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1.发明授权Quinolyl- and isoquinolyl-methoxyphenyl-dithioacetyl derivatives useful as antiinflammatory agents 失效用作抗炎药物的喹诺酮和异喹啉基 - 甲氧基苯基 - 二硫代乙醇衍生物
公开(公告)号：US5081126A
公开(公告)日：1992-01-14
申请号：US538722
申请日：1990-06-15
IPC分类号： C12N9/99 , A61K31/38 , A61K31/42 , A61K31/423 , A61K31/425 , A61K31/428 , A61K31/435 , A61K31/44 , A61K31/4402 , A61K31/4418 , A61K31/4433 , A61K31/47 , A61P29/00 , A61P37/08 , A61P43/00 , C07C67/00 , C07C313/00 , C07C323/16 , C07D213/30 , C07D215/14 , C07D215/20 , C07D235/12 , C07D235/26 , C07D237/08 , C07D237/14 , C07D239/72 , C07D239/74 , C07D241/12 , C07D241/18 , C07D263/56 , C07D263/58 , C07D277/24 , C07D277/32 , C07D277/64 , C07D339/08 , C07D409/12 , C07D471/04 , C07D521/00
CPC分类号： C07D213/30 , C07C323/00 , C07D215/14 , C07D235/12 , C07D239/74 , C07D263/56 , C07D277/32 , C07D277/64 , C07D339/08 , C07D471/04
摘要： The invention relates to dithioacetal compounds having 5-lipoxygenase-inhibiting activity, of the formula: ##STR1## wherein R.sup.1 is lower alkyl, di-(lower)alkylamino, aryl, or heterocyclic group which may have one or more substitutents selected from halogen, lower alkyl, lower alkoxy and phenyl,R.sup.2 and R.sup.3 are each lower alkyl, aryl or ar-(lower)alkyl, or R.sup.2 and R.sup.3 are together to form 1,3-dithian ring,R.sup.4 is hydrogen or lower alkoxy, andn is 0 or an integer 1 to 4 and pharmaceutically acceptable salts thereof.
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2.发明授权Dithioacetal compounds, processes for preparation thereof and pharmaceutical composition comprising the same 失效二硫缩醛化合物，其制备方法和包含其的药物组合物
公开(公告)号：US4963576A
公开(公告)日：1990-10-16
申请号：US191253
申请日：1988-05-06
IPC分类号： C12N9/99 , A61K31/38 , A61K31/42 , A61K31/423 , A61K31/425 , A61K31/428 , A61K31/435 , A61K31/44 , A61K31/4402 , A61K31/4418 , A61K31/4433 , A61K31/47 , A61P29/00 , A61P37/08 , A61P43/00 , C07C67/00 , C07C313/00 , C07C323/16 , C07D213/30 , C07D215/14 , C07D215/20 , C07D235/12 , C07D235/26 , C07D237/08 , C07D237/14 , C07D239/72 , C07D239/74 , C07D241/12 , C07D241/18 , C07D263/56 , C07D263/58 , C07D277/24 , C07D277/32 , C07D277/64 , C07D339/08 , C07D409/12 , C07D471/04 , C07D521/00
CPC分类号： C07D213/30 , C07C323/00 , C07D215/14 , C07D235/12 , C07D239/74 , C07D263/56 , C07D277/32 , C07D277/64 , C07D339/08 , C07D471/04
摘要： The invention relates to dithioacetal compounds having 5-lipoxygenase-inhibiting activity, of the formula: ##STR1## wherein R.sup.1 is lower alkyl, di-(lower)alkylamino, aryl, or heterocyclic group which may have one or more substituents selected from halogen, lower alkyl, lower alkoxy and phenyl,R.sup.2 and R.sup.3 are each lower alkyl, aryl or ar-(lower)alkyl, or R.sup.2 and R.sup.3 are together to form 1,3-dithian ring,R.sup.4 is hydrogen or lower alkoxy, andn is O or an integer 1 to 4 and pharmaceutically acceptable salts thereof.
