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公开(公告)号：US20110129429A1
公开(公告)日：2011-06-02
申请号：US13002005
申请日：2009-07-01
CPC分类号： A61K47/22 , A61K8/63 , A61K8/86 , A61K9/0014 , A61K31/195 , A61K31/375 , A61K31/60 , A61K47/34 , A61Q17/04
摘要： When a poorly water-soluble ultraviolet ray absorber is used, it is difficult to solubilize a sufficient amount of the poorly water-soluble ultraviolet ray absorber by using a surfactant such as a polyoxyethylene alkyl ether or a polyoxyethylene hydrogenated castor oil. Thus, an object aims to provide a water-containing composition in which a poorly water-soluble ultraviolet ray absorber is solubilized or dispersed in water. Another object aims to dissolve a poorly water-soluble ultraviolet ray absorber in water and allow the poorly water-soluble ultraviolet ray absorber to co-exist with a water-soluble component such as a water-soluble medicinal agent and a water-soluble dye in the water to thereby stabilize the water-soluble component. The water-containing composition comprises the components (1) to (3) shown below and may additionally comprise a water-soluble medicinal agent and/or a water-soluble dye: (1) a polyoxyethylene adduct compound represented by formula (I) HO(CH2CH2O)a—R (I) [wherein R represents a phytosterol residue or a phytostanol residue; and n represents a number of 5 to 100]; (2) a poorly water-soluble ultra-violet ray absorber; and (3) water.
摘要翻译： 当使用水溶性差的紫外线吸收剂时，难以通过使用聚氧乙烯烷基醚或聚氧乙烯氢化蓖麻油等表面活性剂溶解足够量的难溶于水的紫外线吸收剂。 因此，目的在于提供一种水难溶性组合物，其中难溶于水的紫外线吸收剂溶解或分散在水中。 另一个目的是将难溶于水的紫外线吸收剂溶解在水中，使难溶于水的紫外线吸收剂与水溶性成分如水溶性药剂和水溶性染料共存， 水，从而稳定水溶性成分。 含水组合物包含下述成分（1）〜（3），还可以含有水溶性药剂和/或水溶性染料：（1）由式（I）表示的聚氧乙烯加合物，HO （CH 2 CH 2 O）a -R（I）[其中R表示植物甾醇残基或植物甾醇残基; n表示5〜100的数。 （2）水溶性差的紫外线吸收剂; 和（3）水。
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公开(公告)号：US08216597B2
公开(公告)日：2012-07-10
申请号：US12670895
申请日：2008-07-22
申请人： Takashi Oka , Reiji Miyahara , Takashi Teshigawara
发明人： Takashi Oka , Reiji Miyahara , Takashi Teshigawara
CPC分类号： A61K8/0295 , A61K8/062 , A61K8/342 , A61K8/361 , A61K8/375 , A61K8/553 , A61K8/63 , A61K8/86 , A61K9/1075 , A61K47/10 , A61K47/12 , A61K47/14 , A61K2800/21 , A61Q19/00 , B01J13/046
摘要： The present invention provides: an oil-in-water emulsion composition, into which an oil-soluble drug is stably incorporated and which is excellent in feeling during use; and a method for producing the aforementioned composition, which does not require complicated operations. An oil-in-water emulsion composition comprising; (A) a polyoxyethylene phytosterol, (B) a glycerin fatty acid diester, (C) a polyoxyethylene-polyoxypropylene random copolymer dialkyl ether, (D) an oil-soluble drug, (E) oil, and (F) water; wherein a layered gel structure composed of the components (A) and (B) is present in an emulsion particle in the emulsion composition.
摘要翻译： 本发明提供一种油包水乳液组合物，其中稳定地掺入油溶性药物，使用时的感觉优异; 以及不需要复杂操作的上述组合物的制造方法。 一种水包油乳液组合物，其包含： （A）聚氧乙烯植物甾醇，（B）甘油脂肪酸二酯，（C）聚氧乙烯 - 聚氧丙烯无规共聚物二烷基醚，（D）油溶性药物，（E）油和（F）水; 其中由所述组分（A）和（B）组成的分层凝胶结构物存在于所述乳液组合物中的乳液颗粒中。
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公开(公告)号：US20100284949A1
公开(公告)日：2010-11-11
申请号：US12810183
申请日：2008-12-25
申请人： Takashi Teshigawara , Reiji Miyahara , Takashi Oka
发明人： Takashi Teshigawara , Reiji Miyahara , Takashi Oka
CPC分类号： A61K8/63 , A61K8/4966 , A61K8/86 , A61K9/0014 , A61K31/575 , A61K47/28 , A61K47/34 , A61Q17/04 , A61Q19/00
摘要： An object of the present invention is to provide means for enhancing ability to solubilize a low water-soluble substance or to disperse the substance in water. The present invention provides a water-containing composition containing water; at least one polyoxyethylene-polyoxypropylene-added phytosterol or phytostanol represented by the following formula (1): [wherein R represents a phytosterol residue or a phytostanol residue; m is a number from 5 to 100; and n is a number from 5 to 100]; and at least one low water-soluble substance which is in a dissolved state.
