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    AGENT FOR IMPROVING NERVOUS SYSTEM CELL FUNCTIONS
    1.
    发明申请
    AGENT FOR IMPROVING NERVOUS SYSTEM CELL FUNCTIONS 审中-公开
    改善神经系统细胞功能的代理

    公开(公告)号：US20090246186A1

    公开(公告)日：2009-10-01

    申请号：US12295258

    申请日：2007-03-29

    申请人： Yoshiyuki Shinagawa ,  Hideyuki Kishida ,  Taizo Kawabe ,  Hirokazu Sakamoto ,  Hiroshi Kubo ,  Kazunori Hosoe

    发明人： Yoshiyuki Shinagawa ,  Hideyuki Kishida ,  Taizo Kawabe ,  Hirokazu Sakamoto ,  Hiroshi Kubo ,  Kazunori Hosoe

    IPC分类号： A61K31/122 ,  A61P25/00

    CPC分类号： A61K31/09 ,  A61K31/122

    摘要： The present invention aims to activate neural cells in brain, and further provide a useful composition having an action to protect intracerebral neural cells from external and internal stresses.An agent for improving a neural cell function containing reduced coenzyme Q as an active ingredient, more specifically, an agent for activating neural cells and an agent for protecting neural cells, is useful, and can be used for the improvement or prophylaxis of central neurological diseases or neuropathy symptoms derived from or associated with a neurodegenerative disease, promotion of cognitive function or improvement of learning and memory disorders.

    摘要翻译： 本发明旨在激活脑中的神经细胞，并进一步提供一种有用的组合物，其具有保护脑内神经细胞免受外部和内部应激的作用。 用于改善包含还原型辅酶Q作为活性成分的神经细胞功能的药剂，更具体地，用于激活神经细胞的药剂和用于保护神经细胞的药剂是有用的，并且可用于改善或预防中枢神经系统疾病 或由神经退行性疾病引起或与之相关的神经病症状，促进认知功能或改善学习和记忆障碍。

    COMPOSITION OF HIGH ABSORBABILITY FOR ORAL ADMINISTRATION COMPRISING OXIDIZED COENZYME Q10
    2.
    发明申请
    COMPOSITION OF HIGH ABSORBABILITY FOR ORAL ADMINISTRATION COMPRISING OXIDIZED COENZYME Q10 审中-公开
    含有氧化聚苯乙烯的口服药物Q10的高可吸收性组合物Q10

    公开(公告)号：US20080145411A1

    公开(公告)日：2008-06-19

    申请号：US11867347

    申请日：2007-10-04

    申请人： Yoshiyuki Shinagawa ,  Taizo Kawabe ,  Hideyuki Kishida ,  Kazunori Hosoe

    发明人： Yoshiyuki Shinagawa ,  Taizo Kawabe ,  Hideyuki Kishida ,  Kazunori Hosoe

    IPC分类号： A61K9/00 ,  A61K38/43 ,  A61K9/48 ,  A61K31/122

    CPC分类号： A61K31/122 ,  A23K20/10 ,  A23K20/111 ,  A23K20/158 ,  A23K50/40 ,  A23L29/06 ,  A23L29/10 ,  A23L33/10 ,  A23L33/17 ,  A61K9/4858

    摘要： The present invention provides a method of increasing the absorbability of oxidized coenzyme Q10 by preparing the oxidized coenzyme Q10 as a composition in the presence of a lysolecithin and an oil and fat. The composition of the present invention comprising oxidized coenzyme Q10, a lysolecithin and an oil and fat, wherein the weight ratio of the lysolecithin to the oxidized coenzyme Q10 is not less than 0.7, shows superior absorption of oxidized coenzyme Q10 and can be utilized for food, food with nutrient function, food for specified health uses, nutritional supplement, nutritional product, animal drug, beverage, feed, pet food, cosmetics, pharmaceutical product, therapeutic drug, preventive drug and the like.

    摘要翻译： 本发明提供了通过在溶血卵磷脂和油脂中存在下制备氧化型辅酶Q 10作为组合物来提高氧化型辅酶Q 10的吸收性的方法 。 包含氧化型辅酶Q 10，溶血卵磷脂和油脂的本发明组合物，其中溶血卵磷脂与氧化型辅酶Q 10重量比不小于 超过0.7，表现出优异的氧化型辅酶Q 10的吸收，可用于食品，具有营养功能的食物，特定健康用途的食物，营养补充剂，营养产品，动物药物，饮料，饲料，宠物 食品，化妆品，医药产品，治疗药物，预防药物等。

    Anti-Fatigue Composition
    3.
    发明申请
    Anti-Fatigue Composition 审中-公开
    抗疲劳成分

    公开(公告)号：US20070293572A1

    公开(公告)日：2007-12-20

    申请号：US11596059

    申请日：2005-05-09

    申请人： Hideyuki Kishida ,  Taizo Kawabe ,  Kazunori Hosoe ,  Kenji Fujii

    发明人： Hideyuki Kishida ,  Taizo Kawabe ,  Kazunori Hosoe ,  Kenji Fujii

    IPC分类号： A61K31/05 ,  A61K31/205 ,  A61P25/26

    CPC分类号： A61K31/205 ,  A23L33/10 ,  A23V2002/00 ,  A61K31/09 ,  A61K31/122 ,  A61K45/06 ,  A61K2300/00 ,  A23V2200/31 ,  A23V2250/314 ,  A23V2250/0612

