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1.发明授权
公开(公告)号：US4996203A
公开(公告)日：1991-02-26
申请号：US362915
申请日：1989-06-08
申请人： Tesfaye Biftu , Robert L. Bugianesi , Nirindar N. Girotra , Mitree M. Ponpipom , Soumya P. Sahoo , Chan H. Kuo
发明人： Tesfaye Biftu , Robert L. Bugianesi , Nirindar N. Girotra , Mitree M. Ponpipom , Soumya P. Sahoo , Chan H. Kuo
IPC分类号： A61K31/34 , A61K31/341 , A61K31/40 , A61K31/41 , A61K31/415 , A61K31/425 , A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/54 , A61P1/04 , A61P9/00 , A61P9/02 , A61P11/08 , A61P13/02 , A61P15/00 , A61P29/00 , A61P37/08 , C07D307/12 , C07D307/14 , C07D307/16 , C07D307/18 , C07D307/20 , C07D307/42 , C07D405/04 , C07D405/10 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/10 , C07D417/04 , C07D417/12 , C07D521/00
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D307/12 , C07D307/14 , C07D307/16 , C07D307/18 , C07D307/20 , C07D307/42 , C07D405/04 , C07D405/12 , C07D405/14 , C07D407/12 , C07D417/04 , C07D417/12
摘要： The present invention is directed to a specifically substituted tetrahydrofuran of the formula (I) ##STR1## wherein R.sup.4 is an alkylthio, alkylsulfinyl or alkylsulfonyl containing group and at least one of the substituents at positions 3,4 or 5 contains a heterocyclic, heteroaryl or substituted phenylthio moiety.
摘要翻译： 本发明涉及式（I）的具体取代的四氢呋喃其中R 4是烷硫基，烷基亚磺酰基或烷基磺酰基基团，并且3,4或5位的至少一个取代基含有杂环，杂芳基或 取代的苯硫基部分。
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2.发明授权
公开(公告)号：US5114961A
公开(公告)日：1992-05-19
申请号：US624449
申请日：1990-12-10
申请人： Tesfaye Biftu , Robert L. Bugianesi , Nirindar N. Girotra , Mitree M. Ponpipom , Soumya P. Sahoo , Chan H. Kuo
发明人： Tesfaye Biftu , Robert L. Bugianesi , Nirindar N. Girotra , Mitree M. Ponpipom , Soumya P. Sahoo , Chan H. Kuo
IPC分类号： C07D307/12 , C07D405/12 , C07D417/12 , C07D521/00
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D307/12 , C07D405/12 , C07D417/12
摘要： The present invention is directed to a specifically substituted tetrahydrofuran of the formula (I) ##STR1## wherein R.sup.4 is an alkylthio, alkylsulfinyl or alkylsulfonyl containing group and at least one of the substituents at positions 3, 4 or 5 contains a heterocyclic, heteroaryl or substituted phenylthio moiety.
摘要翻译： 本发明涉及具体取代的式（I）的四氢呋喃，其中R 4是烷硫基，烷基亚磺酰基或烷基磺酰基基团，并且在3,4或5位上的至少一个取代基含有杂环，杂芳基或 取代的苯硫基部分。
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公开(公告)号：US5001123A
公开(公告)日：1991-03-19
申请号：US362907
申请日：1989-06-08
申请人： Tesfaye Biftu , Nirindar N. Girotra , Robert L. Bugianesi , Mitree M. Ponpipom , Soumya P. Sahoo , Chan H. Kuo
发明人： Tesfaye Biftu , Nirindar N. Girotra , Robert L. Bugianesi , Mitree M. Ponpipom , Soumya P. Sahoo , Chan H. Kuo
IPC分类号： A61K31/44 , A61K31/443 , A61K31/445 , A61K31/495 , A61K31/54 , A61P3/00 , A61P9/00 , A61P9/08 , A61P9/10 , A61P11/00 , A61P37/08 , C07D405/04 , C07D405/14 , C07D417/14 , C07D521/00 , C07F9/6558
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D405/04 , C07D405/14 , C07F9/65586
摘要： The present invention is directed to a specifically substituted tetrahydrofuran of the formula (I) ##STR1## wherein Ar is a pyridyl, a dimethoxy-pyridyl or dimethoxy-pyrazyl group, R.sup.4 is an alkylthio, alkylsulfinyl or alkylsulfonyl containing group and at least one of the substituents at positions 3,4 or 5 contains a heterocyclic, heteroaryl or substituted phenylthio group.
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4.发明授权
公开(公告)号：US4977146A
公开(公告)日：1990-12-11
申请号：US505712
申请日：1990-04-11
IPC分类号： A61K31/34 , A61K31/341 , A61K31/67 , A61P1/04 , A61P7/02 , A61P9/02 , A61P11/00 , A61P11/08 , A61P29/00 , A61P37/06 , A61P37/08 , C07D20060101 , C07D307/12 , C07F9/09 , C07F9/655
CPC分类号： C07D307/12
摘要： The present invention is directed to a specifically substituted tetrahydrofuran of the formula (I) ##STR1## wherein R.sup.4 is an alkylthio, alkylsulfinyl or alkylsulfonyl containing group, Y is an alkyl or substituted alkyl group, R.sup.6 is an alkyl or a substituted alkyl group and the substituents at positions 3, 4 or 5 are acyclic.
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5.发明授权
公开(公告)号：US5011847A
公开(公告)日：1991-04-30
申请号：US362909
申请日：1989-06-08
IPC分类号： A61K31/44 , A61K31/443 , A61K31/495 , A61P1/04 , A61P3/00 , A61P9/00 , A61P9/08 , A61P9/10 , A61P11/00 , A61P37/08 , C07D405/04 , C07F9/6558
CPC分类号： C07D405/04 , C07F9/65586
摘要： The present invention is directed to a specifically substituted tetrahydrofuran of the formula (I) ##STR1## wherein Ar is a pyridyl, dimethoxy-pyridyl or a dimethoxy-pyrazinyl group, R.sup.4 is an alkylthio, alkylsulfinyl or alkylsulfonyl containing group, Y is an alkyl or substituted alkyl group, R.sup.6 is an alkyl or a substituted alkyl and the substituents at positions 3, 4 and 5 are acyclic.
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