摘要翻译： 本发明的目的是提供增强溶解低水溶性物质或将物质分散在水中的能力的方法。 本发明提供含有水的含水组合物， 由下式（1）表示的至少一种聚氧乙烯 - 聚氧丙烯添加的植物甾醇或植物甾醇：[其中R表示植物甾醇残基或植物甾醇残基; m是从5到100的数字; n为5〜100的数。 和至少一种处于溶解状态的低水溶性物质。
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公开(公告)号：US20100196429A1
公开(公告)日：2010-08-05
申请号：US12670895
申请日：2008-07-22
申请人： Takashi Oka , Reiji Miyahara , Takashi Teshigawara
发明人： Takashi Oka , Reiji Miyahara , Takashi Teshigawara
CPC分类号： A61K8/0295 , A61K8/062 , A61K8/342 , A61K8/361 , A61K8/375 , A61K8/553 , A61K8/63 , A61K8/86 , A61K9/1075 , A61K47/10 , A61K47/12 , A61K47/14 , A61K2800/21 , A61Q19/00 , B01J13/046
摘要： The present invention provides: an oil-in-water emulsion composition, into which an oil-soluble drug is stably incorporated and which is excellent in feeling during use; and a method for producing the aforementioned composition, which does not require complicated operations. An oil-in-water emulsion composition comprising; (A) a polyoxyethylene phytosterol, (B) a glycerin fatty acid diester, (C) a polyoxyethylene-polyoxypropylene random copolymer dialkyl ether, (D) an oil-soluble drug, (E) oil, and (F) water; wherein a layered gel structure composed of the components (A) and (B) is present in an emulsion particle in the emulsion composition.
摘要翻译： 本发明提供一种油包水乳液组合物，其中稳定地掺入油溶性药物，使用时的感觉优异; 以及不需要复杂操作的上述组合物的制造方法。 一种水包油乳液组合物，其包含： （A）聚氧乙烯植物甾醇，（B）甘油脂肪酸二酯，（C）聚氧乙烯 - 聚氧丙烯无规共聚物二烷基醚，（D）油溶性药物，（E）油和（F）水; 其中由所述组分（A）和（B）组成的分层凝胶结构物存在于所述乳液组合物中的乳液颗粒中。
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公开(公告)号：US20110135587A1
公开(公告)日：2011-06-09
申请号：US13057329
申请日：2009-08-07
摘要： The present invention provides an easily-handled hair conditioning composition with a very low water content. The hair conditioning composition of the present invention is a composition comprising: (a) 10 to 90% by mass of one or more components selected from higher alcohols, higher fatty acids, and derivatives thereof, (b) 5 to 35% by mass of a cationic surfactant, and (c) a polyhydric alcohol and/or polyethylene glycol having a melting point of 155° C. or less, characterized in that the endothermic peak of a gel which is formed from (a) and (b) in the composition is 50° C. or more as measured by a differential scanning calorimeter (DSC) and that the water content is 10% by mass or less.
摘要翻译： 本发明提供了一种容易处理的具有非常低含水量的头发调理组合物。 本发明的头发调理组合物是包含：（a）10〜90质量％的选自高级醇，高级脂肪酸及其衍生物的一种或多种成分，（b）5〜35质量％ 阳离子表面活性剂，和（c）熔点为155℃以下的多元醇和/或聚乙二醇，其特征在于，在（a）和（b）中形成的凝胶的吸热峰 组成为差示扫描量热计（DSC）测定的50℃以上，含水率为10质量％以下。
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公开(公告)号：US20110110877A1
公开(公告)日：2011-05-12
申请号：US12999767
申请日：2009-06-19
申请人： Tomoko Watanabe , Tomoyuki Kawasoe , Takashi Teshigawara , Reiji Miyahara , Masatoshi Ochiai , Taizo Fujiyama
发明人： Tomoko Watanabe , Tomoyuki Kawasoe , Takashi Teshigawara , Reiji Miyahara , Masatoshi Ochiai , Taizo Fujiyama
摘要： An object of the present invention is to establish means for reliably incorporating a poorly soluble UV-absorbing agent into a hair cosmetic composition, to thereby provide a hair cosmetic composition which has excellent effect of preventing UV-hair damage and which exhibits favorable sensation in use thereof. Specifically, the object can be attained through provision of a hair cosmetic composition including the following ingredients (1) and (2): (1) a polyoxy(lower alkylene) addition compound represented by formula (I): wherein R represents a phytosterol residue or a phytostanol residue; m is a number from 0 to 100; and n is a number from 5 to 100, and (2) a UV-absorbing agent having a triazine group.
