公开(公告)号：US5393742A

公开(公告)日：1995-02-28

申请号：US109614

申请日：1993-08-19

申请人： Takayuki Ishii ,  Makiko Kasano ,  Tae Yasunaga ,  Mariko Ishii ,  Mamoru Sugimoto ,  Kenkichi Tomita ,  Takeshi Miyata ,  Makoto Tanaka

发明人： Takayuki Ishii ,  Makiko Kasano ,  Tae Yasunaga ,  Mariko Ishii ,  Mamoru Sugimoto ,  Kenkichi Tomita ,  Takeshi Miyata ,  Makoto Tanaka

IPC分类号： A61K31/70

CPC分类号： A61K31/7004 ,  A61K31/70

摘要： A preparation is useful for treating renal disease, such as nephritis and especially nephrosis (nephrotic syndrome), which comprises an effective amount of N-acetylneuraminic acid shown by the formula ##STR1## wherein, when n is 1, Z represents hydrogens, lithium, potassium, sodium, ammonium or organic ammonium, and when n is 2, Z represents calcium, barium or magnesium, and a pharmacologically acceptable carrier.

摘要翻译： 一种制剂可用于治疗肾脏疾病，例如肾炎，特别是肾病（肾病综合征），其包含有效量的由马来酰亚胺，锂，钾，钠，铵或有机铵显示的N-乙酰神经氨酸，当n为 2，Z表示钙，钡或镁，以及药理学上可接受的载体。

公开(公告)号：US5516764A

公开(公告)日：1996-05-14

申请号：US219236

申请日：1994-03-28

申请人： Ryoichi Osawa ,  Isao Suda ,  Masaaki Numata ,  Mamoru Sugimoto ,  Kenkichi Tomita ,  Nobuyuki Kibushi ,  Takayuki Ishii ,  Naokazu Sugiyama ,  Makiko Kasano ,  Tae Yasunaga ,  Makoto Tanaka ,  Tomoya Ogawa ,  Mariko Ishii

发明人： Ryoichi Osawa ,  Isao Suda ,  Masaaki Numata ,  Mamoru Sugimoto ,  Kenkichi Tomita ,  Nobuyuki Kibushi ,  Takayuki Ishii ,  Naokazu Sugiyama ,  Makiko Kasano ,  Tae Yasunaga ,  Makoto Tanaka ,  Tomoya Ogawa ,  Mariko Ishii

IPC分类号： C12P19/04 ,  A61K31/70 ,  A61K31/715 ,  A61P7/02 ,  A61P13/02 ,  A61P15/00 ,  A61P37/08 ,  C07H13/04 ,  C12R1/01 ,  A01N43/04 ,  C07H1/00

CPC分类号： A61K31/715 ,  A61K31/70 ,  A61K31/7012 ,  A61K31/7016 ,  A61K31/702 ,  C07H13/04 ,  Y10S514/825 ,  Y10S514/885

摘要： An anti-inflammatory drug comprising as the effective component at least one compound selected from the group consisting of colominic acid, partial hydrolysis products of colominic acid and pharmaceutically acceptable salts thereof. The drug is used as a drug for renal diseases, a drug for hepatitis, an immunomodulator and a drug for inhibiting the chemotaxis of neutrophil.

摘要翻译： 一种抗炎药，其包含选自科洛芬酸，聚洛米酸的部分水解产物和其药学上可接受的盐中的至少一种化合物作为有效成分。 该药用作肾脏疾病的药物，用于肝炎的药物，免疫调节剂和抑制嗜中性粒细胞趋化性的药物。

公开(公告)号：US5668115A

公开(公告)日：1997-09-16

申请号：US450699

申请日：1995-05-25

申请人： Ryoichi Osawa ,  Isao Suda ,  Masaaki Numata ,  Mamoru Sugimoto ,  Kenkichi Tomita ,  Nobuyuki Kibushi ,  Takayuki Ishii ,  Naokazu Sugiyama ,  Makiko Kasano ,  Tae Yasunaga ,  Makoto Tanaka ,  Tomoya Ogawa ,  Mariko Ishii

发明人： Ryoichi Osawa ,  Isao Suda ,  Masaaki Numata ,  Mamoru Sugimoto ,  Kenkichi Tomita ,  Nobuyuki Kibushi ,  Takayuki Ishii ,  Naokazu Sugiyama ,  Makiko Kasano ,  Tae Yasunaga ,  Makoto Tanaka ,  Tomoya Ogawa ,  Mariko Ishii

