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公开(公告)号：US09557321B2
公开(公告)日：2017-01-31
申请号：US13885950
申请日：2011-11-17
CPC分类号： G01N33/5055 , C12N5/0696 , G01N33/6869 , G01N33/6872 , G01N2333/545 , G01N2500/10
摘要： The present invention provides a method for screening drugs for suppressing inflammasome activity, using macrophages derived from induced pluripotent stem cells (iPS cells) having mutant NLRP3 gene.
摘要翻译： 本发明提供了使用衍生自具有突变体NLRP3基因的诱导多能干细胞（iPS细胞）的巨噬细胞来筛选用于抑制炎症性活性的药物的方法。
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公开(公告)号：US20130273588A1
公开(公告)日：2013-10-17
申请号：US13885950
申请日：2011-11-17
IPC分类号： G01N33/50
CPC分类号： G01N33/5055 , C12N5/0696 , G01N33/6869 , G01N33/6872 , G01N2333/545 , G01N2500/10
摘要： The present invention provides a method for screening drugs for suppressing inflammasome activity, using macrophages derived from induced pluripotent stem cells (iPS cells) having mutant NLRP3 gene.
摘要翻译： 本发明提供了使用衍生自具有突变体NLRP3基因的诱导多能干细胞（iPS细胞）的巨噬细胞来筛选用于抑制炎症性活性的药物的方法。
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公开(公告)号：US09005976B2
公开(公告)日：2015-04-14
申请号：US13393528
申请日：2010-09-01
申请人： Shinya Yamanaka , Takayuki Tanaka
发明人： Shinya Yamanaka , Takayuki Tanaka
CPC分类号： C12Q1/6881 , C12N5/0696 , C12N5/10 , C12Q2600/158
摘要： The present invention relates to a method for selecting induced pluripotent stem (iPS) cells. More particularly, the present invention provides: a method for selecting an iPS cell, comprising the steps of: (1a) measuring the expression level of an exogenous nuclear reprogramming gene(s) in a test iPS cell; and (2a) selecting an iPS cell in which the expression level(s) of an exogenous nuclear reprogramming gene(s) is/are less than or equal to the expression level(s) in control iPS cells; and a method for selecting an iPS cell, comprising the steps of: (1b) measuring the expression level of an exogenous nuclear reprogramming gene(s) and the sum the expression levels of the exogenous nuclear reprogramming gene(s) and the corresponding endogenous gene iPS cell; and (2b) selecting an iPS cell in which the ratio of the expression level of an exogenous nuclear reprogramming gene(s) relative to the sum of the expression levels of the exogenous transgene(s) and the corresponding endogenous gene(s) is less than 1 to the ratio in the control iPS cell.
摘要翻译： 本发明涉及一种选择诱导多能干细胞（iPS）细胞的方法。 更具体地，本发明提供：选择iPS细胞的方法，包括以下步骤：（1a）测量测试iPS细胞中外源核重编程基因的表达水平; 和（2a）选择其中外源性核重编程基因的表达水平小于或等于对照iPS细胞中的表达水平的iPS细胞; 和选择iPS细胞的方法，包括以下步骤：（1b）测量外源核重编程基因的表达水平和外源核重编程基因和相应内源基因的表达水平之和 iPS细胞; 和（2b）选择其中外源核重编程基因的表达水平相对于外源转基因和相应的内源基因的表达水平之和的比例更小的iPS细胞 超过1对比控制iPS细胞。
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公开(公告)号：US20120156684A1
公开(公告)日：2012-06-21
申请号：US13393528
申请日：2010-09-01
申请人： Shinya Yamanaka , Takayuki Tanaka
发明人： Shinya Yamanaka , Takayuki Tanaka
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12N5/0696 , C12N5/10 , C12Q2600/158
摘要： The present invention relates to a method for selecting induced pluripotent stem (iPS) cells. More particularly, the present invention provides: a method for selecting an iPS cell, comprising the steps of: (1a) measuring the expression level of an exogenous nuclear reprogramming gene(s) in a test iPS cell; and (2a) selecting an iPS cell in which the expression level(s) of an exogenous nuclear reprogramming gene(s) is/are less than or equal to the expression level(s) in control iPS cells; and a method for selecting an iPS cell, comprising the steps of: (1b) measuring the expression level of an exogenous nuclear reprogramming gene(s) and the sum the expression levels of the exogenous nuclear reprogramming gene(s) and the corresponding endogenous gene iPS cell; and (2b) selecting an iPS cell in which the ratio of the expression level of an exogenous nuclear reprogramming gene(s) relative to the sum of the expression levels of the exogenous transgene(s) and the corresponding endogenous gene(s) is less than 1 to the ratio in the control iPS cell.