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3.发明授权Benzothiazolylmethoxy compounds, pharmaceutical compositions comprising the same and their use as anti-inflammatory or anti-allergenic agents 失效苯并咪唑化合物，包含该化合物的药物组合物及其作为抗炎剂或抗过敏剂的用途
公开(公告)号：US5061718A
公开(公告)日：1991-10-29
申请号：US472231
申请日：1990-01-30
IPC分类号： C12N9/99 , A61K31/085 , A61K31/12 , A61K31/165 , A61K31/275 , A61K31/33 , A61K31/415 , A61K31/4184 , A61K31/425 , A61K31/428 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61K31/47 , A61P1/00 , A61P1/16 , A61P9/08 , A61P9/10 , A61P13/02 , A61P15/00 , A61P29/00 , A61P37/08 , A61P43/00 , C07C41/00 , C07C41/01 , C07C41/26 , C07C43/23 , C07C45/00 , C07C45/67 , C07C45/68 , C07C46/00 , C07C49/747 , C07C49/755 , C07C50/12 , C07C67/00 , C07C231/00 , C07C231/06 , C07C231/12 , C07C235/20 , C07C235/42 , C07C253/00 , C07C253/30 , C07C255/32 , C07C255/52 , C07C255/54 , C07D213/30 , C07D213/64 , C07D215/14 , C07D215/20 , C07D215/26 , C07D231/12 , C07D235/08 , C07D235/12 , C07D237/08 , C07D239/26 , C07D277/64 , C07D277/68 , C07D521/00 , C07F7/18
CPC分类号： C07D213/30 , C07C255/00 , C07C45/673 , C07C45/68 , C07C49/747 , C07C49/755 , C07D215/14 , C07D235/12 , C07D277/64 , C07F7/1856
摘要： The invention relates to an anti-inflammatory or antiallergic composition containing a compound of the formula ##STR1## wherein A is ##STR2## R.sup.1 is aryl which may have cyano or carbamoyl, or heterocyclic group which may have lower alkyl,R.sup.2 is hydrogen or lower alkyl,R.sup.3 is lower alkyl,X is hydrogen, halogen, hydroxy or lower alkyl,m is an integer 1 or 2, andn is an integer 1 to 4, or pharmaceutically acceptable salts thereof.
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公开(公告)号：US5045548A
公开(公告)日：1991-09-03
申请号：US550086
申请日：1990-07-09
IPC分类号： C12N9/99 , A61K31/085 , A61K31/12 , A61K31/165 , A61K31/275 , A61K31/33 , A61K31/415 , A61K31/4184 , A61K31/425 , A61K31/428 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61K31/47 , A61P1/00 , A61P1/16 , A61P9/08 , A61P9/10 , A61P13/02 , A61P15/00 , A61P29/00 , A61P37/08 , A61P43/00 , C07C41/00 , C07C41/01 , C07C41/26 , C07C43/23 , C07C45/00 , C07C45/67 , C07C45/68 , C07C46/00 , C07C49/747 , C07C49/755 , C07C50/12 , C07C67/00 , C07C231/00 , C07C231/06 , C07C231/12 , C07C235/20 , C07C235/42 , C07C253/00 , C07C253/30 , C07C255/32 , C07C255/52 , C07C255/54 , C07D213/30 , C07D213/64 , C07D215/14 , C07D215/20 , C07D215/26 , C07D231/12 , C07D235/08 , C07D235/12 , C07D237/08 , C07D239/26 , C07D277/64 , C07D277/68 , C07D521/00 , C07F7/18
CPC分类号： C07D213/30 , C07C255/00 , C07C45/673 , C07C45/68 , C07C49/747 , C07C49/755 , C07D215/14 , C07D235/12 , C07D277/64 , C07F7/1856
摘要： The invention relates to a method of treating asthma comprising administering a compound of the formula: ##STR1## wherein A is ##STR2## R.sup.1 is quinolyl, R.sup.2 is hydrogen or lower alkyl,R.sup.3 is lower alkyl,X is hydrogen, halogen, hydroxy or lower alkyl,m is integer 1 or 2, andn is an integer 1 or 4, or pharmaceutically acceptable salts thereof.
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公开(公告)号：US4923881A
公开(公告)日：1990-05-08
申请号：US181174
申请日：1988-04-13
IPC分类号： C12N9/99 , A61K31/085 , A61K31/12 , A61K31/165 , A61K31/275 , A61K31/33 , A61K31/415 , A61K31/4184 , A61K31/425 , A61K31/428 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61K31/47 , A61P1/00 , A61P1/16 , A61P9/08 , A61P9/10 , A61P13/02 , A61P15/00 , A61P29/00 , A61P37/08 , A61P43/00 , C07C41/00 , C07C41/01 , C07C41/26 , C07C43/23 , C07C45/00 , C07C45/67 , C07C45/68 , C07C46/00 , C07C49/747 , C07C49/755 , C07C50/12 , C07C67/00 , C07C231/00 , C07C231/06 , C07C231/12 , C07C235/20 , C07C235/42 , C07C253/00 , C07C253/30 , C07C255/32 , C07C255/52 , C07C255/54 , C07D213/30 , C07D213/64 , C07D215/14 , C07D215/20 , C07D215/26 , C07D231/12 , C07D235/08 , C07D235/12 , C07D237/08 , C07D239/26 , C07D277/64 , C07D277/68 , C07D521/00 , C07F7/18
CPC分类号： C07D213/30 , C07C255/00 , C07C45/673 , C07C45/68 , C07C49/747 , C07C49/755 , C07D215/14 , C07D235/12 , C07D277/64 , C07F7/1856
摘要： The invention relates to an anti-inflammatory or antiallergic composition containing a compound of the formula ##STR1## wherein A is ##STR2## R.sup.1 is aryl which may have cyano or carbamoyl, or heterocyclic group which may have lower alkyl,R.sup.2 is hydrogen or lower alkyl,R.sup.3 is lower alkyl,X is hydrogen, halogen, hydroxy or lower alkyl,m is an integer 1 or 2, andn is an integer 1 to 4, or pharmaceutically acceptable salts thereof.
