专利检索 ap:("Tassie Collins" OR "Hossen Mahmud" OR "Jonathan Houze" OR "Alan Xi Huang" OR "Julio C. Medina" OR "Xuemei Wang" OR "Feng Xu" OR "Qingge Xu" OR "Liusheng Zhu") AND inv:"Liusheng Zhu" 第 1 页

1.

发明授权
CCR4 antagonists 失效
标题翻译： CCR4拮抗剂

公开(公告)号：US07144903B2

公开(公告)日：2006-12-05

申请号：US10155605

申请日：2002-05-22

申请人： Tassie Collins , Hossen Mahmud , Jonathan Houze , Alan Xi Huang , Julio C. Medina , Xuemei Wang , Feng Xu , Qingge Xu , Liusheng Zhu

发明人： Tassie Collins , Hossen Mahmud , Jonathan Houze , Alan Xi Huang , Julio C. Medina , Xuemei Wang , Feng Xu , Qingge Xu , Liusheng Zhu

IPC分类号： C07D417/12 , C07D419/12 , C07D401/00 , A61K31/425

CPC分类号： C07D417/12 , A61K31/265 , A61K31/341 , A61K31/351 , A61K31/357 , A61K31/36 , A61K31/381 , A61K31/4245 , A61K31/426 , C07D277/42 , C07D277/82 , C07D513/04

摘要： Compounds, compositions and methods are provided that are useful in the treatment of chemokine receptor-mediated conditions and diseases. In particular, the invention provides compounds which modulate CCR4 function or a CCR4-mediated response. The subject compounds and compositions are useful for the treatment or prevention of inflammatory conditions and diseases.

摘要翻译： 提供了可用于治疗趋化因子受体介导的病症和疾病的化合物，组合物和方法。特别地，本发明提供调节CCR4功能或CCR4介导的应答的化合物。主题化合物和组合物可用于治疗或预防炎性疾病和疾病。

2.

发明授权
Substituted Quinazolin-4(3H)-one compounds, compositions, and methods for their use 有权
标题翻译：取代的喹唑啉-4（3H） - 酮化合物，组合物及其使用方法

公开(公告)号：US07053215B2

公开(公告)日：2006-05-30

申请号：US10231895

申请日：2002-08-29

申请人： Julio C. Medina , Michael G. Johnson , An-Rong Li , Jiwen Liu , Alan Xi Huang , Liusheng Zhu , Andrew P. Marcus

发明人： Julio C. Medina , Michael G. Johnson , An-Rong Li , Jiwen Liu , Alan Xi Huang , Liusheng Zhu , Andrew P. Marcus

IPC分类号： C07D403/12 , A61K31/517

CPC分类号： C07D401/04 , C07D213/40 , C07D235/14 , C07D239/91 , C07D249/12 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/04 , C07D413/14 , C07D417/04 , C07D471/04 , C07D475/04

摘要： Compounds are provided that have the formula: where X, A4, Ra, R1, R2, R3, R4, R14, L and Q are as described herein. These compounds are useful, for example, as modulators of a chemokine receptor and for treatment of inflammatory and immunoregulatory disorders and diseases. Pharmaceutical compositions and methods of using these compounds for the treatment of inflammatory and immunoregulatory disorders and diseases, such as multiple sclerosis, rheumatoid arthritis and type I diabetes, are also provided.

摘要翻译： 提供具有下式的化合物：其中X，A 4，R a，R 1，R 2， R 3，R 4，R 14，L和Q如本文所述。这些化合物可用作例如趋化因子受体的调节剂和治疗炎性和免疫调节性疾病和疾病。还提供了使用这些化合物治疗炎性和免疫调节性疾病和疾病如多发性硬化，类风湿性关节炎和I型糖尿病的药物组合物和方法。

3.

发明授权
CXCR3 antagonists 有权

公开(公告)号：US07067662B2

公开(公告)日：2006-06-27

申请号：US10946935

申请日：2004-09-21

申请人： Julio C. Medina , Michael G. Johnson , An-Rong Li , Jiwen Liu , Alan Xi Huang , Liusheng Zhu , Andrew P. Marcus

发明人： Julio C. Medina , Michael G. Johnson , An-Rong Li , Jiwen Liu , Alan Xi Huang , Liusheng Zhu , Andrew P. Marcus

IPC分类号： C07D239/70

CPC分类号： C07D401/04 , C07D235/14 , C07D239/91 , C07D249/12 , C07D401/12 , C07D403/12 , C07D405/04 , C07D413/14 , C07D471/04

摘要： Compounds, compositions and methods that are useful in the treatment of inflammatory and immune conditions and diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of a chemokine receptor. The subject methods are useful for the treatment of inflammatory and immunoregulatory disorders and diseases, such as multiple sclerosis, rheumatoid arthritis and type I diabetes.

4.

