公开(公告)号：US08822229B2

公开(公告)日：2014-09-02

申请号：US13142262

申请日：2009-12-24

Applicant: Shigeyuki Wakitani ,  Hiroshi Fujita ,  Takeshi Ishimaru ,  Koji Yamamoto ,  Yasuhiro Kurahashi ,  Junichi Onaya ,  Hiroyuki Masuda

Inventor： Shigeyuki Wakitani ,  Hiroshi Fujita ,  Takeshi Ishimaru ,  Koji Yamamoto ,  Yasuhiro Kurahashi ,  Junichi Onaya ,  Hiroyuki Masuda

IPC: G01N33/564

CPC classification number: G01N33/53 ,  G01N2400/40 ,  G01N2800/102

Abstract: The inventions provides a method for immunologically determining a keratan sulfate level which method includes bringing an anti-keratan sulfate monoclonal antibody into contact with a biological sample, the anti-keratan sulfate monoclonal antibody exhibiting a relative reaction specificity between keratan sulfate-I and keratan sulfate-II represented by IC50KS-I/KS-II of 0.4 to 5, to thereby provide a signal; and detecting keratan sulfate contained in the biological sample from the signal. On the basis of the method, the invention also provides a joint disease detection method and a method for assessing the effect of a remedy for a joint disease and a candidate substance therefor. Through these methods, a very small amount of keratan sulfate contained in a sample, can be determined. Particularly, these methods can determine, at high-sensitivity and high-specificity, the total keratan sulfate including keratan sulfate-I, which have been difficult to determine through a conventional technique. The methods also enables detect a joint disease and assess the effect of a remedy for a joint disease or a candidate substance therefor.

Abstract translation: 本发明提供了一种免疫测定硫酸角质素水平的方法，该方法包括使硫酸角质素硫酸单克隆抗体与生物样品接触，硫酸角质素-I与硫酸角质素之间呈现相对反应特异性的硫酸角质素单体抗体 -II由IC50KS-I / KS-II表示，为0.4〜5，从而提供信号; 并从信号中检测生物样品中所含的硫酸角质素。 在该方法的基础上，本发明还提供了关于联合疾病的检测方法和评估对于关节疾病及其候选物质的补救效果的方法。 通过这些方法，可以测定样品中所含的极少量硫酸角质素。 特别地，这些方法可以高灵敏度和高特异性地确定通过常规技术难以确定的总硫酸角质素，包括硫酸角质素-I。 该方法还能够检测关节疾病并评估对于关节疾病或候选物质的补救的效果。

公开(公告)号：US07915389B2

公开(公告)日：2011-03-29

申请号：US12297048

申请日：2007-04-27

Applicant: Kiyoshi Suzuki ,  Takeshi Ishimaru ,  Koji Yamamoto ,  Yeong Shik Kim

Inventor： Kiyoshi Suzuki ,  Takeshi Ishimaru ,  Koji Yamamoto ,  Yeong Shik Kim

IPC: C12P21/08 ,  C07K16/18 ,  C07K16/44 ,  G01N33/53

CPC classification number: C07K16/44 ,  Y10S435/81

Abstract: An anti-acharan sulfate antibody, a hybridoma that produces the antibody, a detection method and a detection kit to which the antibody is applied are disclosed. The anti-acharan sulfate antibody can be produced by immunizing a mammal using as an antigen a substance obtained by chemically bonding a protein to acharan sulfate.

Abstract translation: 本发明公开了一种抗沙眼硫酸酯抗体，产生抗体的杂交瘤，检测方法和应用该抗体的检测试剂盒。 可以通过使用通过将蛋白质化学键合到硫酸阿卡拉酸获得的物质作为抗原来免疫哺乳动物来制备抗沙卡糖硫酸盐抗体。

公开(公告)号：US07722223B2

公开(公告)日：2010-05-25

申请号：US12087403

申请日：2006-12-22

Applicant: Tomihisa Saito ,  Hidemitsu Takeuchi ,  Takeshi Ishimaru

Inventor： Tomihisa Saito ,  Hidemitsu Takeuchi ,  Takeshi Ishimaru

IPC: F21V5/00

CPC classification number: H04N1/02815 ,  G02B6/003 ,  G02B6/0088 ,  G03B27/54 ,  H04N1/02835 ,  H04N1/0284 ,  H04N1/1017 ,  H04N1/193 ,  H04N2201/02462 ,  H04N2201/02474 ,  H04N2201/02481 ,  H04N2201/02485 ,  H04N2201/03112 ,  H04N2201/03125 ,  H04N2201/03141 ,  H04N2201/03145

