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1.发明申请EMULSIFIED SKIN EXTERNAL PREPARATION AND METHOD FOR STABILIZING THE SKIN EXTERNAL PREPARATION 审中-公开用于稳定皮肤外用制剂的乳化皮肤外用制剂和方法公开(公告)号：US20100152139A1
公开(公告)日：2010-06-17
申请号：US11996887
申请日：2006-07-24
申请人： Tadashi Yoneda , Naoko Ito , Kazuo Furuya
发明人： Tadashi Yoneda , Naoko Ito , Kazuo Furuya
CPC分类号： A61K8/676 , A61K8/375 , A61K31/375 , A61K2800/522 , A61Q19/00
摘要： An emulsified skin external preparation containing a salt of a higher fatty acid ester of ascorbic acid-2-phosphate is provided, and the decomposition and consequent decrease of the salt are prevented and thereby the stability of the preparation is enhanced. A method for stabilizing the skin external preparation containing a salt of a higher fatty acid ester of ascorbic acid-2-phosphate is provided. The emulsified skin external preparation includes 0.03 to 25% by mass of a salt of a higher fatty acid ester of ascorbic acid-2-phosphate (A), and 0.05 to 25% by mass of a glycerin mono fatty acid ester (B), the higher fatty acid ester of ascorbic acid-2-phosphate being represented by Formula (1): . . . (1) wherein R is a higher fatty acid residue.
摘要翻译： 提供了含有抗坏血酸-2-磷酸酯的高级脂肪酸酯的盐的乳化皮肤外用剂，防止了盐的分解和随之而来的降低，从而提高了制剂的稳定性。 提供了一种稳定皮肤外用制剂的方法，其含有抗坏血酸-2-磷酸酯的高级脂肪酸酯的盐。 乳化皮肤外用剂含有0.03〜25质量％的抗坏血酸-2-磷酸（A）的高级脂肪酸酯的盐和0.05〜25质量％的甘油单脂肪酸酯（B）， 抗坏血酸-2-磷酸的高级脂肪酸酯由式（1）表示：。 。 。 （1）其中R是高级脂肪酸残基。
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2.发明申请Oil-in-Water Emulsified Composition, and External Preparation for Skin and Cosmetics Using the Composition 审中-公开水包油乳化组合物，以及使用组合物的皮肤和化妆品的外部制剂公开(公告)号：US20080311234A1
公开(公告)日：2008-12-18
申请号：US10593692
申请日：2005-03-22
申请人： Tadashi Yoneda , Naoko Ito , Kazuo Furuya
发明人： Tadashi Yoneda , Naoko Ito , Kazuo Furuya
摘要： An oil-in-water emulsified composition suitable for external preparation for skin and cosmetic product, which comprised 0.1 to 5% by mass of (A) lipopeptide compound derived from a microorganism such as surfactin and its analogous compound, 0.05 to 1.5% by mass of (B) xanthan gum, 25 to 70% by mass of (C) oil component and (D) water, free from non-ionic surfactants and acrylic water-soluble polymers, and is excellent in feeling upon use, moisture retention, emollient property and stability as well as environmental suitability and safety for living organisms, and external preparation for skin and cosmetic product using the composition.
摘要翻译： 一种适用于皮肤和化妆品外用剂的水包油乳化组合物，其含有0.1〜5质量％的（A）衍生自微生物如表面活性素及其类似化合物的脂肽化合物，0.05〜1.5质量％ 的（B）黄原胶，25〜70质量％的（C）油成分和（D）水，不含非离子表面活性剂和丙烯酸类水溶性聚合物，使用感好，保湿性，润肤性 性质和稳定性以及生物体的环境适应性和安全性，以及使用该组合物的皮肤和化妆品的外用制剂。
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公开(公告)号：US08242169B2
公开(公告)日：2012-08-14
申请号：US12307166
申请日：2007-07-03
申请人： Tadashi Yoneda , Naoko Ito , Kazuo Furuya
发明人： Tadashi Yoneda , Naoko Ito , Kazuo Furuya
IPC分类号： A61K31/375 , C07D307/62
摘要： An emulsion composition of the present invention includes (A) a salt of a higher fatty acid ester of ascorbic acid-2-phosphoric acid ester, (B) a polyglycerin fatty acid monoester including polyglycerin having a mean polymerization degree of 8 to 12 and an unsaturated fatty acid residual group of 14 to 22 carbon atoms, (C) a polyglycerin fatty acid monoester comprising polyglycerin having a mean polymerization degree of 2 to 6 and an unsaturated fatty acid residual group of 14 to 22 carbon atoms, and (D) a hydrocarbon oil, wherein the blending ratio by mass between the component (B) and the component (C) is in the range of 1:1 to 3:1, and the blending ratio by mass between the total of the components (B) and (C) and the component (D) is in the range of 10:1 to 1:4. By the use of the emulsion composition of the present invention, a skin external preparation can be provided which is prevented from decrease of a salt of a higher fatty acid ester of ascorbic acid-2-phosphoric acid ester attributable to decomposition of the salt, is excellent in retention of moisture, and has a beautiful appearance.
