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    Reduced coenzyme Q10 crystal with excellent stability and composition containing said reduced coenzyme Q10 crystal
    2.
    发明授权
    Reduced coenzyme Q10 crystal with excellent stability and composition containing said reduced coenzyme Q10 crystal 有权
    具有优异稳定性的还原型辅酶Q10晶体，含有所述还原型辅酶Q10晶体的组合物

    公开(公告)号：US07358402B2

    公开(公告)日：2008-04-15

    申请号：US10938431

    申请日：2004-09-09

    申请人： Takahiro Ueda ,  Shiro Kitamura ,  Taizo Kawabe ,  Hideyuki Kishida ,  Yasuyoshi Ueda

    发明人： Takahiro Ueda ,  Shiro Kitamura ,  Taizo Kawabe ,  Hideyuki Kishida ,  Yasuyoshi Ueda

    IPC分类号： C07C43/20 ,  C07C43/215

    CPC分类号： C07C43/23 ,  A23L33/10

    摘要： The present invention provides a reduced coenzyme Q10 crystal with excellent stability and a composition containing said reduced coenzyme Q10 crystals.According to the present invention, after dissolving reduced coenzyme Q10 in a fat and oil, it is cooled, making it possible to obtain reduced coenzyme Q10 crystals with excellent stability and which exhibit an x-ray diffraction pattern (using a CuKα emission line) that differs from ordinary reduced coenzyme Q10 crystals. Moreover, said crystals are also excellent in bioabsorbability.

    摘要翻译： 本发明提供了具有优异稳定性的还原型辅酶Q 10 O 2结晶和含有所述还原型辅酶Q 10 O 2结晶的组合物。 根据本发明，在将脂肪和油中的还原型辅酶Q 10 O溶解后，将其冷却，可以获得具有优异稳定性的还原型辅酶Q 10 N 2结晶， 其表现出与普通还原​​型辅酶Q 10 N结晶不同的x射线衍射图（使用CuKα发射谱线）。 此外，所述晶体的生物吸收性也优异。

    Whitening composition containing reduced coenzyme Q
    3.
    发明申请
    Whitening composition containing reduced coenzyme Q 审中-公开
    含有还原型辅酶Q的美白组合物

    公开(公告)号：US20070196349A1

    公开(公告)日：2007-08-23

    申请号：US11653974

    申请日：2007-01-17

    申请人： Shiro Kitamura ,  Takahiro Ueda ,  Yasuyoshi Ueda ,  Hideyuki Kishida ,  Kenji Fujii ,  Kazunori Hosoe

    发明人： Shiro Kitamura ,  Takahiro Ueda ,  Yasuyoshi Ueda ,  Hideyuki Kishida ,  Kenji Fujii ,  Kazunori Hosoe

    IPC分类号： A61K8/18

    CPC分类号： A61Q19/02 ,  A23L33/10 ,  A23V2002/00 ,  A61K8/355 ,  A23V2200/318 ,  A23V2250/314

    摘要： The present invention provides a cosmetic or food composition which is excellent in a skincare effect, particularly an effect of whitening the skin browned due to ultraviolet radiation or aging, and which can be safely used for many mammals. The present invention provides a whitening composition comprising reduced coenzyme Q represented by formula (1) as an effective component: wherein n represents an integer of 1 to 12. The present invention also provides a whitening composition further comprising oxidized coenzyme Q represented by formula (2) as an effective component: wherein n represents an integer of 1 to 12. The present invention also provides a method for whitening the skin of a mammal, the method comprising administering the mammal with the composition.

    摘要翻译： 本发明提供一种护肤效果优异的化妆品或食品组合物，特别是由于紫外线照射或老化而使皮肤变白而变白的效果，可以安全地用于许多哺乳动物。 本发明提供一种美白组合物，其包含由式（1）表示的还原型辅酶Q作为有效成分：其中n表示1〜12的整数。本发明还提供了还含有由式（2）表示的氧化型辅酶Q ）作为有效成分：其中n表示1至12的整数。本发明还提供了一种使哺乳动物的皮肤变白的方法，所述方法包括给哺乳动物施用该组合物。

    AGENT FOR IMPROVING NERVOUS SYSTEM CELL FUNCTIONS
    7.
    发明申请
    AGENT FOR IMPROVING NERVOUS SYSTEM CELL FUNCTIONS 审中-公开
    改善神经系统细胞功能的代理

    公开(公告)号：US20090246186A1

    公开(公告)日：2009-10-01

    申请号：US12295258

    申请日：2007-03-29

    申请人： Yoshiyuki Shinagawa ,  Hideyuki Kishida ,  Taizo Kawabe ,  Hirokazu Sakamoto ,  Hiroshi Kubo ,  Kazunori Hosoe

    发明人： Yoshiyuki Shinagawa ,  Hideyuki Kishida ,  Taizo Kawabe ,  Hirokazu Sakamoto ,  Hiroshi Kubo ,  Kazunori Hosoe

    IPC分类号： A61K31/122 ,  A61P25/00

    CPC分类号： A61K31/09 ,  A61K31/122

    摘要： The present invention aims to activate neural cells in brain, and further provide a useful composition having an action to protect intracerebral neural cells from external and internal stresses.An agent for improving a neural cell function containing reduced coenzyme Q as an active ingredient, more specifically, an agent for activating neural cells and an agent for protecting neural cells, is useful, and can be used for the improvement or prophylaxis of central neurological diseases or neuropathy symptoms derived from or associated with a neurodegenerative disease, promotion of cognitive function or improvement of learning and memory disorders.

