公开(公告)号：US5274808A

公开(公告)日：1993-12-28

申请号：US762452

申请日：1991-09-19

申请人： Takeshi Miyao ,  Tomoaki Nakamura ,  Hiroshi Wataya ,  Saburou Iijima ,  Yasuo Sekine

发明人： Takeshi Miyao ,  Tomoaki Nakamura ,  Hiroshi Wataya ,  Saburou Iijima ,  Yasuo Sekine

IPC分类号： G06F9/06 ,  G06F9/445 ,  G06F9/46

CPC分类号： G06F8/67

摘要： A program replacing method is provided for an uninterruptible online computer system. The computer system includes an auxiliary storage unit for storing a program currently running in the computer system and another program to replace the current running program and a replacement request managing table for storing replacement requests and program IDs of such replacing programs. These programs include checkpoints pre-programmed at selected locations therein. At an optional checkpoint, the replacement request managing table is retrieved for checking whether or not the replacement is requested. If a replacement is requested, the new program is started according to the program ID and the current program is terminated.

摘要翻译： 为不间断的在线计算机系统提供了程序替换方法。 计算机系统包括用于存储当前运行在计算机系统中的程序的辅助存储单元和用于替换当前运行程序的另一程序以及用于存储替换程序的替换请求和程序ID的替换请求管理表。 这些程序包括在其中选定位置预编程的检查点。 在可选的检查点，检索替换请求管理表以检查是否请求替换。 如果请求更换，则根据程序ID启动新程序，当前程序终止。

公开(公告)号：US5276150A

公开(公告)日：1994-01-04

申请号：US850201

申请日：1992-03-12

申请人： Hiroshi Ikawa ,  Akiyoshi Kadoiri ,  Nobuo Kobayashi ,  Yasuko Konagai ,  Yasuo Sekine

发明人： Hiroshi Ikawa ,  Akiyoshi Kadoiri ,  Nobuo Kobayashi ,  Yasuko Konagai ,  Yasuo Sekine

IPC分类号： C07D211/90 ,  C07D401/04 ,  C07D401/14 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D473/04 ,  C07D473/08 ,  C07D521/00 ,  C07D217/18 ,  C07D417/04 ,  C07D419/04

CPC分类号： C07D231/12 ,  C07D211/90 ,  C07D233/56 ,  C07D249/08 ,  C07D401/04 ,  C07D401/14 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D473/04 ,  C07D473/08

摘要： 1,4-dihydropyridine derivatives of formula (I): ##STR1## wherein Ar.sup.1 and Ar.sup.2 each represent an unsubstituted or substituted aromatic hydrocarbon or aromatic heterocyclic group; and R.sup.1 represents --CO.sub.2 R.sup.2, --SO.sub.2 R.sup.3, --COR.sup.4, --CON(R.sup.5).sub.2, --CH--or --NO.sub.2 in which R.sup.2 is hydrogen, a straight chain, branched chain or cyclic saturated hydrocarbon group, which may have a substituent or a straight chain, branched chain or cyclic unsaturated hydrocarbon group having 2 to 10 carbon atoms, which may have a substituent, R.sup.3 is an alkyl group having 1 to 4 carbon atoms, R.sup.4 is an alkyl group having 1 to 4 carbon atoms or a phenyl group; and R.sup.5 is an alkyl group having 1 to 4 carbon atoms.

摘要翻译： 式（I）的1,4-二氢吡啶衍生物：其中Ar 1和Ar 2各自表示未取代或取代的芳族烃或芳族杂环基; 和R 1表示可以具有取代基的直链，支链或环状饱和烃基的-CO 2 R 2，-SO 2 R 3，-COR 4，-CON（R 5）2，-CH或-NO 2， 可以具有取代基的碳原子数为2〜10的直链，支链或支链或环状不饱和烃基，R3为碳原子数1〜4的烷基，R4为碳原子数1〜4的烷基或苯基 ; R5为碳原子数为1〜4的烷基。

公开(公告)号：US5424316A

公开(公告)日：1995-06-13

申请号：US058925

申请日：1993-05-10

申请人： Yasushi Honma ,  Yasuo Sekine ,  Sumihiro Nomura ,  Kazuaki Naito ,  Hiroshi Narita

发明人： Yasushi Honma ,  Yasuo Sekine ,  Sumihiro Nomura ,  Kazuaki Naito ,  Hiroshi Narita

IPC分类号： C07D471/04 ,  A61K31/44 ,  C07D471/14

CPC分类号： C07D471/04

摘要： An imidazopyridine derivative is disclosed of the formula [I]: ##STR1## wherein R.sup.1 is lower alkyl, R.sup.2 is hydrogen, lower alkylsulfonyl or a group of the formula ##STR2## where Z is oxygen or two hydrogen atoms, R.sup.0 is lower alkyl, lower alkoxy, phenyl, hydrogen, di(lower alkyl) amino or lower alkenyl, R.sup.3 is carboxyl or lower alkoxycarbonyl and Ring A is substituted phenyl, and pharmaceutically acceptable salts thereof that are useful in prophylaxis and treatment of hypertension.

