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1.发明申请MAGNETIC SUBSTANCE-BIOSUBSTANCE COMPLEX STRUCTURE, PEPTIDE FRAGMENT CAPABLE OF LINKING TO MAGNETIC SUBSTANCE AND GENE THEREFOR, AND PROCESS FOR PRODUCING THE COMPLEX STRUCTURE 审中-公开磁性物质 - 生物传感器复合结构，能够连接到磁性物质及其基因的肽片段，以及用于生产复合结构的方法公开(公告)号：US20080108123A1
公开(公告)日：2008-05-08
申请号：US11937611
申请日：2007-11-09
申请人： Takeshi Imamura , Tetsuya Yano , Tsuyoshi Nomoto , Shinya Kozaki , Tsutomu Honma , Akiko Tsuchitani
发明人： Takeshi Imamura , Tetsuya Yano , Tsuyoshi Nomoto , Shinya Kozaki , Tsutomu Honma , Akiko Tsuchitani
CPC分类号： C12N9/1025 , C07K2319/00 , C12N11/06 , C12N11/14 , C12N15/1013 , G01N33/54326 , G01N33/54353 , Y10S530/811
摘要： A magnetic substance-biosubstance complex structure comprises a magnetic substance-containing carrier and a biosubstance immobilized on the carrier, the biosubstance being immobilized through a spacer comprising an amino acid sequence on a surface of the carrier.
摘要翻译： 磁性物质 - 生物物质复合物结构包括含磁性物质的载体和固定在载体上的生物体，生物质通过包含载体表面上的氨基酸序列的间隔物固定化。
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2.发明授权Magnetic substance-biosubstance complex structure, peptide fragment capable of linking to magnetic substance and gene therefor, and process for producing the complex structure 失效磁性物质 - 生物体复合结构，能够与磁性物质连接的肽片段及其基因，以及复合结构体的制造方法公开(公告)号：US07354995B2
公开(公告)日：2008-04-08
申请号：US10546404
申请日：2004-04-30
申请人： Takeshi Imamura , Tetsuya Yano , Tsuyoshi Nomoto , Shinya Kozaki , Tsutomu Honma , Akiko Tsuchitani
发明人： Takeshi Imamura , Tetsuya Yano , Tsuyoshi Nomoto , Shinya Kozaki , Tsutomu Honma , Akiko Tsuchitani
CPC分类号： C12N9/1025 , C07K2319/00 , C12N11/06 , C12N11/14 , C12N15/1013 , G01N33/54326 , G01N33/54353 , Y10S530/811
摘要： A magnetic substance-biosubstance complex structure comprises a magnetic substance-containing carrier and a bio-substance immobilized on the carrier, the biosubstance being immobilized through a spacer comprising an amino acid sequence on a surface of the carrier.
摘要翻译： 磁性物质 - 生物物质复合结构包括含磁性物质的载体和固定在载体上的生物物质，生物质通过载体表面上的氨基酸序列的间隔物固定化。
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3.发明申请Magnetic substance-biosubstance complex structure, peptide fragment capable of linking to magnetic substance and gene therefor, and process for producing the complex structure 失效磁性物质 - 生物体复合结构，能够与磁性物质连接的肽片段及其基因，以及复合结构体的制造方法公开(公告)号：US20070054315A1
公开(公告)日：2007-03-08
申请号：US10546404
申请日：2004-04-30
申请人： Takeshi Imamura , Tetsuya Yano , Tsuyoshi Nomoto , Shinya Kozaki , Tsutomu Honma , Akiko Tsuchitani
发明人： Takeshi Imamura , Tetsuya Yano , Tsuyoshi Nomoto , Shinya Kozaki , Tsutomu Honma , Akiko Tsuchitani
CPC分类号： C12N9/1025 , C07K2319/00 , C12N11/06 , C12N11/14 , C12N15/1013 , G01N33/54326 , G01N33/54353 , Y10S530/811
摘要： A magnetic substance-biosubstance complex structure comprises a magnetic substance-containing carrier and a bio-substance immobilized on the carrier, the biosubstance being immobilized through a spacer comprising an amino acid sequence on a surface of the carrier.
