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公开(公告)号:US20230009208A1
公开(公告)日:2023-01-12
申请号:US17848523
申请日:2022-06-24
申请人: The Brigham and Women’s Hospital, Inc. , President and Fellows of Harvard College , Vilnius University
摘要: A system and method are provided for harvesting target biological substances. The system includes a substrate and a first and second channel formed in the substrate. The channels longitudinally extending substantially parallel to each other. A series of gaps extend from the first channel to the second channel to create a fluid communication path passing between a series of columns with the columns being longitudinally separated by a predetermined separation distance. The system also includes a first source configured to selectively introduce into the first channel a first biological composition at a first channel flow rate and a second source configured to selectively introduce into the second channel a second biological composition at a second channel flow rate. The sources are configured to create a differential between the first and second channel flow rates to generate physiological shear rates along the second channel that are bounded within a predetermined range.
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公开(公告)号:US11850589B2
公开(公告)日:2023-12-26
申请号:US17848523
申请日:2022-06-24
申请人: The Brigham and Women's Hospital, Inc. , President and Fellows of Harvard College , Vilnius University
CPC分类号: B01L3/502753 , B01L3/502746 , B01L3/502776 , C12M23/16 , C12M23/20 , C12M25/02 , C12M29/04 , C12M29/10 , C12M29/20 , C12M41/36 , C12M41/40 , G01N33/86 , B01L2200/0647 , B01L2200/0668 , B01L2300/0681 , B01L2300/0816 , B01L2400/086 , G01N33/491 , G01N2800/222 , Y10T436/25375
摘要: A system and method are provided for harvesting target biological substances. The system includes a substrate and a first and second channel formed in the substrate. The channels longitudinally extending substantially parallel to each other. A series of gaps extend from the first channel to the second channel to create a fluid communication path passing between a series of columns with the columns being longitudinally separated by a predetermined separation distance. The system also includes a first source configured to selectively introduce into the first channel a first biological composition at a first channel flow rate and a second source configured to selectively introduce into the second channel a second biological composition at a second channel flow rate. The sources are configured to create a differential between the first and second channel flow rates to generate physiological shear rates along the second channel that are bounded within a predetermined range.
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公开(公告)号:US09795965B2
公开(公告)日:2017-10-24
申请号:US14758915
申请日:2013-11-20
申请人: BRIGHAM AND WOMEN'S HOSPITAL, INC. , PRESIDENT AND FELLOWS OF HARVARD COLLEGE , VILNIUS UNIVERSITY , Joseph Italiano , Linas Mazutis , Jonathan N. Thon , David A. Weitz
IPC分类号: G01N33/86 , G01N33/48 , B01L3/00 , C12M1/12 , C12M1/34 , C12M3/06 , C12M1/00 , C12M1/32 , C12N5/078 , G01N33/49
CPC分类号: B01L3/502753 , B01L3/502746 , B01L3/502776 , B01L2200/0647 , B01L2200/0668 , B01L2300/0681 , B01L2300/0816 , B01L2400/086 , C12M23/16 , C12M23/20 , C12M25/02 , C12M29/04 , C12M29/10 , C12M29/20 , C12M41/36 , C12M41/40 , G01N33/491 , G01N33/86 , G01N2800/222 , Y10T436/25375
摘要: A system and method are provided for harvesting target biological substances. The system includes a substrate and a first and second channel formed in the substrate. The channels longitudinally extending substantially parallel to each other. A series of gaps extend from the first channel to the second channel to create a fluid communication path passing between a series of columns with the columns being longitudinally separated by a predetermined separation distance. The system also includes a first source configured to selectively introduce into the first channel a first biological composition at a first channel flow rate and a second source configured to selectively introduce into the second channel a second biological composition at a second channel flow rate. The sources are configured to create a differential between the first and second channel flow rates to generate physiological shear rates along the second channel that are bounded within a predetermined range.
