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1.发明申请POLYPEPTIDES FOR INDUCING A PROTECTIVE IMMUNE RESPONSE AGAINST STAPHYLOCOCCUS AUREUS 审中-公开诱导针对维生素A的保护性免疫应答的多肽公开(公告)号：US20110229509A1
公开(公告)日：2011-09-22
申请号：US13130974
申请日：2009-11-18
IPC分类号： A61K39/085 , C07K14/31 , C07H21/00 , C12N15/63 , C12N1/00 , C12N5/10 , C12P21/02 , A61P31/04 , A61P37/04
CPC分类号： A61K39/085 , A61K2039/55505 , C07K14/31
摘要： Disclosed are polypeptides comprising an amino acid sequence structurally related to SEQ ID NO 1 and uses of such polypeptides and compositions thereof. SEQ ID NO 1 is a full length S. aureus sequence. A derivative of SEQ ID NO 1 containing an amino terminal his-tag was found to produce a protective immune response against S. aureus.
摘要翻译： 公开了包含与SEQ ID NO 1结构相关的氨基酸序列的多肽以及这种多肽及其组合物的用途。 SEQ ID NO 1是全长金黄色葡萄球菌序列。 发现含有氨基末端his标签的SEQ ID NO 1的衍生物产生针对金黄色葡萄球菌的保护性免疫应答。
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2.发明申请POLYPEPTIDES FOR INDUCING A PROTECTIVE IMMUNE RESPONSE AGAINST STAPHYLOCOCCUS AUREUS 审中-公开诱导针对维生素A的保护性免疫应答的多肽公开(公告)号：US20110229508A1
公开(公告)日：2011-09-22
申请号：US13130964
申请日：2009-11-18
CPC分类号： C07K14/31 , A61K39/085 , A61K2039/55505
摘要： The present invention features polypeptides comprising an amino acid sequence structurally related to SEQ ID NO: 1 and uses of such polypeptides and compositions thereof. SEQ ID NO: 1 is a full length S. aureus sequence. A derivative of SEQ ID NO: 1 containing an amino terminus his-tag was found to produce a protective immune response against S. aureus.
摘要翻译： 本发明的特征在于包含与SEQ ID NO：1结构相关的氨基酸序列的多肽及其多肽及其组合物的用途。 SEQ ID NO：1是全长金黄色葡萄球菌序列。 发现含有氨基末端his标签的SEQ ID NO：1的衍生物产生针对金黄色葡萄球菌的保护性免疫应答。
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3.发明申请POLYPEPTIDES FOR INDUCING A PROTECTIVE IMMUNE RESPONSE AGAINST STAPHYLOCOCCUS AUREUS 审中-公开诱导针对维生素A的保护性免疫应答的多肽公开(公告)号：US20100203588A1
公开(公告)日：2010-08-12
申请号：US12720076
申请日：2010-03-09
摘要： The present invention features polypeptides comprising an amino acid sequence structurally related to SEQ ID NO: 1 or a fragment thereof, S. aureus AhpC-AhpF compositions, and uses of such polypeptides and compositions. SEQ ID NO: 1 has a full length S. aureus AhpC sequence. A derivative of SEQ ID NO: 1 containing an amino His-tag and three additional carboxylamino acids was found to produce a protective immune response against S. aureus.
摘要翻译： 本发明的特征在于包含与SEQ ID NO：1结构相关的氨基酸序列或其片段，金黄色葡萄球菌AhpC-AhpF组合物以及这些多肽和组合物的用途的多肽。 SEQ ID NO：1具有全长金黄色葡萄球菌AhpC序列。 发现含有氨基His-标签和三个另外的羧基氨基酸的SEQ ID NO：1的衍生物产生针对金黄色葡萄球菌的保护性免疫应答。
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4.发明授权Polypeptides for inducing a protective immune response against Staphylococcus aureus 有权用于诱导针对金黄色葡萄球菌的保护性免疫应答的多肽公开(公告)号：US07718182B2
公开(公告)日：2010-05-18
申请号：US11795538
申请日：2006-01-17
IPC分类号： A61K39/085 , C12P21/04 , C07H21/02 , C07H21/04 , C07K14/31
摘要： The present invention features polypeptides comprising an amino acid sequence structurally related to SEQ ID NO: 1 or a fragment thereof, S. aureus AhpC-AhpF compositions, and uses of such polypeptides and compositions. SEQ ID NO: 1 has a full length S. aureus AhpC sequence. A derivative of SEQ ID NO: 1 containing an amino His-tag and three additional carboxyl amino acids was found to produce a protective immune response against S. aureus. MGHHHHHHHHHHSSGHIEGRHMSLINKEILPFTAQAFDPKKDQFKEVTQE DLKGSWSVVCFYPADFSFVCPTELEDLQNQYEELQKLGVNVFSVSTDTHF VHKAWHDHSDAISKITYTMIGDPSQTITRNDVLDEATGLAQRGTFIIDPD GVVQASEINADGIGRDASTLAHKIKAAQYVRKNPGEVCPAKWEEGAKTLQ PGLDLVGKIAEQ
摘要翻译： 本发明的特征在于包含与SEQ ID NO：1结构相关的氨基酸序列或其片段，金黄色葡萄球菌AhpC-AhpF组合物以及这些多肽和组合物的用途的多肽。 SEQ ID NO：1具有全长金黄色葡萄球菌AhpC序列。 发现含有氨基His标签和三个另外的羧基氨基酸的SEQ ID NO：1的衍生物产生针对金黄色葡萄球菌的保护性免疫应答。 Q Q H HI R H INK INK S HI Q Q Q Q