摘要翻译： 本发明涉及一种选择诱导多能干细胞（iPS）细胞的方法。 更具体地，本发明提供：选择iPS细胞的方法，包括以下步骤：（1a）测量测试iPS细胞中外源核重编程基因的表达水平; 和（2a）选择其中外源性核重编程基因的表达水平小于或等于对照iPS细胞中的表达水平的iPS细胞; 和选择iPS细胞的方法，包括以下步骤：（1b）测量外源核重编程基因的表达水平和外源核重编程基因和相应内源基因的表达水平之和 iPS细胞; 和（2b）选择其中外源核重编程基因的表达水平相对于外源转基因和相应的内源基因的表达水平之和的比例更小的iPS细胞 超过1对比控制iPS细胞。
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5.发明授权Image forming apparatus configured to perform a primary transfer of a toner image from a plurality of image bearing members to an intermediate transfer belt by following a current in circumferential direction with respect to the intermediate transfer belt 有权图像形成装置，被配置为通过沿相对于中间转印带的圆周方向的电流执行调色剂图像从多个图像承载部件到中间转印带的一次转印公开(公告)号：US09058010B2
公开(公告)日：2015-06-16
申请号：US13877444
申请日：2011-09-30
CPC分类号： G03G15/80 , G03G15/162 , G03G2215/0132 , G03G2215/1661
摘要： An image forming apparatus sequentially transfers toner images formed on a plurality of photosensitive drums onto an intermediate transfer member or a transfer material to form an image. The image forming apparatus includes an intermediate transfer belt provided with electrical conductivity, and a power supply for applying a voltage to a current supply member contacting the outer circumferential surface of the intermediate transfer belt to pass a current from the current supply member to the plurality of photosensitive drums via the intermediate transfer belt, thus primarily transferring the toner images from the plurality of photosensitive drums onto the intermediate transfer belt.
摘要翻译： 图像形成装置将形成在多个感光鼓上的调色剂图像顺序地转印到中间转印部件或转印材料上以形成图像。 图像形成装置包括具有导电性的中间转印带和用于向与中间转印带的外周面接触的电流供给部件施加电压的电源，以将电流从电流供给部件传递到多个 感光鼓经由中间转印带，因此主要将调色剂图像从多个感光鼓转印到中间转印带上。
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公开(公告)号：US09052677B2
公开(公告)日：2015-06-09
申请号：US13877447
申请日：2011-09-30
CPC分类号： G03G15/80 , G03G15/1605 , G03G15/167 , G03G15/1675 , G03G15/1685 , G03G2215/0132 , G03G2215/1623 , G03G2215/1661
摘要： An image forming apparatus sequentially transfers toner images formed on a plurality of photosensitive drums onto an intermediate transfer member or a transfer material to form an image. The image forming apparatus includes an intermediate transfer belt provided with electrical conductivity, and a power supply for applying a voltage to a current supply member contacting the intermediate transfer belt to pass a current from the current supply member to the plurality of photosensitive drums via the intermediate transfer belt, thus generating electric discharge on the upstream side of each of primary transfer sections.
摘要翻译： 图像形成装置将形成在多个感光鼓上的调色剂图像顺序地转印到中间转印部件或转印材料上以形成图像。 图像形成装置包括具有导电性的中间转印带和用于向与中间转印带接触的电流供给部件施加电压的电源，以将电流从电流供给部件经由中间体传递到多个感光鼓 从而在一次转印部的上游侧产生放电。
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公开(公告)号：US20130188980A1
公开(公告)日：2013-07-25
申请号：US13877444
申请日：2011-09-30
IPC分类号： G03G15/00
CPC分类号： G03G15/80 , G03G15/162 , G03G2215/0132 , G03G2215/1661
摘要： An image forming apparatus sequentially transfers toner images formed on a plurality of photosensitive drums onto an intermediate transfer member or a transfer material to form an image. The image forming apparatus includes an intermediate transfer belt provided with electrical conductivity, and a power supply for applying a voltage to a current supply member contacting the outer circumferential surface of the intermediate transfer belt to pass a current from the current supply member to the plurality of photosensitive drums via the intermediate transfer belt, thus primarily transferring the toner images from the plurality of photosensitive drums onto the intermediate transfer belt.
摘要翻译： 图像形成装置将形成在多个感光鼓上的调色剂图像顺序地转印到中间转印部件或转印材料上以形成图像。 图像形成装置包括具有导电性的中间转印带和用于向与中间转印带的外周面接触的电流供给部件施加电压的电源，以将电流从电流供给部件传递到多个 感光鼓经由中间转印带，因此主要将调色剂图像从多个感光鼓转印到中间转印带上。
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公开(公告)号：US08222744B2
公开(公告)日：2012-07-17
申请号：US12688029
申请日：2010-01-15
CPC分类号： H01L21/563 , H01L2224/0554 , H01L2224/05567 , H01L2224/05573 , H01L2224/16225 , H01L2224/32225 , H01L2224/73203 , H01L2224/73204 , H01L2924/00014 , H01L2924/01012 , H01L2924/01019 , H01L2924/00 , H01L2224/05599 , H01L2224/0555 , H01L2224/0556
摘要： A semiconductor device includes: a mounted body in which a wiring pattern is formed on a first main surface; a semiconductor chip mounted on the surface of the mounted body on which the wiring pattern is formed; an underfill material which is filled between the mounted body and the semiconductor chip and forms a fillet on an outer peripheral part of the semiconductor chip; and an injection section which is disposed on the mounted body and on an outside of a side section, on which the fillet is formed to be longest, of four side sections defining a chip mount area on which the semiconductor chip is mounted, and guides the underfill material to between the mounted body and the semiconductor chip.
