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1.发明申请IMMUNOGENIC COMPOSITIONS USEFUL IN PROVOKING AN INTEGRATED RESPONSE TO TUMOR ANTIGENS 审中-公开免疫组化可用于提供肿瘤抗原的综合反应公开(公告)号：US20120328660A1
公开(公告)日：2012-12-27
申请号：US13484884
申请日：2012-05-31
申请人： Takemasa TSUJI , Sacha Gnjatic , Gerd Ritter , Lloyd J. Old
发明人： Takemasa TSUJI , Sacha Gnjatic , Gerd Ritter , Lloyd J. Old
CPC分类号： A61K39/0011 , A61K39/39 , A61K2039/55561 , A61K2039/55583
摘要： The invention relates to an immunogenic composition and its use. It comprises “OLPs,” or overlapping peptides, derived from a longer, tumor antigen, in combination with polyICLC, and Montanide.
摘要翻译： 本发明涉及免疫原性组合物及其用途。 它包括衍生自较长的肿瘤抗原的OLP或重叠的肽，与polyICLC和Montanide组合。
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公开(公告)号：US20120283115A1
公开(公告)日：2012-11-08
申请号：US13392919
申请日：2010-08-30
申请人： Gerd Ritter , Lloyd J. Old , Constance Old , Sacha Gnjatic , Kunle Odunsi , Dirk Jager
发明人： Gerd Ritter , Lloyd J. Old , Constance Old , Sacha Gnjatic , Kunle Odunsi , Dirk Jager
IPC分类号： G01N33/574 , G01N33/82 , C40B30/04 , G01N21/64 , B82Y15/00
CPC分类号： G01N33/57449 , A61K39/0011 , A61K2039/505 , A61K2039/53 , G01N33/564 , G01N2800/56 , G01N2800/60
摘要： The invention relates to the discovery of cancer antigens associated with ovarian cancer. In further aspects, the invention relates to methods, compositions and kits for the diagnosis and treatment of cancer, particularly ovarian and pancreatic cancers.
摘要翻译： 本发明涉及与卵巢癌相关的癌症抗原的发现。 在另外的方面，本发明涉及用于诊断和治疗癌症，特别是卵巢和胰腺癌的方法，组合物和试剂盒。
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3.发明申请Methods for Stimulating an Immune Response Using Bacterial Antigen Delivery System 失效使用细菌抗原递送系统刺激免疫反应的方法公开(公告)号：US20090324651A1
公开(公告)日：2009-12-31
申请号：US12083188
申请日：2006-10-03
CPC分类号： A61K39/0011 , A61K2039/522 , A61K2039/523 , A61K2039/542 , C07K14/255 , C07K2319/036
摘要： The invention relates to the use of the type III secretion system of bacteria to stimulate immune responses against tumor antigen(s) for treating antigen-loss variant tumors. Methods are provided for stimulating and/or increasing an immune response against tumor antigens. The invention also relates to the preparation of antigen presenting cells from peripheral blood mononuclear cells using bacteria having a type III secretion system.
摘要翻译： 本发明涉及细菌的III型分泌系统在刺激抗肿瘤抗原的免疫应答中用于治疗抗原缺失型变体肿瘤的用途。 提供了刺激和/或增加针对肿瘤抗原的免疫应答的方法。 本发明还涉及使用具有III型分泌系统的细菌从外周血单核细胞制备抗原呈递细胞。
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4.发明授权Methods for stimulating an immune response using bacterial antigen delivery system 失效使用细菌抗原递送系统刺激免疫应答的方法公开(公告)号：US08357373B2
公开(公告)日：2013-01-22
申请号：US12083188
申请日：2006-10-03
CPC分类号： A61K39/0011 , A61K2039/522 , A61K2039/523 , A61K2039/542 , C07K14/255 , C07K2319/036
摘要： The invention relates to the use of the type III secretion system of bacteria to stimulate immune responses against tumor antigen(s) for treating antigen-loss variant tumors. Methods are provided for stimulating and/or increasing an immune response against tumor antigens. The invention also relates to the preparation of antigen presenting cells from peripheral blood mononuclear cells using bacteria having a type III secretion system.