摘要翻译： 公开了式[I]的咪唑并吡啶衍生物：其中R 1是低级烷基，R 2是氢，低级烷基磺酰基或下式的基团其中Z是氧或两个氢原子，R 0是 低级烷基，低级烷氧基，苯基，氢，二（低级烷基）氨基或低级烯基，R3为羧基或低级烷氧基羰基，环A为取代苯基及其药学上可接受的盐，可用于预防和治疗高血压。

公开(公告)号：US4963587A

公开(公告)日：1990-10-16

申请号：US446106

申请日：1989-12-05

申请人： Takeo Iwakuma ,  Yasuo Sekine ,  Yasuhiko Sasaki ,  Katsuo Ikezawa ,  Akio Odawara

发明人： Takeo Iwakuma ,  Yasuo Sekine ,  Yasuhiko Sasaki ,  Katsuo Ikezawa ,  Akio Odawara

IPC分类号： A61K31/195 ,  A61P7/02 ,  A61P9/00 ,  A61P9/10 ,  A61P43/00 ,  C07C303/38 ,  C07C311/20

CPC分类号： C07C311/20 ,  C07C2102/08 ,  Y02P20/55

摘要： There are disclosed are glycine derivative of the formula: ##STR1## (wherein R.sup.1 represents a substituted or unsubstituted phenyl group, R.sup.2 represents a carboxyl group which may be protected, Q represents a lower alkylene group and m represents 0 or 1) or a pharmacologically acceptable salt thereof and a process for preparing the same.

公开(公告)号：US20060135525A1

公开(公告)日：2006-06-22

申请号：US10542081

申请日：2004-01-23

申请人： Iwao Takamuro ,  Yasuo Sekine ,  Yasunori Tsuboi ,  Kouji Nogi ,  Hiroyuki Taniguchi

发明人： Iwao Takamuro ,  Yasuo Sekine ,  Yasunori Tsuboi ,  Kouji Nogi ,  Hiroyuki Taniguchi

IPC分类号： A61K31/519 ,  C07D487/02

CPC分类号： C07D487/04

摘要： The present invention provides a novel pyrazolopyrimidine compound of the formula [I]: wherein R′ is (A) a substituted aryl group, (B) an optionally substituted nitrogen-containing aliphatic heteromonocyclic group, (C) a substituted cyclo-lower alkyl group, (D) an optionally substituted amino group, or (E) a substituted heteroaryl group, R2 is (a) an optionally substituted heteroaryl group or (b) an optionally substituted aryl group, Y is a single bond, a lower alkylene group or a lower alkenylene group, Z is a group of the formula: —CO—, —CH2-, S02- or a group of the formula [II]: Q is a lower alkylene group, and q is an integer of 0 or 1 or a pharmaceutically acceptable sait thereof, which has a small conductance potassium channel (SK channel) blocking activity and is useful as a medicament and a process for preparing the same.

摘要翻译： 本发明提供式[I]的新型吡唑并嘧啶化合物：其中R'为（A）取代芳基，（B）任选取代的含氮脂族杂单环基团，（C）取代的环低级烷基 ，（D）任选取代的氨基或（E）取代的杂芳基，R 2是（a）任选取代的杂芳基或（b）任选取代的芳基，Y是 单键，低级亚烷基或低级亚烯基，Z为下式基团：-CO-，-CH 2 - ，SO 2 - 或式[II]基团：Q为低级亚烷基，q为 是0或1的整数或其药学上可接受的sait，其具有小的电导钾通道（SK通道）阻断活性，并且可用作药物及其制备方法。

公开(公告)号：US5409936A

公开(公告)日：1995-04-25

申请号：US940336

申请日：1992-09-03

申请人： Yasushi Honma ,  Yasuo Sekine ,  Sumihiro Nomura ,  Kazuaki Naito ,  Hiroshi Narita

发明人： Yasushi Honma ,  Yasuo Sekine ,  Sumihiro Nomura ,  Kazuaki Naito ,  Hiroshi Narita

IPC分类号： C07D471/04 ,  C07D471/14 ,  A61K31/44

CPC分类号： C07D471/04

摘要： An imidazopyridine derivative is disclosed of the formula [I]: ##STR1## wherein R.sup.1 is lower alkyl, R.sup.2 is a group of the formula ##STR2## where Z is oxygen atom, R.sup.0 is lower alkyl, R.sup.3 is carboxyl or lower alkoxycarbonyl and Ring A is tetrazolyl-substituted or unsubstituted phenyl, and pharmaceutically acceptable salt thereof, that are useful in prophylaxis and treatment of hypertension.

