7/02 ,  G02C7/10 ,  F21V9/00 ,  G02C11/04

Abstract: The purpose of the present invention is to provide a myopia prevention device. A myopia prevention device of the present invention comprises a light transmission part selected from a group consisting of an eyesight correcting tool, an eye protection tool, a face protection tool, a sunshade, a display device, a window, a wall, a light source covering, and a coating material. The light transmission part of the device transmits light having a wavelength within a range of 350 nm to 400 nm inclusive and thus suppresses the occurrence and progression of myopia. Further, a myopia prevention device comprises a light emission part selected from a group consisting of lighting equipment, a display device, and a light irradiation device. The light emission part of the device emits light having a wavelength within a range of 350 nm to 400 nm inclusive and thus suppresses the occurrence and progression of myopia.

公开(公告)号：US12023513B2

公开(公告)日：2024-07-02

申请号：US17301859

申请日：2021-04-16

Applicant: TOSHIBA MATERIALS CO., LTD. ,  TSUBOTA LABORATORY, INC.

Inventor： Masahiko Yamakawa ,  Hidemasa Torii ,  Toshihide Kurihara ,  Kazuo Tsubota

IPC: A61N5/06 ,  A61F9/00 ,  C09K11/77 ,  F21S2/00 ,  F21V9/38 ,  H01L25/075 ,  H01L33/50

CPC classification number: A61N5/0613 ,  A61F9/00 ,  A61N5/06 ,  C09K11/77342 ,  C09K11/77348 ,  C09K11/7738 ,  F21S2/00 ,  F21V9/38 ,  H01L25/0753 ,  H01L33/50 ,  H01L33/504 ,  A61N2005/0651 ,  A61N2005/0654 ,  A61N2005/0663 ,  A61N2005/0667

Abstract: A light source for myopia prevention article includes a light emitter to emit light having an emission spectrum continuing from a first wavelength of not less than 360 nm nor more than 400 nm to a second wavelength of more than 400 nm.

公开(公告)号：US10823982B2

公开(公告)日：2020-11-03

申请号：US16155097

申请日：2018-10-09

Applicant: TSUBOTA LABORATORY, INC.

Inventor： Kazuo Tsubota ,  Kazuno Negishi ,  Hidemasa Torii ,  Toshihide Kurihara

IPC: G02C7/10 ,  G02B5/22 ,  A61F2/16 ,  G02B5/20 ,  B60R1/08 ,  A61N5/06 ,  G02B1/11

Abstract: The purpose of the present invention is to provide a myopia treatment device. A myopia treatment device of the present invention comprises a light transmission part selected from a group consisting of an eyesight correcting tool, an eye protection tool, a face protection tool, a sunshade, a display device, a window, a wall, a light source covering, and a coating material. The light transmission part of the device transmits violet light having a wavelength within a range of 360 nm to 400 nm inclusive and thus treats myopia. Or, the myopia treatment device comprises a light emission part selected from a group consisting of lighting equipment, a display device, and a light irradiation device. The light emission part of the device emits violet light having a wavelength within a range of 360 nm to 400 nm inclusive and thus treats myopia.

公开(公告)号：US20190129204A1

公开(公告)日：2019-05-02

申请号：US16155097

申请日：2018-10-09

Applicant: TSUBOTA LABORATORY, INC.

Inventor： Kazuo Tsubota ,  Kazuno Negishi ,  Hidemasa Torii ,  Toshihide Kurihara

IPC: G02C7/10 ,  G02B5/22 ,  A61F2/16

CPC classification number: G02C7/104 ,  A61F2/1602 ,  A61F2002/1696 ,  A61N2005/0648 ,  A61N2005/0663 ,  A61N2005/0667 ,  B60R1/083 ,  G02B1/11 ,  G02B5/208 ,  G02B5/22 ,  G02C2202/24

Abstract: The purpose of the present invention is to provide a myopia treatment device. A myopia treatment device of the present invention comprises a light transmission part selected from a group consisting of an eyesight correcting tool, an eye protection tool, a face protection tool, a sunshade, a display device, a window, a wall, a light source covering, and a coating material. The light transmission part of the device transmits violet light having a wavelength within a range of 360 nm to 400 nm inclusive and thus treats myopia. Or, the myopia treatment device comprises a light emission part selected from a group consisting of lighting equipment, a display device, and a light irradiation device. The light emission part of the device emits violet light having a wavelength within a range of 360 nm to 400 nm inclusive and thus treats myopia.