摘要翻译： 本发明涉及细菌的III型分泌系统在刺激抗肿瘤抗原的免疫应答中用于治疗抗原缺失型变体肿瘤的用途。 提供了刺激和/或增加针对肿瘤抗原的免疫应答的方法。 本发明还涉及使用具有III型分泌系统的细菌从外周血单核细胞制备抗原呈递细胞。
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公开(公告)号：US09045533B2
公开(公告)日：2015-06-02
申请号：US14037504
申请日：2013-09-26
申请人： Gerd Ritter , Beatrice Yin , Anne Murray , George Mark , Lloyd J. Old , Kenneth Lloyd , Serhiy Souchelnytskiy , Ivan Gout , Valeriy Filonenko , Ramziya Kiyamova
发明人： Gerd Ritter , Beatrice Yin , Anne Murray , George Mark , Lloyd J. Old , Kenneth Lloyd , Serhiy Souchelnytskiy , Ivan Gout , Valeriy Filonenko , Ramziya Kiyamova
IPC分类号： C12P21/08 , C12N5/10 , C07K16/18 , C07K16/28 , C07K14/705 , C07K16/30 , A61K39/395 , C07K7/08 , C07K14/47 , A61K39/00
CPC分类号： C07K16/3069 , A61K39/00 , A61K39/0011 , A61K39/39558 , A61K2039/505 , A61K2039/53 , C07K7/08 , C07K14/4748 , C07K14/705 , C07K16/18 , C07K16/28 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/622 , G01N33/57449 , G01N2333/705 , G01N2500/04
摘要： The present disclosure relates generally to the membrane transporter NaPi2b (SLC34A2) as a target for therapy, including immunotherapy, and particularly cancer therapy. The SLC34A2 epitope peptide encompassing amino acids 312-340 of SLC34A2 has been identified as an ovarian cancer epitope using the monoclonal antibody MX35. The invention also relates to the use of SLC34A2 and particularly SLC34A2 peptides in generating antibodies which have anti-tumor or anti-cancer activity or in stimulating an immunological response. The invention further relates to antibodies specifically directed against NaPi2b (SLC34A2) and the SLC34A2 peptide(s), including veneered, chimeric, single chain and humanized antibodies. Methods for generating an immune response and for treatment of tumors and cancer are also provided. Assays for screening and identifying compounds directed against SLC34A2, including the SLC34A2 epitope peptide, and additional antibodies are provided.
摘要翻译： 本公开总体上涉及作为治疗靶标的膜转运体NaPi2b（SLC34A2），包括免疫治疗，特别是癌症治疗。 包含SLC34A2的氨基酸312-340的SLC34A2表位肽已经使用单克隆抗体MX35鉴定为卵巢癌表位。 本发明还涉及SLC34A2和特别是SLC34A2肽在产生具有抗肿瘤或抗癌活性或刺激免疫应答的抗体中的用途。 本发明进一步涉及特异性针对NaPi2b（SLC34A2）和SLC34A2肽的抗体，包括贴面，嵌合，单链和人源化抗体。 还提供了产生免疫应答和治疗肿瘤和癌症的方法。 提供筛选和鉴定针对SLC34A2的化合物，包括SLC34A2表位肽和其他抗体的测定。
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6.发明授权Method for inducing cell lysis with immunogenic portions of NY-ESO-1 protein 有权用NY-ESO-1蛋白的免疫原性部分诱导细胞裂解的方法公开(公告)号：US08142786B2
公开(公告)日：2012-03-27
申请号：US12930522
申请日：2011-01-10
申请人： Alexander Knuth , Elke Jäger , Yao-tseng Chen , Matthew Scanlan , Ali Gure , Gerd Ritter , Lloyd J. Old , Jan W. Drijfhout
发明人： Alexander Knuth , Elke Jäger , Yao-tseng Chen , Matthew Scanlan , Ali Gure , Gerd Ritter , Lloyd J. Old , Jan W. Drijfhout
CPC分类号： C07K14/4748 , A61K38/00 , Y10S435/81
摘要： The invention relates to peptides which bind to MHC Class I and to MHC Class II molecules. These peptides are useful in different therapeutic and diagnostic contexts.
摘要翻译： 本发明涉及结合MHC I类和MHC II类分子的肽。 这些肽可用于不同的治疗和诊断情境。
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7.发明申请Method for inducing cell lysis with immunogenic portions of NY-ESO-1 protein 有权用NY-ESO-1蛋白的免疫原性部分诱导细胞裂解的方法公开(公告)号：US20110182944A1
公开(公告)日：2011-07-28
申请号：US12930522
申请日：2011-01-10
申请人： Alexander Knuth , Elke Jäger , Yao-tseng Chen , Matthew Scanlan , Ali Gure , Gerd Ritter , Lloyd J. Old , Jan W. Drijfhout
发明人： Alexander Knuth , Elke Jäger , Yao-tseng Chen , Matthew Scanlan , Ali Gure , Gerd Ritter , Lloyd J. Old , Jan W. Drijfhout
CPC分类号： C07K14/4748 , A61K38/00 , Y10S435/81
摘要： The invention relates to peptides which bind to MHC Class I and to MHC Class II molecules. These peptides are useful in different therapeutic and diagnostic contexts.