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5.发明申请Polypeptides for Inducing a Protective Immune Response Against Staphylococcus Aureus 有权用于诱导针对金黄色葡萄球菌的保护性免疫反应的多肽公开(公告)号：US20080131447A1
公开(公告)日：2008-06-05
申请号：US11795538
申请日：2006-01-17
IPC分类号： A61K39/00 , C07K2/00 , C07H21/00 , C12P21/00 , C07K16/00 , A61P31/04 , C07K14/00 , C12N1/00 , C07K7/06
摘要： The present invention features polypeptides comprising an amino acid sequence structurally related to SEQ ID NO: 1 or a fragment thereof, S. aureus AhpC-AhpF compositions, and uses of such polypeptides and compositions. SEQ ID NO: 1 has a full length S. aureus AhpC sequence. A derivative of SEQ ID NO: 1 containing an amino His-tag and three additional carboxyl amino acids was found to produce a protective immune response against S. aureus. MGHHHHHHHHHHSSGHIEGRHMSLINKEILPFTAQAFDPKKDQFKEVTQE DLKGSWSVVCFYPADFSFVCPTELEDLQNQYEELQKLGVNVFSVSTDTHF VHKAWHDHSDAISKITYTMIGDPSQTITRNDVLDEATGLAQRGTFIIDPD GVVQASEINADGIGRDASTLAHKIKAAQYVRKNPGEVCPAKWEEGAKTLQ PGLDLVGKIAEQ
摘要翻译： 本发明的特征在于包含与SEQ ID NO：1结构相关的氨基酸序列或其片段，金黄色葡萄球菌AhpC-AhpF组合物以及这些多肽和组合物的用途的多肽。 SEQ ID NO：1具有全长金黄色葡萄球菌AhpC序列。 发现含有氨基His标签和三个另外的羧基氨基酸的SEQ ID NO：1的衍生物产生针对金黄色葡萄球菌的保护性免疫应答。
MGHHHHHHHHHHSSGHIEGRH MSLINKEILPFTAQAFDPKKDQFKEVTQE DLKGSWSVVCFYPADFSFVCPTELEDLQNQYEELQKLGVNVFSVSTDTHF VHKAWHDHSDAISKITYTMIGDPSQTITRNDVLDEATGLAQRGTFIIDPD GVVQASEINADGIGRDASTLAHKIKAAQYVRKNPGEVCPAKWEEGAKTLQ PGLDLVGKI AEQ -
公开(公告)号：US07700103B2
公开(公告)日：2010-04-20
申请号：US10594064
申请日：2005-03-18
CPC分类号： C07K14/005 , A61K2039/5258 , C12N7/00 , C12N2710/20022 , C12N2710/20023
摘要： Synthetic DNA molecules encoding the HPV 52 L1 protein are provided. Specifically, the present invention provides polynucleotides encoding HPV 52 L1 protein, wherein said polynucleotides are codon-optimized for high level expression in a yeast cell. In alternative embodiments of the invention, the nucleotide sequence of the synthetic molecule is altered to eliminate transcription termination signals that are recognized by yeast. The synthetic molecules may be used to produce HPV 52 virus-like particles (VLPs), and to produce vaccines and pharmaceutical compositions comprising the HPV 52 VLPs. The vaccines of the present invention provide effective immunoprophylaxis against papillomavirus infection through neutralizing antibody and cell-mediated immunity and may also be useful for treatment of existing HPV infections.
摘要翻译： 提供了编码HPV 52 L1蛋白的合成DNA分子。 具体地，本发明提供编码HPV 52 L1蛋白的多核苷酸，其中所述多核苷酸在酵母细胞中用于高水平表达的密码子优化。 在本发明的替代实施方案中，改变合成分子的核苷酸序列以消除由酵母识别的转录终止信号。 合成分子可用于产生HPV 52病毒样颗粒（VLP），并且生产包含HPV 52 VLP的疫苗和药物组合物。 本发明的疫苗通过中和抗体和细胞介导的免疫提供对乳头瘤病毒感染的有效免疫预防，并且还可用于治疗现有的HPV感染。
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公开(公告)号：US20080138361A1
公开(公告)日：2008-06-12
申请号：US11805453
申请日：2007-05-23
IPC分类号： A61K39/12 , A61P31/20 , C07K14/025 , C12P21/00
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/5258 , C12N7/00 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034
摘要： Synthetic DNA molecules encoding the HPV45 L1 protein are provided. Specifically, the present invention provides polynucleotides encoding HPV45 L1 protein, wherein said polynucleotides have been codon-optimized for high level expression in a yeast cell. The synthetic molecules may be used to produce HPV45 virus-like particles (VLPs), and to produce vaccines and pharmaceutical compositions comprising the HPV45 VLPs. The vaccines of the present invention provide effective immunoprophylaxis against papillomavirus infection through neutralizing antibody and cell-mediated immunity.
