公开(公告)号：US4810168A

公开(公告)日：1989-03-07

申请号：US111640

申请日：1987-10-22

申请人： Taro Nogami ,  Tsuyoshi Nishitarumizu ,  Kiwao Seki

发明人： Taro Nogami ,  Tsuyoshi Nishitarumizu ,  Kiwao Seki

IPC分类号： F04B13/00 ,  B01D15/08 ,  F04B9/04 ,  F04B11/00 ,  G01N30/32 ,  F04B49/06 ,  F04B3/00 ,  F04B49/00

CPC分类号： F04B11/00 ,  F04B11/0058 ,  F04B11/0083 ,  F04B2203/0209

摘要： A low pulsation pump device has a pulse motor, two plungers adapted to be driven by the pulse motor, a pressure sensor disposed on the output side of the plungers, a storage for storing values of pressures detected by the pressure sensor during each of a number of periods, a high speed region during which the rotational speed of the pulse motor is increased. The pulse control has an optimization function which determines, on the basis of pressure information which was obtained during the last period, the location of a high speed region in each period in such a manner as to reduce pulsations.

摘要翻译： 低脉动泵装置具有脉冲电动机，适于由脉冲电动机驱动的两个柱塞，设置在柱塞输出侧的压力传感器，用于存储压力传感器在每个数字期间检测到的压力值的存储器 的时间段，其中脉冲电机的转速增加的高速区域。 脉冲控制具有优化功能，其基于在最后期间获得的压力信息，以减少脉动的方式确定每个周期中的高速区域的位置。

公开(公告)号：US5651940A

公开(公告)日：1997-07-29

申请号：US578452

申请日：1995-12-26

申请人： Val Buonaiuto ,  Taro Nogami

发明人： Val Buonaiuto ,  Taro Nogami

IPC分类号： B01L3/14 ,  G01N1/00 ,  G01N35/10 ,  B01L3/00

CPC分类号： G01N35/1079 ,  B01L3/50825

摘要： The sealing apparatus of the present invention is a sample cuvette cap having a hole for inserting the nozzle of an auto-sampler therethrough. Located within the lumen of the hole is a small detent ball that can be positioned to block the lumen. The detent ball, which can be spring-operated or gravity-operated, blocks the fluid flow in the hole in its normal, closed position. When the auto-sampler nozzle hits the ball, the ball becomes deflected to one side into a recess, due to a difference in the nozzle axis relative to the center of the ball. By the dislocating the detent ball, the nozzle can be inserted into the cuvette smoothly as the air goes in and out through the space around the nozzle. This allows the pressure in the cuvette to be kept constant. After the nozzle is removed, the ball returns to its original position by gravity or by the force of a spring, resealing the cuvette. All of the parts for the sealing apparatus are solid parts which can be easily cleaned and reused. Because there is no non-recoverable distortion or damage to the sealing mechanism, it can be re-used after cleaning.

摘要翻译： 本发明的密封装置是具有用于插入自动取样器的喷嘴的孔的样品杯盖。 位于孔腔内的是一个小的止动球，可以将其定位成堵塞管腔。 可以弹簧操作或重力操作的止动球阻止其正常闭合位置的孔中的流体流动。 当自动进样器喷嘴撞击球时，由于喷嘴轴线相对于球的中心的差异，球变成一侧偏入凹槽。 通过脱位球的脱位，当空气通过喷嘴周围的空间进出时，喷嘴可以顺利地插入比色杯中。 这使得比色皿中的压力保持恒定。 在喷嘴被去除之后，球通过重力或弹簧的力返回其初始位置，重新密封比色皿。 用于密封装置的所有部件都是可以容易地清洁和再利用的实心部件。 因为密封机构没有不可恢复的变形或损坏，因此可以在清洁后重新使用。

公开(公告)号：US5500536A

公开(公告)日：1996-03-19

申请号：US215233

申请日：1994-03-21

申请人： Taro Nogami ,  Shunichi Matsuura ,  Akira Kuroda

发明人： Taro Nogami ,  Shunichi Matsuura ,  Akira Kuroda

IPC分类号： G01N21/64 ,  G01N21/01

CPC分类号： G01N21/645 ,  G01N2021/6482 ,  G01N2201/0642

摘要： A fluorescence output port sandwiched between light-shielding members of a sample cell is provided at a position corresponding to an entrance slit of a fluorescence monochromator and an excitation light side port of the sample cell is provided at a position corresponding to an exit slit of an excitation side monochromator.