摘要翻译： 磁性物质 - 生物物质复合结构包括含磁性物质的载体和固定在载体上的生物物质，生物质通过载体表面上的氨基酸序列的间隔物固定化。
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公开(公告)号：US20070003975A1
公开(公告)日：2007-01-04
申请号：US10544942
申请日：2004-05-06
申请人： Takeshi Imamura , Tetsuya Yano , Tsutomu Honma , Shinya Kozaki , Tsuyoshi Nomoto , Akiko Tsuchitani
发明人： Takeshi Imamura , Tetsuya Yano , Tsutomu Honma , Shinya Kozaki , Tsuyoshi Nomoto , Akiko Tsuchitani
CPC分类号： C12N9/93 , C07K2319/23 , C09D167/04 , C12N11/08 , C12P7/625 , G01N33/54326 , G01N33/54393 , G01N2333/21 , G01N2333/245
摘要： There is provided a construct in which at least a part of the magnetic material is coated with a polyhydroxyalkanoate (PHA), and a method for producing a construct by immobilizing a PHA synthesizing enzyme on the surface of the magnetic material, thereby biosynthesizing and coating a PHA.
摘要翻译： 提供了其中至少一部分磁性材料涂覆有聚羟基链烷酸酯（PHA）的构造，以及通过将PHA合成酶固定在磁性材料的表面上来生产构建体的方法，从而生物合成和涂覆 PHA。
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公开(公告)号：US20090029423A1
公开(公告)日：2009-01-29
申请号：US12201338
申请日：2008-08-29
申请人： Takeshi Imamura , Tetsuya Yano , Tsutomu Honma , Shinya Kozaki , Tsuyoshi Nomoto , Akiko Tsuchitani
发明人： Takeshi Imamura , Tetsuya Yano , Tsutomu Honma , Shinya Kozaki , Tsuyoshi Nomoto , Akiko Tsuchitani
CPC分类号： C12N9/93 , C07K2319/23 , C09D167/04 , C12N11/08 , C12P7/625 , G01N33/54326 , G01N33/54393 , G01N2333/21 , G01N2333/245
摘要： A construct in which at least a part of the magnetic material is coated with a polyhydroxyalkanoate (PHA), and a method for producing a construct by immobilizing a PHA synthesizing enzyme on the surface of the magnetic material, thereby biosynthesizing and coating a PHA.
摘要翻译： 其中至少一部分磁性材料涂覆有聚羟基链烷酸酯（PHA）的构建体，以及通过将PHA合成酶固定在磁性材料的表面上从而生物合成和涂覆PHA的制造方法。
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6.发明授权Polyhydroxyalkanoate-containing magnetic structure, and manufacturing method and use thereof 失效含聚羟基链烷酸酯的磁性结构体及其制造方法和用途公开(公告)号：US07527809B2
公开(公告)日：2009-05-05
申请号：US10553221
申请日：2004-04-30
申请人： Tetsuya Yano , Tsuyoshi Nomoto , Shinya Kozaki , Takeshi Imamura , Tsutomu Honma
发明人： Tetsuya Yano , Tsuyoshi Nomoto , Shinya Kozaki , Takeshi Imamura , Tsutomu Honma
CPC分类号： A61K9/5094 , A61K49/226 , Y10T428/12014
摘要： A structure containing polyhydroxyalkanoate and a magnetic substance includes an external phase part containing polyhydroxyalkanoate and an internal phase part contained in the external phase part, at least one of the external phase part and the internal phase part containing a magnetic substance. Accordingly, provided is a microcapsule, which can be suitably used for formation of an active ingredient of a sustained release pharmaceutical preparation or an ultrasonic contrast agent.