发明授权
Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders 有权

公开(公告)号：US07816367B2

公开(公告)日：2010-10-19

申请号：US10591214

申请日：2005-02-24

申请人： Michelle Akerman , Jonathan Houze , Daniel C. H. Lin , Jiwen Liu , Jian Luo , Julio C. Medina , Wei Qiu , Jeffrey D. Reagan , Rajiv Sharma , Stephen J. Shuttleworth , Ying Sun , Jian Zhang , Liusheng Zhu , Jinqian Liu , Zhihua Ma , Yingcai Wang , Michael J. Schmitt

发明人： Michelle Akerman , Jonathan Houze , Daniel C. H. Lin , Jiwen Liu , Jian Luo , Julio C. Medina , Wei Qiu , Jeffrey D. Reagan , Rajiv Sharma , Stephen J. Shuttleworth , Ying Sun , Jian Zhang , Liusheng Zhu , Jinqian Liu , Zhihua Ma , Yingcai Wang , Michael J. Schmitt

IPC分类号： A61K31/44 , C07D213/02

CPC分类号： C07D277/24 , C07D277/30

摘要： The present invention provides compounds useful, for example, for modulating insulin levels in a subject and that have the general formula Q-L1-P-L2-M-X-L3-A wherein the definitions of the variables Q, L1, P, L2, M, X, L3 and A are provided herein. The present invention also provides compositions and methods for use of the compounds, for instance, for treatment of type II diabetes.

5.

发明授权
Substituted biphenyl GPR40 modulators 有权
标题翻译：取代的联苯GPR40调节剂

公开(公告)号：US08030354B2

公开(公告)日：2011-10-04

申请号：US12287036

申请日：2008-10-03

申请人： Sean P. Brown , Qiong Cao , Paul John Dransfield , Xiaohui Du , Zice Fu , Jonathan Houze , Xian Yun Jiao , Yong-Jae Kim , Todd J. Kohn , SuJen Lai , An-Rong Li , Daniel Lin , Jiwen Liu , Jian Luo , Julio C. Medina , Jeffrey D. Reagan , Vatee Pattaropong , Margrit Schwarz , Wang Shen , Yongli Su , Gayathri Swaminath , Marc Vimolratana , Yingcai Wang , Yumei Xiong , Li Yang , Ming Yu , Jie Zhang , Liusheng Zhu

发明人： Sean P. Brown , Qiong Cao , Paul John Dransfield , Xiaohui Du , Zice Fu , Jonathan Houze , Xian Yun Jiao , Yong-Jae Kim , Todd J. Kohn , SuJen Lai , An-Rong Li , Daniel Lin , Jiwen Liu , Jian Luo , Julio C. Medina , Jeffrey D. Reagan , Vatee Pattaropong , Margrit Schwarz , Wang Shen , Yongli Su , Gayathri Swaminath , Marc Vimolratana , Yingcai Wang , Yumei Xiong , Li Yang , Ming Yu , Jie Zhang , Liusheng Zhu

IPC分类号： A61K31/192 , C07C53/134

CPC分类号： C07C323/62 , C07C59/68 , C07C59/72 , C07C217/54 , C07C217/62 , C07C317/22 , C07C323/19 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D213/64 , C07D309/12

摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

摘要翻译： 本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。这些化合物具有通式I：其中本文提供变量的定义。本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。

6.

发明授权
Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders 有权
标题翻译：用于治疗代谢紊乱的化合物，药物组合物和方法

公开(公告)号：US07649110B2

公开(公告)日：2010-01-19

申请号：US11067377

申请日：2005-02-25

申请人： Michelle Akerman , Jonathan Houze , Daniel C. H. Lin , Jinqian Liu , Jiwen Liu , Jian Luo , Zhihua Ma , Julio C. Medina , Wei Qiu , Jeffrey D. Reagan , Rajiv Sharma , Michael J. Schmitt , Stephen J. Shuttleworth , Ying Sun , Yingcai Wang , Jian Zhang , Liusheng Zhu

发明人： Michelle Akerman , Jonathan Houze , Daniel C. H. Lin , Jinqian Liu , Jiwen Liu , Jian Luo , Zhihua Ma , Julio C. Medina , Wei Qiu , Jeffrey D. Reagan , Rajiv Sharma , Michael J. Schmitt , Stephen J. Shuttleworth , Ying Sun , Yingcai Wang , Jian Zhang , Liusheng Zhu

IPC分类号： C07C59/40 , C07C65/03

CPC分类号： C07D277/24 , C07D277/30

摘要： The present invention provides compounds useful, for example, for modulating insulin levels in a subject and that have the general formula Q—L1—P—L2—M—X—L3—A wherein the definitions of the variables Q, L1, P, L2, M, X, L3 and A are provided herein. The present invention also provides compositions and methods for use of the compounds, for instance, for treatment of type II diabetes.

摘要翻译： 本发明提供了可用于调节受试者胰岛素水平的化合物，其具有通式Q-L1-P-L2-MX-L3-A，其中变量Q，L1，P，L2， M，X，L3和A。本发明还提供了用于治疗II型糖尿病的化合物的组合物和方法。

7.

