公开(公告)号：US07608819B2

公开(公告)日：2009-10-27

申请号：US12078523

申请日：2008-04-01

申请人： Takashi Baba ,  Yuichiro Hashimoto

发明人： Takashi Baba ,  Yuichiro Hashimoto

IPC分类号： H01J49/00

CPC分类号： H01J49/4225 ,  H01J49/0054 ,  H01J49/422

摘要： The present invention provides a mass spectrometry capable of high-efficiency and high-throughput ECD. An electron source and a two-dimensional combined ion trap in which a magnetic field along and generally parallel to a central axis is applied are used, thereby to achieve the foregoing object. First, precursor ions are trapped. By adopting the two-dimensional combined ion trap, it is possible to obtain a high ion trapping efficiency upon being injected and trapping. Subsequently, electrons are made incident thereon in such a manner as to be wound along the central axis to which no radio frequency is applied by using a magnetic field. For this reason, it is possible to allow energy-controlled electrons to reach the precursor ions. It is possible to implement a mass spectrometer capable of avoiding heating due to a radio frequency electric field, and effecting high-throughput/high-efficiency ECD.

摘要翻译： 本发明提供能够实现高效率和高通量ECD的质谱。 使用其中施加沿着并且大致平行于中心轴的磁场的电子源和二维组合离子阱，从而实现上述目的。 首先，前体离子被捕获。 通过采用二维组合离子阱，可以在注入和捕获时获得高离子捕获效率。 随后，使电子以这样的方式入射，即沿着不通过使用磁场施加射频的中心轴缠绕。 因此，可以使能量控制的电子达到前体离子。 可以实现能够避免由于射频电场引起的加热并且实现高通量/高效率ECD的质谱仪。

公开(公告)号：US07329862B2

公开(公告)日：2008-02-12

申请号：US11495534

申请日：2006-07-31

申请人： Yuichiro Hashimoto ,  Takashi Baba ,  Hideki Hasegawa ,  Izumi Waki

发明人： Yuichiro Hashimoto ,  Takashi Baba ,  Hideki Hasegawa ,  Izumi Waki

IPC分类号： H01J49/00

CPC分类号： H01J49/4225 ,  H01J49/004 ,  H01J49/401

摘要： A mass spectrometer capable of analyzing a wide mass range with high sensitivity and high mass accuracy. A mass spectrometer has an ionization source generating ions; an ion transfer optics transferring the ions; a first linear trap accumulating the ions and ejecting the ions in the specific mass range; a second linear trap having an end electrode disposed at the exit end ejecting the ions to change a DC potential gradient relative to a DC potential of the end electrode and trapping the ions ejected from the first linear trap to repeatedly eject them in pulse form; a time-of-flight mass spectrometer accelerating the ions ejected from the second linear trap in the orthogonal direction to detect them; and a controller changing the time duration of the ions in which the ions are ejected from the second linear trap or delay time from the completion of ejection to application of an accelerating voltage of the time-of-flight mass spectrometer according to the mass range of the ions ejected from the first linear trap to the second linear trap.

摘要翻译： 能够以高灵敏度和高质量精度分析宽质量范围的质谱仪。 质谱仪具有产生离子的电离源; 离子转移光学器件转移离子; 积聚离子并在特定质量范围内喷射离子的第一线性阱; 第二线性阱，其具有设置在出射端处的终端电极，其排出离子，以相对于端电极的DC电位改变DC电位梯度，并且捕获从第一线性阱捕获的离子重复地以脉冲形式喷射; 飞行时间质谱仪在正交方向加速从第二线性阱捕获的离子以检测它们; 以及控制器，其将离子从第二线性阱捕获的离子或从完成喷射的延迟时间的持续时间改变为根据飞行时间质谱仪的加速电压的质量范围 离子从第一线性捕集器喷射到第二线性阱。