摘要翻译： 本发明的目的在于建立将难溶性紫外线吸收剂可靠地引入到毛发化妆品中的手段，从而提供具有优异的防止紫外线毛发损伤的效果并且在使用中具有良好感觉的毛发化妆品 其中。 具体地，可以通过提供包含以下成分（1）和（2）的毛发化妆品组合物来实现：（1）由式（I）表示的聚氧化（低级亚烷基）加成化合物：其中R表示植物甾醇残基 或植物甾醇残基; m是从0到100的数字; n为5〜100的数，（2）具有三嗪基的紫外线吸收剂。
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公开(公告)号：US08580235B2
公开(公告)日：2013-11-12
申请号：US12999767
申请日：2009-06-19
申请人： Tomoko Watanabe , Tomoyuki Kawasoe , Takashi Teshigawara , Reiji Miyahara , Masatoshi Ochiai , Taizo Fujiyama
发明人： Tomoko Watanabe , Tomoyuki Kawasoe , Takashi Teshigawara , Reiji Miyahara , Masatoshi Ochiai , Taizo Fujiyama
IPC分类号： A61K8/49 , A61K8/86 , A61K31/704 , A61Q5/00 , A61Q5/02
摘要： An object of the present invention is to establish means for reliably incorporating a poorly soluble UV-absorbing agent into a hair cosmetic composition, to thereby provide a hair cosmetic composition which has excellent effect of preventing UV-hair damage and which exhibits favorable sensation in use thereof. Specifically, the object can be attained through provision of a hair cosmetic composition including the following ingredients (1) and (2): (1) a polyoxy(lower alkylene) addition compound represented by formula (I): wherein R represents a phytosterol residue or a phytostanol residue; m is a number from 0 to 100; and n is a number from 5 to 100, and (2) a UV-absorbing agent having a triazine group.
摘要翻译： 本发明的目的在于建立将难溶性紫外线吸收剂可靠地引入到毛发化妆品中的手段，从而提供具有优异的防止紫外线毛发损伤的效果并且在使用中具有良好感觉的毛发化妆品 其中。 具体地，可以通过提供包含以下成分（1）和（2）的毛发化妆品组合物来实现：（1）由式（I）表示的聚氧化（低级亚烷基）加成化合物：其中R表示植物甾醇残基 或植物甾醇残基; m是从0到100的数字; n为5〜100的数，（2）具有三嗪基的紫外线吸收剂。
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公开(公告)号：US20090197948A1
公开(公告)日：2009-08-06
申请号：US12301769
申请日：2007-05-22
申请人： Reiji Miyahara , Kouzou Hiwatari , Kei Watanabe , Takashi Oka , Kei-ichi Maruyama , Keiichi Yokozawa
发明人： Reiji Miyahara , Kouzou Hiwatari , Kei Watanabe , Takashi Oka , Kei-ichi Maruyama , Keiichi Yokozawa
IPC分类号： A61K31/375 , C07C43/13 , A61K47/10 , A61K31/05
摘要： The present invention is to provide a skin external preparation with good moisture retention, a rough skin improving effect, and an improved feeling in use. A skin external preparation comprising a polyoxyalkylene glycol/polyethylene glycol copolymer alkyl ether derivative represented by the below-described general formula (I):(formula I) Y—{O(EO)a/(AO)b—R}k (I) (In the formula, Y is the residue given by removing hydroxyl groups from a polyhydric alcohol having 3 to 6 hydroxyl groups, and k is the number of hydroxyl groups of the polyhydric alcohol. EO is an oxyethylene group; AO is an oxyalkylene group having 3 to 4 carbon atoms, and 1≦a≦70, 1≦b≦70. The percentage of the oxyethylene groups with respect to the sum of the oxyalkylene groups having 3 to 4 carbon atoms and the oxyethylene groups is 20 to 100 mass %. The oxyalkylene group having 3 to 4 carbon atoms and the oxyethylene group are added randomly. Rs are either identical to or different from each other, and they are hydrocarbon groups having 1 to 4 carbon atoms.)