    摘要翻译： 本发明旨在激活脑中的神经细胞，并进一步提供一种有用的组合物，其具有保护脑内神经细胞免受外部和内部应激的作用。 用于改善包含还原型辅酶Q作为活性成分的神经细胞功能的药剂，更具体地，用于激活神经细胞的药剂和用于保护神经细胞的药剂是有用的，并且可用于改善或预防中枢神经系统疾病 或由神经退行性疾病引起或与之相关的神经病症状，促进认知功能或改善学习和记忆障碍。

    Anti-Fatigue Composition
    8.
    发明申请
    Anti-Fatigue Composition 审中-公开
    抗疲劳成分

    公开(公告)号：US20070293572A1

    公开(公告)日：2007-12-20

    申请号：US11596059

    申请日：2005-05-09

    申请人： Hideyuki Kishida ,  Taizo Kawabe ,  Kazunori Hosoe ,  Kenji Fujii

    发明人： Hideyuki Kishida ,  Taizo Kawabe ,  Kazunori Hosoe ,  Kenji Fujii

    IPC分类号： A61K31/05 ,  A61K31/205 ,  A61P25/26

    CPC分类号： A61K31/205 ,  A23L33/10 ,  A23V2002/00 ,  A61K31/09 ,  A61K31/122 ,  A61K45/06 ,  A61K2300/00 ,  A23V2200/31 ,  A23V2250/314 ,  A23V2250/0612

    摘要： Fatigue is significantly involved in the lifestyle of people today. Although many anti-fatigue products are on market, those with definite and reliable effects are still few. Under such circumstances, the inventors of the present invention have conducted studies aiming at providing a composition which exhibits a distinctive anti-fatigue effect, and consequently accomplished the present invention. The present invention provides an anti-fatigue composition containing reduced coenzyme Q and a carnitine derivative. By administering the anti-fatigue composition of the present invention to a mammal, anti-fatigue effects can be synergistically seen even at doses which are not effective when the components are individually used. According to the present invention, an anti-fatigue composition having a reliable effect can be provided.

    摘要翻译： 疲劳显着地涉及到今天人们的生活方式。 虽然许多抗疲劳产品在市场上，但具有确定和可靠影响的产品仍然很少。 在这种情况下，本发明的发明人进行了旨在提供具有显着抗疲劳效果的组合物的研究，从而完成了本发明。 本发明提供含有还原型辅酶Q和肉碱衍生物的抗疲劳组合物。 通过将本发明的抗疲劳组合物施用于哺乳动物，即使在单独使用组分时没有效果的剂量，也可以协同地看到抗疲劳作用。 根据本发明，可以提供具有可靠效果的抗疲劳组合物。

    COMPOSITION OF HIGH ABSORBABILITY FOR ORAL ADMINISTRATION COMPRISING OXIDIZED COENZYME Q10
    10.
    发明申请
    COMPOSITION OF HIGH ABSORBABILITY FOR ORAL ADMINISTRATION COMPRISING OXIDIZED COENZYME Q10 审中-公开
    含有氧化聚苯乙烯的口服药物Q10的高可吸收性组合物Q10

    公开(公告)号：US20080145411A1

    公开(公告)日：2008-06-19

    申请号：US11867347

    申请日：2007-10-04

    申请人： Yoshiyuki Shinagawa ,  Taizo Kawabe ,  Hideyuki Kishida ,  Kazunori Hosoe

    发明人： Yoshiyuki Shinagawa ,  Taizo Kawabe ,  Hideyuki Kishida ,  Kazunori Hosoe

    IPC分类号： A61K9/00 ,  A61K38/43 ,  A61K9/48 ,  A61K31/122

    CPC分类号： A61K31/122 ,  A23K20/10 ,  A23K20/111 ,  A23K20/158 ,  A23K50/40 ,  A23L29/06 ,  A23L29/10 ,  A23L33/10 ,  A23L33/17 ,  A61K9/4858

    摘要： The present invention provides a method of increasing the absorbability of oxidized coenzyme Q10 by preparing the oxidized coenzyme Q10 as a composition in the presence of a lysolecithin and an oil and fat. The composition of the present invention comprising oxidized coenzyme Q10, a lysolecithin and an oil and fat, wherein the weight ratio of the lysolecithin to the oxidized coenzyme Q10 is not less than 0.7, shows superior absorption of oxidized coenzyme Q10 and can be utilized for food, food with nutrient function, food for specified health uses, nutritional supplement, nutritional product, animal drug, beverage, feed, pet food, cosmetics, pharmaceutical product, therapeutic drug, preventive drug and the like.

    摘要翻译： 本发明提供了通过在溶血卵磷脂和油脂中存在下制备氧化型辅酶Q 10作为组合物来提高氧化型辅酶Q 10的吸收性的方法 。 包含氧化型辅酶Q 10，溶血卵磷脂和油脂的本发明组合物，其中溶血卵磷脂与氧化型辅酶Q 10重量比不小于 超过0.7，表现出优异的氧化型辅酶Q 10的吸收，可用于食品，具有营养功能的食物，特定健康用途的食物，营养补充剂，营养产品，动物药物，饮料，饲料，宠物 食品，化妆品，医药产品，治疗药物，预防药物等。