IPC分类号： C12P19/04 ,  A61K31/70 ,  A61K31/715 ,  A61P7/02 ,  A61P13/02 ,  A61P15/00 ,  A61P37/08 ,  C07H13/04 ,  C12R1/01

CPC分类号： A61K31/715 ,  A61K31/70 ,  A61K31/7012 ,  A61K31/7016 ,  A61K31/702 ,  C07H13/04 ,  Y10S514/825 ,  Y10S514/885

摘要： An anti-inflammatory drug comprising as the effective component at least one compound selected from the group consisting of colominic acid, partial hydrolysis products of colominic acid and pharmaceutically acceptable salts thereof. The drug is used as a drug for renal diseases, a drug for hepatitis, an immunomodulator and a drug for inhibiting the chemotaxis of neutrophil.

摘要翻译： 一种抗炎药，其包含选自科洛芬酸，聚洛米酸的部分水解产物和其药学上可接受的盐中的至少一种化合物作为有效成分。 该药用作肾脏疾病的药物，用于肝炎的药物，免疫调节剂和抑制嗜中性粒细胞趋化性的药物。

公开(公告)号：US5763420A

公开(公告)日：1998-06-09

申请号：US450930

申请日：1995-05-25

申请人： Ryoichi Osawa ,  Isao Suda ,  Masaaki Numata ,  Mamoru Sugimoto ,  Kenkichi Tomita ,  Nobuyuki Kibushi ,  Takayuki Ishii ,  Naokazu Sugiyama ,  Makiko Kasano ,  Tae Yasunaga ,  Makoto Tanaka ,  Tomoya Ogawa ,  Mariko Ishii

发明人： Ryoichi Osawa ,  Isao Suda ,  Masaaki Numata ,  Mamoru Sugimoto ,  Kenkichi Tomita ,  Nobuyuki Kibushi ,  Takayuki Ishii ,  Naokazu Sugiyama ,  Makiko Kasano ,  Tae Yasunaga ,  Makoto Tanaka ,  Tomoya Ogawa ,  Mariko Ishii

IPC分类号： C12P19/04 ,  A61K31/70 ,  A61K31/715 ,  A61P7/02 ,  A61P13/02 ,  A61P15/00 ,  A61P37/08 ,  C07H13/04 ,  C12R1/01 ,  A61K31/735

CPC分类号： A61K31/715 ,  A61K31/70 ,  A61K31/7012 ,  A61K31/7016 ,  A61K31/702 ,  C07H13/04 ,  Y10S514/825 ,  Y10S514/885

摘要： An anti-inflammatory drug comprising as the effective component at least one compound selected from the group consisting of colominic acid, partial hydrolysis products of colominic acid and pharmaceutically acceptable salts, thereof. The drug is used as a drug for renal diseases, a drug for hepatitis, an immunomodulator and a drug for inhibiting the chemotaxis of neutrophil.

摘要翻译： 一种抗炎药，其包含选自科洛芬酸，聚洛米酸的部分水解产物和其药学上可接受的盐的至少一种化合物作为有效成分。 该药用作肾脏疾病的药物，用于肝炎的药物，免疫调节剂和抑制嗜中性粒细胞趋化性的药物。

公开(公告)号：US5763413A

公开(公告)日：1998-06-09

申请号：US505352

申请日：1995-08-30

申请人： Masaaki Numata ,  Shigeki Nunomura ,  Shuji Fujita ,  Masami Iida ,  Akira Endo ,  Takayuki Ishii ,  Tomoya Ogawa ,  Mamoru Sugimoto ,  Ryoichi Osawa ,  Masamichi Fujita

发明人： Masaaki Numata ,  Shigeki Nunomura ,  Shuji Fujita ,  Masami Iida ,  Akira Endo ,  Takayuki Ishii ,  Tomoya Ogawa ,  Mamoru Sugimoto ,  Ryoichi Osawa ,  Masamichi Fujita

