摘要:
The present invention relates to Fused Tricyclic Heterocyclic Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2 and R3 are as defined herein. The present invention also relates to compositions comprising at least one Fused Tricyclic Heterocyclic Compound, and methods of using the Fused Tricyclic Heterocyclic Compounds for treating or preventing HIV infection in a subject.
摘要:
The present invention relates to Fused Tricyclic Heterocycle Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, B, X, Y, m, R1, R2, R3, R3, R3, R4, R5 and R9 are as defined herein. The present invention also relates to compositions comprising at least one Fused Tricyclic Heterocycle Derivative, and methods of using the Fused Tricyclic Heterocycle Derivatives for treating or preventing HIV infection in a subject.
摘要:
The present invention relates to Spirocyclic Heterocycle Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, B, X, Y, R1, R2 and R11 are as defined herein. The present invention also relates to compositions comprising at least one Spirocyclic Heterocycle Compound, and methods of using the Spirocyclic Heterocycle Compounds for treating or preventing HIV infection in a subject.
摘要:
The present invention relates to Tricyclic Heterocycle Compounds of Formula (I): (I) and pharmaceutically acceptable salts or prodrug thereof, wherein R1, R2, R3, R4, R5, R6 and n are as defined herein. The present invention also relates to compositions comprising at least one Tricyclic Heterocycle Compound, and methods of using the Tricyclic Heterocycle Compounds for treating or preventing HIV infection in a subject.
摘要:
Disclosed are compounds of Formula A: (structurally represented) where “RG1”, “RG2a”, “RG4”, “RG5”, “MG1”, “n” and “m” are defined herein which compounds are antagonists of A2A receptor. Disclosed herein also are uses of the compounds described herein as antagonists of the A2a receptor in the potential treatment or prevention of neurological disorders and diseases in which A2A receptors are involved. Disclosed herein also are pharmaceutical compositions comprising these compounds and uses of these pharmaceutical compositions.
摘要:
A method for determining a suspect memory leak, including: sampling the throughput and memory usage of an application server; based on the sampled throughput, monitoring whether the throughput decrease continually, and based on the sampled memory usage, monitoring whether the memory usage remains stable within a predefined range; in response to a continual decrease of the throughput and the memory usage remaining stable within the predetermined range, determining that the application server is suspected of having a memory leak. Using the solution of the present invention can free an administrator of the burden of artificially identifying suspect servers, can identify a suspect server during runtime and further determine whether it actually has a memory leak.
摘要:
A business object model, which reflects data that is used during a given business transaction, is utilized to generate interfaces. This business object model facilitates commercial transactions by providing consistent interfaces that are suitable for use across industries, across businesses, and across different departments within a business during a business transaction. In some operations, software creates, updates, or otherwise processes information related to an appointment activity business object.
摘要:
Reversibly and irreversibly-linking amino-polysiloxanes, methods of making such amino-polysiloxanes, and systems and methods of using such amino-polysiloxanes for the containment and/or remediation of a release and/or spill of a crude oil, a petroleum product and/or a chemical is described. Gels and/or emulsions formed from the combination and/or contacting of such an amino-polysiloxane with these materials can be used to recover these oils or chemicals while allowing the amino-polysiloxane to be recovered and reused to clean up or contain additional materials. Such amino-polysiloxanes can be used as well for the selective uptake of one component of liquid mixtures when such mixtures contain more and less lipophilic components. Methods of making and using adhesive and sealants containing such amino-polysiloxanes are described. The adhesive and sealants can be used in a variety of applications to adhere and/or seal various materials including plastics, metals, glass, ceramics, paper, paper products, wood, and wood products.
摘要:
One aspect of the present invention relates to salts that are room-temperature ionic liquids (RTILs), methods of making them, and methods of using them in connection with temporary or permanent gas sequestration. Another aspect of the present invention relates to a class of solvents which can be transformed into RTILs by exposure to a gas, and methods of using them in connection with temporary or permanent gas sequestration.
摘要:
Methods and systems consistent with the present invention provide a data processing system having a business object model reflecting the data used during a business transaction. Consistent interfaces are generated from the business object model. These interfaces are suitable for use across industries, across businesses, and across different departments within a business during a business transaction.