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公开(公告)号：US07279484B2
公开(公告)日：2007-10-09
申请号：US11116310
申请日：2005-04-28
申请人： Tatsuhiro Yamada , Tadakiyo Nakagawa , Yasuhiro Tanaka , Kohichi Fujita , Tomoyuki Tagami , Yuka Ikenoue , Shunsuke Fukuda , Yoshitomo Chujo , Manabu Suzuki , Masahiro Murata
发明人： Tatsuhiro Yamada , Tadakiyo Nakagawa , Yasuhiro Tanaka , Kohichi Fujita , Tomoyuki Tagami , Yuka Ikenoue , Shunsuke Fukuda , Yoshitomo Chujo , Manabu Suzuki , Masahiro Murata
IPC分类号： A61K31/519 , C07D471/04 , C07D471/14 , A61P1/04 , A61P19/02
CPC分类号： C07D471/04 , A61K31/519
摘要： The inventive subject matter relates to compounds, pharmaceutical compositions, and kits containing a heterocyclic compound represented by the formula (I) wherein R is an alkyl group optionally having substituent(s) etc., X is an amino group optionally having substituent(s), Y1 and Y2 are nitrogen atoms etc., an isomer or solvate thereof or a pharmaceutically acceptable salt thereof as an active ingredient.
摘要翻译： 本发明涉及包含式（I）表示的杂环化合物的化合物，药物组合物和试剂盒，其中R是任选具有取代基的烷基等。X是任选具有取代基的氨基， Y 1和Y 2是氮原子等，其异构体或溶剂合物或其药学上可接受的盐作为活性成分。
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公开(公告)号：US20050250796A1
公开(公告)日：2005-11-10
申请号：US11116310
申请日：2005-04-28
申请人： Tatsuhiro Yamada , Tadakiyo Nakagawa , Yasuhiro Tanaka , Kohichi Fujita , Tomoyuki Tagami , Yuka Ikenoue , Shunsuke Fukuda , Yoshitomo Chujo , Manabu Suzuki , Masahiro Murata
发明人： Tatsuhiro Yamada , Tadakiyo Nakagawa , Yasuhiro Tanaka , Kohichi Fujita , Tomoyuki Tagami , Yuka Ikenoue , Shunsuke Fukuda , Yoshitomo Chujo , Manabu Suzuki , Masahiro Murata
IPC分类号： A61K31/519 , A61P1/00 , A61P1/04 , A61P29/00 , A61P31/04 , A61P37/02 , A61P37/06 , A61P43/00 , C07D471/04 , C07D471/02 , A61K31/4745
CPC分类号： C07D471/04 , A61K31/519
摘要： The inventive subject matter relates to compounds, pharmaceutical compositions, and kits containing a heterocyclic compound represented by the formula (I) wherein R is an alkyl group optionally having substituent(s) etc., X is an amino group optionally having substituent(s), Y1 and Y2 are nitrogen atoms etc., an isomer or solvate thereof or a pharmaceutically acceptable salt thereof as an active ingredient.
摘要翻译： 本发明涉及包含式（I）表示的杂环化合物的化合物，药物组合物和试剂盒，其中R是任选具有取代基的烷基等。X是任选具有取代基的氨基， Y 1和Y 2是氮原子等，其异构体或溶剂合物或其药学上可接受的盐作为活性成分。
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公开(公告)号：US07902179B2
公开(公告)日：2011-03-08
申请号：US10475097
申请日：2002-04-26
申请人： Yasuhiro Tanaka , Kohichi Fujita , Yoshitomo Chujoh , Syunsuke Fukuda , Yuka Ikenoue , Tomoyuki Tagami , Akira Chiba , Ariko Kodaira , Hideki Matsumoto , Tadakiyo Nakagawa , Tatsuhiro Yamada , Manabu Suzuki , Masahiro Murata
发明人： Yasuhiro Tanaka , Kohichi Fujita , Yoshitomo Chujoh , Syunsuke Fukuda , Yuka Ikenoue , Tomoyuki Tagami , Akira Chiba , Ariko Kodaira , Hideki Matsumoto , Tadakiyo Nakagawa , Tatsuhiro Yamada , Manabu Suzuki , Masahiro Murata
IPC分类号： A61K31/44
CPC分类号： C07D471/04 , A61K31/437 , Y02A50/411
摘要： A pharmaceutical composition containing a heterocyclic compound of the formula (I) wherein each symbol is as defined in the specification, an isomer thereof, a solvate thereof or a pharmaceutically acceptable salt thereof as an active ingredient has a superior TNF-α production suppressing action. Accordingly, it is useful for the prophylaxis or treatment of various diseases caused by abnormal production of TNF-α.
