-
公开(公告)号：US5045548A
公开(公告)日：1991-09-03
申请号：US550086
申请日：1990-07-09
IPC分类号： C12N9/99 , A61K31/085 , A61K31/12 , A61K31/165 , A61K31/275 , A61K31/33 , A61K31/415 , A61K31/4184 , A61K31/425 , A61K31/428 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61K31/47 , A61P1/00 , A61P1/16 , A61P9/08 , A61P9/10 , A61P13/02 , A61P15/00 , A61P29/00 , A61P37/08 , A61P43/00 , C07C41/00 , C07C41/01 , C07C41/26 , C07C43/23 , C07C45/00 , C07C45/67 , C07C45/68 , C07C46/00 , C07C49/747 , C07C49/755 , C07C50/12 , C07C67/00 , C07C231/00 , C07C231/06 , C07C231/12 , C07C235/20 , C07C235/42 , C07C253/00 , C07C253/30 , C07C255/32 , C07C255/52 , C07C255/54 , C07D213/30 , C07D213/64 , C07D215/14 , C07D215/20 , C07D215/26 , C07D231/12 , C07D235/08 , C07D235/12 , C07D237/08 , C07D239/26 , C07D277/64 , C07D277/68 , C07D521/00 , C07F7/18
CPC分类号： C07D213/30 , C07C255/00 , C07C45/673 , C07C45/68 , C07C49/747 , C07C49/755 , C07D215/14 , C07D235/12 , C07D277/64 , C07F7/1856
摘要： The invention relates to a method of treating asthma comprising administering a compound of the formula: ##STR1## wherein A is ##STR2## R.sup.1 is quinolyl, R.sup.2 is hydrogen or lower alkyl,R.sup.3 is lower alkyl,X is hydrogen, halogen, hydroxy or lower alkyl,m is integer 1 or 2, andn is an integer 1 or 4, or pharmaceutically acceptable salts thereof.
-
公开(公告)号：US4923881A
公开(公告)日：1990-05-08
申请号：US181174
申请日：1988-04-13
IPC分类号： C12N9/99 , A61K31/085 , A61K31/12 , A61K31/165 , A61K31/275 , A61K31/33 , A61K31/415 , A61K31/4184 , A61K31/425 , A61K31/428 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61K31/47 , A61P1/00 , A61P1/16 , A61P9/08 , A61P9/10 , A61P13/02 , A61P15/00 , A61P29/00 , A61P37/08 , A61P43/00 , C07C41/00 , C07C41/01 , C07C41/26 , C07C43/23 , C07C45/00 , C07C45/67 , C07C45/68 , C07C46/00 , C07C49/747 , C07C49/755 , C07C50/12 , C07C67/00 , C07C231/00 , C07C231/06 , C07C231/12 , C07C235/20 , C07C235/42 , C07C253/00 , C07C253/30 , C07C255/32 , C07C255/52 , C07C255/54 , C07D213/30 , C07D213/64 , C07D215/14 , C07D215/20 , C07D215/26 , C07D231/12 , C07D235/08 , C07D235/12 , C07D237/08 , C07D239/26 , C07D277/64 , C07D277/68 , C07D521/00 , C07F7/18
CPC分类号： C07D213/30 , C07C255/00 , C07C45/673 , C07C45/68 , C07C49/747 , C07C49/755 , C07D215/14 , C07D235/12 , C07D277/64 , C07F7/1856
摘要： The invention relates to an anti-inflammatory or antiallergic composition containing a compound of the formula ##STR1## wherein A is ##STR2## R.sup.1 is aryl which may have cyano or carbamoyl, or heterocyclic group which may have lower alkyl,R.sup.2 is hydrogen or lower alkyl,R.sup.3 is lower alkyl,X is hydrogen, halogen, hydroxy or lower alkyl,m is an integer 1 or 2, andn is an integer 1 to 4, or pharmaceutically acceptable salts thereof.