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6.发明授权Quinolyl methoxy compounds, processes for preparation thereof and pharmaceutical composition comprising the same 失效喹啉甲氧基化合物，其制备方法和包含其的药物组合物
公开(公告)号：US4965274A
公开(公告)日：1990-10-23
申请号：US329317
申请日：1989-03-27
IPC分类号： C12N9/99 , A61K31/085 , A61K31/12 , A61K31/165 , A61K31/275 , A61K31/33 , A61K31/415 , A61K31/4184 , A61K31/425 , A61K31/428 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61K31/47 , A61P1/00 , A61P1/16 , A61P9/08 , A61P9/10 , A61P13/02 , A61P15/00 , A61P29/00 , A61P37/08 , A61P43/00 , C07C41/00 , C07C41/01 , C07C41/26 , C07C43/23 , C07C45/00 , C07C45/67 , C07C45/68 , C07C46/00 , C07C49/747 , C07C49/755 , C07C50/12 , C07C67/00 , C07C231/00 , C07C231/06 , C07C231/12 , C07C235/20 , C07C235/42 , C07C253/00 , C07C253/30 , C07C255/32 , C07C255/52 , C07C255/54 , C07D213/30 , C07D213/64 , C07D215/14 , C07D215/20 , C07D215/26 , C07D231/12 , C07D235/08 , C07D235/12 , C07D237/08 , C07D239/26 , C07D277/64 , C07D277/68 , C07D521/00 , C07F7/18
CPC分类号： C07D213/30 , C07C255/00 , C07C45/673 , C07C45/68 , C07C49/747 , C07C49/755 , C07D215/14 , C07D235/12 , C07D277/64 , C07F7/1856
摘要： The invention relates to a method of treating arteriosclerosis or pancreatitis comprising administering a compound of the formula: ##STR1## wherein A is ##STR2## R.sup.1 is quinolyl, R.sup.2 is hydrogen or lower alkyl,R.sup.3 is lower alkyl,X is hydrogen, halogen, hydroxy or lower alkyl,m is an integer 1 or 2, andn is an integer 1 to 4, or pharmaceutically acceptable salts thereof.
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7.发明授权
公开(公告)号：US4857513A
公开(公告)日：1989-08-15
申请号：US42444
申请日：1987-04-24
申请人： Teruo Oku , Eishiro Todo , Chiyoshi Kasahara , Katsuya Nakamura , Hiroshi Kayakiri , Masashi Hashimoto
发明人： Teruo Oku , Eishiro Todo , Chiyoshi Kasahara , Katsuya Nakamura , Hiroshi Kayakiri , Masashi Hashimoto
IPC分类号： C07F9/38 , C07F9/58 , C07F9/60 , C07F9/6506 , C07F9/6553
CPC分类号： C07F9/588 , C07F9/3873 , C07F9/60 , C07F9/65067 , C07F9/655354
摘要： A compound of the formula: ##STR1## wherein R.sup.1 --A-- is a group of the formula: ##STR2## in which R.sup.1 is aryl or a heterocyclic group, each of which may be substituted with substituent(s) selected from the group consisting of lower alkyl, lower alkoxy, lower alkylthio, halo(lower)alkyl, acyl, acylamino and halogen, or lower alkyl which may be substituted with a heterocyclic group optionally substituted with acyl, andX is O or S, andR.sup.2 is hydrogen or lower alkyl, provided that when R.sup.1 is lower alkyl, thenR.sup.1 --A-- is a group of the formula: ##STR3## in which R.sup.1 and X are each as defined above, and pharmaceutically acceptable salts thereof, processes for the preparation thereof and pharmaceutical composition comprising the same.
