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    Pharmaceutical containing HIF-1 alpha and HIF-2 alpha expression inhibitor
    1.
    发明授权
    Pharmaceutical containing HIF-1 alpha and HIF-2 alpha expression inhibitor 有权
    含有HIF-1α和HIF-2α表达抑制剂的药物

    公开(公告)号：US08268794B2

    公开(公告)日：2012-09-18

    申请号：US12672473

    申请日：2008-08-05

    申请人： Takeshi Nakajima ,  Emi Nakajima ,  Mitsuyoshi Azuma

    发明人： Takeshi Nakajima ,  Emi Nakajima ,  Mitsuyoshi Azuma

    IPC分类号： A61K48/00 ,  C07H21/02 ,  C07H21/04

    CPC分类号： A61K45/06 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/713 ,  C12N15/113 ,  C12N15/1136 ,  C12N2310/11 ,  C12N2310/14

    摘要： Provided is a pharmaceutical product exhibiting a high therapeutic effect in the treatment of retinal diseases associated with angiogenesis such as age-related macular degeneration, diabetic retinopathy and the like. A therapeutic agent for a retinal disease, containing a substance specifically inhibiting HIF-1α expression and a substance specifically inhibiting HIF-2α expression. The aforementioned inhibitory substances, which are active ingredients in the therapeutic agent of the present invention, are nucleic acids capable of inducing RNAi, antisense nucleic acids or ribozymes for HIF-1α and HIF-2α, or expression vectors thereof.

    摘要翻译： 本发明提供在治疗与血管生成相关的视网膜疾病如老年性黄斑变性，糖尿病性视网膜病变等中具有高治疗效果的药物。 含有特异性抑制HIF-1α表达的物质的视网膜疾病治疗剂和特异性抑制HIF-2α表达的物质。 作为本发明的治疗剂中的活性成分的上述抑制物质是能够诱导HIF-1α和HIF-2α的RNAi，反义核酸或核酶的核酸或其表达载体。

    PHARMACEUTICAL CONTAINING HIF-1 ALPHA AND HIF-2 ALPHA EXPRESSION INHIBITOR
    2.
    发明申请
    PHARMACEUTICAL CONTAINING HIF-1 ALPHA AND HIF-2 ALPHA EXPRESSION INHIBITOR 有权
    包含HIF-1 ALPHA和HIF-2 ALPHA表达抑制剂的药物

    公开(公告)号：US20110213008A1

    公开(公告)日：2011-09-01

    申请号：US12672473

    申请日：2008-08-05

    申请人： Takeshi Nakajima ,  Emi Nakajima ,  Mitsuyoshi Azuma

    发明人： Takeshi Nakajima ,  Emi Nakajima ,  Mitsuyoshi Azuma

    IPC分类号： A61K31/713 ,  A61P27/02

    CPC分类号： A61K45/06 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/713 ,  C12N15/113 ,  C12N15/1136 ,  C12N2310/11 ,  C12N2310/14

    摘要： Provided is a pharmaceutical product exhibiting a high therapeutic effect in the treatment of retinal diseases associated with angiogenesis such as age-related macular degeneration, diabetic retinopathy and the like. A therapeutic agent for a retinal disease, containing a substance specifically inhibiting HIF-1α expression and a substance specifically inhibiting HIF-2α expression. The aforementioned inhibitory substances, which are active ingredients in the therapeutic agent of the present invention, are nucleic acids capable of inducing RNAi, antisense nucleic acids or ribozymes for HIF-1α and HIF-2α, or expression vectors thereof.

    摘要翻译： 本发明提供在治疗与血管生成相关的视网膜疾病如老年性黄斑变性，糖尿病性视网膜病变等中具有高治疗效果的药物。 含有特异性抑制HIF-1α表达的物质的视网膜疾病治疗剂和特异性抑制HIF-2α表达的物质。 作为本发明的治疗剂中的活性成分的上述抑制物质是能够诱导HIF-1α和HIF-2α的RNAi，反义核酸或核酶的核酸或其表达载体。

    PARTIAL PEPTIDE OF LACRITIN
    3.
    发明申请
    PARTIAL PEPTIDE OF LACRITIN 有权
    LACRITIN的部分肽

    公开(公告)号：US20110008891A1

    公开(公告)日：2011-01-13

    申请号：US12922084

    申请日：2009-03-19

    申请人： Takeshi Nakajima ,  Mitsuyoshi Azuma

    发明人： Takeshi Nakajima ,  Mitsuyoshi Azuma

    IPC分类号： C12N5/071 ,  C07K14/47

    CPC分类号： C07K14/475 ,  A61K9/0048 ,  A61K38/00

    摘要： The invention provides a polypeptide comprising the amino acid sequence of SEQ ID NO: 1, which is a particular partial sequence of lacritin, and having an amino acid length of not more than 70 residues. The polypeptide of the invention can promote adhesion between a cell and an extracellular matrix, and can promote tear fluid secretion from lacrimal gland acinar cells.