摘要翻译： 本发明的乳液组合物包含（A）抗坏血酸-2-磷酸酯的高级脂肪酸酯的盐，（B）包含平均聚合度为8〜12的聚甘油的聚甘油脂肪酸单酯和 14个碳原子的不饱和脂肪酸残基，（C）包含平均聚合度为2〜6的聚甘油和14〜22个碳原子的不饱和脂肪酸残基的聚甘油脂肪酸单酯，（D） 烃类油，其中组分（B）和组分（C）之间的混合重量比在1:1至3:1的范围内，并且组分（B）和 （C）和成分（D）的比例在10:1至1:4的范围内。 通过使用本发明的乳液组合物，可以提供防止由于盐分解引起的抗坏血酸-2-磷酸酯的高级脂肪酸酯的盐的降低的皮肤外用剂，是 优良的保湿性，外观美观。
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4.发明申请EMULSIFIED SKIN EXTERNAL PREPARATION AND METHOD FOR STABILIZING THE SKIN EXTERNAL PREPARATION 审中-公开用于稳定皮肤外用制剂的乳化皮肤外用制剂和方法公开(公告)号：US20100152134A1
公开(公告)日：2010-06-17
申请号：US11997016
申请日：2006-07-24
申请人： Tadashi Yoneda , Naoko Ito , Kazuo Furuya
发明人： Tadashi Yoneda , Naoko Ito , Kazuo Furuya
CPC分类号： A61K47/22 , A61K8/06 , A61K8/375 , A61K8/39 , A61K8/678 , A61K8/732 , A61K31/355 , A61K2800/52 , A61Q19/00
摘要： An emulsified skin external preparation containing a tocopherol glycinate derivative has excellent storage stability without viscosity reduction during storage. The emulsified skin external preparation includes 0.03 to 25% by mass of a tocopherol glycinate derivative, and 0.05 to 25% by mass of at least one fatty acid ester selected from the group consisting of glycerin mono fatty acid ester, polyglycerin fatty acid ester and dextrin fatty acid ester, the tocopherol glycinate derivative being represented by Formula (1): . . . (1) wherein R1 and R2 are each a lower alkyl group or a hydrogen atom and cannot be hydrogen atoms at the same time, and R3, R4 and R5 are each a hydrogen atom or a methyl group.
摘要翻译： 含有生育酚甘氨酸衍生物的乳化皮肤外用制剂具有优异的储存稳定性，而不会在保存期间降低粘度。 乳化皮肤外用制剂包含0.03〜25质量％的生育酚甘氨酸衍生物，0.05〜25质量％的选自甘油单脂肪酸酯，聚甘油脂肪酸酯和糊精中的至少一种脂肪酸酯 脂肪酸酯，生育酚甘氨酸衍生物由式（1）表示：。 。 。 （1）其中R1和R2各自为低级烷基或氢原子，并且不能同时为氢原子，R3，R4和R5各自为氢原子或甲基。
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公开(公告)号：US20090252773A1
公开(公告)日：2009-10-08
申请号：US12307166
申请日：2007-07-03
申请人： Tadashi Yoneda , Naoko Ito , Kazuo Furuya
发明人： Tadashi Yoneda , Naoko Ito , Kazuo Furuya
IPC分类号： A61K9/107 , A61K31/665
摘要： An emulsion composition of the present invention includes (A) a salt of a higher fatty acid ester of ascorbic acid-2-phosphoric acid ester, (B) a polyglycerin fatty acid monoester including polyglycerin having a mean polymerization degree of 8 to 12 and an unsaturated fatty acid residual group of 14 to 22 carbon atoms, (C) a polyglycerin fatty acid monoester comprising polyglycerin having a mean polymerization degree of 2 to 6 and an unsaturated fatty acid residual group of 14 to 22 carbon atoms, and (D) a hydrocarbon oil, wherein the blending ratio by mass between the component (B) and the component (C) is in the range of 1:1 to 3:1, and the blending ratio by mass between the total of the components (B) and (C) and the component (D) is in the range of 10:1 to 1:4. By the use of the emulsion composition of the present invention, a skin external preparation can be provided which is prevented from decrease of a salt of a higher fatty acid ester of ascorbic acid-2-phosphoric acid ester attributable to decomposition of the salt, is excellent in retention of moisture, and has a beautiful appearance.