摘要翻译： 下式的化合物：其中R 1 -A是下式的基团：其中R 1是芳基或杂环基，其各自可以被选自以下的取代基取代： 低级烷基，低级烷硫基，卤代（低级）烷基，酰基，酰氨基和卤素，或可以被任选被酰基取代的杂环基取代的低级烷基，X是O或S，R2是氢或 低级烷基，条件是当R 1是低级烷基时，则R 1 -A是下式的基团：其中R 1和X各自如上定义，及其药学上可接受的盐，其制备方法和药物 包含它的组合物。
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公开(公告)号：US5250528A
公开(公告)日：1993-10-05
申请号：US957759
申请日：1992-10-08
IPC分类号： C07D295/28 , C07D295/32 , A61K31/495 , C07D403/06 , C07D409/06
CPC分类号： C07D295/32 , C07D295/30
摘要： This invention relates to new aminopiperazine derivatives having the potentiation of the cholinergic activity and represented by the general formula [I]: ##STR1## wherein R.sup.1 is lower alkyl, aryl, ar(lower)alkoxy or a heterocyclic group, each of which may be substituted with halogen,R.sup.2 is hydrogen or lower alkyl,R.sup.3 is cyclo(lower)alkyl, aryl or ar(lower)-alkyl, each of which may be substituted with halogen,A is ##STR2## or lower alkylene, and Y is ##STR3## and pharmaceutically acceptable salts thereof, to processes for the preparation thereof and to a pharmaceutical composition comprising the same.
摘要翻译： 本发明涉及具有增强胆碱能活性并由通式[I]表示的新氨基哌嗪衍生物：其中R 1是低级烷基，芳基，芳（低级）烷氧基或杂环基，其各自为 其可以被卤素取代，R 2是氢或低级烷基，R 3是环（低级）烷基，芳基或芳（低级） - 烷基，其各自可以被卤素取代，A是低级亚烷基，和 Y是其和药学上可接受的盐，其制备方法和包含其的药物组合物。
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9.发明授权Diphosphonic acid compounds, and pharmaceutical composition comprising the same useful for treating bone diseases 失效二膦酸化合物，以及包含可用于治疗骨疾病的药物组合物
公开(公告)号：US4963536A
公开(公告)日：1990-10-16
申请号：US333953
申请日：1989-04-06
申请人： Teruo Oku , Eishiro Todo , Chiyoshi Kasahara , Katsuya Nakamura , Hiroshi Kayakiri , Masashi Hashimoto
发明人： Teruo Oku , Eishiro Todo , Chiyoshi Kasahara , Katsuya Nakamura , Hiroshi Kayakiri , Masashi Hashimoto
IPC分类号： C07F9/38 , C07F9/58 , C07F9/60 , C07F9/6506 , C07F9/6553
CPC分类号： C07F9/588 , C07F9/3873 , C07F9/60 , C07F9/65067 , C07F9/655354
摘要： A compound of the formula: ##STR1## wherein R.sup.1 -A- is a group of the formula: ##STR2## in which R.sup.1 is aryl or a heterocyclic group, each of which may be substituted with substituent(s) selected from the group consisting of lower alkyl, lower alkoxy, lower alkylthio, halo(lower)alkyl, acyl, acylamino and halogen, or lower alkyl which may be substituted with a heterocyclic group optionally substituted with acyl, andX is O or S, andR.sup.2 is hydrogen or lower alkyl, provided that when R.sup.1 is lower alkyl, thenR.sup.1 -A- is a group of the formula: ##STR3## in which R.sup.1 and X are each as defined above, processes for the preparation thereof and pharmaceutical composition comprising the same.
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公开(公告)号：US4954496A
公开(公告)日：1990-09-04
申请号：US386232
申请日：1989-07-28
IPC分类号： C07D303/26 , A61K31/335 , A61K31/336 , A61K31/535 , A61P9/00 , C07D303/22 , C07D303/34
CPC分类号： C07D303/22 , C07D303/34 , Y10S514/825 , Y10S514/863 , Y10S514/866
摘要： The invention relates to a cyclohexane derivative, useful as an angiogenesis inhibitor, of the formula: ##STR1## wherein R.sup.1 is halomethyl; or arylthiomethyl which may have amino, lower alkoxy or acylamino,R.sup.2 is lower alkoxy,R.sup.3 is ##STR2## or ##STR3## and R.sup.4 is hydrogen, lower alkylcarbamoyl, lower alkylcarbamoyloxy(lower)alkylcarbamoyl, heterocyclic carbonyl or heterocyclic carbamoyl, or salt thereof.
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