公开(公告)号：US20070069124A1

公开(公告)日：2007-03-29

申请号：US11605437

申请日：2006-11-29

申请人： Takashi Baba ,  Yuichiro Hashimoto

发明人： Takashi Baba ,  Yuichiro Hashimoto

IPC分类号： H01J49/00

CPC分类号： H01J49/4225 ,  H01J49/0054 ,  H01J49/422

摘要： The present invention provides a mass spectrometry capable of high-efficiency and high-throughput ECD. An electron source and a two-dimensional combined ion trap in which a magnetic field along and generally parallel to a central axis is applied are used, thereby to achieve the foregoing object. First, precursor ions are trapped. By adopting the two-dimensional combined ion trap, it is possible to obtain a high ion trapping efficiency upon being injected and trapping. Subsequently, electrons are made incident thereon in such a manner as to be wound along the central axis to which no radio frequency is applied by using a magnetic field. For this reason, it is possible to allow energy-controlled electrons to reach the precursor ions. It is possible to implement a mass spectrometer capable of avoiding heating due to a radio frequency electric field, and effecting high-throughput/high-efficiency ECD.

公开(公告)号：US06967323B2

公开(公告)日：2005-11-22

申请号：US10868933

申请日：2004-06-17

申请人： Yuichiro Hashimoto ,  Takashi Baba ,  Hideki Hasegawa ,  Izumi Waki

发明人： Yuichiro Hashimoto ,  Takashi Baba ,  Hideki Hasegawa ,  Izumi Waki

IPC分类号： G01N27/62 ,  G01N27/64 ,  H01J49/00 ,  H01J49/40 ,  H01J49/42

CPC分类号： H01J49/063 ,  H01J49/004 ,  H01J49/0481

摘要： An ion mass spectrometer comprising an ionization source for generating ions, a linear trap region for accumulation and dissociation of ions, and a time-of-flight mass spectrometer for mass spectroscopy of ions based on the flying time, and having a collision damping region introduced with a buffer gas for reducing the kinetic energy of ions ejected from the linear trap region and converting the ion packet into continuous beam and provided with plural electrodes for generating multipole electric fields in the inside between the linear trap region and the time-of-flight mass spectrometer, and having an ion transmission control mechanism for allowing or inhibiting incidence of ion from the linear trap region to the collision damping region between the linear trap region and the collision damping region.

摘要翻译： 一种离子质谱仪，包括用于产生离子的电离源，用于离子的聚集和离解的线性捕获区域，以及用于基于飞行时间的离子质谱的飞行时间质谱仪，并且具有引入的碰撞阻尼区域 使用缓冲气体，用于降低从线性捕获区域排出的离子的动能，并将离子包转换为连续光束，并设置有多个电极，用于在线性捕获区域和飞行时间之间的内部产生多极电场 并且具有用于允许或抑制从线性捕获区域到线性捕获区域和碰撞阻尼区域之间的碰撞阻尼区域的入射的离子传输控制机构。

公开(公告)号：US20090189065A1

公开(公告)日：2009-07-30

申请号：US11631033

申请日：2006-03-08

申请人： Yuichiro Hashimoto ,  Hideki Hasegawa ,  Takashi Baba ,  Izumi Waki

发明人： Yuichiro Hashimoto ,  Hideki Hasegawa ,  Takashi Baba ,  Izumi Waki

IPC分类号： B01D59/44

CPC分类号： H01J49/427 ,  H01J49/067 ,  H01J49/4225

摘要： In a mass spectrometer introducing ions produced at an ion source, and including quadrupole rods which have an inlet and an outlet and to which a radio-frequency voltage is applied, the mass spectrometer, i.e., a mass spectrometry device implemented by a linear trap which exhibits high ejection efficiency, high mass resolution, and low ejection energy, executes the following steps: Trapping at least part of the ions by a trap potential generated on the central axis of a quadrupole field, oscillating part of the trapped ions in an intermediate direction between the mutually-adjacent quadrupole rods, ejecting the oscillated ions by an extraction field, and detecting the ejected ions or introducing the ejected ions into another detection process.

摘要翻译： 在质谱仪中引入在离子源处产生的离子，并且包括具有入口和出口的四极棒，并且施加射频电压，质谱仪即通过线性捕获器实现的质谱装置 表现出高喷射效率，高质量分辨率和低喷射能量，执行以下步骤：通过在四极场的中心轴上产生的捕获电位捕获至少一部分离子，在中间方向上振荡部分捕获的离子 在相邻的四极棒之间，通过提取场喷射振荡的离子，并检测喷出的离子或将喷出的离子引入另一检测过程。