摘要翻译： 半导体器件包括：安装体，其中在第一主表面上形成布线图案; 安装在其上形成有布线图案的安装体的表面上的半导体芯片; 填充在所述安装体和所述半导体芯片之间的底部填充材料，在所述半导体芯片的外周部形成圆角; 以及喷射部，其设置在所述安装体上并且在所述圆角形状最远的侧部的外侧上限定安装所述半导体芯片的芯片安装区域的四个侧部，并且引导所述注射部 底部填充材料到安装体和半导体芯片之间。
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公开(公告)号：US07903989B2
公开(公告)日：2011-03-08
申请号：US12414002
申请日：2009-03-30
申请人： Takayuki Tanaka
发明人： Takayuki Tanaka
IPC分类号： G03G15/08
CPC分类号： G03G15/0818 , G03G15/0812 , G03G2215/0634
摘要： A developing apparatus includes a developer carrying member rotatably provided for carrying a developer; a regulating member that has conductivity, and is provided to be capable of being in contact with the developer carrying member for regulating a amount of the developer carried by the developer carrying member; a power supply that applies voltage to the regulating member; a deformation detecting unit that detects information relating to the deformation of the developer carrying member; and a control unit that controls the power supply to apply a correction voltage when a deformed portion of the developer carrying member passes through the regulating member in order that the amount of the developer carried by the developer carrying member in the circumferential direction is in uniform based on a result of the detection by the deformation detecting unit.
摘要翻译： 显影装置包括可旋转地设置用于承载显影剂的显影剂承载构件; 具有导电性的调节构件，并且被设置成能够与用于调节由显影剂承载构件承载的显影剂的量的显影剂承载构件接触; 向调节构件施加电压的电源; 变形检测单元，其检测与显影剂承载构件的变形有关的信息; 以及控制单元，当显影剂承载构件的变形部分通过调节构件时，控制电源施加校正电压，以便由显影剂承载构件在周向上承载的显影剂的量基于均匀的 由变形检测单元检测的结果。
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公开(公告)号：US07312239B2
公开(公告)日：2007-12-25
申请号：US10643404
申请日：2003-08-18
申请人： Takayuki Tanaka , Tatsuhiko Mori
发明人： Takayuki Tanaka , Tatsuhiko Mori
IPC分类号： A61K31/4152 , A61K31/381 , A61K31/341
CPC分类号： A61K31/4152
摘要： An object of the present invention is to provide a medicament and method which is useful for prevention and/or therapy of arterial wall injury. According to the present invention, there is provided a method for prevention and/or therapy of arterial wall injury which comprises a step of administering the pyrazolone derivative represented by the following formula (I) or the physiologically acceptable salt thereof, or the hydrate or solvate thereof in a preventively or therapeutically effective amount to mammals including humans: wherein R1 represents a hydrogen atom, an aryl group, an alkyl group, or an alkoxycarbonylalkyl group; R2 represents a hydrogen atom, an aryloxy group, an arylmercapto group, an alkyl group or a hydroxyalkyl group; or R1 and R2 are combined with each other to represent an alkylene group; and R3 represents a hydrogen atom, an alkyl group, a cycloalkyl group, a hydroxyalkyl group, a benzyl group, a naphthyl group, a phenyl group, or a phenyl group substituted with 1 to 3 substituents selected from the group consisting of an alkyl group, an alkoxy group, a hydroxyalkyl group, an alkoxycarbonyl group, an alkylmercapto group, an alkylamino group, a dialkylamino group, a halogen atom, a trifluoromethyl group, a carboxyl group, a cyano group, a hydroxyl group, a nitro group, an amino group and an acetamide group.
摘要翻译： 本发明的目的是提供一种可用于预防和/或治疗动脉壁损伤的药物和方法。 根据本发明，提供了一种预防和/或治疗动脉壁损伤的方法，包括给予由下式（I）表示的吡唑啉酮衍生物或其生理学上可接受的盐，或其水合物或溶剂化物 其具有预防或治疗有效量的哺乳动物包括人：其中R 1表示氢原子，芳基，烷基或烷氧基羰基烷基; R 2表示氢原子，芳氧基，芳基巯基，烷基或羟烷基; 或R 1和R 2彼此结合以表示亚烷基; R 3表示氢原子，烷基，环烷基，羟基烷基，苄基，萘基，苯基或被1〜3个取代基取代的苯基 由烷基，烷氧基，羟基烷基，烷氧基羰基，烷基巯基，烷基氨基，二烷基氨基，卤素原子，三氟甲基，羧基，氰基， 羟基，硝基，氨基和乙酰胺基。
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