公开(公告)号：US5982197A

公开(公告)日：1999-11-09

申请号：US888267

申请日：1997-07-03

申请人： Takeshi Ono ,  Satoshi Nonaka ,  Kaoru Terashima

发明人： Takeshi Ono ,  Satoshi Nonaka ,  Kaoru Terashima

IPC分类号： H01L27/06 ,  H01L21/8249 ,  H03K19/003 ,  H03K19/096 ,  H03K19/0948

CPC分类号： H03K19/0963 ,  H03K19/00361

摘要： A dynamic circuit that prevents a malfunction, even when the operating temperature is high, including a pre-charging circuit connected between a power source node and a signal wiring, a plurality of discharging circuits being connected between a power source node and a signal wiring, a plurality f discharging circuit connected between the signal wiring and a ground potential respectively and for being selectively turn-ON/OFF controlled, a leakage current detecting circuit for detecting a current corresponding to a leakage current generated between the signal wiring and the ground potential in the turn-OFF state of each discharging circuit, and a leakage current correcting circuit connected between the power source node and the signal wiring and for continuously supplying to the signal wiring a leakage correction current equivalent to a leakage current of the signal wiring corresponding to a detected current of the leakage current detecting circuit during a leakage current correction period.

摘要翻译： 一种动态电路，即使在工作温度高的情况下也能够防止故障，包括连接在电源节点和信号线之间的预充电电路，多个放电电路连接在电源节点和信号线之间， 分别连接在信号线和接地电位之间的多个f放电电路，并且用于选择性地导通/截止控制;漏电流检测电路，用于检测与信号布线和地电位之间产生的漏电流相对应的电流 每个放电电路的关断状态和连接在电源节点和信号线之间的漏电流校正电路，并且用于向信号线连续地提供与对应于信号线的信号线的泄漏电流相当的泄漏校正电流 在泄漏电流校正pe期间检测漏电流检测电路的电流 riod。

公开(公告)号：US06852540B2

公开(公告)日：2005-02-08

申请号：US10659928

申请日：2003-09-11

申请人： Haijime Makiuchi ,  Hideaki Tanaka ,  Kaoru Terashima

发明人： Haijime Makiuchi ,  Hideaki Tanaka ,  Kaoru Terashima

IPC分类号： G01N33/96 ,  G01N31/00

CPC分类号： G01N33/96 ,  Y10T436/10 ,  Y10T436/106664 ,  Y10T436/25

摘要： A control serum for a dry process is provided that does not show misfit in measurement values by the dry process and a wet process. The above-mentioned control serum is obtained by freezing or freeze-drying a control serum without dialysis.

摘要翻译： 提供干法处理的对照血清，其通过干法和湿法不显示测量值的错配。 上述对照血清是通过冷冻或冷冻干燥对照血清而不进行透析而得到的。

公开(公告)号：US05998158A

公开(公告)日：1999-12-07

申请号：US158484

申请日：1998-09-22

申请人： Hideaki Tanaka ,  Yoshihiko Abe ,  Kaoru Terashima

发明人： Hideaki Tanaka ,  Yoshihiko Abe ,  Kaoru Terashima

IPC分类号： C12Q1/50

CPC分类号： C12Q1/50

摘要： A dry analytical element for quantitatively analyzing creatine kinase MB isozyme is composed of a support and a creatine kinase MB isozyme-detecting agent layer. The detecting layer contains an antibody which specifically inhibits activity of M sub-unit of creatine kinase, creatine phosphate and adenosine diphosphate which react with each other to give adenosine triphosphate in the presence of creatine kinase MB isozyme, a buffer compound which keeps the layer in the range of pH 5.5 to pH 8.5 for the formation of adenosine triphosphate, and an indicator composition which reacts with the formed adenosine triphosphate to give a spectroscopically detectable compound, said indicator composition having hexokinase, nicotinamide-adenine dinucleotide or its phosphate in an oxidized form, and glucose-6-phosphate dehydrogenase but not containing glucose in such amount as to give the spectroscopically detectable compound.

摘要翻译： 用于定量分析肌酸激酶MB同功酶的干燥分析元件由载体和肌酸激酶MB同工酶检测剂层组成。 检测层含有特异性抑制肌酸激酶，亚磷酸肌酸和磷酸腺苷的M亚单位的活性的抗体，其在肌酸激酶MB同功酶（一种保持该层的缓冲化合物）存在下相互反应，产生三磷酸腺苷 用于形成三磷酸腺苷的pH 5.5至pH 8.5的范围，以及与形成的三磷酸腺苷反应以产生光谱可检测化合物的指示剂组合物，所述指示剂组合物具有己糖激酶，烟酰胺 - 腺嘌呤二核苷酸或其氧化形式的磷酸酯 和葡萄糖-6-磷酸脱氢酶，但不含葡萄糖，其量使得可得到光谱可检测的化合物。

公开(公告)号：US4839278A

公开(公告)日：1989-06-13

申请号：US866349

申请日：1986-05-22

申请人： Kaoru Terashima ,  Takushi Miyazako ,  Harumi Katsuyama

发明人： Kaoru Terashima ,  Takushi Miyazako ,  Harumi Katsuyama

IPC分类号： C12N15/02 ,  C12Q1/00 ,  C12Q1/42 ,  G01N31/22 ,  G01N33/52

CPC分类号： C12Q1/42 ,  G01N33/526 ,  C12Q2334/10 ,  Y10S435/805

摘要： An integral multilayer analytical element for the measurement of alkaline phosphatase activity, which comprises a porous spreading layer containing a self-developable substrate in response to contact with alkaline phosphatase, a buffer layer containing a diffusion-resistant base and a support in a laminated form.