摘要翻译： 夹在样品池的遮光构件之间的荧光输出端口设置在与荧光单色仪的入口狭缝相对应的位置，并且样品池的激发光侧端口设置在对应于 激发侧单色仪。

公开(公告)号：US4822168A

公开(公告)日：1989-04-18

申请号：US897789

申请日：1986-08-19

申请人： Taro Nogami ,  Tetsuyuki Miwa ,  Kenitiro Takahasi

发明人： Taro Nogami ,  Tetsuyuki Miwa ,  Kenitiro Takahasi

IPC分类号： G01N21/27 ,  G01J1/16 ,  G01J3/28 ,  G01J3/42 ,  G01N21/31 ,  G01N30/74 ,  G01J3/427

CPC分类号： G01J3/42 ,  G01J1/1626 ,  G01N30/74 ,  G01J3/2803 ,  G01N2021/3137 ,  G01N2021/3155

摘要： An analyzing apparatus provided with a spectroscopic photometer, in which light emitted by a deuterium lamp enters a flow cell; light transmitted by the flow cell is divided into two light beams by means of a beam splitter, one of which is received by a detecting element for sample measurement and the other of which is received by a detecting element for monitoring through a filter transmitting only light in a predetermined wavelength region, which is not essentially absorbed by the sample; and a signal processing device compares the output signal of the detecting element for sample measurement with that of the detecting element for monitoring and effects necessary operations.

摘要翻译： 一种具有分光光度计的分析装置，其中由氘灯发射的光进入流通池; 由流动池传输的光被分束器分成两束，其中一束由一个用于样品测量的检测元件接收，另一个被检测元件接收，用于通过仅传输光的过滤器 在预定的波长范围内，其基本上不被样品吸收; 并且信号处理装置将用于样本测量的检测元件的输出信号与用于监视的检测元件的输出信号进行比较，并且执行必要的操作。

公开(公告)号：US5212097A

公开(公告)日：1993-05-18

申请号：US616246

申请日：1990-11-20

申请人： Masao Kamahori ,  Mamoru Taki ,  Junkichi Miura ,  Taro Nogami ,  Yoshio Watanabe

发明人： Masao Kamahori ,  Mamoru Taki ,  Junkichi Miura ,  Taro Nogami ,  Yoshio Watanabe

IPC分类号： G01N30/06 ,  G01N30/24 ,  G01N30/54 ,  G01N30/74 ,  G01N30/88 ,  G01N33/58 ,  G01N33/94

CPC分类号： G01N33/58 ,  G01N33/9453 ,  G01N2030/8804 ,  G01N2030/8813 ,  G01N2030/8822 ,  G01N30/24 ,  G01N30/54 ,  G01N30/74 ,  Y10T436/173845 ,  Y10T436/203332

摘要： Catecholamines in a living body fluid are analyzed by a process which involves reacting a living body fluid sample with a boron compound of the formula: ##STR1## wherein R is hydroxyl, aryl or alkyl, to form a complex of the boron compound with a catecholamine; deproteinizing the reaction solution containing the complex; decomposing the complex to release the catecholamine; labeling the released catecholamine to form a labeled catecholamine; eluting the labeled catecholamine adsorbed on a separation column; and detecting the eluted, labeled catecholamine. Advantageously, this process enables catecholamines to be measured with a high recovery ratio and high accuracy by forming the catecholamines into a complex with a boron compound.