摘要翻译： 本发明涉及结合MHC I类和MHC II类分子的肽。 这些肽可用于不同的治疗和诊断情境。
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8.发明授权Isolated nucleic acid molecules which encode immunogenic portions of NY-ESO-1 protein 有权编码NY-ESO-1蛋白免疫原性部分的分离的核酸分子公开(公告)号：US07888100B2
公开(公告)日：2011-02-15
申请号：US11499547
申请日：2006-08-04
申请人： Alexander Knuth , Elke Jäger , Yao-tseng Chen , Matthew Scanlan , Ali Gure , Gerd Ritter , Lloyd J. Old , Jan W. Drijfhout
发明人： Alexander Knuth , Elke Jäger , Yao-tseng Chen , Matthew Scanlan , Ali Gure , Gerd Ritter , Lloyd J. Old , Jan W. Drijfhout
IPC分类号： C07H21/04 , C12N5/10 , C12N15/861 , C12N15/70
CPC分类号： C07K14/4748 , A61K38/00 , Y10S435/81
摘要： The invention relates to peptides which bind to MHC Class I and to MHC Class II molecules. These peptides are useful in different therapeutic and diagnostic contexts.
摘要翻译： 本发明涉及结合MHC I类和MHC II类分子的肽。 这些肽可用于不同的治疗和诊断情境。
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公开(公告)号：US5854007A
公开(公告)日：1998-12-29
申请号：US847369
申请日：1997-04-24
申请人： Gerd Ritter , Lloyd J. Old
发明人： Gerd Ritter , Lloyd J. Old
IPC分类号： G01N33/53 , A61K39/39 , A61K39/395 , A61P31/04 , A61P35/00 , C07K16/12 , C07K16/44 , C12P21/00 , C12R1/01 , G01N33/569 , G01N33/574
CPC分类号： G01N33/56922 , G01N2333/205 , G01N2400/50
摘要： The invention relates to the production of ganglioside specific antibodies. These antibodies are produced following immunization with lipopolysaccharide antigen of Campylobacter jejuni. The antibodies bind to monosialogangliosides, including GM2 and GM1.
摘要翻译： 本发明涉及神经节苷脂特异性抗体的产生。 这些抗体是在空肠弯曲杆菌的脂多糖抗原免疫后产生的。 抗体结合单神经节神经节苷脂，包括GM2和GM1。
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10.发明申请Membrane Transporter NaPi2b (SCL34A2) Epitope for Antibody Therapy, Antibodies Directed Thereto, and Target for Cancer Therapy 有权膜转运体NaPi2b（SCL34A2）抗体治疗表位，针对其的抗体和癌症治疗靶向公开(公告)号：US20160009816A1
公开(公告)日：2016-01-14
申请号：US14693261
申请日：2015-04-22
申请人： Gerd Ritter , Beatrice Yin , Anne Murray , George Mark , Lloyd J. Old , Kenneth Lloyd , Serhiy Souchelnytskiy , Ivan Gout , Valeriy Filonenko , Ramziya Kiyamova
发明人： Gerd Ritter , Beatrice Yin , Anne Murray , George Mark , Lloyd J. Old , Kenneth Lloyd , Serhiy Souchelnytskiy , Ivan Gout , Valeriy Filonenko , Ramziya Kiyamova
IPC分类号： C07K16/30 , A61K39/00 , G01N33/574 , C07K14/705
CPC分类号： C07K16/3069 , A61K39/00 , A61K39/0011 , A61K39/39558 , A61K2039/505 , A61K2039/53 , C07K7/08 , C07K14/4748 , C07K14/705 , C07K16/18 , C07K16/28 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/622 , G01N33/57449 , G01N2333/705 , G01N2500/04
摘要： The present invention relates generally to the membrane transporter NaPi2b (SLC34A2) as a target for therapy, including immunotherapy, and particularly cancer therapy. The SLC34A2 epitope peptide encompassing amino acids 312-340 of SLC34A2 has been identified as an ovarian cancer epitope using the monoclonal antibody MX35. The invention also relates to the use of SLC34A2 and particularly SLC34A2 peptides in generating antibodies which have anti-tumor or anti-cancer activity or in stimulating an immunological response. The invention further relates to antibodies specifically directed against NaPi2b (SLC34A2) and the SLC34A2 peptide(s), including veneered, chimeric, single chain and humanized antibodies. Methods for generating an immune response and for treatment of tumors and cancer are also provided. Assays for screening and identifying compounds directed against SLC34A2, including the SLC34A2 epitope peptide, and additional antibodies are provided.
摘要翻译： 本发明一般涉及作为治疗靶标的膜转运体NaPi2b（SLC34A2），包括免疫治疗，特别是癌症治疗。 包含SLC34A2的氨基酸312-340的SLC34A2表位肽已经使用单克隆抗体MX35鉴定为卵巢癌表位。 本发明还涉及SLC34A2和特别是SLC34A2肽在产生具有抗肿瘤或抗癌活性或刺激免疫应答的抗体中的用途。 本发明进一步涉及特异性针对NaPi2b（SLC34A2）和SLC34A2肽的抗体，包括贴面，嵌合，单链和人源化抗体。 还提供了产生免疫应答和治疗肿瘤和癌症的方法。 提供筛选和鉴定针对SLC34A2的化合物，包括SLC34A2表位肽和其他抗体的测定。
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