摘要翻译： 一种用于测量碱性磷酸酶活性的整体多层分析元件，其包含响应于与碱性磷酸酶接触而含有可自发显影的底物的多孔扩散层，含有扩散抗性碱的缓冲层和层压形式的载体。

公开(公告)号：US07410613B2

公开(公告)日：2008-08-12

申请号：US10397376

申请日：2003-03-27

申请人： Yoshihide Iwaki ,  Kentarou Nakamura ,  Hideaki Tanaka ,  Yoshiki Sakaino ,  Kaoru Terashima ,  Hitoshi Shimizu

发明人： Yoshihide Iwaki ,  Kentarou Nakamura ,  Hideaki Tanaka ,  Yoshiki Sakaino ,  Kaoru Terashima ,  Hitoshi Shimizu

IPC分类号： G01N21/78

CPC分类号： G01N21/78 ,  G01N21/5907

摘要： A humoral testing apparatus in which a measuring light is irradiated to a reagent area forming a color as a result of a reaction and an optical density of the reagent area is detected by a detecting operation of light intensity of the reflected light. The humoral testing apparatus enables a humoral test to be performed accurately in cases where nonuniformity occurs with the reaction of a reagent with a humoral sample within the reagent area, or in cases where fine dust is present within each detecting spot in the reagent areas. The light reflected from the reagent areas is detected with a two-dimensional photodetector. The independent light intensity detecting operations are performed with respect to the subareas of the reagent area of a reagent layer. A photo detection signal S, which represents the intensity of the reflected light is statistically processed with a signal processing section 51.

摘要翻译： 通过反射光的光强度的检测操作来检测其中测量光照射到由于反应而形成颜色的试剂区域和试剂区域的光密度的体液测试装置。 体液检测装置能够在试剂区域内的试剂与体液样品的反应发生不均匀的情况下，或者在试剂区域的每个检测点内存在微细粉尘的情况下，能够准确地进行体液检查。 用二维光电检测器检测从试剂区反射的光。 针对试剂层的试剂区域的子区域进行独立的光强度检测动作。 用信号处理部分51对表示反射光强度的光检测信号S进行统计处理。

公开(公告)号：US5972635A

公开(公告)日：1999-10-26

申请号：US158485

申请日：1998-09-22

申请人： Hideaki Tanaka ,  Yoshihiko Abe ,  Yoshiki Sakaino ,  Kaoru Terashima

发明人： Hideaki Tanaka ,  Yoshihiko Abe ,  Yoshiki Sakaino ,  Kaoru Terashima

IPC分类号： C12Q1/32 ,  C12Q1/48 ,  C12Q1/50 ,  G01N33/52 ,  G01N33/70

CPC分类号： G01N33/70 ,  C12Q1/50

摘要： A dry analytical element for quantitatively analyzing creatine kinase is composed of a support and a creatine kinase-detecting agent layer. The creatine kinase-detecting agent layer contains creatine phosphate and adenosine diphosphate which react with each other to give adenosine triphosphate in the presence of creatine kinase, a buffer compound having a sulfonic acid group which keeps the layer in the range of pH 5.5 to pH 8.5 for the formation of adenosine triphosphate, and an indicator composition which reacts with the formed adenosine triphosphate to give a spectroscopically detectable compound. An analytical element for analysis of creatine kinase MB isozyme further contains in the layer an antibody which specifically inhibits activity of M sub-unit of creatine kinase.

摘要翻译： 用于定量分析肌酸激酶的干燥分析元件由载体和肌酸激酶检测剂层组成。 肌酸激酶检测剂层含有磷酸肌酸和二磷酸腺苷，其在肌酸激酶存在下相互反应以产生腺苷三磷酸，其是具有磺酸基的缓冲化合物，其将该层保持在pH5.5至pH8.5的范围内 用于形成三磷酸腺苷，以及与形成的三磷酸腺苷反应以产生光谱可检测化合物的指示剂组合物。 用于分析肌酸激酶MB同功酶的分析元素在该层中进一步含有特异性抑制肌酸激酶M亚单位活性的抗体。