-
3.发明授权Quinolyl- and isoquinolyl-methoxyphenyl-dithioacetyl derivatives useful as antiinflammatory agents 失效用作抗炎药物的喹诺酮和异喹啉基 - 甲氧基苯基 - 二硫代乙醇衍生物
公开(公告)号：US5081126A
公开(公告)日：1992-01-14
申请号：US538722
申请日：1990-06-15
IPC分类号： C12N9/99 , A61K31/38 , A61K31/42 , A61K31/423 , A61K31/425 , A61K31/428 , A61K31/435 , A61K31/44 , A61K31/4402 , A61K31/4418 , A61K31/4433 , A61K31/47 , A61P29/00 , A61P37/08 , A61P43/00 , C07C67/00 , C07C313/00 , C07C323/16 , C07D213/30 , C07D215/14 , C07D215/20 , C07D235/12 , C07D235/26 , C07D237/08 , C07D237/14 , C07D239/72 , C07D239/74 , C07D241/12 , C07D241/18 , C07D263/56 , C07D263/58 , C07D277/24 , C07D277/32 , C07D277/64 , C07D339/08 , C07D409/12 , C07D471/04 , C07D521/00
CPC分类号： C07D213/30 , C07C323/00 , C07D215/14 , C07D235/12 , C07D239/74 , C07D263/56 , C07D277/32 , C07D277/64 , C07D339/08 , C07D471/04
摘要： The invention relates to dithioacetal compounds having 5-lipoxygenase-inhibiting activity, of the formula: ##STR1## wherein R.sup.1 is lower alkyl, di-(lower)alkylamino, aryl, or heterocyclic group which may have one or more substitutents selected from halogen, lower alkyl, lower alkoxy and phenyl,R.sup.2 and R.sup.3 are each lower alkyl, aryl or ar-(lower)alkyl, or R.sup.2 and R.sup.3 are together to form 1,3-dithian ring,R.sup.4 is hydrogen or lower alkoxy, andn is 0 or an integer 1 to 4 and pharmaceutically acceptable salts thereof.
-
4.发明授权Dithioacetal compounds, processes for preparation thereof and pharmaceutical composition comprising the same 失效二硫缩醛化合物，其制备方法和包含其的药物组合物
公开(公告)号：US4963576A
公开(公告)日：1990-10-16
申请号：US191253
申请日：1988-05-06
IPC分类号： C12N9/99 , A61K31/38 , A61K31/42 , A61K31/423 , A61K31/425 , A61K31/428 , A61K31/435 , A61K31/44 , A61K31/4402 , A61K31/4418 , A61K31/4433 , A61K31/47 , A61P29/00 , A61P37/08 , A61P43/00 , C07C67/00 , C07C313/00 , C07C323/16 , C07D213/30 , C07D215/14 , C07D215/20 , C07D235/12 , C07D235/26 , C07D237/08 , C07D237/14 , C07D239/72 , C07D239/74 , C07D241/12 , C07D241/18 , C07D263/56 , C07D263/58 , C07D277/24 , C07D277/32 , C07D277/64 , C07D339/08 , C07D409/12 , C07D471/04 , C07D521/00
CPC分类号： C07D213/30 , C07C323/00 , C07D215/14 , C07D235/12 , C07D239/74 , C07D263/56 , C07D277/32 , C07D277/64 , C07D339/08 , C07D471/04
摘要： The invention relates to dithioacetal compounds having 5-lipoxygenase-inhibiting activity, of the formula: ##STR1## wherein R.sup.1 is lower alkyl, di-(lower)alkylamino, aryl, or heterocyclic group which may have one or more substituents selected from halogen, lower alkyl, lower alkoxy and phenyl,R.sup.2 and R.sup.3 are each lower alkyl, aryl or ar-(lower)alkyl, or R.sup.2 and R.sup.3 are together to form 1,3-dithian ring,R.sup.4 is hydrogen or lower alkoxy, andn is O or an integer 1 to 4 and pharmaceutically acceptable salts thereof.