摘要翻译： 本发明的乳液组合物包含（A）抗坏血酸-2-磷酸酯的高级脂肪酸酯的盐，（B）包含平均聚合度为8〜12的聚甘油的聚甘油脂肪酸单酯和 14个碳原子的不饱和脂肪酸残基，（C）包含平均聚合度为2〜6的聚甘油和14〜22个碳原子的不饱和脂肪酸残基的聚甘油脂肪酸单酯，（D） 烃类油，其中组分（B）和组分（C）之间的混合重量比在1:1至3:1的范围内，并且组分（B）和 （C）和成分（D）的比例在10:1至1:4的范围内。 通过使用本发明的乳液组合物，可以提供防止由于盐分解引起的抗坏血酸-2-磷酸酯的高级脂肪酸酯的盐的降低的皮肤外用剂，是 优良的保湿性，外观美观。
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公开(公告)号：US07011969B2
公开(公告)日：2006-03-14
申请号：US10381698
申请日：2001-09-28
申请人： Tadashi Yoneda , Yoshiaki Miyota , Kazuo Furuya , Toshi Tsuzuki
发明人： Tadashi Yoneda , Yoshiaki Miyota , Kazuo Furuya , Toshi Tsuzuki
IPC分类号： C12N1/20
摘要： A process for producing Surfactin, comprising culturing a microorganism of the genus Bacillus in a liquid culture medium containing flour of beans such as soybean or an extract thereof as a nitrogen source and accumulating Surfactin in the culture broth, and a microorganism of the genus Bacillus which have an activity to produce a crude Surfactin in a concentration of from 8 to 50 g/L on culturing for 20 to 90 hours.
摘要翻译： 一种生产枯草芽孢杆菌素的方法，包括在含有诸如大豆或其提取物的豆的面粉的液体培养基中培养芽孢杆菌属的微生物作为氮源并在培养肉汤中积累枯草芽孢杆菌素和芽孢杆菌属的微生物 具有在培养20〜90小时时产生浓度为8〜50g / L的粗的枯草菌素的活性。
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公开(公告)号：US20050266521A1
公开(公告)日：2005-12-01
申请号：US10528773
申请日：2003-09-22
申请人： Tadashi Yoneda , Eiichi Kitakuni , Kazuo Furuya
发明人： Tadashi Yoneda , Eiichi Kitakuni , Kazuo Furuya
摘要： (1) A method for producing iturin A and its homologues by cultivating a Bacillus microbe that produces iturin A and its homologue in a medium containing 2 mass % or more of soybean pulverisate or its extract as a nitrogen source to allow the microbe to accumulate iturin A and its homologue in the medium at a concentration of 1.5 g/L or more, (2) a culture containing iturin A and its homologue accumulated by the method, (3) a solid obtained from the culture and (4) a method of using the culture or the solid, are provided.
摘要翻译： （1）通过培养在含有2质量％以上的大豆粉状物质或其提取物作为氮源的培养基中培养产生神经蛋白A的芽孢杆菌微生物及其同系物的方法，以使微生物积累神经元 A和其在1.5g / L以上浓度的培养基中的同系物，（2）含有神经蛋白A的培养物及其通过该方法积累的同源物，（3）从培养物获得的固体，（4） 使用文化或固体。
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公开(公告)号：US06959565B2
公开(公告)日：2005-11-01
申请号：US10492546
申请日：2002-10-15
申请人： Kazuo Furuya
发明人： Kazuo Furuya
CPC分类号： D04B1/18 , D01F6/70 , D02G1/02 , Y10T442/413
摘要： A circularly knitted fabric for fashioning clothes prior to heat treatment, formed out of a polyurethane elastic fiber and a non-elastic fiber, the polyurethane elastic fiber satisfying the condition, 1≦R/S≦12, wherein R/S (%)=(R3/S1)×100, S1 is the forward stress when the fiber is expanded by 200% at the first expansion in a 300% expansion-recovery repetition test, and R3 is the reverse stress when the fiber is recovered at the third 200% recovery in the 300% expansion-recovery repetition test.