    摘要： Fatigue is significantly involved in the lifestyle of people today. Although many anti-fatigue products are on market, those with definite and reliable effects are still few. Under such circumstances, the inventors of the present invention have conducted studies aiming at providing a composition which exhibits a distinctive anti-fatigue effect, and consequently accomplished the present invention. The present invention provides an anti-fatigue composition containing reduced coenzyme Q and a carnitine derivative. By administering the anti-fatigue composition of the present invention to a mammal, anti-fatigue effects can be synergistically seen even at doses which are not effective when the components are individually used. According to the present invention, an anti-fatigue composition having a reliable effect can be provided.

    摘要翻译： 疲劳显着地涉及到今天人们的生活方式。 虽然许多抗疲劳产品在市场上，但具有确定和可靠影响的产品仍然很少。 在这种情况下，本发明的发明人进行了旨在提供具有显着抗疲劳效果的组合物的研究，从而完成了本发明。 本发明提供含有还原型辅酶Q和肉碱衍生物的抗疲劳组合物。 通过将本发明的抗疲劳组合物施用于哺乳动物，即使在单独使用组分时没有效果的剂量，也可以协同地看到抗疲劳作用。 根据本发明，可以提供具有可靠效果的抗疲劳组合物。

    Reduced coenzyme Q10 crystal with excellent stability and composition containing said reduced coenzyme Q10 crystal
    7.
    发明授权
    Reduced coenzyme Q10 crystal with excellent stability and composition containing said reduced coenzyme Q10 crystal 有权
    具有优异稳定性的还原型辅酶Q10晶体，含有所述还原型辅酶Q10晶体的组合物

    公开(公告)号：US07358402B2

    公开(公告)日：2008-04-15

    申请号：US10938431

    申请日：2004-09-09

    申请人： Takahiro Ueda ,  Shiro Kitamura ,  Taizo Kawabe ,  Hideyuki Kishida ,  Yasuyoshi Ueda

    发明人： Takahiro Ueda ,  Shiro Kitamura ,  Taizo Kawabe ,  Hideyuki Kishida ,  Yasuyoshi Ueda

    IPC分类号： C07C43/20 ,  C07C43/215

    CPC分类号： C07C43/23 ,  A23L33/10

    摘要： The present invention provides a reduced coenzyme Q10 crystal with excellent stability and a composition containing said reduced coenzyme Q10 crystals.According to the present invention, after dissolving reduced coenzyme Q10 in a fat and oil, it is cooled, making it possible to obtain reduced coenzyme Q10 crystals with excellent stability and which exhibit an x-ray diffraction pattern (using a CuKα emission line) that differs from ordinary reduced coenzyme Q10 crystals. Moreover, said crystals are also excellent in bioabsorbability.

    摘要翻译： 本发明提供了具有优异稳定性的还原型辅酶Q 10 O 2结晶和含有所述还原型辅酶Q 10 O 2结晶的组合物。 根据本发明，在将脂肪和油中的还原型辅酶Q 10 O溶解后，将其冷却，可以获得具有优异稳定性的还原型辅酶Q 10 N 2结晶， 其表现出与普通还原​​型辅酶Q 10 N结晶不同的x射线衍射图（使用CuKα发射谱线）。 此外，所述晶体的生物吸收性也优异。

    COMPOSITION FOR PREVENTION OR TREATMENT OF DIABETES
    8.
    发明申请
    COMPOSITION FOR PREVENTION OR TREATMENT OF DIABETES 审中-公开
    用于预防或治疗糖尿病的组合物

    公开(公告)号：US20100028319A1

    公开(公告)日：2010-02-04

    申请号：US12525446

    申请日：2008-01-31

    申请人： Hirokazu Sakamoto ,  Hideyuki Kishida ,  Kazunori Hosoe

    发明人： Hirokazu Sakamoto ,  Hideyuki Kishida ,  Kazunori Hosoe

    IPC分类号： A61K38/43 ,  C07H19/20 ,  A61P7/12

    CPC分类号： A61K31/7076 ,  A23K20/10 ,  A23K20/105 ,  A23K20/116 ,  A23K20/121 ,  A23K20/137 ,  A23K20/174 ,  A23K50/40 ,  A23L33/10 ,  A23V2002/00 ,  A23V2200/328 ,  A23V2250/30

    摘要： The present invention aims to provide a composition which has an extremely broad range of applications, has an excellent safety, and can be used for preventing, ameliorating, or therapeutically-treating diabetes.The present invention provides an agent for preventing, ameliorating, or therapeutically-treating diabetes or a diabetic complication, a glycemic control agent, and an insulin secretion-promoting agent, each of which contains reduced coenzyme A as an active ingredient. The present invention also provides a method for preventing, ameliorating, or therapeutically-treating diabetes or a diabetic complication, which includes administration of the aforementioned agent.