Abstract: A structure of a line lighting device permits a rod-like light guide to be attached to a case without rubbing against the case. An end portion of the rod-like light guide provided with a pin is inserted into an opening in a case main body and pushed down, thus making the pin engage with a recess in the case main body. At this time, a distal end of the rod-like light guide is inserted, to some extent, into an opening in a light emitting unit fixing portion. Subsequently, the rod-like light guide is pushed down and pivoted around the pin so as to be completely contained within the case main body. In this state, the distal end of the rod-like light guide is fitted into the opening and the end face of the rod-like light guide is flush with the outer side face of the light emitting unit fixing portion.

Abstract translation: 线路照明装置的结构允许棒状光导件附接到壳体而不与壳体摩擦。 设置有销的棒状光导体的端部插入到壳体主体的开口中并向下推动，从而使销与壳体主体中的凹部接合。 此时，杆状导光体的前端在某种程度上插入发光单元固定部的开口部。 随后，杆状光导被推下并围绕销枢转，以便完全容纳在壳体主体内。 在该状态下，杆状导光体的前端嵌入开口部，杆状导光体的端面与发光单元固定部的外侧面齐平。

公开(公告)号：US20090280502A1

公开(公告)日：2009-11-12

申请号：US12297047

申请日：2007-04-27

Applicant: Kiyoshi Suzuki ,  Takeshi Ishimaru ,  Koji Yamamoto ,  Yeong Shik Kim

Inventor： Kiyoshi Suzuki ,  Takeshi Ishimaru ,  Koji Yamamoto ,  Yeong Shik Kim

IPC: G01N33/53 ,  C07K16/00 ,  C12N5/06

CPC classification number: C07K16/44

Abstract: An antibody that reacts with 2-O-desulfated acharan sulfate, a hybridoma that produces the antibody, a detection method and a detection kit to which the antibody is applied are disclosed. The antibody that reacts with 2-O-desulfated acharan sulfate can be produced by immunizing a mammal using as an antigen a substance obtained by chemically bonding a protein to 2-O-desulfated acharan sulfate.

Abstract translation: 公开了与2-O-脱硫酸阿卡拉酸硫酸反应的抗体，产生抗体的杂交瘤，检测方法和应用抗体的检测试剂盒。 与2-O-脱硫酸阿沙拉硫酸盐反应的抗体可以通过使用通过化学键合蛋白质获得的物质作为抗原免疫哺乳动物来制备，所述物质通过将化学键合到2-O-脱硫酸阿卡拉酸硫酸酯。

公开(公告)号：US07555194B2

公开(公告)日：2009-06-30

申请号：US11296866

申请日：2005-12-07

Applicant: Makoto Ikeda ,  Hiroyuki Nemoto ,  Takashi Kishimoto ,  Takeshi Ishimaru ,  Hirohiko Iwase ,  Hidemitsu Takeuchi ,  Tomihisa Saito

Inventor： Makoto Ikeda ,  Hiroyuki Nemoto ,  Takashi Kishimoto ,  Takeshi Ishimaru ,  Hirohiko Iwase ,  Hidemitsu Takeuchi ,  Tomihisa Saito

IPC: G02B6/10

CPC classification number: H04N1/02815 ,  H04N1/02835

Abstract: An improved illumination device shortens a redundant area of insufficient light intensity close to a longitudinal end thereof. The device includes a casing, a bar-shaped light guide housed in the casing to cause a light-emitting surface thereof to be exposed, a light-emitting unit secured to an end section of the casing, wherein light from the light-emitting unit is introduced into the bar-shaped light guide through the end face thereof and is totally reflected within the bar-shaped light guide to be emitted through the light-emitting surface, and a shielding section provided to cover an end section of the bar-shaped light guide including the redundant area at the end section of the casing close to the light-emitting unit. A notch is formed at the end section of the bar-shaped light guide on the light-emitting surface side close to the light-emitting unit, and light from the light-emitting unit is reflected on a rear surface of the shielding section through a gap between this notch and the light-emitting unit to be introduced into the bar-shaped light guide.

