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公开(公告)号:US07514238B2
公开(公告)日:2009-04-07
申请号:US11550237
申请日:2006-10-17
CPC分类号: C04B38/06 , A61K38/177 , A61K38/18 , A61K38/1866 , A61K38/22 , C04B2111/00224 , C04B2111/00612 , C07K14/52 , C07K2319/00 , C12N2799/022 , C04B20/008 , C04B35/2641 , C04B35/50 , C04B35/64 , C04B38/0054 , C04B38/007 , C04B41/4578 , A61K2300/00
摘要: Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 70% identical to residues 52-179 of SEQ ID NO:2 or residues 258-370 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
摘要翻译: 公开了多肽生长因子,其制备方法,编码它们的多核苷酸,针对它们的抗体以及使用它们的方法。 多肽包含与SEQ ID NO:2的残基52-179或SEQ ID NO:2的残基258-370至少70%相同的氨基酸区段。 还公开了多肽的多聚体。 多肽,多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节,作为细胞培养基的组分和诊断剂。
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公开(公告)号:US07375182B2
公开(公告)日:2008-05-20
申请号:US11080803
申请日:2005-03-15
CPC分类号: C04B38/06 , A61K38/177 , A61K38/18 , A61K38/1866 , A61K38/22 , C04B2111/00224 , C04B2111/00612 , C07K14/52 , C07K2319/00 , C12N2799/022 , C04B20/008 , C04B35/2641 , C04B35/50 , C04B35/64 , C04B38/0054 , C04B38/007 , C04B41/4578 , A61K2300/00
摘要: Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 70% identical to residues 52-179 of SEQ ID NO:2 or residues 258-370 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
摘要翻译: 公开了多肽生长因子,其制备方法,编码它们的多核苷酸,针对它们的抗体以及使用它们的方法。 多肽包含与SEQ ID NO:2的残基52-179或SEQ ID NO:2的残基258-370至少70%相同的氨基酸区段。 还公开了多肽的多聚体。 多肽,多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节,作为细胞培养基的组分和诊断剂。
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公开(公告)号:US20090253172A1
公开(公告)日:2009-10-08
申请号:US12395895
申请日:2009-03-02
CPC分类号: C04B38/06 , A61K38/177 , A61K38/18 , A61K38/1866 , A61K38/22 , C04B2111/00224 , C04B2111/00612 , C07K14/52 , C07K2319/00 , C12N2799/022 , C04B20/008 , C04B35/2641 , C04B35/50 , C04B35/64 , C04B38/0054 , C04B38/007 , C04B41/4578 , A61K2300/00
摘要: Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 70% identical to residues 52-179 of SEQ ID NO:2 or residues 258-370 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
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公开(公告)号:US06962802B2
公开(公告)日:2005-11-08
申请号:US09876813
申请日:2001-06-06
IPC分类号: A61K38/00 , A61K38/18 , A61K38/19 , C07K14/52 , C12N15/09 , A61K38/24 , A61K38/27 , C07H21/04 , C12N15/00
CPC分类号: C04B38/06 , A61K38/177 , A61K38/18 , A61K38/1866 , A61K38/22 , C04B2111/00224 , C04B2111/00612 , C07K14/52 , C07K2319/00 , C12N2799/022 , C04B20/008 , C04B35/2641 , C04B35/50 , C04B35/64 , C04B38/0054 , C04B38/007 , C04B41/4578 , A61K2300/00
摘要: Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 70% identical to residues 52-179 of SEQ ID NO:2 or residues 258-370 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
摘要翻译: 公开了多肽生长因子,其制备方法,编码它们的多核苷酸,针对它们的抗体以及使用它们的方法。 多肽包含与SEQ ID NO:2的残基52-179或SEQ ID NO:2的残基258-370至少70%相同的氨基酸区段。 还公开了多肽的多聚体。 多肽,多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节,作为细胞培养基的组分和诊断剂。
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公开(公告)号:US06495668B1
公开(公告)日:2002-12-17
申请号:US09564595
申请日:2000-05-03
IPC分类号: A61K3824
CPC分类号: C04B38/06 , A61K38/177 , A61K38/18 , A61K38/1866 , A61K38/22 , C04B2111/00224 , C04B2111/00612 , C07K14/52 , C07K2319/00 , C12N2799/022 , C04B20/008 , C04B35/2641 , C04B35/50 , C04B35/64 , C04B38/0054 , C04B38/007 , C04B41/4578 , A61K2300/00
摘要: Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
摘要翻译: 公开了多肽生长因子,其制备方法,编码它们的多核苷酸,针对它们的抗体以及使用它们的方法。 还公开了多肽的多聚体。 多肽,多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节,作为细胞培养基的组分和诊断剂。
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公开(公告)号:US07323446B2
公开(公告)日:2008-01-29
申请号:US11550246
申请日:2006-10-17
CPC分类号: C04B38/06 , A61K38/177 , A61K38/18 , A61K38/1866 , A61K38/22 , C04B2111/00224 , C04B2111/00612 , C07K14/52 , C07K2319/00 , C12N2799/022 , C04B20/008 , C04B35/2641 , C04B35/50 , C04B35/64 , C04B38/0054 , C04B38/007 , C04B41/4578 , A61K2300/00