    摘要翻译： 本发明旨在提供一种应用范围非常广泛，安全性优异的组合物，可用于预防，改善或治疗糖尿病。 本发明提供了用于预防，改善或治疗糖尿病或糖尿病并发症的药剂，血糖控制剂和胰岛素分泌促进剂，其各自含有还原型辅酶A作为活性成分。 本发明还提供了预防，改善或治疗性治疗糖尿病或糖尿病并发症的方法，其包括给药前述药剂。

    COMPOSITION FOR LIFE EXTENSION AND METHOD OF EXTENDING THE LIFE
    9.
    发明申请
    COMPOSITION FOR LIFE EXTENSION AND METHOD OF EXTENDING THE LIFE 审中-公开
    生命延长的组成和延长生命的方法

    公开(公告)号：US20090148426A1

    公开(公告)日：2009-06-11

    申请号：US12067783

    申请日：2006-09-21

    申请人： Hideyuki Kishida ,  Taizuo Kawabe ,  Kazunori Hosoe

    发明人： Hideyuki Kishida ,  Taizuo Kawabe ,  Kazunori Hosoe

    IPC分类号： A61K38/43 ,  C07C43/205 ,  A61K31/09 ,  A61K31/122

    CPC分类号： A61K31/05 ,  A61K31/122

    摘要： The present invention relates to a composition for life extension, comprising reduced coenzyme Q10 as an active ingredient, as well as relates to a method of extending a life span using the composition comprising reduced coenzyme Q10 as an active ingredient. In the present invention, it has been found that long-term ingestion of feed that contains reduced coenzyme Q10 enables the life span of senescence-accelerated model mice to be extended. No sign indicating toxicity is observed in the senescence-accelerated model mice that have been fed with reduced coenzyme Q10 over a long period. Based on these findings, it was found that the composition containing reduce coenzyme Q10 as an active ingredient has potential to be a composition for life extension with high safety, capable of being taken for a long period. The present invention provides a composition, which can extend the life span of humans or animals, enables them to spend active and healthy senectitudes and shows high safety during the ingestion over a long period.

    摘要翻译： 本发明涉及一种延长寿命的组合物，其包含还原型辅酶Q10作为活性成分，以及涉及使用包含还原型辅酶Q10作为活性成分的组合物延长使用寿命的方法。 在本发明中，已经发现，含有还原型辅酶Q10的饲料的长期摄入使得能够延长衰老加速模型小鼠的寿命。 没有迹象表明，在衰老加速模型小鼠中观察到毒性，这些老鼠在长时间内补充还原型辅酶Q10。 基于这些发现，发现含有还原型辅酶Q10作为活性成分的组合物具有潜在的延长寿命的组合物，其安全性高，能够长时间服用。 本发明提供一种能够延长人类或动物寿命的组合物，使其能够在长时间摄取过程中花费积极和健康的感觉并显示高安全性。

    CARDIAC DYSFUNCTION-AMELIORATING AGENT OR CARDIAC FUNCTION-MAINTAINING AGENT
    10.
    发明申请
    CARDIAC DYSFUNCTION-AMELIORATING AGENT OR CARDIAC FUNCTION-MAINTAINING AGENT 审中-公开
    心脏功能改善剂或心脏功能维持剂

    公开(公告)号：US20090246185A1

    公开(公告)日：2009-10-01

    申请号：US12282448

    申请日：2007-03-09

    申请人： Hideyuki Kishida ,  Kenji Fujii ,  Hiroshi Kubo ,  Kazunori Hosoe

    发明人： Hideyuki Kishida ,  Kenji Fujii ,  Hiroshi Kubo ,  Kazunori Hosoe

    IPC分类号： A61K31/122 ,  C07C43/23 ,  A61P9/00

    CPC分类号： A61K31/122 ,  A23K20/111 ,  A23K20/174 ,  A23L33/10 ,  A23L33/15 ,  A23V2002/00 ,  A61K45/06 ,  A23V2200/326 ,  A23V2250/314

    摘要： An object of the present invention is to provide a highly safe oral composition superior in a cardiac dysfunction-ameliorating or cardiac function-maintaining action. The present inventors have conducted intensive studies in an attempt to solve the aforementioned problems and found that use of, particularly, reduced coenzyme Q10 from among highly safe coenzyme Q affords a composition useful for amelioration of cardiac dysfunction and maintenance of cardiac function. Accordingly, the present invention provides a cardiac dysfunction-ameliorating agent or cardiac function-maintaining agent containing reduced coenzyme Q as an active ingredient, and a pharmaceutical product, a food, an animal drug, a feed and the like, which contain the agent.

    摘要翻译： 本发明的目的是提供在心脏功能障碍改善或心脏功能保持作用方面优异的高度安全的口服组合物。 本发明人为了解决上述问题进行了深入研究，发现特别是来自高度安全性的辅酶Q中的还原型辅酶Q10的使用提供了用于改善心脏功能障碍和维持心脏功能的组合物。 因此，本发明提供含有还原型辅酶Q作为活性成分的心脏功能障碍改善剂或心脏功能维持剂，以及含有该药剂的药物，食品，动物药物，饲料等。