Abstract translation: 改进的照明装置缩短靠近其纵向端的光强度不足的冗余区域。 该装置包括壳体，容纳在壳体中以使其发光表面暴露的条形光导;固定到壳体的端部的发光单元，其中来自发光单元的光 通过其端面引入棒形导光体，并且在棒状光导中被全反射以通过发光表面发射;以及屏蔽部，其设置成覆盖棒状导光体的端部 导光体包括靠近发光单元的壳体端部处的冗余区域。 在靠近发光单元的发光面侧的棒状导光体的端部形成有切口，来自发光单元的光通过遮光部的背面被反射 该凹口与发光单元之间的间隙被引入到条形光导中。

公开(公告)号：US20090136964A1

公开(公告)日：2009-05-28

申请号：US11909956

申请日：2006-03-31

Applicant: Kiyoshi Suzuki ,  Takeshi Ishimaru ,  Koji Yamamoto

Inventor： Kiyoshi Suzuki ,  Takeshi Ishimaru ,  Koji Yamamoto

IPC: G01N33/566 ,  C07K16/18 ,  C12N5/06

CPC classification number: C07K16/44 ,  G01N33/5308 ,  G01N2400/40 ,  Y10S435/975

Abstract: An antibody which reacts with N-acetylheparosan and heparan sulfate that is derived from bovine kidney but does not substantially react with heparan sulfate derived from a murine Engelbreath-Holm-Swam tumor tissue, the antibody being produced with a hybridoma which is prepared using a substance composed of a protein and N-acetylheparosan bound to the protein.

Abstract translation: 与来自牛肾但不与源自小鼠Engelbreth-Holm-Swarm肿瘤组织的硫酸乙酰肝素基本上反应的N-乙酰肝素和硫酸乙酰肝素反应的抗体，该抗体由使用物质制备的杂交瘤产生 由与蛋白质结合的蛋白质和N-乙酰西他班组成。

公开(公告)号：US07429432B2

公开(公告)日：2008-09-30

申请号：US10502303

申请日：2003-02-06

Applicant: Katsumi Kozu ,  Takeshi Ishimaru ,  Yoshiki Osawa ,  Satoshi Kataoka ,  Iichiro Mori ,  Koichi Toriyama ,  Masahiro Mizuta ,  Tatsuhisa Chikada ,  Yasuhiro Ogawa

Inventor： Katsumi Kozu ,  Takeshi Ishimaru ,  Yoshiki Osawa ,  Satoshi Kataoka ,  Iichiro Mori ,  Koichi Toriyama ,  Masahiro Mizuta ,  Tatsuhisa Chikada ,  Yasuhiro Ogawa

IPC: H01M2/08 ,  H01M2/02

CPC classification number: H01M2/348 ,  H01M2/1066 ,  H01M2/1241 ,  H01M2/34 ,  Y10T29/49108 ,  Y10T29/4911

Abstract: A rechargeable battery (2) and a circuit substrate (3) are connected by lead plates (4, 5) and united by a primary mold (11) that is formed by filling resin therebetween, after which a secondary mold (12) is formed on the outer face by filling resin at necessary locations and a winding sheet (13) is wound around the periphery, thereby forming a battery pack.

Abstract translation: 可再充电电池（2）和电路基板（3）通过引线板（4,5）连接并由通过在其间填充树脂形成的初级模具（11）联合，之后形成二次模具（12） 通过在必要的位置填充树脂而在外表面上缠绕有绕组片（13），从而形成电池组。

公开(公告)号：US06782162B2

公开(公告)日：2004-08-24

申请号：US10212416

申请日：2002-08-05

Applicant: Takashi Fukuzawa ,  Hiroyuki Tanaka ,  Ikuto Ohyama ,  Takeshi Ishimaru ,  Minoru Taniyama ,  Shigeo Kittaka

Inventor： Takashi Fukuzawa ,  Hiroyuki Tanaka ,  Ikuto Ohyama ,  Takeshi Ishimaru ,  Minoru Taniyama ,  Shigeo Kittaka

IPC: G02B632

CPC classification number: G02B6/2937 ,  G02B6/32

Abstract: An optical module which satisfies a required insertion loss and can be easily assembled with high productivity. The optical module includes first optical fiber, a first lens, an optical device, a second lens, and second optical fiber. The first lens receives an incident light from the first optical fiber and converts the incident light into a parallel light. The optical device receives the parallel light and performs predetermined optical processing on the parallel light. The second lens receives a transmitted parallel light from the optical device and converge the transmitted parallel light to produce an outgoing light. The second optical fiber receives the outgoing light. An optical axis of the first lens and an optical axis of the second lens are substantially coincident with each other. An optical axis of the first optical fiber and an optical axis of the second optical fiber are substantially parallel with each other and substantially parallel to the optical axes of the first and the second lenses.