-
5.发明授权Benzothiazolylmethoxy compounds, pharmaceutical compositions comprising the same and their use as anti-inflammatory or anti-allergenic agents 失效苯并咪唑化合物，包含该化合物的药物组合物及其作为抗炎剂或抗过敏剂的用途
公开(公告)号：US5061718A
公开(公告)日：1991-10-29
申请号：US472231
申请日：1990-01-30
IPC分类号： C12N9/99 , A61K31/085 , A61K31/12 , A61K31/165 , A61K31/275 , A61K31/33 , A61K31/415 , A61K31/4184 , A61K31/425 , A61K31/428 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61K31/47 , A61P1/00 , A61P1/16 , A61P9/08 , A61P9/10 , A61P13/02 , A61P15/00 , A61P29/00 , A61P37/08 , A61P43/00 , C07C41/00 , C07C41/01 , C07C41/26 , C07C43/23 , C07C45/00 , C07C45/67 , C07C45/68 , C07C46/00 , C07C49/747 , C07C49/755 , C07C50/12 , C07C67/00 , C07C231/00 , C07C231/06 , C07C231/12 , C07C235/20 , C07C235/42 , C07C253/00 , C07C253/30 , C07C255/32 , C07C255/52 , C07C255/54 , C07D213/30 , C07D213/64 , C07D215/14 , C07D215/20 , C07D215/26 , C07D231/12 , C07D235/08 , C07D235/12 , C07D237/08 , C07D239/26 , C07D277/64 , C07D277/68 , C07D521/00 , C07F7/18
CPC分类号： C07D213/30 , C07C255/00 , C07C45/673 , C07C45/68 , C07C49/747 , C07C49/755 , C07D215/14 , C07D235/12 , C07D277/64 , C07F7/1856
摘要： The invention relates to an anti-inflammatory or antiallergic composition containing a compound of the formula ##STR1## wherein A is ##STR2## R.sup.1 is aryl which may have cyano or carbamoyl, or heterocyclic group which may have lower alkyl,R.sup.2 is hydrogen or lower alkyl,R.sup.3 is lower alkyl,X is hydrogen, halogen, hydroxy or lower alkyl,m is an integer 1 or 2, andn is an integer 1 to 4, or pharmaceutically acceptable salts thereof.
-
6.发明授权Quinolyl methoxy compounds, processes for preparation thereof and pharmaceutical composition comprising the same 失效喹啉甲氧基化合物，其制备方法和包含其的药物组合物
公开(公告)号：US4965274A
公开(公告)日：1990-10-23
申请号：US329317
申请日：1989-03-27
IPC分类号： C12N9/99 , A61K31/085 , A61K31/12 , A61K31/165 , A61K31/275 , A61K31/33 , A61K31/415 , A61K31/4184 , A61K31/425 , A61K31/428 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61K31/47 , A61P1/00 , A61P1/16 , A61P9/08 , A61P9/10 , A61P13/02 , A61P15/00 , A61P29/00 , A61P37/08 , A61P43/00 , C07C41/00 , C07C41/01 , C07C41/26 , C07C43/23 , C07C45/00 , C07C45/67 , C07C45/68 , C07C46/00 , C07C49/747 , C07C49/755 , C07C50/12 , C07C67/00 , C07C231/00 , C07C231/06 , C07C231/12 , C07C235/20 , C07C235/42 , C07C253/00 , C07C253/30 , C07C255/32 , C07C255/52 , C07C255/54 , C07D213/30 , C07D213/64 , C07D215/14 , C07D215/20 , C07D215/26 , C07D231/12 , C07D235/08 , C07D235/12 , C07D237/08 , C07D239/26 , C07D277/64 , C07D277/68 , C07D521/00 , C07F7/18
CPC分类号： C07D213/30 , C07C255/00 , C07C45/673 , C07C45/68 , C07C49/747 , C07C49/755 , C07D215/14 , C07D235/12 , C07D277/64 , C07F7/1856
摘要： The invention relates to a method of treating arteriosclerosis or pancreatitis comprising administering a compound of the formula: ##STR1## wherein A is ##STR2## R.sup.1 is quinolyl, R.sup.2 is hydrogen or lower alkyl,R.sup.3 is lower alkyl,X is hydrogen, halogen, hydroxy or lower alkyl,m is an integer 1 or 2, andn is an integer 1 to 4, or pharmaceutically acceptable salts thereof.