IPC分类号： C07H3/06 ,  C07H13/04 ,  C07H15/04 ,  C07H15/10 ,  A61K31/70 ,  C07H15/00 ,  C07H17/00

CPC分类号： C07H13/04 ,  C07H15/04 ,  C07H15/10 ,  C07H3/06

摘要： A Lewis-associated compound, represented by general formula (I), a process for producing the same, and an anti-inflammatory, wherein R.sup.1 and R.sup.3 represent each hydrogen, m SO.sub.3 H or CH.sub.2 COOH; R.sup.2 represents hydrogen, SO.sub.3 H, CH.sub.2 COOH or N-acetyl-neutraminic acid residue; R.sup.4 represents hydrogen; R.sup.5 represents O-lower alkyl, O-lower alkenyl, O-ceramide residue, O-mannose residue, O-galactose residue or O-lactose residue; R.sup.6 represents acetylamine; and R.sup.7 and R.sup.8 represent each hydrogen. ##STR1##

摘要翻译： PCT No.PCT / JP94 / 00352 Sec。 371日期：1995年8月30日 102（e）日期1995年8月30日PCT 1994年3月4日PCT公布。 第WO94 / 20514号公报 1994年9月15日由通式（I）表示的路易斯相关化合物，其制造方法和抗炎剂，其中，R 1和R 3表示各自的氢，m SO 3 H或CH 2 COOH; R2表示氢，SO3H，CH2COOH或N-乙酰基 - 中甲酰赖氨酸残基; R4代表氢; R5表示O-低级烷基，O-低级烯基，O-神经酰胺残基，O-甘露糖残基，O-半乳糖残基或O-乳糖残基; R6表示乙酰胺; 并且R7和R8表示每个氢。 （一）

公开(公告)号：US5177062A

公开(公告)日：1993-01-05

申请号：US325649

申请日：1989-03-20

申请人： Takeshi Miyata ,  Kazuo Takahama ,  Hirofumi Kai ,  Takayuki Ishii ,  Keiji Komatsu

发明人： Takeshi Miyata ,  Kazuo Takahama ,  Hirofumi Kai ,  Takayuki Ishii ,  Keiji Komatsu

IPC分类号： A61K31/70

CPC分类号： A61K31/7004

摘要： A preparation for treating immune complex diseases which comprises injection containing the following compound: ##STR1## wherein when n is 1, Z represents a hydrogen, lithium, potassium, sodium, ammonium or organic ammonium, and when n is 2, Z represents calcium, barium or magnesium, as an active ingredient and pharmacologically acceptable carrier. The preparation of the present invention may be used in any administration method such as hypodermic, intramuscular and intravenous.

摘要翻译： 一种用于治疗免疫复合物疾病的制剂，其包含含有以下化合物的注射剂：其中当n为1时，Z表示氢，锂，钾，钠，铵或有机铵，当n为2时，Z表示钙， 钡或镁，作为活性成分和药理学上可接受的载体。 本发明的制剂可以以任何施用方法如皮下注射，肌内注射和静脉内使用。

公开(公告)号：US08948439B2

公开(公告)日：2015-02-03

申请号：US13110100

申请日：2011-05-18

申请人： Tsutomu Nagumo ,  Koji Matsuda ,  Koji Nageno ,  Takeshi Hara ,  Takahiro Suzuki ,  Takayuki Ishii ,  Kenji Hiraiwa

发明人： Tsutomu Nagumo ,  Koji Matsuda ,  Koji Nageno ,  Takeshi Hara ,  Takahiro Suzuki ,  Takayuki Ishii ,  Kenji Hiraiwa

IPC分类号： H04R1/00 ,  H04R9/06 ,  H04R11/02 ,  H04R25/00 ,  H04R9/08 ,  H04R11/04 ,  H04R17/02 ,  H04R19/04 ,  H04R21/02

CPC分类号： H04R11/02

摘要： An acoustic conversion device includes: a driving unit including a pair of magnets disposed so as to face each other, a yoke to which the pair of magnets are attached, a coil to which driving current is supplied, a vibrating portion which vibrates when driving current is supplied to the coil, and an armature disposed between the pair of magnets with the vibrating portion being passed through the coil; and a diaphragm unit including a diaphragm, and a beam portion for propagating the vibration of the vibrating portion to the diaphragm; with a coil attachment portion to which the coil is attached, located in a state in parallel with the vibrating portion, being provided to the armature.