公开(公告)号：US4299486A

公开(公告)日：1981-11-10

申请号：US118725

申请日：1980-02-05

申请人： Taro Nogami ,  Hiroshi Hirose

发明人： Taro Nogami ,  Hiroshi Hirose

IPC分类号： G01N21/64

CPC分类号： G01N21/6445

摘要： In order to provide a spectrofluorometer which measures the emission polarization spectrum of a sample at high precision and with ease, a first spectrum signal I.sub.HV (.lambda..sub.EM) and a second spectrum signal I.sub.HH (.lambda..sub.EM) are formed by scanning the wavelength of an emission monochromator. A third spectrum signal I.sub.VH (.lambda..sub.EM) and a fourth spectrum signal I.sub.VV (.lambda..sub.EM) are also formed. In these terms, the first suffix H of the signals means that excitation light irradiated at the sample has a horizontal polarization direction while the first suffix V of the signals means that excitation light irradiated at the sample has a vertical polarization direction. The second suffix H of the signals means that fluorescence light detected by the detector has a horizontal polarization direction. The second suffix V of the signal means that fluorescence light detected by the detector has a vertical polarization direction. Using these signals the spectrofluorometer produces a signal G(.lambda..sub.EM) representative of the ratio between the signal I.sub.HV (.lambda..sub.EM) and the signal I.sub.HH (.lambda..sub.EM). Also, a correction signal G(.lambda..sub.EM).multidot.I.sub.VH (.lambda..sub.EM) is formed of the ratio signal G(.lambda..sub.EM) and the third spectrum signal I.sub.VH (.lambda..sub.EM). Then, a signal I.sub.VV (.lambda..sub.EM)-G(.lambda..sub.EM).multidot.I.sub.VH (.lambda..sub.EM) representative of the difference between the correction signal G(.lambda..sub.EM).multidot.I.sub.VH (.lambda..sub.EM) and the fourth spectrum signal I.sub.VV (.lambda..sub.EM) is divided by a signal I.sub.VV (.lambda..sub.EM)+G(.lambda..sub.EM).multidot.I.sub.VH (.lambda..sub.EM) representative of the sum between them. The resulting signal ##EQU1## is indicated as the emission polarization spectrum by the spectrofluorometer.

摘要翻译： 为了提供以高精度和容易地测量样品的发射极化光谱的分光荧光计，通过扫描发射波长来形成第一光谱信号IHV（λEM）和第二光谱信号IHH（λEM） 单色仪 还形成第三频谱信号IVH（λEM）和第四频谱信号IVV（λEM）。 在这些术语中，信号的第一后缀H意味着在样品处照射的激发光具有水平极化方向，而信号的第一后缀V意味着在样品处照射的激发光具有垂直偏振方向。 信号的第二个后缀H表示由检测器检测到的荧光具有水平偏振方向。 信号的第二个后缀V表示由检测器检测到的荧光具有垂直偏振方向。 使用这些信号，分光荧光计产生代表信号IHV（λEM）和信号IHH（λEM）之间的比率的信号G（λEM）。 此外，校正信号G（λEM）xIVH（λEM）由比率信号G（λEM）和第三频谱信号IVH（λEM）形成。 然后，分配表示校正信号G（λEM）xIVH（λEM）和第四频谱信号IVV（λEM）之间的差的信号IVV（λEM）-G（λEM）xIVH（λEM） 通过代表它们之间的和的信号IVV（λEM）+ G（λEM）xIVH（λEM）。 所得到的信号“IMAGE”由分光荧光计表示为发射偏振光谱。

公开(公告)号：US5661558A

公开(公告)日：1997-08-26

申请号：US492879

申请日：1995-06-20

申请人： Taro Nogami ,  Yoshiaki Yamada ,  Synichi Mathuura

发明人： Taro Nogami ,  Yoshiaki Yamada ,  Synichi Mathuura

IPC分类号： G01N21/05 ,  G01J1/42 ,  G01N21/27 ,  G01N21/59 ,  G01N21/85

CPC分类号： G01J1/42 ,  G01N21/85

摘要： An optical detector for flowing sample comprises a light condenser for condensing a diverging monochrome light, a flow cell arranged in the course of convergence of the converged light beam, and a sample-side detector for receiving a sample-side light. Such a construction makes it possible to correct delicate changes of the light axis due to intensity, position, temperature changes of the light source, density change of the flowing liquid, and any change of other causes effectively for stable sample analysis without difficult optical adjustment.