公开(公告)号：US20080156979A1

公开(公告)日：2008-07-03

申请号：US12010977

申请日：2008-01-31

申请人： Yuichiro Hashimoto ,  Hideki Hasegawa ,  Takashi Baba ,  Hiroyuki Satake ,  Izumi Waki

发明人： Yuichiro Hashimoto ,  Hideki Hasegawa ,  Takashi Baba ,  Hiroyuki Satake ,  Izumi Waki

IPC分类号： B01D59/44

CPC分类号： H01J49/4225 ,  H01J49/004 ,  H01J49/4265

摘要： Amass spectrometer includes: an ion source for ionizing a specimen to generate ions, an ion transport portion for transporting the ions, a linear ion trap portion for accumulating the transported ions by a potential formed axially, and a control portion of ejecting the ions within a second m/z range different from a first m/z range, from the linear ion trap portion, and substantially at the same timing as the timing of accumulating the ions within the first m/z range from the transport portion into the linear ion trap portion. The ion transportation portion having a mass selection means for selecting the ions in the first m/z range.

摘要翻译： 阿马斯光谱仪包括：用于电离样品以产生离子的离子源，用于输送离子的离子传输部分，用于通过轴向形成的电势积聚所运送的离子的线性离子捕获部分，以及将离子喷射到 第二m / z范围与第一m / z范围不同于线性离子阱部分，并且基本上与从运输部分到线性离子阱的第一m / z范围内积聚离子的定时基本相同 一部分。 该离子传送部分具有用于选择第一m / z范围内的离子的质量选择装置。

公开(公告)号：US20080073508A1

公开(公告)日：2008-03-27

申请号：US11671562

申请日：2007-02-06

申请人： Yuichiro Hashimoto ,  Hideki Hasegawa ,  Takashi Baba ,  Izumi Waki

发明人： Yuichiro Hashimoto ,  Hideki Hasegawa ,  Takashi Baba ,  Izumi Waki

IPC分类号： H01J49/00

CPC分类号： H01J49/4295 ,  H01J49/005 ,  H01J49/0054

摘要： An ion trap in which highly accurate isolation, ECD, and CID can be efficiently performed. A reaction cell and a mass spectrometer of the present invention include an ion-trap which has a plurality of rod electrodes and creates a multipole field, a means for generating a magnetic field in the axial direction of the ion-trap, a means for creating a DC harmonic potential in the axial direction of the ion-trap, and an electron source for introducing electrons into the central axis of the ion-trap. The identification ability is greatly improved compared with the prior art.

摘要翻译： 可以有效地执行高精度隔离，ECD和CID的离子阱。 本发明的反应池和质谱仪包括具有多个棒电极并产生多极场的离子阱，用于在离子阱的轴向产生磁场的装置，用于产生 在离子阱的轴向上的DC谐波电位和用于将电子引入离子阱的中心轴的电子源。 与现有技术相比，识别能力大大提高。

公开(公告)号：US20060284072A1

公开(公告)日：2006-12-21

申请号：US11495534

申请日：2006-07-31

申请人： Yuichiro Hashimoto ,  Takashi Baba ,  Hideki Hasegawa ,  Izumi Waki

发明人： Yuichiro Hashimoto ,  Takashi Baba ,  Hideki Hasegawa ,  Izumi Waki

IPC分类号： H01J49/00

CPC分类号： H01J49/4225 ,  H01J49/004 ,  H01J49/401

摘要： A mass spectrometer capable of analyzing a wide mass range with high sensitivity and high mass accuracy. A mass spectrometer has an ionization source generating ions; an ion transfer optics transferring the ions; a first linear trap accumulating the ions and ejecting the ions in the specific mass range; a second linear trap having an end electrode disposed at the exit end ejecting the ions to change a DC potential gradient relative to a DC potential of the end electrode and trapping the ions ejected from the first linear trap to repeatedly eject them in pulse form; a time-of-flight mass spectrometer accelerating the ions ejected from the second linear trap in the orthogonal direction to detect them; and a controller changing the time duration of the ions in which the ions are ejected from the second linear trap or delay time from the completion of ejection to application of an accelerating voltage of the time-of-flight mass spectrometer according to the mass range of the ions ejected from the first linear trap to the second linear trap.