摘要翻译： 一种声转换装置，包括：驱动单元，包括一对彼此相对配置的磁体;一对磁体附接的磁轭;供给驱动电流的线圈;驱动电流时振动的振动部; 设置在所述一对磁体之间的电枢，所述振动部分通过所述线圈; 以及包括隔膜的隔膜单元和用于将振动部分的振动传播到隔膜的梁部分; 其中线圈附接部分位于与振动部分平行的状态下，被设置在电枢上。

公开(公告)号：US08419180B2

公开(公告)日：2013-04-16

申请号：US11484619

申请日：2006-07-12

申请人： Takayuki Ishii ,  Yoshitaka Shimada

发明人： Takayuki Ishii ,  Yoshitaka Shimada

IPC分类号： B41J2/01

CPC分类号： B41J11/0085 ,  B41J11/0065 ,  B41J11/06

摘要： A fixed material transportation surface of the fixed material transportation apparatus is formed inclining so as to become higher toward a downstream side from an upstream side of transportation direction of the fixed material, and is transported while sucking the fixed material supplied on the fixed material transportation surface. Thus, since the cockling is drawn when the fixed material is transported while being raised to transportation direction on the fixed material transportation surface even if cockling extending to transportation direction generates on the fixed material after fixing, growth of the cockling can be prevented.

公开(公告)号：US20110311090A1

公开(公告)日：2011-12-22

申请号：US13108489

申请日：2011-05-16

申请人： Tsutomu Nagumo ,  Koji Matsuda ,  Kenji Hiraiwa ,  Takayuki Ishii ,  Koji Nageno ,  Takeshi Hara ,  Takahiro Suzuki

发明人： Tsutomu Nagumo ,  Koji Matsuda ,  Kenji Hiraiwa ,  Takayuki Ishii ,  Koji Nageno ,  Takeshi Hara ,  Takahiro Suzuki

IPC分类号： H04R1/00

CPC分类号： H04R11/02

摘要： An acoustic conversion device includes: a driving unit including a pair of magnets disposed so as to face each other, a yoke to which the pair of magnets are attached, a coil to which driving current is supplied, a vibrating portion which vibrates when driving current is supplied to the coil, and an armature disposed between the pair of magnets with the vibrating portion passed through the coil; and a diaphragm unit including a holding frame having an opening, a resin film adhered to the holding frame in a state covering the opening of the holding frame, a diaphragm held on the inner side of the holding frame in a state adhered to the resin film, and a beam portion of which the tip portion formed integrally with the diaphragm is combined with the vibrating portion of the armature, for propagating the vibration of the vibrating portion to the diaphragm.

摘要翻译： 一种声转换装置，包括：驱动单元，包括一对彼此相对配置的磁体;一对磁体附接的磁轭;供给驱动电流的线圈;驱动电流时振动的振动部; 设置在所述一对磁体之间的电枢，所述振动部通过所述线圈; 以及膜片单元，其包括具有开口的保持框架，在覆盖所述保持框架的开口的状态下粘附到所述保持框架的树脂膜，以与所述树脂膜粘附的状态保持在所述保持框架的内侧的隔膜 并且将与隔膜一体形成的前端部的梁部与电枢的振动部结合，将振动部的振动传播到振动膜。

公开(公告)号：US20110311089A1

公开(公告)日：2011-12-22

申请号：US13110100

申请日：2011-05-18

申请人： Tsutomu Nagumo ,  Koji Matsuda ,  Koji Nageno ,  Takeshi Hara ,  Takahiro Suzuki ,  Takayuki Ishii ,  Kenji Hiraiwa

发明人： Tsutomu Nagumo ,  Koji Matsuda ,  Koji Nageno ,  Takeshi Hara ,  Takahiro Suzuki ,  Takayuki Ishii ,  Kenji Hiraiwa

IPC分类号： H04R1/00

CPC分类号： H04R11/02

摘要： An acoustic conversion device includes: a driving unit including a pair of magnets disposed so as to face each other, a yoke to which the pair of magnets are attached, a coil to which driving current is supplied, a vibrating portion which vibrates when driving current is supplied to the coil, and an armature disposed between the pair of magnets with the vibrating portion being passed through the coil; and a diaphragm unit including a diaphragm, and a beam portion for propagating the vibration of the vibrating portion to the diaphragm; with a coil attachment portion to which the coil is attached, located in a state in parallel with the vibrating portion, being provided to the armature.

摘要翻译： 一种声转换装置，包括：驱动单元，包括一对彼此相对配置的磁体;一对磁体附接的磁轭;供给驱动电流的线圈;驱动电流时振动的振动部; 设置在所述一对磁体之间的电枢，所述振动部分通过所述线圈; 以及包括隔膜的隔膜单元和用于将振动部分的振动传播到隔膜的梁部分; 其中线圈附接部分位于与振动部分平行的状态下，被设置在电枢上。