-
公开(公告)号：US5478827A
公开(公告)日：1995-12-26
申请号：US269520
申请日：1994-07-01
申请人： Teruo Oku , Yoshio Kawai , Hiroshi Marusawa , Hitoshi Yamazaki , Yoshito Abe , Hirokazu Tanaka
发明人： Teruo Oku , Yoshio Kawai , Hiroshi Marusawa , Hitoshi Yamazaki , Yoshito Abe , Hirokazu Tanaka
IPC分类号： A61K31/415 , A61K31/505 , A61K31/53 , A61P29/00 , A61P37/00 , A61P43/00 , C07D487/04
CPC分类号： C07D487/04
摘要： This invention relates to heterocyclic derivatives useful for inhibiting the production of Interleukin-1 (IL-1) and tumor necrosis factor (TNF) and the like, which can be represented by the following formula: ##STR1## to a process for their production, to a pharmaceutical composition containing the same and to uses thereof.
摘要翻译： 本发明涉及可用于抑制白细胞介素-1（IL-1）和肿瘤坏死因子（TNF）等的产生的杂环衍生物，其可以由下式表示：（I） 它们的生产，涉及含有该组合物的药物组合物及其用途。
-
公开(公告)号：US5858995A
公开(公告)日：1999-01-12
申请号：US727627
申请日：1996-10-25
申请人： Yoshio Kawai , Hitoshi Yamazaki , Natsuko Kayakiri , Kousei Yoshihara , Takumi Yatabe , Teruo Oku
发明人： Yoshio Kawai , Hitoshi Yamazaki , Natsuko Kayakiri , Kousei Yoshihara , Takumi Yatabe , Teruo Oku
IPC分类号： C07D333/54 , A61K31/34 , A61K31/343 , A61K31/38 , A61K31/381 , A61K31/415 , A61K31/42 , A61K31/44 , A61K31/443 , A61K31/4433 , A61K31/55 , A61P3/02 , A61P43/00 , C07C233/76 , C07D209/94 , C07D223/32 , C07D307/79 , C07D307/80 , C07D307/81 , C07D307/82 , C07D307/91 , C07D405/04 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D491/052 , C07D495/04 , C07D521/00 , C07F7/18 , C07F9/655
CPC分类号： C07D307/79 , C07C233/76 , C07D209/94 , C07D223/32 , C07D231/12 , C07D233/56 , C07D249/08 , C07D307/80 , C07D307/81 , C07D307/82 , C07D307/91 , C07D405/04 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D495/04 , C07F7/1856 , C07F9/65517 , C07C2103/30
摘要： This invention relates to a novel heterocyclic compound represented by formula (I), wherein each symbol is as defined in the specification and a pharmaceutically acceptable salt thereof which are the inhibitors of bone resorption and bone metabolism, to processes for preparation thereof, to a pharmaceutical composition comprising the same and to a method for the treatment of diseases caused by abnormal bone metabolism in human being or an animal.
摘要翻译： PCT No.PCT / JP95 / 00787 Sec。 371日期1996年10月25日第 102（e）日期1996年10月25日PCT提交1995年4月21日PCT公布。 WO95 / 29907 PCT公开号 （I）日本本发明涉及由式（I）表示的新型杂环化合物，其中每个符号如说明书中所定义，和其药学上可接受的盐，其为骨吸收抑制剂， 骨代谢，其制备方法，包含其的药物组合物和治疗由人或动物异常骨代谢引起的疾病的方法。
-
公开(公告)号：US5356897A
公开(公告)日：1994-10-18
申请号：US931093
申请日：1992-08-17
申请人： Teruo Oku , Yoshio Kawai , Hiroshi Marusawa , Hitoshi Yamazaki , Yoshito Abe , Hirokazu Tanaka
发明人： Teruo Oku , Yoshio Kawai , Hiroshi Marusawa , Hitoshi Yamazaki , Yoshito Abe , Hirokazu Tanaka
IPC分类号： A61K31/415 , A61K31/505 , A61K31/53 , A61P29/00 , A61P37/00 , A61P43/00 , C07D487/04
CPC分类号： C07D487/04
摘要： This invention relates to heterocyclic derivatives useful for inhibiting the production of Interleukin-1 (IL-1) and tumor necrosis factor (TNF) and the like, which can be represented by the following formula: ##STR1## to a process for their production, to a pharmaceutical composition containing the same and to uses thereof.