摘要翻译： 提供了编码HPV45 L1蛋白的合成DNA分子。 具体地，本发明提供了编码HPV45 L1蛋白的多核苷酸，其中所述多核苷酸已被密码子优化用于酵母细胞中的高水平表达。 合成分子可用于产生HPV45病毒样颗粒（VLP），以及产生包含HPV45 VLP的疫苗和药物组合物。 本发明的疫苗通过中和抗体和细胞介导的免疫来提供对乳头瘤病毒感染的有效免疫预防。
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公开(公告)号：US20080166371A1
公开(公告)日：2008-07-10
申请号：US11879905
申请日：2007-07-19
IPC分类号： A61K39/12 , C07K14/025 , C12P21/00
CPC分类号： C07K14/005 , A61J1/035 , A61J7/04 , A61K31/66 , A61K31/675 , A61K2039/5258 , C12N7/00 , C12N2710/20022 , C12N2710/20023 , C12N2800/22
摘要： Synthetic DNA molecules encoding the HPV31 L1 protein are provided. Specifically, the present invention provides polynucleotides encoding HPV31 L1 protein, wherein said polynucleotides are free from internal transcription termination signals that are recognized by yeast. Also provided are synthetic polynucleotides encoding HPV31 L1 wherein the polynucleotides have been codon-optimized for high level expression in a yeast cell. The synthetic molecules may be used to produce HPV31 virus-like particles (VLPs), and to produce vaccines and pharmaceutical compositions comprising the HPV31 VLPs. The vaccines of the present invention provide effective immunoprophylaxis against papillomavirus infection through neutralizing antibody and cell-mediated immunity.
摘要翻译： 提供编码HPV31 L1蛋白的合成DNA分子。 具体地，本发明提供编码HPV31 L1蛋白的多核苷酸，其中所述多核苷酸不含被酵母识别的内部转录终止信号。 还提供了编码HPV31 L1的合成多核苷酸，其中多核苷酸已被密码子优化用于酵母细胞中的高水平表达。 合成分子可用于产生HPV31病毒样颗粒（VLP），以及生产包含HPV31 VLP的疫苗和药物组合物。 本发明的疫苗通过中和抗体和细胞介导的免疫来提供对乳头瘤病毒感染的有效免疫预防。
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公开(公告)号：US07001995B1
公开(公告)日：2006-02-21
申请号：US09642405
申请日：2000-08-21
申请人： Michael P Neeper , William L. McClements , Kathrin U. Jansen , Loren D. Schultz , Ling Chen , Xin-Min Wang
发明人： Michael P Neeper , William L. McClements , Kathrin U. Jansen , Loren D. Schultz , Ling Chen , Xin-Min Wang
CPC分类号： C07K14/005 , A61K39/00 , C12N2710/10343 , C12N2710/20022
摘要： Synthetic DNA molecules encoding papillomavirus proteins are provided. The codons of the synthetic molecules are codons preferred by the projected host cell. The synthetic molecules may be used as a polynucleotide vaccine which provides effective immunoprophylaxis against papillomavirus infection through stimulation of neutralizing antibody and cell-mediated immunity.
摘要翻译： 提供编码乳头瘤病毒蛋白的合成DNA分子。 合成分子的密码子是被投影的宿主细胞优选的密码子。 合成分子可以用作多核苷酸疫苗，其通过刺激中和抗体和细胞介导的免疫来提供对乳头瘤病毒感染的有效免疫预防。
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公开(公告)号：US20100272749A1
公开(公告)日：2010-10-28
申请号：US12321797
申请日：2009-01-26
CPC分类号： C07K14/005 , A61K48/00 , A61K2039/5256 , A61K2039/5258 , C12N7/00 , C12N2710/20022 , C12N2710/20023 , C12N2800/22
摘要： Synthetic DNA molecules encoding the HPV58 L1 protein are provided. Specifically, the present invention provides polynucleotides encoding HPV58 L1 protein, wherein said polynucleotides are codon-optimized for high level expression in a yeast cell. The synthetic molecules may be used to produce HPV58 virus-like particles (VLPs), and to produce vaccines and pharmaceutical compositions comprising the HPV58 VLPs. The vaccines of the present invention provide effective immunoprophylaxis against papillomavirus infection through neutralizing antibody and cell-mediated immunity and are also useful for treatment of existing HPV infections.
摘要翻译： 提供编码HPV58 L1蛋白的合成DNA分子。 具体地，本发明提供了编码HPV58L1蛋白的多核苷酸，其中所述多核苷酸在酵母细胞中用于高水平表达的密码子优化。 合成分子可用于产生HPV58病毒样颗粒（VLP），以及产生包含HPV58 VLP的疫苗和药物组合物。 本发明的疫苗通过中和抗体和细胞介导的免疫提供对乳头瘤病毒感染的有效免疫预防性，并且也可用于治疗现有的HPV感染。
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