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18 条记录 (耗时 0.027 秒)

    Method and device for specific binding assay
    1.
    发明授权
    Method and device for specific binding assay 失效
    用于特异性结合测定的方法和装置

    公开(公告)号：US5723345A

    公开(公告)日：1998-03-03

    申请号：US495028

    申请日：1995-06-27

    申请人： Tadakazu Yamauchi ,  Hideyuki Terasawa

    发明人： Tadakazu Yamauchi ,  Hideyuki Terasawa

    IPC分类号： G01N33/53 ,  G01N33/543 ,  G01N33/558 ,  G01N33/536

    CPC分类号： G01N33/53 ,  G01N33/543 ,  G01N33/558 ,  Y10S435/817 ,  Y10S436/805 ,  Y10S436/806

    摘要： The present invention provides a general purpose specific binding assay method which has the advantages of highly accurate and quick measurements which exclude the effects of various factors that decrease reliability of the measured values, such as non-specific reactants in test samples, assay conditions and inactivation and the like changes in the activity of reagents. The present invention is further drawn to a specific binding assay device suitable for the practice thereof. The binding assay of the present invention is achieved by allowing a signal substance generator which takes part in a specific binding reaction and generates a signal substance, together with a liquid sample, to flow through a predetermined channel in a predetermined direction, thereby effecting generation of the specific binding reaction of a substance to be assayed to form a distribution of the signal substance generator in the channel in response to the concentration of the substance to be assayed, allowing the signal substance generator distributed in the channel to generate the signal substance, detecting the generated signal substance by a plurality of detection means arranged at different positions in the liquid flow direction, and arithmetically processing the plural detection results to minimize influence of other factors than the concentration of the substance to be assayed upon the assay result.

    摘要翻译： 本发明提供了一种通用特异性结合测定方法，其具有高精度和快速测量的优点，其排除了降低测量值的可靠性的各种因素的影响，例如测试样品中的非特异性反应物，测定条件和灭活 等等，试剂活性的变化。 本发明进一步涉及适用于其实践的特异性结合测定装置。 本发明的结合试验通过使参与特异性结合反应的信号物质发生器与液体样品一起产生信号物质，以预定方向流过预定通道，从而实现 要测定的物质的特异性结合反应，以响应待测物质的浓度，在通道中形成信号物质发生器的分布，允许分布在通道中的信号物质发生器产生信号物质，检测 所生成的信号物质由布置在液体流动方向的不同位置的多个检测装置进行运算，并对多个检测结果进行算术处理，以最大限度地减少除了待检测物质的浓度以外的其他因素对测定结果的影响。

    Electrochemical assay method with novel p-phenylenediamine compound
    2.
    发明授权
    Electrochemical assay method with novel p-phenylenediamine compound 失效
    新型对苯二胺化合物的电化学测定方法

    公开(公告)号：US5609749A

    公开(公告)日：1997-03-11

    申请号：US366040

    申请日：1994-12-29

    申请人： Tadakazu Yamauchi ,  Hideyuki Terasawa

    发明人： Tadakazu Yamauchi ,  Hideyuki Terasawa

    IPC分类号： C07C215/16 ,  C12Q1/00 ,  G01N33/487 ,  G01N27/327

    CPC分类号： C12Q1/004 ,  C07C215/16 ,  G01N33/48707 ,  Y10S435/817 ,  Y10S436/806

    摘要： An enzyme electrode, specific binding or the like electrochemical assay method capable of performing always stably high detection sensitivity (responsibility) and reappearance even in the case of blood, urine and the like samples that contain interfering substances and also of applying suitably to disposable use, and a novel p-phenylenediamine compound which is used in the assay method. Particularly, an electrochemical assay method in which a substance in a liquid sample is assayed using at least one oxidoreductase, wherein an oxidoreductase, an electron mediator and an electrode which performs electron transfer with the mediator are arranged in the assay system, and a compound of the following formula [I] or a salt thereof is used as the mediator which is highly soluble in water, dried (by freeze-, vacuum- or air-drying) easily and stable under dry condition, shows a high electron transfer rate with enzymes and is almost free from the influence of interfering substances in blood, urine and the like samples: ##STR1## wherein R.sup.1 to R.sup.4 may be the same or different from one another and each means a hydrogen, a straight- or branched-chain alkyl group having 1 to 4 carbon atoms, optionally having a substituent, providing that at least one of R.sup.1 to R.sup.4 has one or more groups selected from hydroxyl, mercapto, carboxyl, phosphonooxy and sulfo.