摘要翻译： 包含聚羟基链烷酸酯和磁性物质的结构包括含有聚羟基链烷酸酯的外相部分和包含在外部相部分中的内相部分，外相部分和内相部分中的至少一个含有磁性物质。 因此，提供了一种微胶囊，其可适用于形成持续释放药物制剂或超声造影剂的活性成分。
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7.发明申请Structure and method for producing structure, toner containing structure, image forming method and device using toner 审中-公开用于生产结构的结构和方法，含调色剂的结构，成像方法和使用调色剂的装置公开(公告)号：US20070027291A1
公开(公告)日：2007-02-01
申请号：US10534040
申请日：2004-04-30
申请人： Tetsuya Yano , Tsuyoshi Nomoto , Shinya Kozaki , Takeshi Imamura , Tsutomu Honma
发明人： Tetsuya Yano , Tsuyoshi Nomoto , Shinya Kozaki , Takeshi Imamura , Tsutomu Honma
CPC分类号： C12N9/93 , C07K2319/23 , C09D167/04 , C12N11/08 , C12P7/625 , G01N33/54326 , G01N33/54393 , G01N2333/21 , G01N2333/245
摘要： A structure, comprising a base material, coated with polymer which can be compatible with reduced load against environment and living organisms and various functionalities is provided. The base material is covered with polyhydroxyalkanoate (PHA). The invention also relates to a method for production of the structure comprising immobilizing the enzyme which synthesize PHA on the surface of the base material, biosynthesizing the PHA and coating the base material. The invention also provides toner containing such the structure and production thereof. Further, the invention relates to an image forming method comprising forming the image by providing such toner to the medium to be recorded.
摘要翻译： 提供了一种结构，其包括涂覆有聚合物的基材，该聚合物可以与降低的环境负荷和生物体相容并具有各种功能。 基材用聚羟基链烷酸酯（PHA）覆盖。 本发明还涉及一种生产该结构的方法，其包括将在基材表面上合成PHA的酶固定化，生物合成PHA并涂覆该基材。 本发明还提供含有这种结构和其制备的调色剂。 此外，本发明涉及一种图像形成方法，包括通过向要记录的介质提供这种调色剂来形成图像。
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8.发明申请公开(公告)号：US20060263432A1
公开(公告)日：2006-11-23
申请号：US10553221
申请日：2004-04-30
申请人： Tetsuya Yano , Tsuyoshi Nomoto , Shinya Kozaki , Takeshi Imamura , Tsutomu Honma
发明人： Tetsuya Yano , Tsuyoshi Nomoto , Shinya Kozaki , Takeshi Imamura , Tsutomu Honma
CPC分类号： A61K9/5094 , A61K49/226 , Y10T428/12014
摘要： A structure containing polyhydroxyalkanoate and a magnetic substance includes an external phase part containing polyhydroxyalkanoate and an internal phase part contained in the external phase part, at least one of the external phase part and the internal phase part containing a magnetic substance. Accordingly, provided is a microcapsule, which can be suitably used for formation of an active ingredient of a sustained release pharmaceutical preparation or an ultrasonic contrast agent.
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9.发明授权公开(公告)号：US07186459B2
公开(公告)日：2007-03-06
申请号：US10190490
申请日：2002-07-09
申请人： Tsuyoshi Nomoto , Tetsuya Yano , Shinya Kozaki , Tsutomu Honma
发明人： Tsuyoshi Nomoto , Tetsuya Yano , Shinya Kozaki , Tsutomu Honma
CPC分类号： A61K9/5073 , A61K9/1271 , A61K9/5031 , Y10T428/2989 , Y10T428/2991 , Y10T428/2998
摘要： A structure, which has both a drug holding capability and a sustained release ability utilizing a liposome and mechanical strength of a polyhydroxyalkanoate. This structure is excellent in holding capability for hydrophilic drugs and other water-soluble substances, as well as lipophilic drugs and other hydrophobic substances, and is capable of controlling the sustained release ability. The polyhydroxyalkanoate coats at least a part of the outer wall of the liposome.