摘要: Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 70% identical to residues 52-179 of SEQ ID NO:2 or residues 258-370 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
摘要翻译: 公开了多肽生长因子,其制备方法,编码它们的多核苷酸,针对它们的抗体以及使用它们的方法。 多肽包含与SEQ ID NO:2的残基52-179或SEQ ID NO:2的残基258-370至少70%相同的氨基酸区段。 还公开了多肽的多聚体。 多肽,多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节,作为细胞培养基的组分和诊断剂。
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公开(公告)号:US06432673B1
公开(公告)日:2002-08-13
申请号:US09457066
申请日:1999-12-07
申请人: Zeren Gao , Charles E. Hart , Christopher S. Piddington , Paul O. Sheppard , Kimberly E. Shoemaker , Debra G. Gilbertson , James W. West
发明人: Zeren Gao , Charles E. Hart , Christopher S. Piddington , Paul O. Sheppard , Kimberly E. Shoemaker , Debra G. Gilbertson , James W. West
IPC分类号: C12N1500
CPC分类号: C07K14/52 , A01K2217/05 , A61K38/1858 , C07K14/475 , C12N2799/022
摘要: Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO:2 or residues 235-345 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
摘要翻译: 公开了多肽生长因子,其制备方法,编码它们的多核苷酸,针对它们的抗体及其使用方法。 多肽包含与SEQ ID NO:2的残基46-163或SEQ ID NO:2的残基235-345至少90%相同的氨基酸区段。 还公开了多肽的多聚体。 多肽,多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节,作为细胞培养基的组分和诊断剂。
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公开(公告)号:US06814965B2
公开(公告)日:2004-11-09
申请号:US10139583
申请日:2002-05-02
申请人: Zeren Gao , Charles E. Hart , Christopher S. Piddington , Paul O. Sheppard , Kimberly E. Shoemaker , Debra G. Gilbertson , James W. West
发明人: Zeren Gao , Charles E. Hart , Christopher S. Piddington , Paul O. Sheppard , Kimberly E. Shoemaker , Debra G. Gilbertson , James W. West
IPC分类号: A61K39395
CPC分类号: C07K14/52 , A01K2217/05 , A61K38/1858 , C07K14/475 , C12N2799/022
摘要: Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO: 2 or residues 235-345 of SEQ ID NO: 2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
摘要翻译: 公开了多肽生长因子,其制备方法,编码它们的多核苷酸,针对它们的抗体以及使用它们的方法。 多肽包含与SEQ ID NO:2的残基46-163或SEQ ID NO:2的残基235-345至少90%相同的氨基酸区段。多肽的多聚体也被公开。 多肽,多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节,作为细胞培养基的组分和诊断剂。
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公开(公告)号:US20100167391A1
公开(公告)日:2010-07-01
申请号:US12107571
申请日:2008-04-22
申请人: Zeren Gao , Charles E. Hart , Christopher S. Piddington , Paul O. Sheppard , Kimberty E. Shoemaker , Debra G. Gilbertson , James W. West
发明人: Zeren Gao , Charles E. Hart , Christopher S. Piddington , Paul O. Sheppard , Kimberty E. Shoemaker , Debra G. Gilbertson , James W. West
IPC分类号: C12N5/071
CPC分类号: C07K14/52 , A01K2217/05 , A61K38/1858 , C07K14/475 , C12N2799/022
摘要: Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO:2 or residues 235-345 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
摘要翻译: 公开了多肽生长因子,其制备方法,编码它们的多核苷酸,针对它们的抗体以及使用它们的方法。 多肽包含与SEQ ID NO:2的残基46-163或SEQ ID NO:2的残基235-345至少90%相同的氨基酸区段。 还公开了多肽的多聚体。 多肽,多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节,作为细胞培养基的组分和诊断剂。
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公开(公告)号:US07691981B2
公开(公告)日:2010-04-06
申请号:US11552378
申请日:2006-10-24
申请人: Zeren Gao , Charles E. Hart , Christopher S. Piddington , Paul O. Sheppard , Kimberly E. Shoemaker
发明人: Zeren Gao , Charles E. Hart , Christopher S. Piddington , Paul O. Sheppard , Kimberly E. Shoemaker
IPC分类号: C12N15/00
CPC分类号: C07K14/52 , A01K2217/05 , A61K38/1858 , C07K14/475 , C12N2799/022
摘要: Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO:2 or residues 235-345 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
摘要翻译: 公开了多肽生长因子,其制备方法,编码它们的多核苷酸,针对它们的抗体以及使用它们的方法。 多肽包含与SEQ ID NO:2的残基46-163或SEQ ID NO:2的残基235-345至少90%相同的氨基酸区段。 还公开了多肽的多聚体。 多肽,多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节,作为细胞培养基的组分和诊断剂。
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