    摘要翻译： 本发明提供了包含SEQ ID NO：1的氨基酸序列的多肽，其是lacritin的特定部分序列，并且具有不超过70个残基的氨基酸长度。 本发明的多肽可以促进细胞和细胞外基质之间的粘附，并且可以促进泪腺腺泡细胞的泪液分泌。

    CELL CAPABLE OF EXPRESSING LACRITIN AT HIGH LEVEL
    4.
    发明申请
    CELL CAPABLE OF EXPRESSING LACRITIN AT HIGH LEVEL 审中-公开
    细胞能够在高水平上表达LACRITIN

    公开(公告)号：US20100183572A1

    公开(公告)日：2010-07-22

    申请号：US12449833

    申请日：2008-02-27

    申请人： Takeshi Nakajima ,  Mitsuyoshi Azuma

    发明人： Takeshi Nakajima ,  Mitsuyoshi Azuma

    IPC分类号： A61K35/44 ,  C12N15/85 ,  C12N5/10 ,  C12N15/00 ,  C12P21/02 ,  A61P27/02

    CPC分类号： C12N15/67 ,  A61K35/30 ,  A61K38/22 ,  A61K48/00 ,  C07K14/4702 ,  C12N5/0621 ,  C12N15/85 ,  C12N2510/02 ,  C12N2830/42 ,  C12N2830/85 ,  A61K2300/00

    摘要： The present invention relates to a means that allows supplying lacritin stably and in large amounts, and provides a vector containing polynucleotide that encodes lacritin, wherein said nucleotide is operatively linked to a cytomegalovirus immediate early enhancer/promoter and an SV40 late polyA signal, a lacritin-expressing cell prepared by introducing the vector into a cell, a method of producing recombinant lacritin, including the step of culturing the lacritin-expressing cell in a medium, and the step of isolating lacritin in the culture supernatant, and an agent for treating ocular disease containing the lacritin-expressing cell.

    摘要翻译： 本发明涉及一种能够稳定和大量供应lacritin的方法，并且提供了编码lacritin的含有多核苷酸的载体，其中所述核苷酸可操作地连接到巨细胞病毒立即早期增强子/启动子和SV40晚期polyA信号，lacritin 通过将载体导入细胞而制备的表达细胞，制备重组lacritin的方法，包括在培养基中培养表达lacritin的细胞的步骤，以及分离培养上清液中的lacritin的步骤和用于治疗眼睛的药剂 含有lacritin表达细胞的疾病。

    Partial peptide of lacritin
    5.
    发明授权
    Partial peptide of lacritin 有权
    泪蛋白的部分肽

    公开(公告)号：US08383130B2

    公开(公告)日：2013-02-26

    申请号：US12922084

    申请日：2009-03-19

    申请人： Takeshi Nakajima ,  Mitsuyoshi Azuma

    发明人： Takeshi Nakajima ,  Mitsuyoshi Azuma

    IPC分类号： A61K38/18 ,  C07K14/435 ,  C07K14/475

    CPC分类号： C07K14/475 ,  A61K9/0048 ,  A61K38/00

    摘要： The invention provides a polypeptide comprising the amino acid sequence of SEQ ID NO: 1, which is a particular partial sequence of lacritin, and having an amino acid length of not more than 70 residues. The polypeptide of the invention can promote adhesion between a cell and an extracellular matrix, and can promote tear fluid secretion from lacrimal gland acinar cells.

    摘要翻译： 本发明提供了包含SEQ ID NO：1的氨基酸序列的多肽，其是lacritin的特定部分序列，并且具有不超过70个残基的氨基酸长度。 本发明的多肽可以促进细胞和细胞外基质之间的粘附，并且可以促进泪腺腺泡细胞的泪液分泌。

    Rotating device and robot arm device
    10.
    发明授权
    Rotating device and robot arm device 失效
    旋转装置和机器人手臂装置

    公开(公告)号：US08567281B2

    公开(公告)日：2013-10-29

    申请号：US13418061

    申请日：2012-03-12

    申请人： Takeshi Nakajima

    发明人： Takeshi Nakajima

    IPC分类号： B25J18/00 ,  H01F21/06 ,  H04B5/00

    CPC分类号： B25J19/0029 ,  B25J19/0041 ,  B25J19/0045 ,  Y10T74/20305 ,  Y10T74/20311

    摘要： A rotating device includes a communication unit including a transmitting portion having a first ring-shaped coil, a first ring-shaped magnetic body covering the first ring-shaped coil and a first terminal connected to the first ring-shaped coil, and a receiving portion having a second ring-shaped coil, a second ring-shaped magnetic body covering the second ring-shaped coil and a second terminal connected to the second ring-shaped coil, and a bearing connecting a hollow fixed portion to a hollow rotating portion.

    摘要翻译： 旋转装置包括：通信单元，包括具有第一环形线圈的传输部分，覆盖第一环形线圈的第一环形磁体和连接到第一环形线圈的第一端子;以及接收部分 具有第二环形线圈，覆盖第二环形线圈的第二环形磁体和连接到第二环形线圈的第二端子，以及将中空固定部分连接到中空旋转部分的轴承。