公开(公告)号：US5786223A

公开(公告)日：1998-07-28

申请号：US650877

申请日：1996-05-17

申请人： Kaoru Terashima ,  Osamu Seshimoto

发明人： Kaoru Terashima ,  Osamu Seshimoto

IPC分类号： G01N33/52 ,  G01N37/00

CPC分类号： G01N33/521 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/115831

摘要： The concentration of an analyte in a sample liquid is determined on the basis of the optical density of a chemical analysis element spotted with the sample liquid according to a standard curve representing the relation between the concentration and the optical density of the analysis element which is obtained when the concentration is measured using an analysis element of a first lot. A plurality of first standard liquids containing the analyte in known levels are spotted onto analysis elements of a second lot, the concentrations of the analyte in the first standard liquids are determined according to the standard curve and a first calibration curve for correcting the concentrations of the analyte is prepared. A plurality of second standard liquids containing the analyte in known levels are spotted onto analysis elements of the second lot, the concentrations of the analyte in the second standard liquids are determined according to the standard curve on the particular analysis system, the concentrations of the analyte in the second standard liquids thus determined are corrected according to the first calibration curve, and a second calibration curve for correcting the concentrations of the specific analyte in the second standard liquids thus corrected is prepared.

摘要翻译： 基于用样品液体点样的化学分析元件的光密度来确定样品液体中的分析物的浓度，该标准曲线表示所获得的分析元素的浓度与光密度之间的关系 当使用第一批次的分析元素测量浓度时。 将含有已知水平的分析物的多种第一标准液体点样到第二批次的分析元件上，根据标准曲线确定第一标准液体中分析物的浓度，以及用于校正第二批次的浓度的第一校准曲线 制备分析物。 将含有已知水平的分析物的多种第二标准液体点样到第二批次的分析元件上，根据特定分析系统上的标准曲线确定第二标准液体中分析物的浓度，分析物的浓度 在第二标准液中根据第一校准曲线校正如此确定的液体，并且准备用于校正如此校正的第二标准液体中特定分析物的浓度的第二校准曲线。

公开(公告)号：US5231300A

公开(公告)日：1993-07-27

申请号：US716783

申请日：1991-06-18

申请人： Kaoru Terashima ,  Kazuo Ishikawa

发明人： Kaoru Terashima ,  Kazuo Ishikawa

IPC分类号： H01L21/822 ,  H01L27/02 ,  H01L27/04

CPC分类号： H01L27/0218 ,  H01L27/0203

摘要： In a semiconductor integrated circuit, a digital circuit section and an analog circuit section are formed on a substrate. A pair of first power source lines connects a circuit element in the digital circuit section to a power source, while a pair of second power source lines connects a substrate region in the digital circuit section to the power source. The pair of second power source lines is formed separately from the pair of first power source lines in the digital circuit section. The substrate region in the digital circuit section is surrounded by a guard ring well, to which one of the pair of second power source lines is connected.

公开(公告)号：US20100062454A1

公开(公告)日：2010-03-11

申请号：US12461983

申请日：2009-08-31

申请人： Hiroshi Kido ,  Kaoru Terashima

发明人： Hiroshi Kido ,  Kaoru Terashima

IPC分类号： G01N33/53

CPC分类号： G01N33/6854 ,  G01N33/56983 ,  G01N33/582 ,  G01N2333/11 ,  G01N2800/50

摘要： An object of the present invention is to provide a method for predicting the risk of acquiring influenza, which is characterized by low price, low invasiveness, and applicability to total automation. The present invention provides a method for predicting the risk of acquiring influenza, which comprises measuring the ratio of anti-influenza IgA to the total IgA in a specimen collected from a subject.

摘要翻译： 本发明的目的是提供一种用于预测感冒风险的方法，其特征在于价格低廉，侵入性低，适用于全自动化。 本发明提供了一种预测获得流感的风险的方法，其包括测量从受试者收集的样本中抗流感IgA与总IgA的比例。

公开(公告)号：US07369243B2

公开(公告)日：2008-05-06

申请号：US10849777

申请日：2004-05-21

申请人： Yoshiki Sakaino ,  Yoshihiko Abe ,  Kaoru Terashima

发明人： Yoshiki Sakaino ,  Yoshihiko Abe ,  Kaoru Terashima

IPC分类号： G01N21/47

CPC分类号： G01N21/8483 ,  G01N21/31 ,  G01N21/4738

摘要： An optical measuring apparatus comprises: an illuminating section that illuminates a first object with a first light; a light changing section that changes an intensity of the first light illuminating the first object; a light receiving device that receives a second light transmitted through or reflected from the first object; and an output section that outputs a measurement result according to i) a state of the light changing section and ii) an amount of the second light received by the light receiving device. In addition, an optical measuring apparatus comprises: the illuminating section; the light receiving device; a light receiving time changing section that changes a light receiving time of the light receiving device; and an output section that outputs a measurement result according to i) the light receiving time and ii) an amount of the second light received by the light receiving device.

摘要翻译： 光学测量装置包括：用第一光照亮第一物体的照明部分; 光改变部，其改变照射第一物体的第一光的强度; 光接收装置，其接收透过或者从第一物体反射的第二光; 以及输出部，其根据i）光改变部的状态输出测量结果，以及ii）由光接收装置接收的第二光的量。 另外，光学测量装置包括：照明部; 光接收装置; 光接收时间改变部，其改变所述光接收装置的光接收时间; 以及输出部，其根据i）光接收时间输出测量结果，以及ii）由光接收装置接收的第二光的量。