摘要翻译： 用于流动样品的光学检测器包括用于聚焦发散单色光的光聚光器，在会聚光束会聚过程中布置的流动池和用于接收样品侧光的样品侧检测器。 这种结构使得可以在没有困难的光学调节的情况下，由于强度，位置，光源的温度变化，流动液体的密度变化以及其它原因的任何变化而有效地校正光轴的微小变化，从而稳定的样品分析。

公开(公告)号：US5294336A

公开(公告)日：1994-03-15

申请号：US896784

申请日：1992-06-09

申请人： Masako Mizuno ,  Kenji Tochigi ,  Yutaka Misawa ,  Hiroyuki Miyagi ,  Yoshio Watanabe ,  Taro Nogami ,  Junkichi Miura ,  Yoshinori Takata

发明人： Masako Mizuno ,  Kenji Tochigi ,  Yutaka Misawa ,  Hiroyuki Miyagi ,  Yoshio Watanabe ,  Taro Nogami ,  Junkichi Miura ,  Yoshinori Takata

IPC分类号： G01N30/32 ,  B01D15/08 ,  B01J20/281 ,  G01N30/02 ,  G01N30/86 ,  G01N30/88 ,  G01N33/487 ,  G01N33/72

CPC分类号： G01N33/723 ,  B01D15/08 ,  G01N2030/027

摘要： Stable hemoglobin A.sub.lc (s-A.sub.lc) can be separated from other hemoglobin components and quantitated in a short time by means of a liquid-chromatographic apparatus comprising a separation column packed with a packing material consisting essentially of a porous substance having a carboxyalkyl group combined thereinto, as ion exchanger, a means for injecting a sample into the separation column, a means for passing one or more eluents through the separation column, and a means for detecting hemoglobin, hemoglobin derivatives or glycosylated hemoglobin, the average particle size of the packing material in dry state being 4 .mu.m or less.

摘要翻译： 稳定的血红蛋白Alc（s-Alc）可以与其他血红蛋白成分分离，并通过液相色谱装置在短时间内定量，该​​液相色谱装置包括一个分离柱，该分离柱填充有基本上由其中组合有羧基烷基的多孔物质组成的包装材料 作为离子交换剂，将样品注入分离塔的方法，使一个或多个洗脱液通过分离塔的装置和用于检测血红蛋白，血红蛋白衍生物或糖基化血红蛋白的装置，包装材料的平均粒径 在干燥状态下为4（my）m或更小。

公开(公告)号：US4781456A

公开(公告)日：1988-11-01

申请号：US76212

申请日：1987-07-22

申请人： Taro Nogami

发明人： Taro Nogami

IPC分类号： G01N21/27 ,  G01J1/16 ,  G01J3/427 ,  G01N21/31

CPC分类号： G01J3/427 ,  G01J1/1626 ,  G01N2021/3155

摘要： An absorption photometer for measuring the absorption by conducting the light to a thin flow cell in which a liquid sample flows, wherein the sample light for measuring the absorption peak is superimposed on the reference light selected from the transparent (window) range of the liquid and the absorbance is detected by separating the sample light and reference light after transmission of the flow cell. Changes in the light path conditions can be monitored accurately, and therefore high-accuracy measurement immune to noises is made possible even using an elongated flow cell.

摘要翻译： 一种吸收光度计，用于通过将光传导到液体样品流动的薄流通池来测量吸收，其中用于测量吸收峰的样品光重叠在从液体的透明（窗）范围中选择的参考光上， 通过在流通池传输之后分离样品光和参考光来检测吸光度。 可以准确地监视光路条件的变化，因此即使使用细长的流动池也可以实现免受噪声的高精度测量。

公开(公告)号：US4531834A

公开(公告)日：1985-07-30

申请号：US482248

申请日：1983-04-05

申请人： Taro Nogami

发明人： Taro Nogami

IPC分类号： G01N21/64

CPC分类号： G01N21/645 ,  G01N2021/6491

摘要： A fluorimeter comprises an excitation optical system projecting the excitation light having a selected wavelength for a sample to said sample, a sample cell for accommodating the sample; fluorescent light sensors for sensing the fluorescent light emitted from the sample; a transmission light sensor for sensing the light transmitted through the sample; and an arithmetic divider which divides the output of the fluorescent light sensor by the output of the transmission light sensor, and provides a signal representing the intensity of the fluorescent light which is corrected against the variation of the excitation light intensity.

摘要翻译： 荧光计包括激发光学系统，将具有用于样品的选定波长的激发光投射到所述样品，用于容纳样品的样品池; 用于感测从样品发出的荧光的荧光灯传感器; 用于感测通过样品的光的透射光传感器; 以及分频器，其通过透射光传感器的输出分割荧光传感器的输出，并且提供表示根据激发光强度的变化校正的荧光强度的信号。