摘要翻译： 含有式（I）的杂环化合物的药物组合物，其中每个符号如说明书中所定义，其异构体，其溶剂化物或其药学上可接受的盐作为活性成分具有优异的TNF-α产生抑制作用。 因此，可以预防或治疗由TNF-α异常产生引起的各种疾病。
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公开(公告)号：US06703379B2
公开(公告)日：2004-03-09
申请号：US09803107
申请日：2001-03-12
申请人： Yukio Iino , Kohichi Fujita , Takashi Tsuji , Ariko Kodaira , Kenji Takehana , Tsuyoshi Kobayashi , Takashi Yamamoto
发明人： Yukio Iino , Kohichi Fujita , Takashi Tsuji , Ariko Kodaira , Kenji Takehana , Tsuyoshi Kobayashi , Takashi Yamamoto
IPC分类号： C07C23360
CPC分类号： C07D209/48 , C07B2200/05 , C07B2200/07 , C07C233/60 , C07C233/61 , C07C233/62 , C07C233/63 , C07C235/38 , C07C235/56 , C07C237/20 , C07C237/42 , C07C247/10 , C07C251/48 , C07C255/44 , C07C309/66 , C07C311/46 , C07C317/40 , C07C323/40 , C07C2601/02 , C07D207/16 , C07D209/76 , C07D213/81
摘要： The present invention provides an AP-1 activation inhibitor, NF-kappa B activation inhibitor, inflammatory cytokine production inhibitor, matrix metalloprotease production inhibitor, inflammatory cell adhesion molecule expression inhibitor, anti-inflammatory agent, antirheumatic agent, immunosuppressant, cancer metastasis inhibitor, remedy for arteriosclerosis and antiviral agent which contain the benzene derivative of the following general formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient.
摘要翻译： 本发明提供了AP-1活化抑制剂，NF-κB活化抑制剂，炎性细胞因子产生抑制剂，基质金属蛋白酶产生抑制剂，炎症细胞粘附分子表达抑制剂，抗炎剂，抗风湿剂，免疫抑制剂，癌症转移抑制剂 用于含有下列通式（I）的苯衍生物或其药学上可接受的盐作为活性成分的动脉硬化和抗病毒剂。
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公开(公告)号：US20050165114A1
公开(公告)日：2005-07-28
申请号：US11087531
申请日：2005-03-24
申请人： Yukio Iino , Kohichi Fujita , Takashi Tsuji , Ariko Kodaira , Kenji Takehana , Tsuyoshi Kobayashi , Takashi Yamamoto
发明人： Yukio Iino , Kohichi Fujita , Takashi Tsuji , Ariko Kodaira , Kenji Takehana , Tsuyoshi Kobayashi , Takashi Yamamoto
IPC分类号： C07C233/60 , C07C233/61 , C07C233/62 , C07C233/63 , C07C235/38 , C07C235/56 , C07C237/20 , C07C237/42 , C07C247/10 , C07C251/48 , C07C255/44 , C07C309/66 , C07C311/46 , C07C317/40 , C07C323/40 , C07D207/16 , C07D209/48 , C07D209/76 , C07D213/81 , C07D491/18 , A61K31/165
CPC分类号： C07D209/48 , C07B2200/05 , C07B2200/07 , C07C233/60 , C07C233/61 , C07C233/62 , C07C233/63 , C07C235/38 , C07C235/56 , C07C237/20 , C07C237/42 , C07C247/10 , C07C251/48 , C07C255/44 , C07C309/66 , C07C311/46 , C07C317/40 , C07C323/40 , C07C2601/02 , C07D207/16 , C07D209/76 , C07D213/81
摘要： The present invention provides an AP-1 activation inhibitor, NF-kappa B activation inhibitor, inflammatory cytokine production inhibitor, matrix metalloprotease production inhibitor, inflammatory cell adhesion molecule expression inhibitor, anti-inflammatory agent, antirheumatic agent, immunosuppressant, cancer metastasis inhibitor, remedy for arteriosclerosis and antiviral agent which contain the benzene derivative of the following general formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient.