摘要翻译： 能够以高灵敏度和高质量精度分析宽质量范围的质谱仪。 质谱仪具有产生离子的电离源; 离子转移光学器件转移离子; 积聚离子并在特定质量范围内喷射离子的第一线性阱; 第二线性阱，其具有设置在出射端处的终端电极，其排出离子，以相对于端电极的DC电位改变DC电位梯度，并且捕获从第一线性阱捕获的离子重复地以脉冲形式喷射; 飞行时间质谱仪在正交方向加速从第二线性阱捕获的离子以检测它们; 以及控制器，其将离子从第二线性阱捕获的离子或从完成喷射的延迟时间的持续时间改变为根据飞行时间质谱仪的加速电压的质量范围 离子从第一线性捕集器喷射到第二线性阱。

公开(公告)号：US20050178955A1

公开(公告)日：2005-08-18

申请号：US11006591

申请日：2004-12-08

申请人： Takashi Baba ,  Yuichiro Hashimoto

发明人： Takashi Baba ,  Yuichiro Hashimoto

IPC分类号： G01N27/62 ,  H01J49/04 ,  H01J49/34 ,  H01J49/40 ,  H01J49/42 ,  H01J49/26

CPC分类号： H01J49/4225 ,  H01J49/0054 ,  H01J49/422

摘要： The present invention provides a mass spectrometry capable of high-efficiency and high-throughput ECD. An electron source and a two-dimensional combined ion trap in which a magnetic field along and generally parallel to a central axis is applied are used, thereby to achieve the foregoing object. First, precursor ions are trapped. By adopting the two-dimensional combined ion trap, it is possible to obtain a high ion trapping efficiency upon being injected and trapping. Subsequently, electrons are made incident thereon in such a manner as to be wound along the central axis to which no radio frequency is applied by using a magnetic field. For this reason, it is possible to allow energy-controlled electrons to reach the precursor ions. It is possible to implement a mass spectrometer capable of avoiding heating due to a radio frequency electric field, and effecting high-throughput/high-efficiency ECD.

摘要翻译： 本发明提供能够实现高效率和高通量ECD的质谱。 使用其中施加沿着并且大致平行于中心轴的磁场的电子源和二维组合离子阱，从而实现上述目的。 首先，前体离子被捕获。 通过采用二维组合离子阱，可以在注入和捕获时获得高离子捕获效率。 随后，使电子以这样的方式入射，即沿着不通过使用磁场施加射频的中心轴缠绕。 因此，可以使能量控制的电子达到前体离子。 可以实现能够避免由于射频电场引起的加热并且实现高通量/高效率ECD的质谱仪。

公开(公告)号：US06888134B2

公开(公告)日：2005-05-03

申请号：US10608263

申请日：2003-06-30

申请人： Yuichiro Hashimoto ,  Hideki Hasegawa ,  Takashi Baba ,  Izumi Waki

发明人： Yuichiro Hashimoto ,  Hideki Hasegawa ,  Takashi Baba ,  Izumi Waki

IPC分类号： G01N27/62 ,  H01J49/42 ,  B01D59/44 ,  H01J49/00

CPC分类号： H01J49/424 ,  H01J49/0481

摘要： There is provided an ion trap mass spectrometer which can detect fragment ions having a low mass and enables high-sensitivity measurement. A mass spectrometer has an ion source generating sample ions; an ion trap having a pair of and endcap electrodes and a ring electrode and accumulating ions generated by the ion source and isolating precursor ions from the accumulated ion and dissociating the isolated precursor ions and ejecting the dissociated ions from the ion trap. A gas introduction hole is arranged in the endcap electrode or the ring electrode for introducing in intermittently-introduced bath gas therethrough into the ion trap. A detector detects the ions ejected from the ion trap. The center axis of the gas introduction hole is arranged so as to pass through a region near the center of gravity of the ion trap.

摘要翻译： 提供了一种离子阱质谱仪，可以检测低质量的碎片离子，并实现高灵敏度测量。 质谱仪具有产生样品离子的离子源; 具有一对和端盖电极和环形电极的离子阱，并且积聚由离子源产生的离子并且从累积的离子中分离前体离子并解离分离的前体离子并将离解的离子从离子阱中排出。 在端盖电极或环形电极中布置有气体导入孔，用于将间歇导入的浴气引入到离子阱中。 检测器检测从离子阱排出的离子。 气体导入孔的中心轴配置成通过离子阱重心附近的区域。