摘要翻译： 一种由聚氨酯弹性纤维和非弹性纤维形成的热处理前的衣服的圆形针织物，满足条件的聚氨酯弹性纤维1 <= R / S <= 12，其中R / S（％ ）=（R 3 / S 1）x 100，S 1是当第一次膨胀时纤维膨胀200％时的正应力 在300％膨胀恢复重复试验中，当在300％膨胀恢复重复试验中第三次200％回收时纤维回收时，R 3是反应力。
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公开(公告)号：US20130008257A1
公开(公告)日：2013-01-10
申请号：US13518597
申请日：2010-12-24
申请人： Hisao Ito , Eiichiro Araki , Kazuo Furuya
发明人： Hisao Ito , Eiichiro Araki , Kazuo Furuya
IPC分类号： G01B13/24
CPC分类号： G01B13/24
摘要： To easily change internal pressure of a container according to a change in external pressure.In a strain gauge device 100, a piston 54 attached to a tubular opening portion 53A provided at a housing part 53 slides in response to external pressure. Thereby varying the volumes of a regulator oil containing region 52 and a sensitive region 15 so as to achieve a balance with the external pressure, to change the internal pressure. Then, in the above-described strain gauge device, because the internal pressures of the regulator oil containing region 52 and the sensitive region 15 are changed according to a change in external pressure only by sliding of the piston 54, it is possible to easily perform regulation of the internal pressure. Further, because the above-described pressure balance mechanism 51 is achieved with a simple configuration, it is possible to easily perform regulation of the external pressure and the internal pressure even in a high-temperature/high-pressure environment.
摘要翻译： 根据外部压力的变化容易地改变容器的内部压力。 在应变计装置100中，附接到设置在壳体部53的管状开口部53A的活塞54响应于外部压力而滑动。 从而改变调节器油容纳区域52和敏感区域15的体积，以实现与外部压力的平衡，以改变内部压力。 而且，在上述的应变计装置中，由于调节器油容纳区域52和敏感区域15的内部压力仅通过活塞54的滑动而根据外部压力的变化而变化，因此能够容易地进行 调节内压。 此外，由于通过简单的结构实现了上述的压力平衡机构51，所以即使在高温高压环境下也能够容易地进行外部压力和内部压力的调节。
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公开(公告)号：US20120319021A1
公开(公告)日：2012-12-20
申请号：US13518638
申请日：2010-12-24
申请人： Hisao Ito , Eiichiro Araki , Kazuo Furuya
发明人： Hisao Ito , Eiichiro Araki , Kazuo Furuya
IPC分类号： F16K5/00
摘要： In the valve mechanism 60, when a valve sleeve 62 and a valve plunger 63 move in an inside of a valve holder 61 by driving of a power unit 65, to be at a predetermined position, a coupling port 63C provided in a flow path 63A of the valve plunger 63 and a slit 610 in the valve holder 61 are communicated with one another, thereby connecting a regulator oil containing region 52 and a sensitive region 15, and in the case where the internal pressures of the regulator oil containing region 52 and the sensitive region 15 are different from each other, the pressures fluctuate so as to equalize those. On the other hand, when those are at positions other than the predetermined position, the coupling port 63C and the slit 610 are not communicated with one another, thereby cutting off the connection between the regulator oil containing region and the sensitive region, and therefore, it is possible to easily perform a pressure regulation even in a high-temperature and high-pressure environment.
摘要翻译： 在阀机构60中，当阀套62和阀柱塞63通过驱动动力单元65在阀保持器61的内部移动到预定位置时，设置在流路63A中的联接口63C 并且阀保持器61中的狭缝610彼此连通，从而连接调节器油容纳区域52和敏感区域15，并且在调节器油容纳区域52和 敏感区域15彼此不同，所以压力波动，以使其均衡。 另一方面，当它们处于除了预定位置之外的位置时，联接口63C和狭缝610彼此不连通，从而切断调节器油容纳区域和敏感区域之间的连接，因此， 即使在高温高压环境下也可以容易地进行压力调节。
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