Abstract translation: 一种满足所需插入损耗并且可以以高生产率容易地组装的光学模块。 光学模块包括第一光纤，第一透镜，光学装置，第二透镜和第二光纤。 第一透镜接收来自第一光纤的入射光并将入射光转换成平行光。 光学装置接收平行光并对平行光进行预定的光学处理。 第二透镜从光学装置接收透射的平行光，并且会聚发射的平行光以产生出射光。 第二光纤接收出射光。 第一透镜的光轴和第二透镜的光轴基本上彼此重合。 第一光纤的光轴和第二光纤的光轴基本上彼此平行并且基本上平行于第一和第二透镜的光轴。

公开(公告)号：US06759152B2

公开(公告)日：2004-07-06

申请号：US10282884

申请日：2002-10-29

Applicant: Yoshinori Iwaizono ,  Shoji Konishi ,  Shigeru Kajiwara ,  Takeshi Ishimaru ,  Masaru Kawabe ,  Katsuyuki Shirasawa

Inventor： Yoshinori Iwaizono ,  Shoji Konishi ,  Shigeru Kajiwara ,  Takeshi Ishimaru ,  Masaru Kawabe ,  Katsuyuki Shirasawa

IPC: H01M1400

CPC classification number: H01M10/425 ,  H01M2/1022 ,  H01M10/42 ,  H01M10/48 ,  H01M2200/00 ,  H01M2200/10

Abstract: A rechargeable battery pack includes a rechargeable battery having a first electrode and a second electrode; a circuit assembly disposed at one end on a side of a sealing portion of the rechargeable battery; a battery protection circuit for protecting the rechargeable battery from overcharging, the battery protection circuit arranged on a side of the circuit assembly which faces the sealing portion of the rechargeable battery; a plurality of input and output terminals arranged on another side of the circuit assembly, said input and output terminals to which said first electrode and said second electrode are respectively each connected via the battery protection circuit, thereby constituting an intermediate unit in which the rechargeable battery and the circuit assembly are integrated; and an outer case for sealing therein said intermediate unit, the outer case having openings formed at locations corresponding to the input and output terminals.

Abstract translation: 可充电电池组包括具有第一电极和第二电极的可充电电池; 电路组件，设置在可再充电电池的密封部分的一侧的一端; 电池保护电路，用于保护可再充电电池免于过充电，电池保护电路布置在电路组件的面对可再充电电池的密封部分的一侧; 布置在电路组件的另一侧的多个输入和输出端子，所述第一电极和所述第二电极分别通过电池保护电路连接到所述输入和输出端子，由此构成中间单元，其中可再充电电池 并且电路组件被集成; 以及用于在其中密封所述中间单元的外壳，所述外壳具有形成在与所述输入和输出端子相对应的位置处的开口。

公开(公告)号：US09458579B2

公开(公告)日：2016-10-04

申请号：US14124609

申请日：2012-05-30

Applicant: Takeshi Ishimaru

Inventor： Takeshi Ishimaru

IPC: E01C13/08 ,  D06N7/00

CPC classification number: E01C13/08 ,  D06N7/0065 ,  D06N2201/0245 ,  D06N2201/0254 ,  D06N2209/141 ,  Y10T428/23957 ,  Y10T428/23993

Abstract: Provided are artificial turf with which a temperature alleviation effect can be sustained over an extended period and which is easily maintained, and an artificial turf facility wherein the artificial turf is laid. A first pile (41), and a second pile (42) which comprises a water absorbent void therein which absorbs water, which configure the artificial turf, are placed mixed among each other in a base fabric (31) at a prescribed proportion.

Abstract translation: 本发明提供能够延长时间并且易于维持的温度降低效果的人造草坪，以及铺设人造草坪的人造草坪设施。 第一堆（41）和第二堆（42），其包括其中吸收水分的吸水空隙，其构成人造草皮，以规定比例彼此混合在基底织物（31）中。