公开(公告)号：US20170333371A1

公开(公告)日：2017-11-23

申请号：US15525375

申请日：2015-11-12

Applicant: The Brigham and Women`s Hospital, Inc.

Inventor： Mauricio Farez ,  Francisco J. Quintana ,  Jorge Correale

IPC: A61K31/165 ,  C07D209/16 ,  A61K31/343 ,  G01N33/74 ,  A61K31/4045 ,  A61K45/06

CPC classification number: A61K31/165 ,  A61K31/202 ,  A61K31/343 ,  A61K31/4045 ,  A61K45/06 ,  C07D209/16 ,  G01N33/74 ,  G01N2800/285 ,  G01N2800/50 ,  G01N2800/52

Abstract: Methods for treating, or reducing risk of developing, seasonal worsening of multiple sclerosis (MS) in a subject who has MS, comprising administering a melatonin agonist to a subject.

公开(公告)号：US20220323521A1

公开(公告)日：2022-10-13

申请号：US17637771

申请日：2020-08-26

Applicant: The Brigham and Women`s Hospital, Inc. ,  THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO

Inventor： Francisco J. Quintana ,  Benjamin M. Scott ,  Sergio G. Peisajovich ,  Belinda S. W. Chang

IPC: A61K36/064 ,  C07K14/72 ,  C12N9/14 ,  C07K14/47 ,  C07K14/565 ,  C07K14/55 ,  C07K14/54 ,  A61P37/06

Abstract: Described herein are microbial probiotics that, in response to metabolite extracellular ATP (eATP) produced in the microenvironment of inflamed tissues detected, e.g., via an engineered mammalian P2Y2 receptor, secrete an anti-inflammatory protein, e.g., IL-2, IL-10, or the CD39-like eATP-degrading enzyme apyrase. Thus, provided herein is an isolated Saccharomyces cell (or cells, e.g., a population of such cells) that has been engineered to express one, two, or all three exogenous proteins selected from: (I) a mammalian P2Y purinoceptor 2 (P2Y2) protein, preferably human P2Y2; 15 (ii) a mutant Gpa1 protein comprising at least 5 C-terminal residues from a mammalian G alpha, preferably Gai3, wherein the mutant Gpa1 protein couples the P2Y2 protein to the yeast mating pathway; and (iii) an anti-inflammatory protein.

公开(公告)号：US20180071376A1

公开(公告)日：2018-03-15

申请号：US15560276

申请日：2016-03-23

Applicant: The Brigham and Women`s Hospital, Inc.

Inventor： Ada Yeste Bornal ,  Francisco J. Quintana

IPC: A61K39/00 ,  A61K31/427 ,  A61K45/06 ,  A61K35/17 ,  A61K31/135 ,  A61K47/69 ,  A61K47/52

CPC classification number: A61K39/0008 ,  A61K31/135 ,  A61K31/427 ,  A61K35/17 ,  A61K38/00 ,  A61K45/06 ,  A61K47/52 ,  A61K47/6923 ,  A61K47/6929 ,  A61K2039/55555 ,  A61K2039/577 ,  A61P3/10 ,  C07K14/4702

Abstract: Methods and compositions for increasing the number and/or activity of regulatory T cells (Tregs) in vivo and in vitro, to induce tolerance to diabetogenic autoantigens.

公开(公告)号：US20240189289A1

公开(公告)日：2024-06-13

申请号：US18278078

申请日：2022-03-04

Applicant: The Brigham and Women`s Hospital, Inc.

Inventor： Francisco J. Quintana ,  Kevin Julian Hodgetts ,  Veit Johannes Rothhammer ,  Cristina Gutierrez Vazquez

IPC: A61K31/437 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/501 ,  A61K31/506 ,  A61P25/00

CPC classification number: A61K31/437 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/501 ,  A61K31/506 ,  A61P25/00

Abstract: The present application provides EphB3 kinase inhibitors, useful intreating neurodegenerative or demyelinating diseases or conditions such as autoimmune encephalomyelitis and multiple sclerosis.

公开(公告)号：US20180125971A1

公开(公告)日：2018-05-10

申请号：US15782606

申请日：2017-10-12

Applicant: The Brigham and Women`s Hospital, Inc.

Inventor： Howard Weiner ,  Francisco J. Quintana

IPC: A61K39/395 ,  G01N33/50 ,  A61K31/427 ,  A61K31/137 ,  A61K31/357 ,  C12N5/0783 ,  A61K31/135 ,  A61K31/407 ,  A61K31/405 ,  A61K31/4045 ,  A61K35/12

CPC classification number: A61K39/3955 ,  A61K31/135 ,  A61K31/137 ,  A61K31/357 ,  A61K31/4045 ,  A61K31/405 ,  A61K31/407 ,  A61K31/427 ,  A61K35/17 ,  A61K2035/122 ,  C12N5/0636 ,  C12N2501/38 ,  C12N2501/60 ,  G01N33/5088

Abstract: Methods for identifying compounds that modulate the generation of regulatory T cells (Treg) in vivo and in vitro, i.e., compounds that act on the transcription factors that increase or decrease expression of Foxp3.

公开(公告)号：US20240151709A1

公开(公告)日：2024-05-09

申请号：US18279778

申请日：2022-03-01

Applicant: The Brigham and Women`s Hospital, Inc.

Inventor： Francisco J. Quintana ,  Michael A. Wheeler ,  Iain C. Clark

IPC: G01N33/50 ,  C12N15/86

CPC classification number: G01N33/5032 ,  C12N15/86 ,  G01N33/5023 ,  G01N33/5058 ,  C12N2760/20122 ,  C12N2760/20143 ,  C12N2760/20162 ,  G01N2333/145

Abstract: The present application relates to compositions and methods for tracing cell networks, e.g., for investigation of cell interactions in the CNS with single cell resolution.