摘要翻译： 本发明提供了AP-1活化抑制剂，NF-κB活化抑制剂，炎性细胞因子产生抑制剂，基质金属蛋白酶产生抑制剂，炎症细胞粘附分子表达抑制剂，抗炎剂，抗风湿剂，免疫抑制剂，癌症转移抑制剂 用于含有下列通式（I）的苯衍生物或其药学上可接受的盐作为活性成分的动脉硬化和抗病毒剂。
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公开(公告)号：US06710056B2
公开(公告)日：2004-03-23
申请号：US10161779
申请日：2002-06-05
申请人： Masayuki Sugiki , Kazuyuki Sagi , Kohichi Fujita , Takashi Kayahara , Shunji Takehana , Kuniya Sakurai , Kazumi Tashiro
发明人： Masayuki Sugiki , Kazuyuki Sagi , Kohichi Fujita , Takashi Kayahara , Shunji Takehana , Kuniya Sakurai , Kazumi Tashiro
IPC分类号： C07D21548
CPC分类号： C07D213/73 , C07C257/18 , C07C279/14 , C07C279/18 , C07C279/22 , C07C2601/04 , C07C2601/08 , C07D213/56 , C07D215/48 , C07D231/12 , C07D233/56 , C07D235/08 , C07D235/30 , C07D239/84 , C07D249/08 , C07D277/64 , C07D277/82 , C07D307/79 , C07D333/24 , C07D333/38 , C07D401/04
摘要： An amidinophenylpyruvic acid derivative of the following formula, analogs thereof and pharmaceutically acceptable salts thereof have an excellent antagonistic effect against activated blood coagulation factor VII.
摘要翻译： 下式的脒基苯基丙酮酸衍生物及其类似物及其药学上可接受的盐对活化凝血因子VII具有优异的拮抗作用。
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公开(公告)号：US06563002B2
公开(公告)日：2003-05-13
申请号：US10085073
申请日：2002-03-01
IPC分类号： C07C23357
CPC分类号： C07D213/75 , C07C233/60 , C07C233/62 , C07C317/22 , C07C2601/02
摘要： The present invention discloses biscyclopropanecarboxamide compounds and pharmaceutically acceptable salts thereof; and also NF-kappa B activation inhibitors, Inflammatory cytokine production inhibitors, matrix metalloprotease production inhibitors, inflammatory cell adhesion molecules incidence inhibitors, antiinflammatory agents, antirheumatic agents, immunosuppressive agents, cancerous metastasis inhibitors or antiviral agents each containing such a compound as the active ingredient.
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公开(公告)号：US07459585B2
公开(公告)日：2008-12-02
申请号：US11087531
申请日：2005-03-24
申请人： Yukio Iino , Kohichi Fujita , Takashi Tsuji , Ariko Kodaira , Kenji Takehana , Tsuyoshi Kobayashi , Takashi Yamamoto
发明人： Yukio Iino , Kohichi Fujita , Takashi Tsuji , Ariko Kodaira , Kenji Takehana , Tsuyoshi Kobayashi , Takashi Yamamoto
IPC分类号： C07C233/60 , C07C233/61 , C07C233/62 , C07C233/63 , C07C309/66 , C07C311/21 , C07D209/38 , C07D209/48 , C07D211/78
CPC分类号： C07D209/48 , C07B2200/05 , C07B2200/07 , C07C233/60 , C07C233/61 , C07C233/62 , C07C233/63 , C07C235/38 , C07C235/56 , C07C237/20 , C07C237/42 , C07C247/10 , C07C251/48 , C07C255/44 , C07C309/66 , C07C311/46 , C07C317/40 , C07C323/40 , C07C2601/02 , C07D207/16 , C07D209/76 , C07D213/81
摘要： The present invention provides an AP-1 activation inhibitor, NF-kappa B activation inhibitor, inflammatory cytokine production inhibitor, matrix metalloprotease production inhibitor, inflammatory cell adhesion molecule expression inhibitor, anti-inflammatory agent, antirheumatic agent, immunosuppressant, cancer metastasis inhibitor, remedy for arteriosclerosis and antiviral agent which contain the benzene derivative of the following general formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient.
摘要翻译： 本发明提供了AP-1活化抑制剂，NF-κB活化抑制剂，炎性细胞因子产生抑制剂，基质金属蛋白酶产生抑制剂，炎症细胞粘附分子表达抑制剂，抗炎剂，抗风湿剂，免疫抑制剂，癌症转移抑制剂 用于含有下列通式（I）的苯衍生物或其药学上可接受的盐作为活性成分的动脉硬化和抗病毒剂。
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