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公开(公告)号:US20150336095A1
公开(公告)日:2015-11-26
申请号:US14758915
申请日:2013-11-20
申请人: BRIGHAM AND WOMEN'S HOSPITAL, INC. , PRESIDENT AND FELLOWS OF HARVARD COLLEGE , VILNIUS UNIVERSITY
CPC分类号: B01L3/502753 , B01L3/502746 , B01L3/502776 , B01L2200/0647 , B01L2200/0668 , B01L2300/0681 , B01L2300/0816 , B01L2400/086 , C12M23/16 , C12M23/20 , C12M25/02 , C12M29/04 , C12M29/10 , C12M29/20 , C12M41/36 , C12M41/40 , G01N33/491 , G01N33/86 , G01N2800/222 , Y10T436/25375
摘要: A system and method are provided for harvesting target biological substances. The system includes a substrate and a first and second channel formed in the substrate. The channels longitudinally extending substantially parallel to each other. A series of gaps extend from the first channel to the second channel to create a fluid communication path passing between a series of columns with the columns being longitudinally separated by a predetermined separation distance. The system also includes a first source configured to selectively introduce into the first channel a first biological composition at a first channel flow rate and a second source configured to selectively introduce into the second channel a second biological composition at a second channel flow rate. The sources are configured to create a differential between the first and second channel flow rates to generate physiological shear rates along the second channel that are bounded within a predetermined range.
摘要翻译: 提供了用于收集目标生物物质的系统和方法。 该系统包括基板和形成在基板中的第一和第二通道。 纵向延伸的通道彼此平行。 一系列间隙从第一通道延伸到第二通道,以产生通过一系列柱之间的流体连通路径,其中柱纵向间隔预定间隔距离。 该系统还包括被配置为以第一通道流速选择性地将第一生物组合物引入第一通道的第一源和被配置为以第二通道流速选择性地将第二生物组合物引入第二通道的第二源。 源被配置为在第一和第二通道流量之间产生差分,以产生沿着第二通道的限制在预定范围内的生理剪切速率。
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公开(公告)号:US11566214B2
公开(公告)日:2023-01-31
申请号:US16792484
申请日:2020-02-17
申请人: BRIGHAM AND WOMEN'S HOSPITAL, INC. , President and Fellows of Harvard College , Vilnius University
摘要: Systems and methods generating physiologic models that can produce functional biological substances are provided. In some aspects, a system includes a substrate and a first and second channel formed therein. The channels extend longitudinally and are substantially parallel to each other. A series of apertures extend between the first channel and second channel to create a fluid communication path passing through columns separating the channels that extends further along the longitudinal dimension than other dimensions. The system also includes a first source configured to selectively introduce into the first channel a first biological composition at a first channel flow rate and a second source configured to selectively introduce into the second channel a second biological composition at a second channel flow rate, wherein the first channel flow rate and the second channel flow rate create a differential configured to generate physiological shear rates within a predetermined range in the channels.
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公开(公告)号:US10343163B2
公开(公告)日:2019-07-09
申请号:US15709989
申请日:2017-09-20
申请人: Brigham and Women's Hospital, Inc. , President and Fellows of Harvard College , Vilnius University
IPC分类号: B01L3/00 , G01N33/86 , G01N33/49 , C12M1/12 , C12M1/34 , C12M3/06 , C12M1/00 , C12M1/32 , C12N5/078
摘要: A system and method are provided for harvesting target biological substances. The system includes a substrate and a first and second channel formed in the substrate. The channels longitudinally extending substantially parallel to each other. A series of gaps extend from the first channel to the second channel to create a fluid communication path passing between a series of columns with the columns being longitudinally separated by a predetermined separation distance. The system also includes a first source configured to selectively introduce into the first channel a first biological composition at a first channel flow rate and a second source configured to selectively introduce into the second channel a second biological composition at a second channel flow rate. The sources are configured to create a differential between the first and second channel flow rates to generate physiological shear rates along the second channel that are bounded within a predetermined range.