摘要翻译： 本发明提供一种具有良好的保湿性，粗糙的皮肤改善效果和改善的使用感的皮肤外用剂。 包含由下述通式（I）表示的聚氧化亚烷基二醇/聚乙二醇共聚物烷基醚衍生物的皮肤外用制剂：（式I）<？in-line-formula description =“In-line Formulas”end =“lead “？”Y- {O（EO）a /（AO）bR} k（I）<？in-line-formula description =“In-line Formulas”end =“tail”？>（在公式中，Y是 通过从具有3〜6个羟基的多元醇除去羟基而得到的残基，k为多元醇的羟基数，EO为氧化乙烯基，AO为碳原子数3〜4的氧化烯基， 1 <= a <= 70，1 <= b <= 70，氧化乙烯基相对于具有3〜4个碳原子的氧化烯和氧化乙烯基的总和的比例为20〜100质量％，氧化烯 随机添加3〜4个碳原子的基团和氧化乙烯基，Rs可以相同也可以不同，它们是具有1〜4个碳原子的烃基 n原子）
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公开(公告)号：US20110274731A1
公开(公告)日：2011-11-10
申请号：US13144114
申请日：2010-01-14
申请人： Reiji Miyahara , Hidefumi Araki
发明人： Reiji Miyahara , Hidefumi Araki
摘要： The present invention provides a production method of a fine O/W emulsion external preparation having the emulsion particle size of 50 to 500 nm comprising the steps of: mixing with stirring, at 70 to 80° C., (A) a hydrophilic nonionic surfactant, (B) a linear higher alcohol having 16 or more carbon atoms, (C) an oil component, (D) an aqueous solvent which can be soluble in water, wherein the critical micelle concentration (c.m.c.) of the hydrophilic nonionic surfactant in the aqueous solvent is higher than that in water, and (E) water in the amount of 5 to 25 mass % of the total amount of (A) to (E), to prepare a W/O emulsion; and adding, while mixing with stirring, (F) water or an aqueous formulation at 10 to 35° C. into the W/O emulsion to invert the W/O emulsion to a fine O/W emulsion. The production method needs not to use any cooling apparatus, has excellent economical efficiency, can easily produce a fine O/W emulsion external preparation excellent in safety and stability.
摘要翻译： 本发明提供乳液粒径为50〜500nm的精细O / W乳液外用制剂的制造方法，其特征在于，在70〜80℃下搅拌混合（A）亲水性非离子表面活性剂 ，（B）具有16个或更多个碳原子的直链高级醇，（C）油组分，（D）可溶于水的水性溶剂，其中亲水性非离子表面活性剂的临界胶束浓度（cmc） 水溶剂的含量高于水，和（E）水的量为（A）〜（E）的总量的5〜25质量％，制备W / O乳液; 并在搅拌下加入（F）水或10至35℃的水性制剂进入W / O乳液，以将W / O乳液反转为细O / W乳液。 生产方法不需要使用任何冷却装置，具有优良的经济效益，可以方便地生产出安全稳定性优良的O / W乳液外用制剂。
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10.发明申请公开(公告)号：US20110165110A1
公开(公告)日：2011-07-07
申请号：US13063208
申请日：2010-02-03
摘要： A hair conditioning composition containing very little water from which a hair conditioner can be easily produced by diluting with water, and a low energy production method thereof. A hair conditioning composition including (a) 10 to 90% by mass of specifically structured higher alcohols and/or derivatives thereof, (b) 5 to 35% by mass of cationic surfactant, and (c) a polyhydric alcohol and/or polyethylene glycol having a melting point of 70° C. or less, wherein the melting point of a gel which is formed from (a) and (b) in the composition is 70° C. or less, the water content is 10% by mass or less, and the molar ratio of (a) to (b) is 2.5 or more to less than 6.0. Also, a low energy method of producing a hair conditioner by melting the hair conditioning composition under heating at the temperature of the melting point of gel or more to 70° C. or less, and diluting it with water in an amount of 3 to 15 times by mass.
摘要翻译： 含有很少水的头发调理组合物及其能量的制造方法可以通过水稀释从而容易地制造护发素。 一种头发调理剂组合物，其包含（a）10〜90质量％的特定结构的高级醇和/或其衍生物，（b）5〜35质量％的阳离子表面活性剂，和（c）多元醇和/或聚乙二醇 其熔点为70℃以下，其中，由组合物中的（a）和（b）形成的凝胶的熔点为70℃以下，水含量为10质量％ （a）〜（b）的摩尔比为2.5以上且小于6.0。 另外，通过在凝胶熔点以上至70℃以下的温度下加热熔融毛发调理组合物，以3〜15的量稀释，从而制造护发素的低能量法 次数。
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