摘要翻译： 具有药物保持能力和利用脂质体的持续释放能力和聚羟基链烷酸酯的机械强度的结构。 该结构对于亲水性药物和其他水溶性物质以及亲油性药物和其它疏水物质的保持能力优异，并且能够控制持续释放能力。 聚羟基链烷酸酯涂覆脂质体外壁的至少一部分。
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10.发明授权Electrostatic charge image developing toner, producing method therefor, image forming method and image forming apparatus utilizing the toner, construct and method for making the construct 失效静电荷图像显影用调色剂及其制造方法，图像形成方法及使用该调色剂的成像装置，构成物及其制造方法公开(公告)号：US07153622B2
公开(公告)日：2006-12-26
申请号：US10827670
申请日：2004-04-20
申请人： Tsutomu Honma , Tetsuya Yano , Tsuyoshi Nomoto , Shinya Kozaki
发明人： Tsutomu Honma , Tetsuya Yano , Tsuyoshi Nomoto , Shinya Kozaki
CPC分类号： G03G9/09775 , C01P2002/86 , C01P2002/88 , C01P2004/03 , C01P2004/20 , C01P2004/50 , C01P2004/51 , C01P2004/61 , C01P2004/62 , C01P2004/84 , C01P2006/12 , C01P2006/40 , C01P2006/60 , C01P2006/90 , C08G63/06 , C08G63/6882 , C09C1/407 , C09C3/10 , C09D167/04 , C12P7/625 , C12P11/00 , G03G5/056 , G03G5/0589 , G03G5/0592 , G03G5/0596 , G03G9/08755 , G03G9/08791 , G03G9/08795 , G03G9/08797 , G03G9/09733 , G03G9/09758
摘要： A construct that comprises a base material and a polyhydroxyalkanoate, wherein at least a part of the base material is coated with the polyhydroxyalkanoate, and the polyhydroxyalkanoate comprises a 3-hydroxyalkanoic acid unit other than 3-hydroxypropionic acid unit, 3-hydroxy-n-butyric acid unit, and 3-hydroxy-n-valeric acid unit.In addition, an electrostatic charge image developing toner allows to design the toner characteristics such as chargeability, flowability, stability in time and environmental stability uniform among the toners of different colors. The toner has a small particle size enough for enabling uniform dispersion and being excellent in color saturation and transparency. The toner also shows higher contribution to the environmental security. The toner includes a coloring agent of which at least a part of the surface is covered with polyhydroxyalkanoate (PHA). The toner is produced by dispersing the coloring agent in aqueous medium, then fixing PHA synthesizing enzyme to the coloring agent dispersed in the aqueous medium, then adding 3-hydroxyacyl CoA, and executing a PHA synthesizing reaction to cover at least a part of the surface of the coloring agent with PHA. The toner thus obtained is used for an image forming method.
摘要翻译： 一种包含基础材料和聚羟基链烷酸酯的构建体，其中所述基材的至少一部分涂覆有聚羟基链烷酸酯，并且所述聚羟基链烷酸酯包含3-羟基丙酸单元以外的3-羟基链烷酸单元，3-羟基 - 丁酸单元和3-羟基正戊酸单元。 此外，静电荷图像显影调色剂允许设计不同颜色的调色剂之间的调色剂特性如充电性，流动性，时间稳定性和环境稳定性均匀。 调色剂具有足够小的粒径以实现均匀分散并且具有优异的色饱和度和透明度。 调色剂对环境安全的贡献也更大。 调色剂包括其表面的至少一部分被聚羟基链烷酸酯（PHA）覆盖的着色剂。 调色剂通过将着色剂分散在水性介质中，然后将PHA合成酶固定在分散在水性介质中的着色剂上，然后加入3-羟酰基CoA，并执行PHA合成反应以覆盖表面的至少一部分 的着色剂与PHA。 由此获得的调色剂用于图像形成方法。
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