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公开(公告)号:US20180021780A1
公开(公告)日:2018-01-25
申请号:US15709989
申请日:2017-09-20
申请人: Brigham and Women's Hospital, Inc. , President and Fellows of Harvard College , Vilnius University
CPC分类号: B01L3/502753 , B01L3/502746 , B01L3/502776 , B01L2200/0647 , B01L2200/0668 , B01L2300/0681 , B01L2300/0816 , B01L2400/086 , C12M23/16 , C12M23/20 , C12M25/02 , C12M29/04 , C12M29/10 , C12M29/20 , C12M41/36 , C12M41/40 , G01N33/491 , G01N33/86 , G01N2800/222 , Y10T436/25375
摘要: A system and method are provided for harvesting target biological substances. The system includes a substrate and a first and second channel formed in the substrate. The channels longitudinally extending substantially parallel to each other. A series of gaps extend from the first channel to the second channel to create a fluid communication path passing between a series of columns with the columns being longitudinally separated by a predetermined separation distance. The system also includes a first source configured to selectively introduce into the first channel a first biological composition at a first channel flow rate and a second source configured to selectively introduce into the second channel a second biological composition at a second channel flow rate. The sources are configured to create a differential between the first and second channel flow rates to generate physiological shear rates along the second channel that are bounded within a predetermined range.
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公开(公告)号:US20200255781A1
公开(公告)日:2020-08-13
申请号:US16792484
申请日:2020-02-17
申请人: BRIGHAM AND WOMEN'S HOSPITAL, INC. , President and Fellows of Harvard College , Vilnius University
摘要: Systems and methods generating physiologic models that can produce functional biological substances are provided. In some aspects, a system includes a substrate and a first and second channel formed therein. The channels extend longitudinally and are substantially parallel to each other. A series of apertures extend between the first channel and second channel to create a fluid communication path passing through columns separating the channels that extends further along the longitudinal dimension than other dimensions. The system also includes a first source configured to selectively introduce into the first channel a first biological composition at a first channel flow rate and a second source configured to selectively introduce into the second channel a second biological composition at a second channel flow rate, wherein the first channel flow rate and the second channel flow rate create a differential configured to generate physiological shear rates within a predetermined range in the channels.
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公开(公告)号:US10710073B2
公开(公告)日:2020-07-14
申请号:US16422030
申请日:2019-05-24
申请人: The Brigham and Women's Hospital, Inc. , President and Fellows of Harvard College , Vilnius University
摘要: A system and method are provided for harvesting target biological substances. The system includes a substrate and a first and second channel formed in the substrate. The channels longitudinally extending substantially parallel to each other. A series of gaps extend from the first channel to the second channel to create a fluid communication path passing between a series of columns with the columns being longitudinally separated by a predetermined separation distance. The system also includes a first source configured to selectively introduce into the first channel a first biological composition at a first channel flow rate and a second source configured to selectively introduce into the second channel a second biological composition at a second channel flow rate. The sources are configured to create a differential between the first and second channel flow rates to generate physiological shear rates along the second channel that are bounded within a predetermined range.
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公开(公告)号:US10590373B2
公开(公告)日:2020-03-17
申请号:US15300070
申请日:2015-03-30
申请人: BRIGHAM AND WOMEN'S HOSPITAL, INC. , PRESIDENT AND FELLOWS OF HARVARD COLLEGE , VILNIUS UNIVERSITY
摘要: Systems and methods generating physiologic models that can produce functional biological substances are provided. In some aspects, a system includes a substrate and a first and second channel formed therein. The channels extend longitudinally and are substantially parallel to each other. A series of apertures extend between the first channel and second channel to create a fluid communication path passing through columns separating the channels that extends further along the longitudinal dimension than other dimensions. The system also includes a first source configured to selectively introduce into the first channel a first biological composition at a first channel flow rate and a second source configured to selectively introduce into the second channel a second biological composition at a second channel flow rate, wherein the first channel flow rate and the second channel flow rate create a differential configured to generate physiological shear rates within a predetermined range in the channels.
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