发明授权
Compounds, pharmaceutical compositions and methods for their use in treating metabolic disorders 有权
标题翻译：用于治疗代谢紊乱的化合物，药物组合物和方法

公开(公告)号：US07465804B2

公开(公告)日：2008-12-16

申请号：US11436732

申请日：2006-05-17

申请人： Jonathan Houze , Jiwen Liu , Zhihua Ma , Julio C. Medina , Michael J. Schmitt , Rajiv Sharma , Ying Sun , Yingcai Wang , Liusheng Zhu

发明人： Jonathan Houze , Jiwen Liu , Zhihua Ma , Julio C. Medina , Michael J. Schmitt , Rajiv Sharma , Ying Sun , Yingcai Wang , Liusheng Zhu

IPC分类号： C07D263/32 , C07D257/04 , C07D249/04 , C07D249/08 , C07D277/22 , C07D277/24 , C07C59/13

CPC分类号： C07D277/24 , C07B2200/07 , C07C235/34 , C07D233/64 , C07D249/08 , C07D257/04 , C07D263/32 , C07D417/12

摘要： The present invention provides compounds useful, for example, for modulating insulin levels in a subject, having the general formula I: wherein Q is an optionally substituted phenyl; L is a bond or O; P is a benzene or an optionally substituted thiazole ring; and R1 has the values provided herein. The present invention also provides compositions, uses, and methods for use of the compounds, for instance, for treatment of type II diabetes.

摘要翻译： 本发明提供了可用于例如用于调节受试者中具有通式I的胰岛素水平的化合物：其中Q是任选取代的苯基; L是一个键或O; P是苯或任选取代的噻唑环; 并且R1具有本文提供的值。本发明还提供了用于治疗II型糖尿病的化合物的组合物，用途和方法。

8.

发明申请
SPIROCYCLIC GPR40 MODULATORS 有权
标题翻译：螺旋GPR40调制器

公开(公告)号：US20110190330A1

公开(公告)日：2011-08-04

申请号：US13119951

申请日：2009-10-13

申请人： Sean P. Brown , Paul Dransfield , Xiaohui Du , Zice Fu , Jonathan Houze , XianYun Jiao , Sujen Lai , An-Rong Li , Jiwen Liu , Zhihua Ma , Julio C. Medina , Vatee Pattaropong , Wang Shen , Marc Vimolratana , Yingcai Wang , Zhongyu Wang , Ming Yu , Liusheng Zhu

发明人： Sean P. Brown , Paul Dransfield , Xiaohui Du , Zice Fu , Jonathan Houze , XianYun Jiao , Sujen Lai , An-Rong Li , Jiwen Liu , Zhihua Ma , Julio C. Medina , Vatee Pattaropong , Wang Shen , Marc Vimolratana , Yingcai Wang , Zhongyu Wang , Ming Yu , Liusheng Zhu

IPC分类号： A61K31/4418 , C07C69/757 , C07C62/34 , C07D213/64 , C07D249/08 , C07D311/96 , C07D217/24 , C07D231/12 , A61K31/216 , A61K31/192 , A61K31/4196 , A61K31/352 , A61K31/415 , A61K31/426 , A61P3/10

CPC分类号： C07C62/34 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07D213/643 , C07D217/24 , C07D253/065 , C07D277/22 , C07D311/04 , C07D401/12

摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula IA, IB, I′A or I′B: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

摘要翻译： 本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。这些化合物具有通式IA，IB，I'A或I'B：其中本文提供变量的定义。本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。

9.

发明授权
Spirocyclic GPR40 modulators 有权
标题翻译：螺环GPR40调节剂

公开(公告)号：US08748462B2

公开(公告)日：2014-06-10

申请号：US13119951

申请日：2009-10-13

申请人： Sean P. Brown , Paul Dransfield , Xiaohui Du , Zice Fu , Jonathan Houze , XianYun Jiao , Sujen Lai , An-Rong Li , Jiwen Liu , Zhihua Ma , Julio C. Medina , Vatee Pattaropong , Wang Shen , Marc Vimolratana , Yingcai Wang , Zhongyu Wang , Ming Yu , Liusheng Zhu

发明人： Sean P. Brown , Paul Dransfield , Xiaohui Du , Zice Fu , Jonathan Houze , XianYun Jiao , Sujen Lai , An-Rong Li , Jiwen Liu , Zhihua Ma , Julio C. Medina , Vatee Pattaropong , Wang Shen , Marc Vimolratana , Yingcai Wang , Zhongyu Wang , Ming Yu , Liusheng Zhu

IPC分类号： A61K31/19 , C07C69/76 , C07D211/72 , C07D211/84 , C07D213/62 , A61K31/44

CPC分类号： C07C62/34 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07D213/643 , C07D217/24 , C07D253/065 , C07D277/22 , C07D311/04 , C07D401/12

摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula IA, IB, I′A or I′B: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

摘要翻译： 本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。这些化合物具有通式IA，IB，I'A或I'B：其中本文提供变量的定义。本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。