    摘要翻译： 即使在含有干扰物质的血液，尿等样品的情况下，也能够适用于一次性使用的酶电极，特异性结合等电化学测定方法能够始终稳定地高度检测灵敏度（责任）和再现， 和用于测定方法的新型对苯二胺化合物。 特别地，其中使用至少一种氧化还原酶测定液体样品中的物质的电化学测定方法，其中将氧化还原酶，电子介体和与介体进行电子转移的电极排列在测定系统中，并且将化合物 使用下式[I]或其盐作为高度可溶于水的介质，在干燥条件下容易且稳定地干燥（通过冷冻，真空或空气干燥），显示出与酶的高电子转移速率 并且几乎不受血液，尿液等样品中干扰物质的影响：其中R 1至R 4可以相同或不同，并且各自表示氢，直链或支链的取代基， 具有1至4个碳原子的直链烷基，任选具有取代基，条件是R 1至R 4中的至少一个具有一个或多个选自羟基，巯基，羧基，膦酰氧基和磺基的基团。

    Target Protein And Target Gene In Drug Designing And Screening Method
    4.
    发明申请
    Target Protein And Target Gene In Drug Designing And Screening Method 失效
    靶蛋白和靶基因在药物设计与筛选中的应用

    公开(公告)号：US20080102457A1

    公开(公告)日：2008-05-01

    申请号：US11718946

    申请日：2005-11-09

    申请人： Yorimasa Suwa ,  Tadakazu Yamauchi ,  Tsuyoshi Yamada ,  Hironori Oosaki ,  Morikazu Kito

    发明人： Yorimasa Suwa ,  Tadakazu Yamauchi ,  Tsuyoshi Yamada ,  Hironori Oosaki ,  Morikazu Kito

    IPC分类号： C12Q1/68 ,  G01N33/53 ,  C07H21/04 ,  C07K16/00

    CPC分类号： G01N33/5023 ,  G01N33/5008 ,  G01N33/502

    摘要： The present invention provides target proteins and target genes for bioactive substances such as drugs, and means that enable the development of novel bioactive substances using the same. To be specific, the present invention provides target proteins and target genes for bioactive substances; screening methods for substances capable of regulating bioactivities; bioactivity regulators; a bioactive substance derivative production method; a complex comprising a bioactive substance and a target protein, and a method of producing the complex; and kits comprising a bioactive substance or a salt thereof; determination methods for the onset or risk of onset of a specified disease or condition, determination methods for susceptibility to a bioactive substance, and determination kits used for the determination methods, and the like.

    摘要翻译： 本发明提供了用于生物活性物质如药物的靶蛋白和靶基因，并且使得能够开发使用其的新型生物活性物质的手段。 具体而言，本发明提供了用于生物活性物质的靶蛋白和靶基因; 能够调节生物活性的物质的筛选方法; 生物活性调节剂 生物活性物质衍生物生产方法; 包含生物活性物质和靶蛋白质的复合物，以及生产该复合物的方法; 和包含生物活性物质或其盐的试剂盒; 特定疾病或病症的发病或发病风险的确定方法，对生物活性物质易感性的测定方法和用于测定方法的测定试剂盒等。

    DRUG TARGET PROTEIN AND TARGET GENE, AND SCREENING METHOD
    7.
    发明申请
    DRUG TARGET PROTEIN AND TARGET GENE, AND SCREENING METHOD 审中-公开
    药物靶标蛋白和目标基因，筛选方法

    公开(公告)号：US20090136482A1

    公开(公告)日：2009-05-28

    申请号：US12065303

    申请日：2006-09-01

    申请人： Yorimasa Suwa ,  Tadakazu Yamauchi ,  Morikazu Kito ,  Yuko Isono ,  Tsuruki Tamura ,  Motoi Tobita

    发明人： Yorimasa Suwa ,  Tadakazu Yamauchi ,  Morikazu Kito ,  Yuko Isono ,  Tsuruki Tamura ,  Motoi Tobita

    IPC分类号： A61K39/395 ,  G01N33/00 ,  C12Q1/68 ,  G01N33/566 ,  A61K38/02 ,  A61K31/7088 ,  A61K31/7105

    CPC分类号： G01N33/68 ,  A61K45/06 ,  C07K14/47 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/6845 ,  G01N33/94 ,  G01N2500/00 ,  Y10T436/143333

    摘要： The present invention provides target proteins and target genes for bioactive substances such as drugs, and means that enable the development of novel bioactive substances using the same. More specifically, the present invention provides target proteins and target genes for bioactive substances; screening methods for substances capable of regulating bioactivities; bioactivity regulators; a bioactive substance derivative production method; a complex comprising a bioactive substance and a target protein, and a method of producing the complex; and kits comprising a bioactive substance or a salt thereof; determination methods for the onset or risk of onset of a specified disease or condition, determination methods for susceptibility to a bioactive substance, and determination kits used for the determination methods, and the like.