摘要翻译： 公开了式[I]的咪唑并吡啶衍生物：其中R 1是低级烷基，R 2是下式的基团其中Z是氧原子，R 0是低级烷基，R 3是羧基或更低级 烷氧基羰基和环A是可用于预防和治疗高血压的四唑基取代或未取代的苯基及其药学上可接受的盐。

公开(公告)号：US5268377A

公开(公告)日：1993-12-07

申请号：US939652

申请日：1992-09-03

申请人： Yasushi Honma ,  Yasuo Sekine ,  Sumihiro Nomura ,  Kazuaki Naito ,  Hiroshi Narita

发明人： Yasushi Honma ,  Yasuo Sekine ,  Sumihiro Nomura ,  Kazuaki Naito ,  Hiroshi Narita

IPC分类号： A61K31/435 ,  A61P9/12 ,  A61P43/00 ,  C07D471/04 ,  C07D471/14 ,  C07D487/04 ,  A61K31/395 ,  C07D515/12 ,  C07D515/14

CPC分类号： C07D471/04 ,  C07D471/14

摘要： An inidazoindolizine derivative of the formula [I]: ##STR1## wherein R.sup.1 is lower alkyl, R.sup.2 is hydrogen, cyano, lower alkyl, lower alkanoyl, lower alkoxycarbonyl, phenyl-lower alkoxycarbonyl, lower alkylsulfonyl, substituted or unsubstituted phenyl, arylcarbonyl, or 5- or 6-membered nitrogen-containing heteromonocyclic group-substituted carbonyl, Ring A is substituted or unsubstituted phenyl, and m is 0 or 1, or a pharmaceutically acceptable salt thereof, and process for preparation thereof, said imidazoindolizine derivatives and pharmaceutically acceptable salts thereof show excellent angiotensin II inhibitory activities and are useful in the prophylaxis or treatment of hypertension.

公开(公告)号：US5324728A

公开(公告)日：1994-06-28

申请号：US801501

申请日：1991-12-02

申请人： Yasuo Sekine ,  Tetsuaki Yamaura ,  Masato Nishimura ,  Eri Kojima ,  Yasuko Emoto ,  Yasushi Higashide

发明人： Yasuo Sekine ,  Tetsuaki Yamaura ,  Masato Nishimura ,  Eri Kojima ,  Yasuko Emoto ,  Yasushi Higashide

IPC分类号： A61K31/16 ,  A61K31/215 ,  A61K31/34 ,  A61K31/341 ,  A61K31/38 ,  A61K31/381 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/4427 ,  A61K31/4433 ,  A61K31/445 ,  A61K31/495 ,  A61P37/08 ,  A61P43/00 ,  C07C233/22 ,  C07C235/66 ,  C07C317/28 ,  C07C323/25 ,  C07C323/41 ,  C07C323/42 ,  C07D211/46 ,  C07D211/54 ,  C07D213/30 ,  C07D213/32 ,  C07D213/34 ,  C07D213/38 ,  C07D233/60 ,  C07D295/12 ,  C07D295/13 ,  C07D295/22 ,  C07D307/38 ,  C07D307/42 ,  C07D317/56 ,  C07D333/16 ,  C07D333/18 ,  C07D333/28 ,  C07D401/06 ,  C07D401/12 ,  C07D403/12 ,  C07D409/04 ,  C07D409/12 ,  C07D401/00 ,  C07D241/04 ,  C07D295/00

CPC分类号： C07D213/30 ,  C07D211/46 ,  C07D211/54 ,  C07D213/32 ,  C07D213/38 ,  C07D295/13 ,  C07D307/38 ,  C07D317/56 ,  C07D333/18 ,  C07D333/28 ,  C07D401/12

摘要： A naphthoic acid derivative represented by the following general formula or a salt thereof: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are each independently a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxy group, a lower alkanoyloxy group, a hydroxy-lower alkyl group, a lower alkoxy-lower alkyl group, a lower alkanoyloxy-lower alkyl group or an aralkyloxy group;R.sub.4 is a hydrogen atom or a lower alkyl group;R.sub.5 is a substituted or unsubstituted aryl group or a substituted or unsubstituted heteroaromatic group;X is a group ##STR2## a cycloalkylene group, a bivalent nitrogen-containing heterocyclic group, or a group ##STR3## --R.sub.8 --NH-- or --NH--R.sub.8, where R.sub.6 and R.sub.7 are each a hydrogen atom or a lower alkyl group and R.sub.8 is a cycloalkylene group, or R.sub.6 and R.sub.7, together with R.sub.4, may form an alkylene group of 1-3 carbon atoms;Y is --S(O).sub.p --, --(CH.sub.2).sub.n -- or --O--;Z is a substituted or unsubstituted alkylene group or a single bond;l is an integer of 0-4;m is an integer of 0-8;n is 0 or 1;p is an integer of 0-2; andg is 0 or 1.The compound is useful as an antiallergic agent.