摘要翻译： 本发明涉及可用于抑制白细胞介素-1（IL-1）和肿瘤坏死因子（TNF）等的产生的杂环衍生物，其可以由下式表示：（I） 它们的生产，涉及含有该组合物的药物组合物及其用途。
-
公开(公告)号：US6008230A
公开(公告)日：1999-12-28
申请号：US51093
申请日：1998-04-14
申请人： Teruo Oku , Yoshio Kawai , Shigeki Satoh , Hitoshi Yamazaki , Natsuko Kayakiri , Yasuharu Urano , Kousei Yoshihara , Noriko Yoshida
发明人： Teruo Oku , Yoshio Kawai , Shigeki Satoh , Hitoshi Yamazaki , Natsuko Kayakiri , Yasuharu Urano , Kousei Yoshihara , Noriko Yoshida
IPC分类号： A61K31/00 , A61K31/435 , A61K31/4353 , A61K31/4365 , A61K31/47 , A61K31/4706 , A61K31/472 , A61K31/4725 , A61K31/4738 , A61K31/4745 , A61K31/495 , A61K31/496 , A61K31/505 , A61K31/513 , A61K31/517 , A61K31/529 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K31/542 , A61P19/00 , A61P19/08 , C07D215/20 , C07D215/40 , C07D215/42 , C07D215/44 , C07D215/46 , C07D215/48 , C07D215/54 , C07D215/56 , C07D215/60 , C07D221/12 , C07D237/28 , C07D239/74 , C07D239/88 , C07D239/94 , C07D241/42 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D495/04 , C07D513/04 , C07D513/14 , C07D521/00 , C07F7/08 , C07F7/10 , C07F7/18
CPC分类号： C07D231/12 , C07D215/40 , C07D215/42 , C07D215/44 , C07D215/46 , C07D215/48 , C07D215/54 , C07D215/56 , C07D215/60 , C07D221/12 , C07D233/56 , C07D237/28 , C07D239/74 , C07D239/88 , C07D241/42 , C07D249/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D495/04 , C07D513/14 , C07F7/0812 , C07F7/1856
摘要： This invention relates to a quinoline compound of the formula: ##STR1## wherein R.sup.1 is a pyridyl group or aryl, each of which may be substituted with suitable substituent(s),A is --COHN-- or --NHCO--,n is an integer of 0 or 1, and ##STR2## is a group of the formula: ##STR3## In which R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 are as defined,and pharmaceutically acceptable salt thereof, to processes for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for the prevention and/or the treatment of bone diseases caused by abnormal bone metabolism in human being or animals.
摘要翻译： PCT No.PCT / JP96 / 02981 Sec。 371日期：1998年4月14日 102（e）1998年4月14日PCT PCT 1996年10月15日PCT公布。 公开号WO97 / 14681 日本特开2006年4月24日本发明涉及下式的喹啉化合物：其中R 1为吡啶基或芳基，其各自可被适当的取代基取代，A为-COHN-或-NHCO-，n为 0或1的整数，并且是下式的基团：其中R 2，R 3，R 4，R 5，R 6和R 7如上所定义，及其药学上可接受的盐，其制备方法， 以及用于预防和/或治疗由人或动物的异常骨代谢引起的骨疾病的方法。
-
-
-
-
-
-
-
-
-
搜索结果
135 条记录 (耗时 0.03 秒)