    摘要翻译： 本发明提供了用于生物活性物质如药物的靶蛋白和靶基因，并且使得能够开发使用其的新型生物活性物质的手段。 更具体地，本发明提供用于生物活性物质的靶蛋白和靶基因; 能够调节生物活性的物质的筛选方法; 生物活性调节剂 生物活性物质衍生物生产方法; 包含生物活性物质和靶蛋白质的复合物，以及生产该复合物的方法; 和包含生物活性物质或其盐的试剂盒; 特定疾病或病症的发病或发病风险的确定方法，对生物活性物质易感性的测定方法和用于测定方法的测定试剂盒等。

    Medical measurement apparatus
    8.
    发明授权
    Medical measurement apparatus 失效
    医疗测量仪器

    公开(公告)号：US5730124A

    公开(公告)日：1998-03-24

    申请号：US505212

    申请日：1995-08-14

    申请人： Tadakazu Yamauchi

    发明人： Tadakazu Yamauchi

    IPC分类号： G06F19/00 ,  A61B5/00

    CPC分类号： G06F19/363 ,  G06F19/3487

    摘要： A medical measurement apparatus which includes a measuring unit for outputting electrical signals in the amount of a target analyte measured in a specimen, and a control unit. The control unit has an identification unit for receiving identification data specific to a subject and for identifying that subject on the basis of the identification data; a criterion setting unit only for use by a controller who sets comments and/or commands about measurements regarding the measuring items and the criteria set for the subject and who is capable of making a specialized judgment on the amount of the target analyte in the specimen; and a judgment and display unit and/or judgment and execution unit for computing the measured results based on the electrical signals from the measuring unit and for selectively displaying and/or executing the comments and/or the command relevant to the criteria with respect to the computed measured results.

    摘要翻译： PCT No.PCT / JP94 / 02099 Sec。 371日期1995年8月14日 102（e）日期1995年8月14日PCT 1994年12月14日PCT PCT。 公开号WO95 / 16970 日期：1995年6月22日一种医疗测量装置，其包括用于输出在样本中测量的目标分析物的量的电信号的测量单元和控制单元。 控制单元具有识别单元，用于接收特定于对象的识别数据，并且用于基于识别数据识别该对象; 标准设置单元，仅供控制者使用，该控制器设置关于测量项目的测量的评论和/或命令以及为该对象设定的标准，并且能够对样本中的目标分析物的量进行专门判断; 以及判断和显示单元和/或判断和执行单元，用于基于来自测量单元的电信号来计算测量结果，并且用于选择性地显示和/或执行与该标准相关的评论和/或命令 计算测量结果。

    Method of interaction analysis and interaction analyzer
    10.
    发明申请
    Method of interaction analysis and interaction analyzer 审中-公开
    交互分析与交互分析仪的方法

    公开(公告)号：US20070009895A1

    公开(公告)日：2007-01-11

    申请号：US10569951

    申请日：2004-10-14

    申请人： Tadakazu Yamauchi ,  Kouichi Tsuchiya ,  Hideaki Sueoka

    发明人： Tadakazu Yamauchi ,  Kouichi Tsuchiya ,  Hideaki Sueoka

    IPC分类号： C12Q1/68 ,  G01N33/53 ,  C12M3/00

    CPC分类号： G01N30/88 ,  G01N2030/8813

    摘要： A method is provided in which an extremely small amount of a solution containing a substance to be analyzed can be analyzed with high throughput and without any loss of the solution. The method comprises the steps of introducing into a separation channel a first solution containing a substance that is eluted from the separation channel faster and a second solution containing a substance that is eluted from the separation channel more slowly, wherein at least a portion of the first solution is introduced into the separation channel after introducing at least a portion of the second solution thereinto, and detecting a chromatogram of the substances eluted from the separation channel.

    摘要翻译： 提供了一种方法，其中可以以高通量分析极少量含有待分析物质的溶液，并且不会有溶液的任何损失。 该方法包括以下步骤：将分离通道中含有从分离通道洗脱的物质的第一溶液和含有从分离通道中缓慢洗脱的物质的第二溶液引入分离通道，其中第一溶液的至少一部分 在将至少一部分第二溶液引入其中之后，将溶液引入分离通道，并检测从分离通道洗脱的物质的色谱图。