摘要翻译： 由以下通式表示的萘甲酸衍生物或其盐：其中R 1，R 2和R 3各自独立地为氢原子，卤素原子，羟基，低级烷基，低级烷氧基， 低级烷酰氧基，羟基低级烷基，低级烷氧基 - 低级烷基，低级烷酰氧基 - 低级烷基或芳烷氧基; R4是氢原子或低级烷基; R5是取代或未取代的芳基或取代或未取代的杂芳基; X是亚环烷基，二价含氮杂环基或基团-R8-NH-或-NH-R8基团，其中R6和R7各自为氢原子或低级烷基 并且R 8为亚环烷基，或者R 6和R 7与R 4一起可以形成1-3个碳原子的亚烷基; Y是-S（O）对 - ， - （CH 2）n - 或-O-; Z是取代或未取代的亚烷基或单键; l是0-4的整数; m为0-8的整数; n为0或1; p是0-2的整数; 并且g为0或1.该化合物可用作抗过敏剂。

公开(公告)号：US4977267A

公开(公告)日：1990-12-11

申请号：US301856

申请日：1989-01-26

申请人： Nobuhiko Hirakawa ,  Noriaki Kashiwaba ,  Hajime Matsumoto ,  Akihiko Hosoda ,  Yasuo Sekine ,  Yoshikazu Isowa ,  Tetsuaki Yamura ,  Akihiro Sekine ,  Masashi Nishikawa

发明人： Nobuhiko Hirakawa ,  Noriaki Kashiwaba ,  Hajime Matsumoto ,  Akihiko Hosoda ,  Yasuo Sekine ,  Yoshikazu Isowa ,  Tetsuaki Yamura ,  Akihiro Sekine ,  Masashi Nishikawa

IPC分类号： C07D213/64 ,  C07D405/12 ,  C07D405/14

CPC分类号： C07D213/64 ,  C07D405/12 ,  C07D405/14

摘要： The compounds of the formulas (VI) and (VII) are useful intermediates in producing pyridyloxy derivatives of the formula (I), such as, for instance, N-{4-[4-(piperidinomethyl)pyridyl-2-oxy]-2-butenyl}-2-(furfurylthio)acetamide, which are useful as anti-peptic ulcer agents. The compounds of formula (VI) have the formula ##STR1## wherein A represents a formyl group, a protected formyl group, a hydroxymethyl group or a protected hydroxymethyl group. The compounds of formula (VIII) have the formula ##STR2## wherein G represents a formyl group, a protected formyl group, a hydroxymethyl group, a hydroxymethyl group in which the hydroxyl group is protected, or a halogenomethyl group, Y represents --CH.sub.2 --CH.sub.2 -- or --CH.dbd.CH--, and n is 0, 1 or 2.

公开(公告)号：US4912101A

公开(公告)日：1990-03-27

申请号：US166022

申请日：1988-03-09

申请人： Nobuhiko Hirakawa ,  Noriaki Kashiwaba ,  Hajime Matsumoto ,  Akihiko Hosoda ,  Yasuo Sekine ,  Yoshikazu Isowa ,  Tetsuaki Yamaura ,  Akihiro Sekine ,  Masashi Nishikawa

发明人： Nobuhiko Hirakawa ,  Noriaki Kashiwaba ,  Hajime Matsumoto ,  Akihiko Hosoda ,  Yasuo Sekine ,  Yoshikazu Isowa ,  Tetsuaki Yamaura ,  Akihiro Sekine ,  Masashi Nishikawa

IPC分类号： C07D213/64 ,  C07D405/12 ,  C07D405/14

CPC分类号： C07D213/64 ,  C07D405/12 ,  C07D405/14

摘要： A compound represented by the following formula or a salt thereof ##STR1## wherein each of R.sub.1 and R.sub.2 represents a lower alkyl group, or R.sub.1 and R.sub.2, together with the nitrogen atom to which they are bonded, may form a substituted or unsubstituted, saturated or partially unsaturated 4- to 8-membered heterocyclic group which may contain a hetero atom selected from N, O and S, Y represents a group of the formula --CH.sub.2 --CH.sub.2 -- or --CH.dbd.CH--, and n is 0, 1 or 2. This compound is useful as anti-peptic ulcer agent.